Quantitative phosphoproteomic analysis reveals γ-bisabolene inducing p53-mediated apoptosis of human oral squamous cell carcinoma via HDAC2 inhibition and ERK1/2 activation

Proteomics

Volumn 15, Issue 19, 2015, Pages 3296-3309

  Jou, Yu Jen ^a,b   Chen, Chao Jung ^a,c   Liu, Yu Ching ^c   Way, Tzong Der ^a   Lai, Chih Ho ^d   Hua, Chun Hung ^c   Wang, Ching Ying ^a   Huang, Su Hua ^e   Kao, Jung Yie ^b   Lin, Cheng Wen ^a,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

Cell biology; Histone deacetylase; Oral squamous cell carcinoma; P53 acetylation; Phosphoproteomics; Bisabolene

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 9; GAMMA BISABOLENE; HISTONE DEACETYLASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLANT EXTRACT; PROTEIN P53; TERPENOID; UNCLASSIFIED DRUG; GAMMA-BISABOLENE; HDAC2 PROTEIN, HUMAN; PHOSPHOPROTEIN; SESQUITERPENE; TP53 PROTEIN, HUMAN;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CARDAMOM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOUSE; MOUTH SQUAMOUS CELL CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; QUANTITATIVE ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, SQUAMOUS CELL; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MOUTH NEOPLASMS; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; HISTONE DEACETYLASE 2; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOUTH NEOPLASMS; PHOSPHOPROTEINS; PROTEOMICS; SESQUITERPENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84942988999     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201400568     Document Type: Article

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