Acetaldehyde accelerates HCV-induced impairment of innate immunity by suppressing methylation reactions in liver cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 309, Issue 7, 2015, Pages G566-G577

  Ganesan, Murali ^a,b   Zhang, Jinjin ^c   Bronich, Tatiana ^c   Poluektova, Larisa I ^b,d   Donohue, Terrence M ^a,b   Tuma, Dean J ^a,b   Kharbanda, Kusum K ^a,b   Osna, Natalia A ^a,b  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d NONE   (United States)

Author keywords

Betaine; Ethanol metabolism; Hepatitis C virus; Hepatocytes; IFN signaling

Indexed keywords

ACETALDEHYDE; ALPHA INTERFERON; BETAINE; JANUS KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN INHIBITOR OF ACTIVATED STAT; STAT1 PROTEIN; VIRUS RNA; ALCOHOL; STAT1 PROTEIN, MOUSE;

ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VIVO STUDY; INNATE IMMUNITY; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN METHYLATION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL LINE; DNA METHYLATION; DRUG EFFECTS; GENETIC TRANSFECTION; HEPACIVIRUS; IMMUNOBLOTTING; IMMUNOLOGY; IMMUNOPRECIPITATION; MALE; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; VIROLOGY;

ACETALDEHYDE; ANIMALS; BETAINE; CELL LINE; DNA METHYLATION; ETHANOL; HEPACIVIRUS; HEPATOCYTES; HUMANS; IMMUNITY, INNATE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTERFERON-ALPHA; MALE; MICE; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANSFECTION;

EID: 84943144728     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00183.2015     Document Type: Article

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