메뉴 건너뛰기




Volumn , Issue , 2015, Pages 25-47

The role of innate immune signaling in regulation of tumor-associated myeloid cells

Author keywords

Cancer; Immune suppression; Innate immunity; Myeloid derived suppressor cells (Mdscs); Tlr; Tumor Associated macrophages (Tams)

Indexed keywords


EID: 84943376382     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-4-431-55327-4_3     Document Type: Chapter
Times cited : (4)

References (129)
  • 1
    • 1642362512 scopus 로고    scopus 로고
    • Combined tlr and cd40 triggering induces potent cd8+t cell expansion with variable dependence on type i ifn
    • Ahonen CL, Doxsee CL, McGurran SM et al (2004) Combined TLR and CD40 triggering induces potent CD8+T cell expansion with variable dependence on type I IFN. J Exp Med 199:775–784. doi: 10.1084/jem.20031591
    • (2004) J Exp Med , vol.199 , pp. 775-784
    • Ahonen, C.L.1    Doxsee, C.L.2    McGurran, S.M.3
  • 2
    • 33846039130 scopus 로고    scopus 로고
    • Antitumor nk activation induced by the toll-like receptor 3-ticam-1 (Trif) pathway in myeloid dendritic cells
    • Akazawa T, Ebihara T, Okuno M et al (2007) Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells. Proc Natl Acad Sci U S A 104:252–257. doi: 10.1073/pnas.0605978104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 252-257
    • Akazawa, T.1    Ebihara, T.2    Okuno, M.3
  • 3
    • 84855817522 scopus 로고    scopus 로고
    • Immunology in the clinic review series; focus on cancer: Tumour associated macrophages: Undisputed stars of the inflammatory tumour microenvironment
    • Allavena P, Mantovani A (2012) Immunology in the clinic review series; focus on cancer: tumour associated macrophages: undisputed stars of the inflammatory tumour microenvironment. Clin Exp Immunol 167:195–205. doi: 10.1111/j.1365-2249.2011.04515
    • (2012) Clin Exp Immunol , vol.167 , pp. 195-205
    • Allavena, P.1    Mantovani, A.2
  • 4
    • 0035164478 scopus 로고    scopus 로고
    • Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer
    • Almand B, Clark JI, Nikitina E et al (2001) Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol 166:678–689
    • (2001) J Immunol , vol.166 , pp. 678-689
    • Almand, B.1    Clark, J.I.2    Nikitina, E.3
  • 5
    • 84876271525 scopus 로고    scopus 로고
    • Cross-priming for antitumor ctl induced by solubleag + polyi:C depends on the ticam-1 pathway in mouse cd11c(+)/cd8α(+) dendritic cells
    • Azuma M, Ebihara T, Oshiumi H et al (2012) Cross-priming for antitumor CTL induced by solubleAg + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8α(+) dendritic cells. Oncoimmunology 1:581–592. doi: 10.4161/onci.19893
    • (2012) Oncoimmunology , vol.1 , pp. 581-592
    • Azuma, M.1    Ebihara, T.2    Oshiumi, H.3
  • 6
    • 77949872871 scopus 로고    scopus 로고
    • Cancer and inflammation: Implications for pharmacology and therapeutics
    • Balkwill F, Mantovani A (2010) Cancer and inflammation: implications for pharmacology and therapeutics. Clin Pharmacol Ther 87:401–406. doi: 10.1038/clpt.2009.312
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 401-406
    • Balkwill, F.1    Mantovani, A.2
  • 7
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets:Cancer as a paradigm
    • Biswas SKS, Mantovani AA (2010) Macrophage plasticity and interaction with lymphocyte subsets:cancer as a paradigm. Nat Immunol 11:889–896. doi: 10.1038/ni.1937
    • (2010) Nat Immunol , vol.11 , pp. 889-896
    • Biswas, S.1    Mantovani, A.A.2
  • 8
    • 0025849163 scopus 로고
    • Tumor suppression after tumor-cell targeted tumornecrosis-factor-alpha gene-transfer
    • Blankenstein T, Qin ZH, Uberla K et al (1991) Tumor suppression after tumor-cell targeted tumornecrosis-factor-alpha gene-transfer. J Exp Med 173:1047–1052. doi: 10.1084/jem.173.5.1047
    • (1991) J Exp Med , vol.173 , pp. 1047-1052
    • Blankenstein, T.1    Qin, Z.H.2    Uberla, K.3
  • 9
    • 77949940198 scopus 로고    scopus 로고
    • Intracellular toll-like receptors
    • Blasius AL, Beutler B (2010) Intracellular toll-like receptors. Immunity 32:305–315. doi: 10.1016/j.immuni.2010.03.012
    • (2010) Immunity , vol.32 , pp. 305-315
    • Blasius, A.L.1    Beutler, B.2
  • 10
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated hsp72 from tumor-derived exosomes mediates stat3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • Chalmin F, Ladoire S, Mignot G et al (2010) Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest 120:457–471. doi: 10.1172/JCI40483
    • (2010) J Clin Invest , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3
  • 11
    • 34547469630 scopus 로고    scopus 로고
    • Macrophage polarization and insulin resistance: Pparγ in control
    • Charo IF (2007) Macrophage polarization and insulin resistance: PPARγ in control. Cell Metab 6:96–98. doi: 10.1016/j.cmet.2007.07.006
    • (2007) Cell Metab , vol.6 , pp. 96-98
    • Charo, I.F.1
  • 12
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by s100a9 protein
    • Cheng P, Corzo CA, Luetteke N et al (2008) Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J ExpMed 205:2235–2249. doi: 10.1084/jem.20080132
    • (2008) J Expmed , vol.205 , pp. 2235-2249
    • Cheng, P.1    Corzo, C.A.2    Luetteke, N.3
  • 13
    • 78650756969 scopus 로고    scopus 로고
    • Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
    • Condamine T, Gabrilovich DI (2011) Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol 32:19–25. doi: 10.1016/j.it.2010.10.002
    • (2011) Trends Immunol , vol.32 , pp. 19-25
    • Condamine, T.1    Gabrilovich, D.I.2
  • 14
    • 84863151366 scopus 로고    scopus 로고
    • Origins of tumor-associated macrophages and neutrophils
    • Cortez-Retamozo V, Etzrodt M, Newton A et al (2012) Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A 109:2491–2496. doi: 10.1073/pnas.1113744109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 2491-2496
    • Cortez-Retamozo, V.1    Etzrodt, M.2    Newton, A.3
  • 15
    • 78149330949 scopus 로고    scopus 로고
    • Hif-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo CA, Condamine T, Lu L et al (2010) HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med 207:2439–2453. doi: 10.1084/jem.20100587
    • (2010) J Exp Med , vol.207 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3
  • 16
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860–867. doi: 10.1038/nature01322
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 17
    • 84861787202 scopus 로고    scopus 로고
    • Dendritic cell-activating vaccine adjuvants differ in the ability to elicit antitumor immunity due to an adjuvant-specific induction of immune suppressive cells
    • Dang Y, Wagner WM, Gad E et al (2012) Dendritic cell-activating vaccine adjuvants differ in the ability to elicit antitumor immunity due to an adjuvant-specific induction of immune suppressive cells. Clin Cancer Res 18:3122–3131. doi: 10.1158/1078-0432.CCR-12-0113
    • (2012) Clin Cancer Res , vol.18 , pp. 3122-3131
    • Dang, Y.1    Wagner, W.M.2    Gad, E.3
  • 18
    • 84876424760 scopus 로고    scopus 로고
    • Macrophage regulation of tumor responses to anticancer therapies
    • De Palma M, Lewis CE (2013) Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell 23:277–286. doi: 10.1016/j.ccr.2013.02.013
    • (2013) Cancer Cell , vol.23 , pp. 277-286
    • De Palma, M.1    Lewis, C.E.2
  • 19
    • 34548644772 scopus 로고    scopus 로고
    • The histone h3 lysine-27 demethylase jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
    • De Santa F, Totaro MG, Prosperini E et al (2007) The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 130:1083–1094. doi: 10.1016/j.cell.2007.08.019
    • (2007) Cell , vol.130 , pp. 1083-1094
    • De Santa, F.1    Totaro, M.G.2    Prosperini, E.3
  • 20
    • 67651160649 scopus 로고    scopus 로고
    • Cd4(+) t cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • DeNardo DG, Barreto JB, Andreu P et al (2009) CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16:91–102. doi: 10.1016/j.ccr.2009.06.018
    • (2009) Cancer Cell , vol.16 , pp. 91-102
    • DeNardo, D.G.1    Barreto, J.B.2    Reu, P.3
  • 21
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy
    • Diaz-Montero CM, Salem ML, Nishimura MI et al (2009) Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy. Cancer Immunol Immunother 58:49–59. doi: 10.1007/s00262-008-0523-4
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3
  • 22
    • 75649141166 scopus 로고    scopus 로고
    • Identification of a polyi: C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation
    • Ebihara T, Azuma M, Oshiumi H et al (2010) Identification of a polyI: C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation. J Exp Med 207:2675–2687. doi: 10.1084/jem.20091573
    • (2010) J Exp Med , vol.207 , pp. 2675-2687
    • Ebihara, T.1    Azuma, M.2    Oshiumi, H.3
  • 23
    • 67649208478 scopus 로고    scopus 로고
    • The endogenous toll-like receptor 4 agonist s100a8/s100a9 (Calprotectin) as innate amplifier of infection, autoimmunity, and cancer
    • Ehrchen JM, Sunderkötter C, Foell D (2009) The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol 86:557–566. doi: 10.1189/jlb.1008647
    • (2009) J Leukoc Biol , vol.86 , pp. 557-566
    • Ehrchen, J.M.1    Sunderkötter, C.2    Foell, D.3
  • 24
    • 64849106667 scopus 로고    scopus 로고
    • Tumor-specific bacteriophages induce tumor destruction through activation of tumor-associated macrophages
    • Eriksson F, Tsagozis P, Lundberg K et al (2009) Tumor-specific bacteriophages induce tumor destruction through activation of tumor-associated macrophages. J Immunol 182(5):3105–3111. doi: 10.4049/jimmunol.0800224
    • (2009) J Immunol , vol.182 , Issue.5 , pp. 3105-3111
    • Eriksson, F.1    Tsagozis, P.2    Lundberg, K.3
  • 25
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by tlr induced chromatin modifications
    • Foster SL, Hargreaves DC, Medzhitov R (2007) Gene-specific control of inflammation by TLR induced chromatin modifications. Nature 447:972–978. doi: 10.1038/nature05836
    • (2007) Nature , vol.447 , pp. 972-978
    • Foster, S.L.1    Hargreaves, D.C.2    Medzhitov, R.3
  • 26
    • 33745003285 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide induces hif-1 activation in human monocytes via p44/42 mapk and nf-kappab
    • Frede S, Stockmann C, Freitag P, Fandrey J (2006) Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem J 396(3):517–527. doi: 10.1042/BJ20051839
    • (2006) Biochem J , vol.396 , Issue.3 , pp. 517-527
    • Frede, S.1    Stockmann, C.2    Freitag, P.3    Fandrey, J.4
  • 27
    • 84860484044 scopus 로고    scopus 로고
    • Tumor-associated neutrophils: Friend or foe?
    • Fridlender ZG, Albelda SM (2012) Tumor-associated neutrophils: friend or foe? Carcinogenesis 33:949–955. doi: 10.1093/carcin/bgs123
    • (2012) Carcinogenesis , vol.33 , pp. 949-955
    • Fridlender, Z.G.1    Albelda, S.M.2
  • 28
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • Gabrilovich D (2004) Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol 4:941–952. doi: 10.1038/nri1498
    • (2004) Nat Rev Immunol , vol.4 , pp. 941-952
    • Gabrilovich, D.1
  • 29
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9:162–174. doi: 10.1038/nri2506
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 31
    • 84884151496 scopus 로고    scopus 로고
    • Tumor associated macrophages and neutrophils in cancer
    • Galdiero MR, Bonavita E, Barajon I et al (2013) Tumor associated macrophages and neutrophils in cancer. Immunobiology 218:1402–1410. doi: 10.1016/j.imbio.2013.06.003
    • (2013) Immunobiology , vol.218 , pp. 1402-1410
    • Galdiero, M.R.1    Bonavita, E.2    Barajon, I.3
  • 32
    • 84872801225 scopus 로고    scopus 로고
    • Trial watch: Experimental toll-like receptor agonists for cancer therapy
    • Galluzzi L, Vacchelli E, Eggermont A et al (2012) Trial watch: experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology 1:699–716. doi: 10.4161/onci.20696
    • (2012) Oncoimmunology , vol.1 , pp. 699-716
    • Galluzzi, L.1    Vacchelli, E.2    Eggermont, A.3
  • 33
    • 84873597334 scopus 로고    scopus 로고
    • Role of macrophage targeting in the antitumor activity of trabectedin
    • Germano G, Frapolli R, Belgiovine C et al (2013) Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell 23:249–262. doi: 10.1016/j.ccr.2013.01.008
    • (2013) Cancer Cell , vol.23 , pp. 249-262
    • Germano, G.1    Frapolli, R.2    Belgiovine, C.3
  • 34
    • 79953328298 scopus 로고    scopus 로고
    • Tumor-associated neutrophils: New targets for cancer therapy
    • Gregory AD, Houghton AM (2011) Tumor-associated neutrophils: new targets for cancer therapy. Cancer Res 71:2411–2416. doi: 10.1158/0008-5472.CAN-10-2583
    • (2011) Cancer Res , vol.71 , pp. 2411-2416
    • Gregory, A.D.1    Houghton, A.M.2
  • 35
    • 17144398046 scopus 로고    scopus 로고
    • Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    • Guiducci C, Vicari AP, Sangaletti S et al (2005) Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res 65:3437–3446.
    • (2005) Cancer Res , vol.65 , pp. 3437-3446
    • Guiducci, C.1    Vicari, A.P.2    Sangaletti, S.3
  • 36
    • 84943421400 scopus 로고    scopus 로고
    • doi: 10.1158/0008-5472.CAN-04-4262
  • 37
    • 45149134605 scopus 로고    scopus 로고
    • Re-educating tumor-associated macrophages by targeting nf-kappa b
    • Hagemann T, Lawrence T, McNeish I et al (2008) “Re-educating” tumor-associated macrophages by targeting NF-kappa B. J Exp Med 205:1261–1268. doi: 10.1084/jem.20080108
    • (2008) J Exp Med , vol.205 , pp. 1261-1268
    • Hagemann, T.1    Lawrence, T.2    McNeish, I.3
  • 38
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM (2012) Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21:309–322. doi: 10.1016/j.ccr.2012.02.022
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 39
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA (2010) Hallmarks of cancer: the next generation. Cell 144:646–674. doi: 10.1016/j.cell.2011.02.013
    • (2010) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 40
    • 70249140303 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells down-regulatel-selectin expression on cd4+ and cd8+t cells
    • Hanson EM, Clements VK, Sinha P et al (2009) Myeloid-derived suppressor cells down-regulateL-selectin expression on CD4+ and CD8+T cells. J Immunol 183:937–944. doi: 10.4049/jimmunol.0804253
    • (2009) J Immunol , vol.183 , pp. 937-944
    • Hanson, E.M.1    Clements, V.K.2    Sinha, P.3
  • 41
    • 33751504690 scopus 로고    scopus 로고
    • Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
    • Hiratsuka S, Watanabe A, Aburatani H, Maru Y (2006) Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 8:1369–1375. doi: 10.1038/ncb1507
    • (2006) Nat Cell Biol , vol.8 , pp. 1369-1375
    • Hiratsuka, S.1    Watanabe, A.2    Aburatani, H.3    Maru, Y.4
  • 42
    • 55549128598 scopus 로고    scopus 로고
    • The s100a8-serum amyloid a3-tlr4 paracrine cascade establishes a pre-metastatic phase
    • Hiratsuka S, Watanabe A, Sakurai Y et al (2008) The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat Cell Biol 10:1349–1355. doi: 10.1038/ncb1794
    • (2008) Nat Cell Biol , vol.10 , pp. 1349-1355
    • Hiratsuka, S.1    Watanabe, A.2    Sakurai, Y.3
  • 43
    • 33748051738 scopus 로고    scopus 로고
    • Irfs: Master regulators of signalling by toll-like receptors and cytosolic pattern-recognition receptors
    • Honda K, Taniguchi T (2006) IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 6:644–658. doi: 10.1038/nri1900
    • (2006) Nat Rev Immunol , vol.6 , pp. 644-658
    • Honda, K.1    Taniguchi, T.2
  • 44
    • 34547736572 scopus 로고    scopus 로고
    • Crosstalk among jak-stat, toll-like receptor, and itam-dependent pathways in macrophage activation
    • Hu X, Chen J, Wang L, Ivashkiv LB (2007) Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. J Leukoc Biol 82:237–243. doi: 10.1189/jlb.1206763
    • (2007) J Leukoc Biol , vol.82 , pp. 237-243
    • Hu, X.1    Chen, J.2    Wang, L.3    Ivashkiv, L.B.4
  • 45
    • 31544446571 scopus 로고    scopus 로고
    • Gr-1+cd115+ immature myeloid suppressor cells mediate the development of tumor-induced t regulatory cells and t-cell anergy in tumor-bearing host
    • Huang B, Pan P-Y, Li Q et al (2006) Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 66:1123–1131. doi: 10.1158/0008-5472.CAN-05-1299
    • (2006) Cancer Res , vol.66 , pp. 1123-1131
    • Huang, B.1    Pan, P.-Y.2    Li, Q.3
  • 46
    • 34248328368 scopus 로고    scopus 로고
    • Ccl2/ccr2 pathway mediates recruitment of myeloid suppressor cells to cancers
    • Huang B, Lei Z, Zhao J et al (2007) CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers. Cancer Lett 252:86–92. doi: 10.1016/j.canlet.2006.12.012
    • (2007) Cancer Lett , vol.252 , pp. 86-92
    • Huang, B.1    Lei, Z.2    Zhao, J.3
  • 47
    • 37849035627 scopus 로고    scopus 로고
    • Tlr signaling by tumor and immune cells: A doubleedged sword
    • Huang B, Zhao J, Unkeless JC et al (2008) TLR signaling by tumor and immune cells: a doubleedged sword. Oncogene 27:218–224. doi: 10.1038/sj.onc.1210904
    • (2008) Oncogene , vol.27 , pp. 218-224
    • Huang, B.1    Zhao, J.2    Unkeless, J.C.3
  • 48
    • 70350435962 scopus 로고    scopus 로고
    • Epigenetic regulation of the alternatively activated macrophage phenotype
    • Ishii M, Wen H, Corsa CAS et al (2009) Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 114:3244–3254. doi: 10.1182/blood-2009-04-217620
    • (2009) Blood , vol.114 , pp. 3244-3254
    • Ishii, M.1    Wen, H.2    Corsa, C.3
  • 49
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • Iwasaki A, Medzhitov R (2010) Regulation of adaptive immunity by the innate immune system. Science 327:291–295. doi: 10.1126/science.1183021
    • (2010) Science , vol.327 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 50
    • 84883820837 scopus 로고    scopus 로고
    • Putting the brakes on anticancer therapies: Suppression of innate immune pathways by tumor-associated myeloid cells
    • Jinushi M, Yagita H, Yoshiyama H, Tahara H (2013) Putting the brakes on anticancer therapies: suppression of innate immune pathways by tumor-associated myeloid cells. Trends Mol Med 19:536–545. doi: 10.1016/j.molmed.2013.06.001
    • (2013) Trends Mol Med , vol.19 , pp. 536-545
    • Jinushi, M.1    Yagita, H.2    Yoshiyama, H.3    Tahara, H.4
  • 51
    • 84878414390 scopus 로고    scopus 로고
    • Tlr agonists: Our best frenemy in cancer immunotherapy
    • Kaczanowska S, Joseph AM, Davila E (2013) TLR agonists: our best frenemy in cancer immunotherapy. J Leukoc Biol 93:847–863. doi: 10.1189/jlb.1012501
    • (2013) J Leukoc Biol , vol.93 , pp. 847-863
    • Kaczanowska, S.1    Joseph, A.M.2    Davila, E.3
  • 52
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:637–650. doi: 10.1016/j.immuni.2011.05.006
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 53
    • 79952282422 scopus 로고    scopus 로고
    • The significant role of mast cells in cancer
    • Khazaie K, Blatner NR, Khan MW et al (2011) The significant role of mast cells in cancer. Cancer Metastasis Rev 30:45–60. doi: 10.1007/s10555-011-9286
    • (2011) Cancer Metastasis Rev , vol.30 , pp. 45-60
    • Khazaie, K.1    Blatner, N.R.2    Khan, M.W.3
  • 54
    • 58149269348 scopus 로고    scopus 로고
    • Carcinoma-produced factors activate myeloid cells through tlr2 to stimulate metastasis
    • Kim S, Takahashi H, Lin W-W et al (2009) Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 457:102–106. doi: 10.1038/nature07623
    • (2009) Nature , vol.457 , pp. 102-106
    • Kim, S.1    Takahashi, H.2    Lin, W.-W.3
  • 55
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski M, Kujawski M, Wang T et al (2005) Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 11:1314–1321. doi: 10.1038/nm1325
    • (2005) Nat Med , vol.11 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3
  • 56
    • 79951671510 scopus 로고    scopus 로고
    • Irf5 promotes inflammatory macrophage polarization and th1-th17 responses
    • Krausgruber T, Blazek K, Smallie T et al (2011) IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol 12:231–238. doi: 10.1038/ni.1990
    • (2011) Nat Immunol , vol.12 , pp. 231-238
    • Krausgruber, T.1    Blazek, K.2    Smallie, T.3
  • 57
    • 80355146399 scopus 로고    scopus 로고
    • Transcriptional regulation of macrophage polarization: Enabling diversity with identity
    • Lawrence T, Natoli G (2011) Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol 11:750–761. doi: 10.1038/nri3088
    • (2011) Nat Rev Immunol , vol.11 , pp. 750-761
    • Lawrence, T.1    Natoli, G.2
  • 58
    • 74349124255 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling promotes tumor growth
    • Lee C-H, Wu C-L, Shiau A-L (2010) Toll-like receptor 4 signaling promotes tumor growth. J Immunother 33:73–82. doi: 10.1097/CJI.0b013e3181b7a0a4
    • (2010) J Immunother , vol.33 , pp. 73-82
    • Lee, C.-H.1    Wu, C.-L.2    Shiau, A.-L.3
  • 59
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW (2006) Distinct role of macrophages in different tumor microenvironments. Cancer Res 66:605–612. doi: 10.1158/0008-5472.CAN-05-4005
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 60
    • 59849126377 scopus 로고    scopus 로고
    • Cancer-expanded myeloid-derived suppressor cells induce anergy of nk cells through membrane-bound tgf-beta 1
    • Li H, Han Y, Guo Q et al (2009) Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J Immunol 182:240–249
    • (2009) J Immunol , vol.182 , pp. 240-249
    • Li, H.1    Han, Y.2    Guo, Q.3
  • 61
    • 34347226359 scopus 로고    scopus 로고
    • Tumor-associated macrophages press the angiogenic switch in breast cancer
    • Lin EY, Pollard JW (2007) Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res. doi: 10.1158/0008-5472.CAN-07-0912
    • (2007) Cancer Res
    • Lin, E.Y.1    Pollard, J.W.2
  • 62
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin EY, Nguyen AV, Russell RG, Pollard JW (2001) Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193:727–739. doi: 10.1084/jem.193.6.727
    • (2001) J Exp Med , vol.193 , pp. 727-739
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 63
    • 84879663836 scopus 로고    scopus 로고
    • M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through tlr4/il-10 signaling pathway
    • Liu C-Y, Xu J-Y, Shi X-Y et al (2013) M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway. Lab Invest 93:844–854. doi: 10.1038/labinvest.2013.69
    • (2013) Lab Invest , vol.93 , pp. 844-854
    • Liu, C.-Y.1    Xu, J.-Y.2    Shi, X.-Y.3
  • 64
    • 80053421470 scopus 로고    scopus 로고
    • Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic t cells in mice
    • Lu T, Ramakrishnan R, Altiok S et al (2011) Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice. J Clin Invest 121:4015–4029. doi: 10.1172/JCI45862
    • (2011) J Clin Invest , vol.121 , pp. 4015-4029
    • Lu, T.1    Ramakrishnan, R.2    Altiok, S.3
  • 65
    • 77952937103 scopus 로고    scopus 로고
    • The m1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time
    • Ma J, Liu L, Che G et al (2010) The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time. BMC Cancer 10:112. doi: 10.1186/1471-2407-10-112
    • (2010) BMC Cancer , vol.10 , pp. 112
    • Ma, J.1    Liu, L.2    Che, G.3
  • 66
    • 79952772423 scopus 로고    scopus 로고
    • Paired immunoglobin-like receptor-b regulates the suppressive function and fate of myeloid-derived suppressor cells
    • Ma G, Pan P-Y, Eisenstein S et al (2011) Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity 34:385–395. doi: 10.1016/j.immuni.2011.02.004
    • (2011) Immunity , vol.34 , pp. 385-395
    • Ma, G.1    Pan, P.-Y.2    Eisenstein, S.3
  • 67
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized m2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M et al (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23:549–555
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3
  • 69
    • 41149119143 scopus 로고    scopus 로고
    • Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells
    • Marigo I, Dolcetti L, Serafi ni P et al (2008) Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol Rev 222:162–179. doi: 10.1111/j.1600-065X.2008.00602
    • (2008) Immunol Rev , vol.222 , pp. 162-179
    • Marigo, I.1    Dolcetti, L.2    Serafi Ni, P.3
  • 70
    • 54549109936 scopus 로고    scopus 로고
    • Modulation of the antitumor immune response by complement
    • Markiewski MM, DeAngelis RA, Benencia F et al (2008) Modulation of the antitumor immune response by complement. Nat Immunol 9:1225–1235. doi: 10.1038/ni.1655
    • (2008) Nat Immunol , vol.9 , pp. 1225-1235
    • Markiewski, M.M.1    DeAngelis, R.A.2    Benencia, F.3
  • 71
    • 79953750307 scopus 로고    scopus 로고
    • Targeting the ang2/tie2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells
    • Mazzieri R, Pucci F, Moi D et al (2011) Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell 19:512–526. doi: 10.1016/j.ccr.2011.02.005
    • (2011) Cancer Cell , vol.19 , pp. 512-526
    • Mazzieri, R.1    Pucci, F.2    Moi, D.3
  • 72
    • 73949135474 scopus 로고    scopus 로고
    • Distinct and complementary functions of mda5 and tlr3 in poly(I:C)-mediated activation of mouse nk cells
    • McCartney S, Vermi W, Gilfillan S et al (2009) Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells. J Exp Med 206:2967–2976. doi: 10.1084/jem.20091181
    • (2009) J Exp Med , vol.206 , pp. 2967-2976
    • McCartney, S.1    Vermi, W.2    Gilfillan, S.3
  • 73
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct t cell-suppressive activity
    • Movahedi K, Guilliams M, Van den Bossche J et al (2008) Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 111:4233–4244. doi: 10.1182/blood-2007-07-099226
    • (2008) Blood , vol.111 , pp. 4233-4244
    • Movahedi, K.1    Guilliams, M.2    Van Den Bossche, J.3
  • 74
    • 0842286646 scopus 로고    scopus 로고
    • Ido and tolerance to tumors
    • Munn DH, Mellor AL (2004) IDO and tolerance to tumors. Trends Mol Med 10:15–18
    • (2004) Trends Mol Med , vol.10 , pp. 15-18
    • Munn, D.H.1    Mellor, A.L.2
  • 75
    • 34447118098 scopus 로고    scopus 로고
    • Altered recognition of antigen is a mechanism of cd8+t cell tolerance in cancer
    • Nagaraj S, Gupta K, Pisarev V et al (2007) Altered recognition of antigen is a mechanism of CD8+T cell tolerance in cancer. Nat Med 13:828–835. doi: 10.1038/nm1609
    • (2007) Nat Med , vol.13 , pp. 828-835
    • Nagaraj, S.1    Gupta, K.2    Pisarev, V.3
  • 76
    • 58949086448 scopus 로고    scopus 로고
    • Mononuclear myeloid-derived “suppressor” cells express rae-1 and activate natural killer cells
    • Nausch N, Galani IE, Schlecker E, Cerwenka A (2008) Mononuclear myeloid-derived “suppressor” cells express RAE-1 and activate natural killer cells. Blood 112:4080–4089. doi: 10.1182/blood-2008-03-143776
    • (2008) Blood , vol.112 , pp. 4080-4089
    • Nausch, N.1    Galani, I.E.2    Schlecker, E.3    Cerwenka, A.4
  • 77
    • 27144538568 scopus 로고    scopus 로고
    • Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus activated kinase 2/signal transducers and activators of transcription 3 pathway
    • Nefedova Y, Nagaraj S, Rosenbauer A et al (2005) Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res 65:9525–9535. doi: 10.1158/0008-5472.CAN-05-0529
    • (2005) Cancer Res , vol.65 , pp. 9525-9535
    • Nefedova, Y.1    Nagaraj, S.2    Rosenbauer, A.3
  • 78
    • 33947590063 scopus 로고    scopus 로고
    • Whatever turns you on: Accessory-cell-dependent activation of nkcells by pathogens
    • Newman KC, Riley EM (2007) Whatever turns you on: accessory-cell-dependent activation of NKcells by pathogens. Nat Rev Immunol 7:279–291. doi: 10.1038/nri2057
    • (2007) Nat Rev Immunol , vol.7 , pp. 279-291
    • Newman, K.C.1    Riley, E.M.2
  • 79
    • 0037320451 scopus 로고    scopus 로고
    • Ticam-1, an adaptor molecule that participates in toll-like receptor 3-mediated interferon-beta induction
    • Oshiumi H, Matsumoto M, Funami K et al (2003) TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol 4:161–167.doi: 10.1038/ni886
    • (2003) Nat Immunol , vol.4 , pp. 161-167
    • Oshiumi, H.1    Matsumoto, M.2    Funami, K.3
  • 80
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: Linking inflammation and cancer
    • Ostrand-Rosenberg S, Sinha P (2009) Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 182:4499–4506. doi: 10.4049/jimmunol.0802740
    • (2009) J Immunol , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 81
    • 84875364025 scopus 로고    scopus 로고
    • Inhibition of tgf-β signaling in combination with tlr7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages
    • H. Shime et al. Peng J, Tsang JYS, Li D et al (2013) Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages. Cancer Lett 331:239–249. doi: 10.1016/j.canlet.2013.01.001
    • (2013) Cancer Lett , vol.331 , pp. 239-249
    • Shime, H.1    Peng, J.2    Tsang, J.3    Li, D.4
  • 82
    • 77951258918 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell heterogeneity and subset definition
    • Peranzoni E, Zilio S, Marigo I et al (2010) Myeloid-derived suppressor cell heterogeneity and subset definition. Curr Opin Immunol 22:238–244. doi: 10.1016/j.coi.2010.01.021
    • (2010) Curr Opin Immunol , vol.22 , pp. 238-244
    • Peranzoni, E.1    Zilio, S.2    Marigo, I.3
  • 83
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW (2010) Macrophage diversity enhances tumor progression and metastasis. Cell 141:39–51. doi: 10.1016/j.cell.2010.03.014
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 84
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail DF, Joyce JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nat Med 19:1423–1437. doi: 10.1038/nm.3394
    • (2013) Nat Med , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 85
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein myd88
    • Rakoff-Nahoum S, Medzhitov R (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317:124–127. doi: 10.1126/science.1140488
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 87
    • 80054075147 scopus 로고    scopus 로고
    • Tumour macrophages as potential targets of bisphosphonates
    • Rogers TL, Holen I (2011) Tumour macrophages as potential targets of bisphosphonates. J Transl Med 9:177. doi: 10.1186/1479-5876-9-177
    • (2011) J Transl Med , vol.9 , pp. 177
    • Rogers, T.L.1    Holen, I.2
  • 88
    • 84875511757 scopus 로고    scopus 로고
    • Tumor necrosis factor-α blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation
    • Sade-Feldman M, Kanterman J, Ish-Shalom E et al (2013) Tumor necrosis factor-α blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation. Immunity 38:541–554. doi: 10.1016/j.immuni.2013.02.007
    • (2013) Immunity , vol.38 , pp. 541-554
    • Sade-Feldman, M.1    Kanterman, J.2    Ish-Shalom, E.3
  • 89
    • 77956954197 scopus 로고    scopus 로고
    • The jmjd3-irf4 axis regulates m2 macrophage polarization and host responses against helminth infection
    • Satoh T, Takeuchi O, Vandenbon A et al (2010) The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol 11:936–944. doi: 10.1038/ni.1920
    • (2010) Nat Immunol , vol.11 , pp. 936-944
    • Satoh, T.1    Takeuchi, O.2    Vandenbon, A.3
  • 90
    • 47049126742 scopus 로고    scopus 로고
    • Chemokine-mediated rapid turnover of myeloidderived suppressor cells in tumor-bearing mice
    • Sawanobori Y, Ueha S, Kurachi M et al (2008) Chemokine-mediated rapid turnover of myeloidderived suppressor cells in tumor-bearing mice. Blood 111:5457–5466. doi: 10.1182/blood-2008-01-136895
    • (2008) Blood , vol.111 , pp. 5457-5466
    • Sawanobori, Y.1    Ueha, S.2    Kurachi, M.3
  • 91
    • 79958696667 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and tlr/il1rs unexpectedly activate myeloid cell pi3kγ, a single convergent point promoting tumor inflammation and progression
    • Schmid MC, Avraamides CJ, Dippold HC et al (2011) Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell 19:715–727. doi: 10.1016/j.ccr.2011.04.016
    • (2011) Cancer Cell , vol.19 , pp. 715-727
    • Schmid, M.C.1    Avraamides, C.J.2    Dippold, H.C.3
  • 92
    • 48549085973 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells promote cross-tolerance in b-cell lymphoma by expanding regulatory t cells
    • Serafi ni P, Mgebroff S, Noonan K, Borrello I (2008) Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res 68:5439–5449. doi: 10.1158/0008-5472.CAN-07-6621
    • (2008) Cancer Res , vol.68 , pp. 5439-5449
    • Serafi Ni, P.1    Mgebroff, S.2    Noonan, K.3    Borrello, I.4
  • 93
    • 75649100153 scopus 로고    scopus 로고
    • Pattern recognition receptors of innate immunity and their application to tumor immunotherapy
    • Seya T, Shime H, Ebihara T et al (2010) Pattern recognition receptors of innate immunity and their application to tumor immunotherapy. Cancer Sci 101:313–320.doi: 10.1111/j.1349-7006.2009.01442
    • (2010) Cancer Sci , vol.101 , pp. 313-320
    • Seya, T.1    Shime, H.2    Ebihara, T.3
  • 94
    • 84880865534 scopus 로고    scopus 로고
    • Tamable tumor-associated macrophages in response to innate rna sensing
    • Seya T, Shime H, Matsumoto M (2012) TAMable tumor-associated macrophages in response to innate RNA sensing. Oncoimmunology 1:1000–1001. doi: 10.4161/onci.19894
    • (2012) Oncoimmunology , vol.1 , pp. 1000-1001
    • Seya, T.1    Shime, H.2    Matsumoto, M.3
  • 95
    • 33646896173 scopus 로고    scopus 로고
    • Antitumor activity of the tlr-5 ligand flagellin in mouse models of cancer
    • Sfondrini L, Rossini A, Besusso D et al (2006) Antitumor activity of the TLR-5 ligand flagellin in mouse models of cancer. J Immunol 176:6624–6630
    • (2006) J Immunol , vol.176 , pp. 6624-6630
    • Sfondrini, L.1    Rossini, A.2    Besusso, D.3
  • 96
    • 84857136783 scopus 로고    scopus 로고
    • Toll-like receptor 3 signaling converts tumor supporting myeloid cells to tumoricidal effectors
    • Shime H, Matsumoto M, Oshiumi H et al (2012) Toll-like receptor 3 signaling converts tumor supporting myeloid cells to tumoricidal effectors. Proc Natl Acad Sci U S A 109:2066–2071. doi: 10.1073/pnas.1113099109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 2066-2071
    • Shime, H.1    Matsumoto, M.2    Oshiumi, H.3
  • 97
    • 84898597440 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells confer tumor suppressive functions on natural killer cells via polyinosinic: Polycytidylic acid treatment in mouse tumor models
    • Shime H, Kojima A, Maruyama A et al (2014) Myeloid-derived suppressor cells confer tumor suppressive functions on natural killer cells via polyinosinic: polycytidylic acid treatment in mouse tumor models. J Innate Immun 6:293–305. doi: 10.1159/000355126
    • (2014) J Innate Immun , vol.6 , pp. 293-305
    • Shime, H.1    Kojima, A.2    Maruyama, A.3
  • 98
    • 84856824651 scopus 로고    scopus 로고
    • Intratumoral injection of cpg oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells
    • Shirota Y, Shirota H, Klinman DM (2012) Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells. J Immunol 188:1592–1599. doi: 10.4049/jimmunol.1101304
    • (2012) J Immunol , vol.188 , pp. 1592-1599
    • Shirota, Y.1    Shirota, H.2    Klinman, D.M.3
  • 99
    • 36849013036 scopus 로고    scopus 로고
    • Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    • Shojaei F, Wu X, Zhong C et al (2007) Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450:825–831. doi: 10.1038/nature06348
    • (2007) Nature , vol.450 , pp. 825-831
    • Shojaei, F.1    Wu, X.2    Zhong, C.3
  • 100
    • 48449097002 scopus 로고    scopus 로고
    • Role of myeloid cells in tumor angiogenesis and growth
    • Shojaei F, Zhong C, Wu X et al (2008) Role of myeloid cells in tumor angiogenesis and growth. Trends Cell Biol 18:372–378. doi: 10.1016/j.tcb.2008.06.003
    • (2008) Trends Cell Biol , vol.18 , pp. 372-378
    • Shojaei, F.1    Zhong, C.2    Wu, X.3
  • 101
    • 77957735624 scopus 로고    scopus 로고
    • Role of tumour-associated macrophages in cancer-related inflammation
    • Sica A (2010) Role of tumour-associated macrophages in cancer-related inflammation. Exp Oncol 32:153–158
    • (2010) Exp Oncol , vol.32 , pp. 153-158
    • Sica, A.1
  • 102
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122:787–795. doi: 10.1172/JCI59643
    • (2012) J Clin Invest , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 103
    • 53349125963 scopus 로고    scopus 로고
    • Pro inflammatory s100 proteins regulate the accumulation of myeloid-derived suppressor cells
    • Sinha P, Okoro C, Foell D et al (2008) Pro inflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J Immunol 181:4666–4675. doi: 10.4049/jimmunol.181.7.4666
    • (2008) J Immunol , vol.181 , pp. 4666-4675
    • Sinha, P.1    Okoro, C.2    Foell, D.3
  • 104
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (Tam) as major players of the cancer-related inflammation
    • Solinas G, Germano G, Mantovani A, Allavena P (2009) Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 86:1065–1073. doi: 10.1189/jlb.0609385
    • (2009) J Leukoc Biol , vol.86 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 105
    • 79953113052 scopus 로고    scopus 로고
    • Transcription factors in myeloid-derived suppressor cell recruitment and function
    • Sonda N, Chioda M, Zilio S et al (2011) Transcription factors in myeloid-derived suppressor cell recruitment and function. Curr Opin Immunol 23:279–285. doi: 10.1016/j.coi.2010.12.006
    • (2011) Curr Opin Immunol , vol.23 , pp. 279-285
    • Sonda, N.1    Chioda, M.2    Zilio, S.3
  • 106
    • 84872794136 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization
    • Spence S, Fitzsimons A, Boyd CR et al (2013) Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization. Immunity 38:66–78. doi: 10.1016/j.immuni.2012.09.013
    • (2013) Immunity , vol.38 , pp. 66-78
    • Spence, S.1    Fitzsimons, A.2    Boyd, C.R.3
  • 107
    • 83555164774 scopus 로고    scopus 로고
    • S100a8 and s100a9: New insights into their roles in malignancy
    • Srikrishna G (2011) S100A8 and S100A9: new insights into their roles in malignancy. J InnateImmun 4:31–40. doi: 10.1159/000330095
    • (2011) J Innateimmun , vol.4 , pp. 31-40
    • Srikrishna, G.1
  • 108
    • 75149123468 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells inhibit t-cell activation by depleting cystine and cysteine
    • Srivastava MK, Sinha P, Clements VK et al (2010) Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res 70:68–77. doi: 10.1158/0008-5472.CAN-09-2587
    • (2010) Cancer Res , vol.70 , pp. 68-77
    • Srivastava, M.K.1    Sinha, P.2    Clements, V.K.3
  • 109
    • 84863991235 scopus 로고    scopus 로고
    • Myeloid suppressor cell depletion augments antitumor activity in lung cancer
    • Srivastava MK, Zhu L, Harris-White M et al (2012) Myeloid suppressor cell depletion augments antitumor activity in lung cancer. PLoS ONE 7:e40677. doi: 10.1371/journal.pone.0040677
    • (2012) Plos ONE , vol.7
    • Srivastava, M.K.1    Zhu, L.2    Harris-White, M.3
  • 110
    • 77949345555 scopus 로고    scopus 로고
    • Tumor-associated macrophages and survival in classichodgkin’s lymphoma
    • Steidl C, Lee T, Shah SP et al (2010) Tumor-associated macrophages and survival in classicHodgkin’s lymphoma. N Engl J Med 362:875–885. doi: 10.1056/NEJMoa0905680
    • (2010) N Engl J Med , vol.362 , pp. 875-885
    • Steidl, C.1    Lee, T.2    Shah, S.P.3
  • 111
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • Talmadge JE, Gabrilovich DI (2013) History of myeloid-derived suppressor cells. Nat Rev Cancer 13:739–752. doi: 10.1038/nrc3581
    • (2013) Nat Rev Cancer , vol.13 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 112
    • 0036222241 scopus 로고    scopus 로고
    • Tlr4, but not tlr2, mediates ifn-β–inducedstat1α/β-dependent gene expression in macrophages
    • Toshchakov V, Jones BW, Perera P-Y et al (2002) TLR4, but not TLR2, mediates IFN-β–inducedSTAT1α/β-dependent gene expression in macrophages. Nat Immunol 3:392–398. doi: 10.1038/ni774
    • (2002) Nat Immunol , vol.3 , pp. 392-398
    • Toshchakov, V.1    Jones, B.W.2    Perera, P.-Y.3
  • 113
    • 68849128500 scopus 로고    scopus 로고
    • Therapeutic targeting of myeloid-derived suppressor cells
    • Ugel S, Delpozzo F, Desantis G et al (2009) Therapeutic targeting of myeloid-derived suppressor cells. Curr Opin Pharmacol 9:470–481. doi: 10.1016/j.coph.2009.06.014
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 470-481
    • Ugel, S.1    Delpozzo, F.2    Desantis, G.3
  • 114
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • Vanneman M, Dranoff G (2012) Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer 12:237–251. doi: 10.1038/nrc3237
    • (2012) Nat Rev Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 115
    • 84875866083 scopus 로고    scopus 로고
    • Stat3 regulates arginase-i in myeloid-derived suppressor cells from cancer patients
    • Vasquez-Dunddel D, Pan F, Zeng Q et al (2013) STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. J Clin Invest 123:1580–1589. doi: 10.1172/JCI60083
    • (2013) J Clin Invest , vol.123 , pp. 1580-1589
    • Vasquez-Dunddel, D.1    Pan, F.2    Zeng, Q.3
  • 116
    • 84885029080 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell development is regulated by a stat/irf-8 axis
    • Waight JD, Netherby C, Hensen ML et al (2013) Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis. J Clin Invest 123:4464–4478. doi: 10.1172/JCI68189
    • (2013) J Clin Invest , vol.123 , pp. 4464-4478
    • Waight, J.D.1    Netherby, C.2    Hensen, M.L.3
  • 117
    • 37849014248 scopus 로고    scopus 로고
    • Toll-like receptors and immune regulation: Implications for cancer therapy
    • Wang R-F, Miyahara Y, Wang HY (2008) Toll-like receptors and immune regulation: implications for cancer therapy. Oncogene 27:181–189. doi: 10.1038/sj.onc.1210906
    • (2008) Oncogene , vol.27 , pp. 181-189
    • Wang, R.-F.1    Miyahara, Y.2    Wang, H.Y.3
  • 118
    • 77953752609 scopus 로고    scopus 로고
    • Notch signaling determines the m1 versus m2 polarization of macrophages in antitumor immune responses
    • Wang Y-C, He F, Feng F et al (2010) Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses. Cancer Res 70:4840–4849. doi: 10.1158/0008-5472.CAN-10-0269
    • (2010) Cancer Res , vol.70 , pp. 4840-4849
    • Wang, Y.-C.1    He, F.2    Feng, F.3
  • 119
    • 84862591151 scopus 로고    scopus 로고
    • Notch-rbp-j signaling regulates the transcription factor irf8 to promote inflammatory macrophage polarization
    • Xu H, Zhu J, Smith S et al (2012) Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol 13:642–650. doi: 10.1038/ni.2304
    • (2012) Nat Immunol , vol.13 , pp. 642-650
    • Xu, H.1    Zhu, J.2    Smith, S.3
  • 120
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor trif in the myd88-independent toll-like receptor signaling pathway
    • Yamamoto M, Sato S, Hemmi H et al (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301:640–643. doi: 10.1126/science.1087262
    • (2003) Science , vol.301 , pp. 640-643
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3
  • 121
    • 84877990693 scopus 로고    scopus 로고
    • Polarization and reprogramming of myeloid-derived suppressor cells
    • Yang W-C, Ma G, Chen S-H, Pan P-Y (2013) Polarization and reprogramming of myeloid-derived suppressor cells. J Mol Cell Biol 5:207–209. doi: 10.1093/jmcb/mjt009
    • (2013) J Mol Cell Biol , vol.5 , pp. 207-209
    • Yang, W.-C.1    Ma, G.2    Chen, S.-H.3    Pan, P.-Y.4
  • 122
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    • Youn J-I, Nagaraj S, Collazo M, Gabrilovich DI (2008) Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol 181:5791–5802
    • (2008) J Immunol , vol.181 , pp. 5791-5802
    • Youn, J.-I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 123
    • 85027923251 scopus 로고    scopus 로고
    • Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer
    • Youn J-I, Kumar V, Collazo M et al (2013) Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat Immunol 14:211–220. doi: 10.1038/ni.2526
    • (2013) Nat Immunol , vol.14 , pp. 211-220
    • Youn, J.-I.1    Kumar, V.2    Collazo, M.3
  • 124
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of stat3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D (2007) Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 7:41–51. doi: 10.1038/nri1995
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 125
    • 20244367914 scopus 로고    scopus 로고
    • Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: A mechanism of tumor evasion
    • Zea AH, Rodriguez PC, Atkins MB et al (2005) Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res 65:3044–3048. doi: 10.1158/0008-5472.CAN-04-4505
    • (2005) Cancer Res , vol.65 , pp. 3044-3048
    • Zea, A.H.1    Rodriguez, P.C.2    Atkins, M.B.3
  • 126
    • 34249274905 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis
    • Zhao X, Mohaupt M, Jiang J et al (2007) Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis. Cancer Res 67:4443–4450. doi: 10.1158/0008-5472.CAN-07-0185
    • (2007) Cancer Res , vol.67 , pp. 4443-4450
    • Zhao, X.1    Mohaupt, M.2    Jiang, J.3
  • 127
    • 84868629269 scopus 로고    scopus 로고
    • Tnf signaling drives myeloid-derived suppressor cell accumulation
    • Zhao X, Rong L, Zhao X et al (2012) TNF signaling drives myeloid-derived suppressor cell accumulation. J Clin Invest 122:4094–4104. doi: 10.1172/JCI64115
    • (2012) J Clin Invest , vol.122 , pp. 4094-4104
    • Zhao, X.1    Rong, L.2    Zhao, X.3
  • 128
    • 33748987908 scopus 로고    scopus 로고
    • Cancer despite immunosurveillance: Immunoselection and immunosubversion
    • Zitvogel L, Tesniere A, Kroemer G (2006) Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol 6:715–727. doi: 10.1038/nri1936
    • (2006) Nat Rev Immunol , vol.6 , pp. 715-727
    • Zitvogel, L.1    Tesniere, A.2    Kroemer, G.3
  • 129
    • 79953300942 scopus 로고    scopus 로고
    • Cpg blocks immunosuppression by myeloidderived suppressor cells in tumor-bearing mice
    • Zoglmeier C, Bauer H, Nörenberg D et al (2011) CpG blocks immunosuppression by myeloidderived suppressor cells in tumor-bearing mice. Clin Cancer Res 17:1765–1775. doi: 10.1158/1078-0432.CCR-10-2672
    • (2011) Clin Cancer Res , vol.17 , pp. 1765-1775
    • Zoglmeier, C.1    Bauer, H.2    Nörenberg, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.