메뉴 건너뛰기




Volumn 240, Issue 10, 2015, Pages 1279-1286

Sex hormone affects the severity of non-alcoholic steatohepatitis through the MyD88-dependent IL-6 signaling pathway

Author keywords

Non alcoholic steatohepatitis; Sex hormone specific intervention; Sex associated differences; TLR MyD88 IL 6 signaling pathway

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BETA ACTIN; ESTRADIOL; ESTRADIOL BENZOATE; INTERLEUKIN 6; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; TESTOSTERONE; TESTOSTERONE PROPIONATE; ANDROGEN; ESTROGEN; MYD88 PROTEIN, MOUSE; SEX HORMONE;

EID: 84942854090     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370215570189     Document Type: Article
Times cited : (24)

References (37)
  • 1
    • 0021992966 scopus 로고
    • The long-term serological course of asymptomatic hepatitis B virus carriers and the development of primary hepatocellular carcinoma
    • W.L.AlwardB.J.McMahonD.B.HallW.L.HeywardD.P.FrancisT.R.Bender. The long-term serological course of asymptomatic hepatitis B virus carriers and the development of primary hepatocellular carcinoma. J Infect Dis1985; 151(4): 604–9.
    • (1985) J Infect Dis , vol.151 , Issue.4 , pp. 604-609
    • Alward, W.L.1    McMahon, B.J.2    Hall, D.B.3    Heyward, W.L.4    Francis, D.P.5    Bender, T.R.6
  • 2
    • 23944517762 scopus 로고    scopus 로고
    • Current understanding of gender dimorphism in hepatic pathophysiology
    • Y.YokoyamaY.NimuraM.NaginoK.I.BlandI.H.Chaudry. Current understanding of gender dimorphism in hepatic pathophysiology. J Surg Res2005; 128(1): 147–56.
    • (2005) J Surg Res , vol.128 , Issue.1 , pp. 147-156
    • Yokoyama, Y.1    Nimura, Y.2    Nagino, M.3    Bland, K.I.4    Chaudry, I.H.5
  • 4
    • 0037413953 scopus 로고    scopus 로고
    • Hormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: A nested case-control study among men
    • M.W.YuY.C.YangS.Y.YangS.W.ChengY.F.LiawS.M.LinC.J.Chen. Hormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: A nested case-control study among men. J Natl Cancer Inst2001; 95(7): 559–60.
    • (2001) J Natl Cancer Inst , vol.95 , Issue.7 , pp. 559-560
    • Yu, M.W.1    Yang, Y.C.2    Yang, S.Y.3    Cheng, S.W.4    Liaw, Y.F.5    Lin, S.M.6    Chen, C.J.7
  • 5
    • 0032944066 scopus 로고    scopus 로고
    • Hepatitis B surface antigen disappearance and hepatitis B surface antigen subtype: A prospective, long-term, follow-up study of Japanese residents of Okinawa, Japan with chronic hepatitis B virus infection
    • N.FurusyoJ.HayashiY.SawayamaY.KishiharaS.Kashiwagi. Hepatitis B surface antigen disappearance and hepatitis B surface antigen subtype: A prospective, long-term, follow-up study of Japanese residents of Okinawa, Japan with chronic hepatitis B virus infection. Am J Trop Med Hyg1999; 60(4): 616–22.
    • (1999) Am J Trop Med Hyg , vol.60 , Issue.4 , pp. 616-622
    • Furusyo, N.1    Hayashi, J.2    Sawayama, Y.3    Kishihara, Y.4    Kashiwagi, S.5
  • 9
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • H.B.El-SeragK.L.Rudolph. Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology2007; 132(7): 2557–76.
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 10
    • 84874645372 scopus 로고    scopus 로고
    • Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988–1994 to 2007–2010
    • J.A.WelshS.KarpenM.B.Vos. Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988–1994 to 2007–2010. J Pediatr2013; 162(3): 496–500.
    • (2013) J Pediatr , vol.162 , Issue.3 , pp. 496-500
    • Welsh, J.A.1    Karpen, S.2    Vos, M.B.3
  • 11
    • 34247182474 scopus 로고    scopus 로고
    • The importance of metabolic factors for the increasing prevalence of fatty liver in Shanghai factory workers
    • J.G.FanF.LiX.B.CaiY.D.PengQ.H.AoY.Gao. The importance of metabolic factors for the increasing prevalence of fatty liver in Shanghai factory workers. J Gastroenterol Hepatol2007; 22(5): 663–8.
    • (2007) J Gastroenterol Hepatol , vol.22 , Issue.5 , pp. 663-668
    • Fan, J.G.1    Li, F.2    Cai, X.B.3    Peng, Y.D.4    Ao, Q.H.5    Gao, Y.6
  • 12
    • 33947527268 scopus 로고    scopus 로고
    • Prevalence and risk factors of fatty liver disease in the Shuiguohu district of Wuhan city, central China
    • Z.WangB.XiaC.MaZ.HuX.ChenP.Cao. Prevalence and risk factors of fatty liver disease in the Shuiguohu district of Wuhan city, central China. Postgrad Med J2007; 83(977): 192–5.
    • (2007) Postgrad Med J , vol.83 , Issue.977 , pp. 192-195
    • Wang, Z.1    Xia, B.2    Ma, C.3    Hu, Z.4    Chen, X.5    Cao, P.6
  • 13
    • 78651352067 scopus 로고    scopus 로고
    • Prevalence, gender, ethnic variations, and prognosis of NASH
    • E.HashimotoK.Tokushige. Prevalence, gender, ethnic variations, and prognosis of NASH. J Gastroenterol2011; 46(Suppl 1): 63–9.
    • (2011) J Gastroenterol , vol.46 , pp. 63-69
    • Hashimoto, E.1    Tokushige, K.2
  • 14
    • 35649017612 scopus 로고    scopus 로고
    • Influence of age and gender in Japanese patients with non-alcoholic steatohepatitis
    • S.YatsujiE.HashimotoM.TobariK.TokushigeK.Shiratori. Influence of age and gender in Japanese patients with non-alcoholic steatohepatitis. Hepatol Res2007; 37(12): 1034–43.
    • (2007) Hepatol Res , vol.37 , Issue.12 , pp. 1034-1043
    • Yatsuji, S.1    Hashimoto, E.2    Tobari, M.3    Tokushige, K.4    Shiratori, K.5
  • 16
    • 84877264082 scopus 로고    scopus 로고
    • Female mice are more susceptible to nonalcoholic fatty liver disease: Sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response
    • A.SprussJ.HenkelG.KanuriD.BlankG.P.PüschelS.C.BischoffI.Bergheim. Female mice are more susceptible to nonalcoholic fatty liver disease: Sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response. Mol Med2012; 18: 1346–55.
    • (2012) Mol Med , vol.18 , pp. 1346-1355
    • Spruss, A.1    Henkel, J.2    Kanuri, G.3    Blank, D.4    Püschel, G.P.5    Bischoff, S.C.6    Bergheim, I.7
  • 20
    • 0742305244 scopus 로고    scopus 로고
    • Sex differences in choline-deficient diet-induced steatohepatitis in mice
    • P.R.KashireddyM.S.Rao. Sex differences in choline-deficient diet-induced steatohepatitis in mice. Exp Biol Med (Maywood)2004; 229(2): 158–62.
    • (2004) Exp Biol Med (Maywood) , vol.229 , Issue.2 , pp. 158-162
    • Kashireddy, P.R.1    Rao, M.S.2
  • 22
    • 69949096681 scopus 로고    scopus 로고
    • Effects of estrogen and androgen deprivation on the progression of non-alcoholic steatohepatitis (NASH) in male Sprague-Dawley rats
    • Y.MuR.SheH.ZhangB.DongC.HuangW.LinD.LiX.Li. Effects of estrogen and androgen deprivation on the progression of non-alcoholic steatohepatitis (NASH) in male Sprague-Dawley rats. Hepatol Res2009; 39(9): 910–20.
    • (2009) Hepatol Res , vol.39 , Issue.9 , pp. 910-920
    • Mu, Y.1    She, R.2    Zhang, H.3    Dong, B.4    Huang, C.5    Lin, W.6    Li, D.7    Li, X.8
  • 24
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • W.E.NauglerT.SakuraiS.KimS.MaedaK.KimA.M.ElsharkawyM.Karin. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science2007; 317(5834): 121–4.
    • (2007) Science , vol.317 , Issue.5834 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6    Karin, M.7
  • 25
    • 70949094933 scopus 로고    scopus 로고
    • IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis
    • E.MasM.DanjouxV.GarciaS.CarpentierB.SéguiT.Levade. IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PLoS One2009; 4(11): e7929–e7929.
    • (2009) PLoS One , vol.4 , Issue.11 , pp. 7929
    • Mas, E.1    Danjoux, M.2    Garcia, V.3    Carpentier, S.4    Ségui, B.5    Levade, T.6
  • 26
    • 77955150888 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice
    • K.YamaguchiY.ItohC.YokomizoT.NishimuraT.NiimiH.FujiiT.OkanoueT.Yoshikawa. Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice. Lab Invest2010; 90(8): 1169–78.
    • (2010) Lab Invest , vol.90 , Issue.8 , pp. 1169-1178
    • Yamaguchi, K.1    Itoh, Y.2    Yokomizo, C.3    Nishimura, T.4    Niimi, T.5    Fujii, H.6    Okanoue, T.7    Yoshikawa, T.8
  • 27
    • 79953176357 scopus 로고    scopus 로고
    • Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice
    • K.YamaguchiY.ItohC.YokomizoT.NishimuraT.NiimiA.UmemuraT.OkanoueT.Yoshikawa. Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice. Lab Invest2011; 91(4): 609–18.
    • (2011) Lab Invest , vol.91 , Issue.4 , pp. 609-618
    • Yamaguchi, K.1    Itoh, Y.2    Yokomizo, C.3    Nishimura, T.4    Niimi, T.5    Umemura, A.6    Okanoue, T.7    Yoshikawa, T.8
  • 28
    • 84880425458 scopus 로고    scopus 로고
    • Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis
    • Y.S.RohE.Seki. Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol2013; 28(Suppl 1): 38–42.
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 38-42
    • Roh, Y.S.1    Seki, E.2
  • 29
    • 84860326669 scopus 로고    scopus 로고
    • NASH is an inflammatory disorder: Pathogenic, prognostic and therapeutic implications
    • G.C.FarrellD.van RooyenL.GanS.Chitturi. NASH is an inflammatory disorder: Pathogenic, prognostic and therapeutic implications. Gut Liver2012; 6(2): 149–71.
    • (2012) Gut Liver , vol.6 , Issue.2 , pp. 149-171
    • Farrell, G.C.1    van Rooyen, D.2    Gan, L.3    Chitturi, S.4
  • 30
    • 0030043606 scopus 로고    scopus 로고
    • Sex and strain differences in constitutive expression of fatty acid ω-hydroxylase (CYP4A-related proteins) in mice
    • M.HiratsukaT.MatsuuraE.WatanabeM.SatoY.Suzuki. Sex and strain differences in constitutive expression of fatty acid ω-hydroxylase (CYP4A-related proteins) in mice. J Biochem1996; 119(2): 340–5.
    • (1996) J Biochem , vol.119 , Issue.2 , pp. 340-345
    • Hiratsuka, M.1    Matsuura, T.2    Watanabe, E.3    Sato, M.4    Suzuki, Y.5
  • 32
    • 51949117828 scopus 로고    scopus 로고
    • Sex hormone influence on hepatitis in young male A/JCr mice infected with Helicobacter hepaticus
    • E.J.TheveY.FengK.TaghizadehK.S.CormierD.R.BellJ.G.FoxA.B.Rogers. Sex hormone influence on hepatitis in young male A/JCr mice infected with Helicobacter hepaticus. Infect Immun2008; 76(9): 4071–8.
    • (2008) Infect Immun , vol.76 , Issue.9 , pp. 4071-4078
    • Theve, E.J.1    Feng, Y.2    Taghizadeh, K.3    Cormier, K.S.4    Bell, D.R.5    Fox, J.G.6    Rogers, A.B.7
  • 33
    • 33646147362 scopus 로고    scopus 로고
    • Toll-like receptor function and signaling
    • T.KaishoS.Akira. Toll-like receptor function and signaling. J Allergy Clin Immunol2006; 117(5): 979–87.
    • (2006) J Allergy Clin Immunol , vol.117 , Issue.5 , pp. 979-987
    • Kaisho, T.1    Akira, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.