Molecular mechanism of statin-mediated LOX-1 inhibition

Cell Cycle

Volumn 14, Issue 10, 2015, Pages 1583-1595

  Biocca, Silvia ^a   Iacovelli, Federico ^b   Matarazzo, Sara ^a   Vindigni, Giulia ^a   Oteri, Francesco ^c   Desideri, Alessandro ^b   Falconi, Mattia ^b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

LOX 1 receptor; Molecular docking; Molecular dynamics simulation; Monomer dimer ratio; Statin; Substrate recognition

Indexed keywords

ATORVASTATIN; C TYPE LECTIN LIKE DOMAIN; DIMER; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LECTIN; MEVINOLIN; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PITAVASTATIN; PRAVASTATIN; UNCLASSIFIED DRUG; FLUORESCENT DYE; LOW DENSITY LIPOPROTEIN; OLR1 PROTEIN, HUMAN; PROTEIN BINDING;

ARTICLE; CELL ASSAY; CELL MEMBRANE; COMPUTER MODEL; CONTROLLED STUDY; DIMERIZATION; DRUG EFFECT; DRUG MECHANISM; ELECTROPHORESIS; ENZYME INHIBITION; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS CELL LINE; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; FLUORESCENT DYES; HEK293 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPOPROTEINS, LDL; LOVASTATIN; MICROSCOPY, FLUORESCENCE; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SCAVENGER RECEPTORS, CLASS E;

EID: 84943759685     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2015.1026486     Document Type: Article

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