Alcohol impairs interferon signaling and enhances full cycle hepatitis C virus JFH-1 infection of human hepatocytes

Drug and Alcohol Dependence

Volumn 112, Issue 1-2, 2010, Pages 107-116

  Ye, Li ^a   Wang, Shihong ^b   Wang, Xu ^a   Zhou, Yu ^c   Li, Jieliang ^a   Persidsky, Yuri ^a   Ho, Wenzhe ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alcohol; Hepatitis C virus; Innate immunity; Type I interferon

Indexed keywords

ALCOHOL; ALPHA INTERFERON; BETA INTERFERON; CD81 ANTIGEN; CLAUDIN 1; GENE PRODUCT; GLYCOPROTEIN E1; GLYCOPROTEIN E2; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 7; LOW DENSITY LIPOPROTEIN RECEPTOR; NONSTRUCTURAL PROTEIN 3; OCCLUDIN; PROTEIN PIAS 1; PROTEIN PIAS 3; PROTEIN SB RI; RECOMBINANT ALPHA INTERFERON; STAT1 PROTEIN; STAT2 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG; VIRUS RECEPTOR; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; INNATE IMMUNITY; INTRACELLULAR SIGNALING; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS ENTRY; VIRUS REPLICATION;

ALCOHOL DRINKING; CELL LINE; CELLS, CULTURED; ETHANOL; HEPACIVIRUS; HEPATOCYTES; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-7; INTERFERON REGULATORY FACTORS; INTERFERON-ALPHA; INTERFERON-BETA; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 78049353258     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2010.05.008     Document Type: Article

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