Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages

Cancer Letters

Volumn 331, Issue 2, 2013, Pages 239-249

  Peng, Jiao ^a   Tsang, Julia Yuen Shan ^a,b   Li, Daxu ^a   Niu, Na ^a   Ho, Derek Hoi Hang ^c   Lau, Kwok Fai ^d   Lui, Vincent Chi Hang ^a   Lamb, Jonathan Robert ^e   Chen, Yan ^a,b,c   Tam, Paul Kwong Hang ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b Research Centre of Infection and Immunity   (Hong Kong)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Functional re programming; TGF ; TLR4; TLR7; Tumor associated macrophages

Indexed keywords

B7 ANTIGEN; CD19 ANTIGEN; CD31 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR AGONIST; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CAPILLARY; CELL COUNT; CELL NUCLEUS; CELL TYPE; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; FIBROSARCOMA; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; LIGAND BINDING; MACROPHAGE FUNCTION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RECEPTOR BLOCKING; SARCOMA CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR VASCULARIZATION;

ANIMALS; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 7; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84875364025     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2013.01.001     Document Type: Article

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