메뉴 건너뛰기




Volumn 29, Issue 1, 2013, Pages 349-354

Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells

Author keywords

Akt; Apoptosis; D limonene

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3BETA; LIMONENE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SERINE; THREONINE;

EID: 84872873809     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2093     Document Type: Article
Times cited : (141)

References (38)
  • 1
    • 35348929897 scopus 로고    scopus 로고
    • D-limonene: Safety and clinical applications
    • Sun J: D-Limonene: safety and clinical applications. Altern Med Rev 12: 259-264, 2007.
    • (2007) Altern Med Rev , vol.12 , pp. 259-264
    • Sun, J.1
  • 2
    • 0033637602 scopus 로고    scopus 로고
    • Citrus peel use is associated with reduced risk of squamous cell carcinoma of the skin
    • Hakim IA, Harris RB and Ritenbaugh C: Citrus peel use is associated with reduced risk of squamous cell carcinoma of the skin. Nutr Cancer 37: 161-168, 2000.
    • (2000) Nutr Cancer , vol.37 , pp. 161-168
    • Hakim, I.A.1    Harris, R.B.2    Ritenbaugh, C.3
  • 3
    • 0024519869 scopus 로고
    • The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil
    • Maltzman TH, Hurt LM, Elson CE, Tanner MA and Gould MN: The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil. Carcinogenesis 10: 781-783, 1989.
    • (1989) Carcinogenesis , vol.10 , pp. 781-783
    • Maltzman, T.H.1    Hurt, L.M.2    Elson, C.E.3    Tanner, M.A.4    Gould, M.N.5
  • 4
    • 0023870472 scopus 로고
    • Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of dmba-induced rat mammary carcinogenesis
    • Elson CE, Maltzman TH, Boston JL, Tanner MA and Gould MN: Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis. Carcinogenesis 9: 331-332, 1988.
    • (1988) Carcinogenesis , vol.9 , pp. 331-332
    • Elson, C.E.1    Maltzman, T.H.2    Boston, J.L.3    Tanner, M.A.4    Gould, M.N.5
  • 5
    • 0032905653 scopus 로고    scopus 로고
    • Inhibition by d-limonene of gastric carcinogenesis induced by n-methyl-n'-nitro-n-nitrosoguanidine in wistar rats
    • Uedo N, Tatsuta M, Iishi H, et al: Inhibition by D-limonene of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Cancer Lett 137: 131-136, 1999.
    • (1999) Cancer Lett , vol.137 , pp. 131-136
    • Uedo, N.1    Tatsuta, M.2    Iishi, H.3
  • 6
    • 0033194729 scopus 로고    scopus 로고
    • D-limonene chemoprevention of hepatocarcinogenesis in akr mice: Inhibition of c-jun and c-myc
    • Giri RK, Parija T and Das BR: d-limonene chemoprevention of hepatocarcinogenesis in AKR mice: Inhibition of c-jun and c-myc. Oncol Rep 6: 1123-1127, 1999.
    • (1999) Oncol Rep , vol.6 , pp. 1123-1127
    • Giri, R.K.1    Parija, T.2    Das, B.R.3
  • 7
    • 0030763805 scopus 로고    scopus 로고
    • D-limonene inhibits n-nitrosobis(2-oxopropyl) amine induced hamster pancreatic carcinogenesis
    • Nakaizumi A, Baba M, Uehara H, Iishi H and Tatsuta M: d-Limonene inhibits N-nitrosobis(2-oxopropyl)amine induced hamster pancreatic carcinogenesis. Cancer Lett 117: 99-103, 1997.
    • (1997) Cancer Lett , vol.117 , pp. 99-103
    • Nakaizumi, A.1    Baba, M.2    Uehara, H.3    Iishi, H.4    Tatsuta, M.5
  • 8
    • 0024378052 scopus 로고
    • Inhibition of n-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes
    • Wattenberg LW, Sparnins VL and Barany G: Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes. Cancer Res 49: 2689-2692, 1989.
    • (1989) Cancer Res , vol.49 , pp. 2689-2692
    • Wattenberg, L.W.1    Sparnins, V.L.2    Barany, G.3
  • 9
    • 0031834303 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of d-limonene in patients with advanced cancer. Cancer research campaign phase i/ii clinical trials committee
    • Vigushin DM, Poon GK, Boddy A, et al: Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. Cancer Chemother Pharmacol 42: 111-117, 1998.
    • (1998) Cancer Chemother Pharmacol , vol.42 , pp. 111-117
    • Vigushin, D.M.1    Poon, G.K.2    Boddy, A.3
  • 10
    • 0025228499 scopus 로고
    • Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents
    • Steele VE, Kelloff GJ, Wilkinson BP and Arnold JT: Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents. Cancer Res 50: 2068-2074, 1990.
    • (1990) Cancer Res , vol.50 , pp. 2068-2074
    • Steele, V.E.1    Kelloff, G.J.2    Wilkinson, B.P.3    Arnold, J.T.4
  • 11
    • 0025948240 scopus 로고
    • Effects of monoterpenoids on in vivo dmba-dna adduct formation and on phase i hepatic metabolizing enzymes
    • Maltzman TH, Christou M, Gould MN and Jefcoate CR: Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes. Carcinogenesis 12: 2081-2087, 1991.
    • (1991) Carcinogenesis , vol.12 , pp. 2081-2087
    • Maltzman, T.H.1    Christou, M.2    Gould, M.N.3    Jefcoate, C.R.4
  • 12
    • 2442497423 scopus 로고    scopus 로고
    • Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal udp-glucuronosyltransferases
    • Van der Logt EM, Roelofs HM, van Lieshout EM, Nagengast FM and Peters WH: Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases. Anticancer Res 24: 843-849, 2004.
    • (2004) Anticancer Res , vol.24 , pp. 843-849
    • Van Der Logt, E.M.1    Roelofs, H.M.2    Van Lieshout, E.M.3    Nagengast, F.M.4    Peters, W.H.5
  • 13
    • 77149166308 scopus 로고    scopus 로고
    • Limonene exerts antiproliferative effects and increases nitric oxide levels on a lymphoma cell line by dual mechanism of the erk pathway: Relationship with oxidative stress
    • Manuele MG, Barreiro Arcos ML, Davicino R, Ferraro G, Cremaschi G and Anesini C: Limonene exerts antiproliferative effects and increases nitric oxide levels on a lymphoma cell line by dual mechanism of the ERK pathway: relationship with oxidative stress. Cancer Invest 28: 135-145, 2010.
    • (2010) Cancer Invest , vol.28 , pp. 135-145
    • Manuele, M.G.1    Barreiro Arcos, M.L.2    Davicino, R.3    Ferraro, G.4    Cremaschi, G.5    Anesini, C.6
  • 14
    • 4043135688 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of human gastric cancer implanted in nude mice by d-limonene
    • Lu XG, Zhan LB, Feng BA, Qu MY, Yu LH and Xie JH: Inhibition of growth and metastasis of human gastric cancer implanted in nude mice by d-limonene. World J Gastroenterol 10: 2140-2144, 2004.
    • (2004) World J Gastroenterol , vol.10 , pp. 2140-2144
    • Lu, X.G.1    Zhan, L.B.2    Feng, B.A.3    Qu, M.Y.4    Yu, L.H.5    Xie, J.H.6
  • 15
    • 0842329598 scopus 로고    scopus 로고
    • Induction of apoptosis by citrus paradisi essential oil in human leukemic (hl-60) cells
    • Hata T, Sakaguchi I, Mori M, et al: Induction of apoptosis by Citrus paradisi essential oil in human leukemic (HL-60) cells. In Vivo 17: 553-559, 2003.
    • (2003) Vivo , vol.17 , pp. 553-559
    • Hata, T.1    Sakaguchi, I.2    Mori, M.3
  • 16
    • 33845590531 scopus 로고    scopus 로고
    • Induction of apoptosis by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia cells
    • Ji J, Zhang L, Wu YY, Zhu XY, Lv SQ and Sun XZ: Induction of apoptosis by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia cells. Leuk Lymphoma 47: 2617-2624, 2006.
    • (2006) Leuk Lymphoma , vol.47 , pp. 2617-2624
    • Ji, J.1    Zhang, L.2    Wu, Y.Y.3    Zhu, X.Y.4    Lv, S.Q.5    Sun, X.Z.6
  • 18
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic pi3k deregulates transcription and translation
    • Bader AG, Kang S, Zhao L and Vogt PK: Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 5: 921-929, 2005.
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 19
    • 67049137382 scopus 로고    scopus 로고
    • Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit cxcr4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: A novel therapeutic approach
    • Niedermeier M, Hennessy BT, Knight ZA, et al: Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood 113: 5549-5557, 2009.
    • (2009) Blood , vol.113 , pp. 5549-5557
    • Niedermeier, M.1    Hennessy, B.T.2    Knight, Z.A.3
  • 20
    • 84855578581 scopus 로고    scopus 로고
    • Studies on the expression patterns of class i pi3k catalytic subunits and its prognostic significance in colorectal cancer
    • Cui B, Tao J and Yang Y: Studies on the expression patterns of class I PI3K catalytic subunits and its prognostic significance in colorectal cancer. Cell Biochem Biophys 62: 47-54, 2012.
    • (2012) Cell Biochem Biophys , vol.62 , pp. 47-54
    • Cui, B.1    Tao, J.2    Yang, Y.3
  • 21
    • 0034027514 scopus 로고    scopus 로고
    • Overexpression of akt/akt can modulate chemotherapy-induced apoptosis
    • Page C, Lin HJ, Jin Y, et al: Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis. Anticancer Res 20: 407-416, 2000.
    • (2000) Anticancer Res , vol.20 , pp. 407-416
    • Page, C.1    Lin, H.J.2    Jin, Y.3
  • 22
    • 79956017530 scopus 로고    scopus 로고
    • Targeting aberrant pi3k/akt activation by pi103 restores sensitivity to trail-induced apoptosis in neuroblastoma. Clin
    • Opel D, Naumann I, Schneider M, Bertele D, Debatin KM and Fulda S: Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma. Clin Cancer Res 17: 3233-3247, 2011.
    • (2011) Cancer Res , vol.17 , pp. 3233-3247
    • Opel, D.1    Naumann, I.2    Schneider, M.3    Bertele, D.4    Debatin, K.M.5    Fulda, S.6
  • 23
    • 51849098272 scopus 로고    scopus 로고
    • Drug discovery approaches targeting the pi3k/akt pathway in cancer
    • Garcia-Echeverria C and Sellers WR: Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 27: 5511-5526, 2008.
    • (2008) Oncogene , vol.27 , pp. 5511-5526
    • Garcia-Echeverria, C.1    Sellers, W.R.2
  • 24
    • 0034602179 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or akt but not for death caused by nerve growth factor withdrawal
    • Crowder RJ and Freeman RS: Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal. J Biol Chem 275: 34266-34271, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 34266-34271
    • Crowder, R.J.1    Freeman, R.S.2
  • 25
    • 61449258534 scopus 로고    scopus 로고
    • Critical role of bad phosphorylation by akt in cytostatic resistance of human bladder cancer cells
    • Szanto A, Bognar Z, Szigeti A, Szabo A, Farkas L and Gallyas F Jr.: Critical role of bad phosphorylation by Akt in cytostatic resistance of human bladder cancer cells. Anticancer Res 29: 159-164, 2009.
    • (2009) Anticancer Res , vol.29 , pp. 159-164
    • Szanto, A.1    Bognar, Z.2    Szigeti, A.3    Szabo, A.4    Farkas, L.5    Gallyas Jr., F.6
  • 26
    • 0032515027 scopus 로고    scopus 로고
    • Regulation of cell death protease caspase-9 by phosphorylation
    • Cardone MH, Roy N, Stennicke HR, et al: Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318-1321, 1998.
    • (1998) Science , vol.282 , pp. 1318-1321
    • Cardone, M.H.1    Roy, N.2    Stennicke, H.R.3
  • 27
    • 84860312860 scopus 로고    scopus 로고
    • Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in pc-3 prostate cancer cells
    • Kim SH, Park EJ, Lee CR, et al: Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells. Int J Oncol 40: 1683-1690, 2012.
    • (2012) Int J Oncol , vol.40 , pp. 1683-1690
    • Kim, S.H.1    Park, E.J.2    Lee, C.R.3
  • 28
    • 84865205746 scopus 로고    scopus 로고
    • D-limonene modulates inflammation, oxidative stress and ras-erk pathway to inhibit murine skin tumorigenesis
    • Chaudhary SC, Siddiqui MS, Athar M and Alam MS: D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis. Hum Exp Toxicol 31: 798-811, 2012.
    • (2012) Hum Exp Toxicol , vol.31 , pp. 798-811
    • Chaudhary, S.C.1    Siddiqui, M.S.2    Athar, M.3    Alam, M.S.4
  • 29
    • 0035427196 scopus 로고    scopus 로고
    • Inhibition by d-limonene of experimental hepatocarcinogenesis in sprague-dawley rats does not involve p21(ras) plasma membrane association
    • Kaji I, Tatsuta M, Iishi H, Baba M, Inoue A and Kasugai H: Inhibition by d-limonene of experimental hepatocarcinogenesis in Sprague-Dawley rats does not involve p21(ras) plasma membrane association. Int J Cancer 93: 441-444, 2001.
    • (2001) Int J Cancer , vol.93 , pp. 441-444
    • Kaji, I.1    Tatsuta, M.2    Iishi, H.3    Baba, M.4    Inoue, A.5    Kasugai, H.6
  • 30
    • 67649484490 scopus 로고    scopus 로고
    • D-limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
    • Rabi T and Bishayee A: d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis. J Carcinog 8: 9, 2009.
    • (2009) J Carcinog , vol.8 , pp. 9
    • Rabi, T.1    Bishayee, A.2
  • 31
    • 56149125452 scopus 로고    scopus 로고
    • Apoptosis by dietary agents for prevention and treatment of cancer
    • Khan N, Adhami VM and Mukhtar H: Apoptosis by dietary agents for prevention and treatment of cancer. Biochem Pharmacol 76: 1333-1339, 2008.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1333-1339
    • Khan, N.1    Adhami, V.M.2    Mukhtar, H.3
  • 32
    • 77953541212 scopus 로고    scopus 로고
    • Novel seed peptide sensitizes human breast cancer mda-mb-231 cells to aspirin-arrested cell cycle induced apoptosis
    • Hsieh CC, Hernandez-Ledesma B and de Lumen BO: Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact 186: 127-134, 2010.
    • (2010) Chem Biol Interact , vol.186 , pp. 127-134
    • Hsieh, C.C.1    Hernandez-Ledesma, B.2    De Lumen, B.O.3    Lunasin, A.4
  • 33
    • 2442561553 scopus 로고    scopus 로고
    • Apoptosis as a novel target for cancer chemoprevention
    • Sun SY, Hail N Jr. and Lotan R: Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 96: 662-672, 2004.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 662-672
    • Sun, S.Y.1    Hail Jr., N.2    Lotan, R.3
  • 34
    • 34047271640 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of bax and bim in human b cells
    • Baysan A, Yel L, Gollapudi S, Su H and Gupta S: Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells. Int J Oncol 30: 313-318, 2007.
    • (2007) Int J Oncol , vol.30 , pp. 313-318
    • Baysan, A.1    Yel, L.2    Gollapudi, S.3    Su, H.4    Gupta, S.5
  • 35
    • 34247527336 scopus 로고    scopus 로고
    • Mitochondrial permeabilization relies on bh3 ligands engaging multiple prosurvival bcl-2 relatives, not bak
    • Uren RT, Dewson G, Chen L, et al: Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak. J Cell Biol 177: 277-287, 2007.
    • (2007) J Cell Biol , vol.177 , pp. 277-287
    • Uren, R.T.1    Dewson, G.2    Chen, L.3
  • 36
    • 36348934636 scopus 로고    scopus 로고
    • Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic bcl-2 family members
    • Chen M, Guerrero AD, Huang L, et al: Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members. J Biol Chem 282: 33888-33895, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 33888-33895
    • Chen, M.1    Guerrero, A.D.2    Huang, L.3
  • 37
    • 0036729867 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase-akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
    • Krystal GW, Sulanke G and Litz J: Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. Mol Cancer Ther 1: 913-922, 2002.
    • (2002) Mol Cancer Ther , vol.1 , pp. 913-922
    • Krystal, G.W.1    Sulanke, G.2    Litz, J.3
  • 38
    • 33645462548 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/akt pathway sensitizes mda-mb468 human breast cancer cells to cerulenin-induced apoptosis
    • Liu X, Shi Y, Giranda VL and Luo Y: Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis. Mol Cancer Ther 5: 494-501, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 494-501
    • Liu, X.1    Shi, Y.2    Giranda, V.L.3    Luo, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.