TAMable tumor-associated macrophages in response to innate RNA sensing

OncoImmunology

Volumn 1, Issue 6, 2012, Pages 1000-1001

  Seya, Tsukasa ^a   Shime, Hiroaki ^a   Matsumoto, Misako ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Immunotherapy; PolyI:C; TICAM 1; TLR3; Tumor infiltrating macrophages

Indexed keywords

INTERFERON; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ANTINEOPLASTIC ACTIVITY; ARTHRALGIA; ARTICLE; BONE MARROW CELL; CELL MATURATION; CROSS PRESENTATION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; EFFECTOR CELL; ENTEROCOLITIS; ERYTHEMA; FEVER; HUMAN; HYPOTONIC SHOCK; INNATE RNA SENSING; LUNG CARCINOMA; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SHOCK; TUMOR ASSOCIATED LEUKOCYTE;

EID: 84880865534     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.19894     Document Type: Article

References (10)

1. Talmadge JE, Adams J, Phillips H, Collins M, Lenz B, Schneider M, et al. Immunomodulatory effects in mice of polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose. Cancer Res 1985; 45:1058-65; PMID:3155990.
2. Matsumoto M, Oshiumi H, Seya T. Antiviral responses induced by the TLR3 pathway. Rev Med Virol 2011; 21:67-77; PMID:21312311; http://dx.doi. org/10.1002/rmv.680.
3. Watanabe A, Tatematsu M, Saeki K, Shibata S, Shime H, Yoshimura A, et al. Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J Biol Chem 2011; 286:10702-11; PMID:21266579; http://dx.doi.org/10.1074/jbc. M110.185793.
4. Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, et al. Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation. J Exp Med 2010; 207:2675-87; PMID:21059856; http://dx.doi.org/10.1084/jem.20091573.
5. Azuma M, Ebihara T, Oshiumi H, Matsumoto M, Seya T. Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+/CD8a+ dendritic cells. OncoImmunol 2012; In press.
6. Shime H, Matsumoto M, Oshiumi H, Tanaka S, Nakane A, Iwakura Y, et al. Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proc Natl Acad Sci USA 2012; 109:2066-71; PMID:22308357; http://dx.doi. org/10.1073/pnas.1113099109.
7. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 1975; 72:3666-70; PMID:1103152; http://dx.doi. org/10.1073/pnas.72.9.3666.
8. Jelinek I, Leonard JN, Price GE, Brown KN, Meyer-Manlapat A, Goldsmith PK, et al. TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses and antiviral protection. J Immunol 2011; 186:2422-9; PMID:21242525; http://dx.doi.org/10.4049/jimmunol. 1002845.
9. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388:394-7; PMID:9237759; http://dx.doi. org/10.1038/41131.
10. Caskey M, Lefebvre F, Filali-Mouhim A, Cameron MJ, Goulet JP, Haddad EK, et al. Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans. J Exp Med 2011; 208:2357-66; PMID:22065672; http://dx.doi. org/10.1084/jem.20111171.