Interferons activate the p42/44 mitogen-activated protein kinase and JAK-STAT (Janus kinase-signal transducer and activator transcription factor) signalling pathways in hepatocytes: Differential regulation by acute ethanol via a protein kinase C-dependent mechanism

Biochemical Journal

Volumn 349, Issue 2, 2000, Pages 427-434

  Nguyen, Van Anh T ^a   Chen, Jianping ^a   Hong, Feng ^a   Ishac, Edward J N ^a   Gao, Bin ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Interleukin 6; Proteasome; Protein tyrosine phosphatase; Tyrosine phosphorylation; Viral hepatitis

Indexed keywords

ALCOHOL; ALPHA INTERFERON; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA INTERFERON; GAMMA INTERFERON; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN KINASE C; TRANSCRIPTION FACTOR; UBIQUITIN; VANADATE SODIUM;

ALCOHOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; DNA-BINDING PROTEINS; DRUG INTERACTIONS; DRUG SYNERGISM; ENZYME ACTIVATION; ETHANOL; HEPATOCYTES; INTERFERON TYPE II; INTERFERON-ALPHA; INTERFERON-BETA; INTERFERONS; JANUS KINASE 1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIENZYME COMPLEXES; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYROSINE; UBIQUITINS;

EID: 0034662145     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3490427     Document Type: Article

References (42)

1. 1 De Maeyer, E. and De Maeyer-Guignard, J. (1998) Interferons. In Cytokine Handbook (Thomson, A., ed.), pp. 491-516, Academic Press, San Diego
2. 2 Davis, G. L. (1999) Combination therapy with interferon-α and ribavirin as retreatment of interteron relapse in chronic hepatitis C. Semin. Liver Dis. 19, 49-55
3. 3 Younossi, Z. M. and Perrillo, R. P. (1999) The roles of amantadine, rimantadine, ursodeoxycholic acid, and NSAIDs, alone or in combination with α interferons, in the treatment of chronic hepatitis C. Semin. Liver Dis 19, 95-102
4. 4 Gish, R. G. (1999) Standards of treatment in chronic hepatitis C. Semin Liver Dis. 19, 35-47
5. 5 Lindsay, K. L. (1997) Therapy of hepatitis C: overview. Hepatology 26, 71S-77S
6. 6 Keeffe, E. B. and Hollinger, F. B. (1997) Therapy of hepatitis C: consensus interferon trials: Consensus Interferon Study Group Hepatology 26, 101S-107S
7. 7 Zein, N. N. (1998) Interferons in the management of viral hepatitis. Cytokines Cell. Mol. Ther. 4, 229-241
8. 8 Christie, J. M. and Chapman, R. W. (1999) Combination therapy for chronic hepatitis C: interferon and ribavirin. Hosp. Med 60, 357-361
9. 9 Schiff, E. R. (1999) The alcoholic patient with hepatitis C virus infection. Hepatology 26, 39S-42S
10. 10 Ohnishi, K., Matsuo, S., Matsutani, K., Itahashi, M., Kakihara, K., Suzuki, K., Ito, S. and Fujiwara, K. (1996) Interferon therapy for chronic hepatitis C in habitual drinkers: comparison with chronic hepatitis C in infrequent drinkers. Am. J. Gastroenterol. 91, 1374-1379
11. 11 Okazaki, T., Yoshihara, H., Suzuki, K., Yamada, Y., Tsujimura, T., Kawano, K., Yamada, Y. and Abe, H. (1994) Efficacy of interferon therapy in patients with chronic hepatitis C. Comparison between non-drinkers and drinkers. Scand. J. Gastroenterol. 29, 1039-1043
12. 12 Mochida, S., Ohnishi, K., Matsuo, S., Kakihara, K. and Fujiwara, K. (1996) Effect of alcohol intake on the efficacy of interferon therapy in patients with chronic hepatitis C as evaluated by multivariate logistic regression analysis. Alcohol Clin. Exp. Res 20, 371-377
13. 13 Stark, G. R., Kerr, I. M., Willams, B. R. G., Silverman, R. H. and Schreiber, R. D. (1998) How cells respond to interferons. Annu. Rev. Biochem. 67, 227-264
14. 14 Platanias, L. C. and Fish, E. N. (1999) Signalling pathways activated by interferons. Exp. Hematol. 27, 1583-1592
15. 15 Hague, S. J. and Williams, B. R. (1998) Signal transduction in the Interferon system. Semin. Oncol. 25, 14-22
16. 16 Liu, M. K., Brouwnsey, R. W. and Reiner, N. E. (1994) Gamma interferon induces rapid and coordinate activation of mitogen-activated protein kinase (extracellular signal-regulated kinase) and calcium-independent protein kinase C in human monocytes. Infect. Immun. 62, 2722-2731
17. 17 Stancato, L. F., Yu, C. R., Petricoin, E. F. and Larner, A. C. (1998) Activation of Raf-1 by interferon gamma and oncostatin M requires expression of the Stat1 transcription factor. J. Biol. Chem. 273, 18701-18704
18. 18 David, M., Petricoin, E., Benjamin, C., Pine, R., Weber, M. J. and Larner, A. C. (1995) Requirement for MAP kinase (ERK2) activity in interferon alpha-and interferon beta-stimulated gene expression through STAT proteins. Science 269, 1721-1723
19. 19 Uddin, S., Yenush, L., Sun, X. J., Sweet, M. E., White, M. F. and Platanias, L. C. (1995) Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3′-kinase. J. Biol. Chem 270, 15938-15941
20. 20 Burfoot, M. S., Rogers, N. C., Walting, D., Smith, J. M., Pons, S., Paonessaw, G., Pellegrini, S., White, M. F. and Kerr, I. M. (1997) Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. J. Biol. Chem. 272, 24183-24190
21. 21 Durbin, J. E., Hackenmiller, R., Simon, M. C. and Levy, D. E. (1996) Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84, 443-450
22. 22 Meraz, M, A., Whitem, J. M., Sheehan, K. C., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D H., Riley, J. K., Greenlund, A. C., Campbell, D. et al. (1996) Targeted disruption of the Slat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signalling pathway. Cell 84, 431-442
23. 23 Gao, B., Jiang, L. and Kunos, G. (1996) Transcriptional regulation of alpha(1b)adrenergic receptors [alpha(1b)AR] by nuclear factor 1 (NF1): a decline in the concentration of NF1 correlates with the downregulation of alpha(1b)AR gene expression in regenerating liver Mol. Cell. Biol 16, 5997-6008
24. 1BAR inhibits IL-6-activated STAT3 in hepatic cells by a p42/44 mitogen-activated protein kinase-dependent mechanism. J. Biol. Chem. 274, 35492-35498
25. 25 Chen, J. P., Bao, H. F., Sawyer, S., Kunos, G. and Gao, B. (1997) Effects of short and long term ethanol on the activation of signal transducer and activator transcription factor 3 in normal and regenerating liver. Biochem. Biophys. Res. Commun. 239, 666-669
26. 26 Kraft, A. S. and Anderson, W. B. (1983) Characterization of cytosolic calcium-activated phospholipid-dependent protein kinase activity in embryonal carcinoma cells. Eflect of retinoic acid-induced differentiation of F9 cells to parietal endoderm. J. Biol. Chem. 258, 9178-9183
27. 27 Roivainen, R., Hundle, B. and Messing. O. R. (1995) Ethanol enhances growth factor activation of mitogen-activated protein kinases by a protein kinase C-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A 92, 1891-1895
28. 28 Higashi, K. and Hoek, J. B. (1991) Ethanol causes desensitization of receptor-mediated phospholipase C activation in isolated hepatocytes. J. Biol. Chem 266, 2178-2190
29. 29 Starr, R. and Hilton, D. J. (1999) Negative regulation of the JAK/STAT pathway. Bioessays 47, 47-52
30. 30 Yoshimura, A. (1998) The CIS family: negative regulators of JAK-STAT signalling Cytokine Growth Factor Rev. 9, 197-204
31. 31 Hilton, D. J. (1999) Negative regulators of cytokine signal transduction. Cell Mol. Life. Sci. 55, 1568-1577
32. 32 Schindler, C., Fu, X. Y., Improta, T., Aebersold, R. and Darnel, Jr., J. E. (1992) Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc. Natl. Acad. Sci. U.S.A. 89, 7386-7389
33. 33 Shuai, K., Schindler, C., Preioso, V. R. and Darnell, Jr., J. E. (1992) A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 258, 1808-1812
34. 34 Stephens, J. M., Lumpkin, S. J. and Fishman, J. B (1998) Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-gamma in adipocytes. J. Biol. Chem. 273, 31408-31416
35. 35 Meinke, A., Barahmand-pour, F., Wohrl, S., Stoiber, D. and Decker, T. (1996) Activation of different Stat5 isoforms contributes to cell-type-restricted signalling in response to interferons. Mol. Cell. Biol. 16, 6937-6944
36. 36 Chung, J., Uchida, E., Grammer, T. C. and Blenis, J. (1997) STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol. Cell. Biol 17, 6508-6516
37. 37 Sengupta, T. K., Talbot, E. S., Scherle, P. A. and Ivashkiv, L. B. (1998) Rapid inhibition of interleukin-6 signalling and Stat3 activation mediated by mitogen-activated protein kinases. Proc. Natl. Acad. Sci. U.S.A. 95, 11107-11112
38. 38 Chen, J. P., Kunos, G. and Gao, B. (1999) Ethanol rapidly inhibits IL-6-activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes. FEBS Lett. 457, 162-168
39. 39 Sasaki, Y. and Wands, J. R. (1994) Ethanol impairs insulin receptor substrate-1 mediated signal transduction during rat liver regeneration. Biochem. Biophys. Res. Commun. 199, 403-409
40. 40 Xu, Y. Y., Bhavani, K., Wands, J. R. and de la Monte, S. M. (1995) Ethanol inhibits insulin receptor substrate-1 tyrosine phosphorylation and insulin-stimulated neuronal thread protein gene expression. Biochem. J. 310, 125-132
41. 41 Resnicott, M., Rubini, M., Baserga, R. and Rubin, R. (1994) Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat gliobiastoma cells. Lab. Invest. 71, 657-662
42. 42 Monr, L., Tanaka, S. and Wands, J. R. (1998) Ethanol inhibits hepatocyte proliferation in insulin receptor substrate 1 transgenic mice. Gastroenterology 115, 1558-1565