TIGIT expression levels on human NK cells correlate with functional heterogeneity among healthy individuals

European Journal of Immunology

Volumn 45, Issue 10, 2015, Pages 2886-2897

  Wang, Feng ^a   Hou, Hongyan ^a   Wu, Shiji ^a   Tang, Qing ^a   Liu, Weiyong ^a   Huang, Min ^a   Yin, Botao ^a   Huang, Jing ^a   Mao, Lie ^a   Lu, Yanfang ^a   Sun, Ziyong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cytokine secretion; Cytotoxity; Human; NK cells; TIGIT

Indexed keywords

IMMUNOGLOBULIN RECEPTOR; T CELL IMMUNOGLOBULIN AND ITIM DOMAIN; UNCLASSIFIED DRUG; GAMMA INTERFERON; IFNG PROTEIN, HUMAN; TIGIT PROTEIN, HUMAN;

ARTICLE; AUTOIMMUNITY; CELL FUNCTION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RELEASE; CYTOTOXICITY; DEGRANULATION; HUMAN; HUMAN CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; CLINICAL TRIAL; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; IMMUNOLOGY; MALE; SIGNAL TRANSDUCTION;

FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; MALE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 84943199467     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201545480     Document Type: Article

References (43)

1. Vivier, E., Tomasello, E., Baratin, M., Walzer, T. and Ugolini, S., Functions of natural killer cells. Nat. Immunol. 2008. 9: 503-510.
2. Korbel, D. S., Newman, K. C., Almeida, C. R., Davis, D. M. and Riley, E. M., Heterogeneous human NK cell responses to Plasmodium falciparum-infected erythrocytes. J. Immunol. 2005. 175: 7466-7473.
3. Korbel, D. S., Norman, P. J., Newman, K. C., Horowitz, A., Gendzekhadze, K., Parham, P. and Riley, E. M., Killer Ig-like receptor (KIR) genotype predicts the capacity of human KIR-positive CD56dim NK cells to respond to pathogen-associated signals. J. Immunol. 2009. 182: 6426-6434.
4. Della Chiesa, M., Falco, M., Podesta, M., Locatelli, F., Moretta, L., Frassoni, F. and Moretta, A., Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus? Blood 2012. 119: 399-410.
5. Portevin, D., Via, L. E., Eum, S. and Young, D., Natural killer cells are recruited during pulmonary tuberculosis and their ex vivo responses to mycobacteria vary between healthy human donors in association with KIR haplotype. Cell Microbiol. 2012. 14: 1734-1744.
6. Vanherberghen, B., Olofsson, P. E., Forslund, E., Sternberg-Simon, M., Khorshidi, M. A., Pacouret, S., Guldevall, K. et al., Classification of human natural killer cells based on migration behavior and cytotoxic response. Blood 2013. 121: 1326-1334.
7. Sivori, S., Falco, M., Della Chiesa, M., Carlomagno, S., Vitale, M., Moretta, L. and Moretta, A., CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc. Natl. Acad. Sci. USA 2004. 101: 10116-10121.
8. Cooper, M. A., Fehniger, T. A. and Caligiuri, M. A., The biology of human natural killer-cell subsets. Trends Immunol. 2001. 22: 633-640.
9. Artavanis-Tsakonas, K. and Riley, E. M., Innate immune response to malaria: rapid induction of IFN-gamma from human NK cells by live Plasmodium falciparum-infected erythrocytes. J. Immunol. 2002. 169: 2956-2963.
10. Artavanis-Tsakonas, K., Eleme, K., McQueen, K. L., Cheng, N. W., Parham, P., Davis, D. M. and Riley, E. M., Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes. J. Immunol. 2003. 171: 5396-5405.
11. Kulkarni, S., Martin, M. P. and Carrington, M., The Yin and Yang of HLA and KIR in human disease. Semin. Immunol. 2008. 20: 343-352.
12. Parham, P., MHC class I molecules and KIRs in human history, health and survival. Nat. Rev. Immunol. 2005. 5: 201-214.
13. Lanier, L. L., Up on the tightrope: natural killer cell activation and inhibition. Nat. Immunol. 2008. 9: 495-502.
14. Watzl, C. and Long, E. O., Signal transduction during activation and inhibition of natural killer cells. Curr. Protoc. Immunol. 2010. Chapter 11: Unit 11.9B.
15. Cheent, K. and Khakoo, S. I., Natural killer cells: integrating diversity with function. Immunology 2009. 126: 449-457.
16. Kumar, V. and McNerney, M. E., A new self: MHC-class-I-independent natural-killer-cell self-tolerance. Nat. Rev. Immunol. 2005. 5: 363-374.
17. Cantoni, C., Bottino, C., Augugliaro, R., Morelli, L., Marcenaro, E., Castriconi, R., Vitale, M. et al., Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. Eur. J. Immunol. 1999. 29: 3148-3159.
18. Markel, G., Lieberman, N., Katz, G., Arnon, T. I., Lotem, M., Drize, O., Blumberg, R. S. et al., CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity. J. Immunol. 2002. 168: 2803-2810.
19. Simhadri, V. R., Andersen, J. F., Calvo, E., Choi, S. C., Coligan, J. E. and Borrego, F., Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells. Blood 2012. 119: 2799-2809.
20. Yu, X., Harden, K., Gonzalez, L. C., Francesco, M., Chiang, E., Irving, B., Tom, I. et al., The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol. 2009. 10: 48-57.
21. Boles, K. S., Vermi, W., Facchetti, F., Fuchs, A., Wilson, T. J., Diacovo, T. G., Cella, M. et al., A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. Eur. J. Immunol. 2009. 39: 695-703.
22. Stanietsky, N., Simic, H., Arapovic, J., Toporik, A., Levy, O., Novik, A., Levine, Z. et al., The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc. Natl. Acad. Sci. USA 2009. 106: 17858-17863.
23. Joller, N., Hafler, J. P., Brynedal, B., Kassam, N., Spoerl, S., Levin, S. D., Sharpe, A. H. et al., Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. J. Immunol. 2011. 186: 1338-1342.
24. Lozano, E., Dominguez-Villar, M., Kuchroo, V. and Hafler, D. A., The TIGIT/CD226 axis regulates human T cell function. J. Immunol. 2012. 188: 3869-3875.
25. Stanietsky, N., Rovis, T. L., Glasner, A., Seidel, E., Tsukerman, P., Yamin, R., Enk, J. et al., Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR. Eur. J. Immunol. 2013. 43: 2138-2150.
26. Li, M., Xia, P., Du, Y., Liu, S., Huang, G., Chen, J., Zhang, H. et al., T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-gamma production of natural killer cells via beta-arrestin 2-mediated negative signaling. J. Biol. Chem. 2014. 289: 17647-17657.
27. Bi, J., Zhang, Q., Liang, D., Xiong, L., Wei, H., Sun, R. and Tian, Z., T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis. Hepatology 2014. 59: 1715-1725.
28. Bi, J., Zheng, X., Chen, Y., Wei, H., Sun, R. and Tian, Z., TIGIT safeguards liver regeneration through regulating natural killer cell-hepatocyte crosstalk. Hepatology 2014. 60: 1389-1398.
29. Joller, N., Lozano, E., Burkett, P. R., Patel, B., Xiao, S., Zhu, C., Xia, J. et al., Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 2014. 40: 569-581.
30. Chan, C. J., Martinet, L., Gilfillan, S., Souza-Fonseca-Guimaraes, F., Chow, M. T., Town, L., Ritchie, D. S. et al., The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nat. Immunol. 2014. 15: 431-438.
31. Horowitz, A., Strauss-Albee, D. M., Leipold, M., Kubo, J., Nemat-Gorgani, N., Dogan, O. C., Dekker, C. L. et al., Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Sci. Transl. Med. 2013. 5: 208ra145.
32. Parham, P. and Moffett, A., Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution. Nat. Rev. Immunol. 2013. 13: 133-144.
33. Hazeldine, J. and Lord, J. M., The impact of ageing on natural killer cell function and potential consequences for health in older adults. Ageing Res. Rev. 2013. 12: 1069-1078.
34. Brodin, P., Karre, K. and Hoglund, P., NK cell education: not an on-off switch but a tunable rheostat. Trends Immunol. 2009. 30: 143-149.
35. Stanietsky, N. and Mandelboim, O., Paired NK cell receptors controlling NK cytotoxicity. FEBS Lett. 2010. 584: 4895-4900.
36. Sun, H., Sun, C. and Xiao, W., Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations. Cytokine 2014. 65: 33-41.
37. Levin, S. D., Taft, D. W., Brandt, C. S., Bucher, C., Howard, E. D., Chadwick, E. M., Johnston, J. et al., Vstm3 is a member of the CD28 family and an important modulator of T-cell function. Eur. J. Immunol. 2011. 41: 902-915.
38. Garner, W. L., Minton, J. P., James, A. G. and Hoffmann, C. C., Human breast cancer and impaired NK cell function. J. Surg. Oncol. 1983. 24: 64-66.
39. Johansson, S., Hall, H., Berg, L. and Hoglund, P., NK cells in autoimmune disease. Curr. Top Microbiol. Immunol. 2006. 298: 259-277.
40. Lok, A. S. and McMahon, B. J., Chronic hepatitis B. Hepatology 2007. 45: 507-539.
41. Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., McShane, D. J., Rothfield, N. F., Schaller, J. G. et al., The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982. 25: 1271-1277.
42. Arnett, F. C., Edworthy, S. M., Bloch, D. A., McShane, D. J., Fries, J. F., Cooper, N. S., Healey, L. A. et al., The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988. 31: 315-324.
43. Fu, X., Liu, Y., Li, L., Li, Q., Qiao, D., Wang, H., Lao, S. et al., Human natural killer cells expressing the memory-associated marker CD45RO from tuberculous pleurisy respond more strongly and rapidly than CD45RO- natural killer cells following stimulation with interleukin-12. Immunology 2011. 134: 41-49.