Sex hormone influence on hepatitis in young male A/JCr mice infected with Helicobacter hepaticus

Infection and Immunity

Volumn 76, Issue 9, 2008, Pages 4071-4078

  Theve, Elizabeth J ^a   Feng, Yan ^a   Taghizadeh, Koli ^b   Cormier, Kathleen S ^a   Bell, David R ^c   Fox, James G ^a,b   Rogers, Arlin B ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology   (United States)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; BEZAFIBRATE; CYTOCHROME P450; CYTOCHROME P450 4A; CYTOCHROME P450 4A12; CYTOCHROME P450 4A14; DUTASTERIDE; FLUFENAMIC ACID; FLUTAMIDE; LINOLEIC ACID; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OLEIC ACID; SEX HORMONE; TREFOIL FACTOR 3; TREFOIL PEPTIDE; UBIQUITIN D; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CASTRATED MALE; COMPARATIVE STUDY; CONTROLLED STUDY; GENE; HELICOBACTER HEPATICUS; HEPATITIS; HEPATITIS B VIRUS; HISTOPATHOLOGY; HORMONAL THERAPY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACUTE-PHASE PROTEINS; ANDROGEN ANTAGONISTS; ANIMALS; CASTRATION; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION PROFILING; HELICOBACTER HEPATICUS; HELICOBACTER INFECTIONS; HEPATITIS; LIPOCALINS; LIVER; MALE; MICE; MICE, INBRED A; MUCINS; ONCOGENE PROTEINS; SEVERITY OF ILLNESS INDEX; TESTOSTERONE; TESTOSTERONE CONGENERS; UBIQUITIN;

EID: 51949117828     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00401-08     Document Type: Article

References (44)

1. Alikor, E. A., and O. N. Erhabor. 2007. Seroprevalence of hepatitis B surface antigenaemia in children in a tertiary health institution in the Niger Delta of Nigeria. Niger J. Med. 16:326-329.
2. Amador-Noguez, D., K. Yagi, S. Venable, and G. Darlington. 2004. Gene expression profile of long-lived Ames dwarf mice and Little mice. Aging Cell 3:423-441.
3. Bahrami, H., N. E. Daryani, B. Haghpanah, A. Moayyeri, K. F. Moghadam, S. Mirmomen, and F. Kamangar. 2005. Effects of indomethacin on viral replication markers in asymptomatic carriers of hepatitis B: a randomized, placebo-controlled trial. Am. J. Gastroenterol. 100:856-861.
4. Bosch, F. X., J. Ribes, R. Cleries, and M. Diaz. 2005. Epidemiology of hepatocellular carcinoma. Clin. Liver Dis. 9:191-211, v.
5. Boutin, S. R., A. B. Rogers, Z. Shen, R. C. Fry, J. A. Love, P. R. Nambiar, S. Suerbaum, and J. G. Fox. 2004. Hepatic temporal gene expression profiling in Helicobacter hepaticus-intected A/JCr mice. Toxicol. Pathol. 32:678-693.
6. Cai, Y., T. Dai, Y. Ao, T. Konishi, K. H. Chuang, Y. Lue, C. Chang, and Y. J. Wan. 2003. Cytochrome P450 genes are differentially expressed in female and male hepatocyte retinoid X receptor alpha-deficient mice. Endocrinology 144:2311-2318.
7. Capdevila, J. H., J. R. Falck, and J. D. Imig. 2007. Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension. Kidney Int. 72:683-689.
8. Chen, J. C., C. C. Chen, W. J. Chen, H. S. Lai, W. T. Hung, and P. H. Lee. 1998. Hepatocellular carcinoma in children: clinical review and comparison with adult cases. J. Pediatr. Surg. 33:1350-1354.
9. Clark, R. V., D. J. Hermann, G. R. Cunningham, T. H. Wilson, B. B. Morrill, and S. Hobbs. 2004. Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor. J. Clin. Endocrinol. Metab. 89:2179-2184.
10. Clodfelter, K. H., M. G. Holloway, P. Hodor, S. H. Park, W. J. Ray, and D. J. Waxman. 2006. Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol. Endocrinol. 20:1333-1351.
11. Deaciuc, I. V., D. E. Doherty, R. Burikhanov, E. Y. Lee, A. J. Stromberg, X. Peng, and W. J. de Villiers. 2004. Large-scale gene profiling of the liver in a mouse model of chronic, intragastric ethanol infusion. J. Hepatol. 40:219-227.
12. Djouadi, F., C. J. Weinheimer, J. E. Safftz, C. Pitchford, J. Bastin, F. J. Gonzalez, and D. P. Kelly. 1998. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice. J. Clin. Investig. 102:1083-1091.
13. Elisofon, S. A., and M. M. Jonas. 2006. Hepatitis B and C in children: current treatment and future strategies. Clin. Liver Dis. 10:133-148, vii.
14. El-Serag, H. B., and K. L. Rudolph. 2007. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132:2557-2576.
15. Fox, J. G., F. E. Dewhirst, J. G. Tully, B. J. Paster, L. Yan, N. S. Taylor, M. J. Collins, Jr., P. L. Gorelick, and J. M. Ward. 1994. Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. J. Clin. Microbiol. 32:1238-1245.
16. Fox, J. G., X. Li, L. Yan, R. J. Cahill, R. Hurley, R. Lewis, and J. C. Murphy. 1996. Chronic proliferative hepatitis in A/JCr mice associated with persistent Helicobacter hepaticus infection: a model of helicobacter-induced carcinogenesis. Infect. Immun. 64:1548-1558.
17. Goodman, Z. D., H. R. Makhlouf, L. Liu, W. Balistreri, R. P. Gonzalez-Peralta, B. Haber, M. M. Jonas, P. Mohan, J. P. Molleston, K. F. Murray, M. R. Narkewicz, P. Rosenthal, L. J. Smith, P. R. Robuck, and K. B. Schwarz. 2008. Pathology of chronic hepatitis C in children: liver biopsy findings in the Peds-C Trial. Hepatology 47:836-843.
18. Hays, T., I. Rusyn, A. M. Burns, M. J. Kennett, J. M. Ward, F. J. Gonzalez, and J. M. Peters. 2005. Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis 26:219-227.
19. Heng, Y. M., C. S. Kuo, P. S. Jones, R. Savory, R. M. Schulz, S. R. Tomlinson, T. J. Gray, and D. R. Bell. 1997. A novel murine P-450 gene, Cyp4al4, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Biochem. J. 325:741-749.
20. Jeffery, B., A. I. Choudhury, N. Horley, M. Bruce, S. R. Tomlinson, R. A. Roberts, T. J. Gray, D. A. Barrett, P. N. Shaw, D. Kendall, and D. R. Bell. 2004. Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver. Arch. Biochem. Biophys. 429:231-236.
21. Lai, C. L., and M. F. Yuen. 2007. The natural history of chronic hepatitis B. J. Viral Hepatol. 14(Suppl. 1):6-10.
22. Lukka, H., T. Waldron, L. Klotz, E. Winquist, and J. Trachtenberg. 2006. Maximal androgen blockade for the treatment of metastatic prostate cancer - a systematic review. Curr. Oncol. 13:81-93.
23. Mast, E. E., M. J. Alter, and H. S. Margolis. 1999. Strategies to prevent and control hepatitis B and C virus infections: a global perspective. Vaccine 17:1730-1733.
24. Murphy, J. C., S. Srinivas, and M. K. Terris. 2004. Flutamide administration at 500 mg daily has similar effects on serum testosterone to 750 mg daily. J. Androl. 25:630-634.
25. Nakatani, T., G. Roy, N. Fujimoto, T. Asahara, and A. Ito. 2001. Sex hormone dependency of diethylnitrosamine-induced liver tumors in mice and chemoprevention by leuprorelin. Jpn. J. Cancer Res. 92:249-256.
26. Percy, D. H., and S. W. Barthold. 2001. Mouse, p. 3-106. Pathology of laboratory rodents and rabbits, 2nd ed. Iowa State Press, Ames, IA.
27. Perz, J. F., G. L. Armstrong, L. A. Farrington, Y. J. Hutin, and B. P. Bell. 2006. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J. Hepatol. 45:529-538.
28. Petersson, H., S. Basu, T. Cederholm, and U. Riserus. 2008. Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: longitudinal analyses in middle-aged men. Br J. Nutr. 99:1186-1189.
29. Rapicetta, M., T. Stroffolini, T. Ngatchu, P. Chionne, A. R. Ciccaglione, D. Lantum, and M. Chiaramonte. 1991. Age- and sex-related study of HBV-DNA in HBsAg asymptomatic children from an endemic area (Cameroon). Ann. Trop. Paediatr. 11:325-329.
30. Rogers, A. B., S. R. Boutin, M. T. Whary, N. Sundina, Z. Ge, K. Cormier, and J. G. Fox. 2004. Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice. Toxicol. Pathol. 32:668-677.
31. Rogers, A. B., and J. G. Fox. 2004. Inflammation and cancer. I. Rodent models of infectious gastrointestinal and liver cancer. Am. J. Physiol. Gas-trointest. Liver Physiol. 286:G361-G366.
32. Rogers, A. B., E. J. Theve, Y. Feng, R. C. Fry, K. Taghizadeh, K. M. Clapp, C. Boussahmain, K. S. Cormier, and J. G. Fox. 2007. Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res. 67:11536-11546.
33. Steckelbroeck, S., Y. Jin, S. Gopishetty, B. Oyesanmi, and T. M. Penning. 2004. Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. J. Biol. Chem. 279:10784-10795.
34. Sunil, V. R., K. J. Patel, M. Nilsen-Hamilton. D. E. Heck, J. D. Laskin, and D. L. Laskin. 2007. Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Exp. Mol. Pathol. 83:177-187.
35. Taghizadeh, K., and P. L. Skipper. 1994. Benzo[a]pyrene diol epoxide and related polynuclear aromatic hydrocarbon adducts of hemoglobin. Methods Enzymol. 231:668-674.
36. Ugwu, C., P. Varkey, S. Bagniewski, and T. Lesnick. 8 December 2007, posting date. Sero-epidemiology of hepatitis B among new refugees to Minnesota. J. Immigr. Minor. Health. doi:10.1007/sl0903-007-9111-5.
37. Veldhuis, J. D., and C. Y. Bowers. 2003. Three-peptide control of pulsatile and entropic feedback-sensitive modes of growth hormone secretion: modulation by estrogen and aromatizable androgen. J. Pediatr. Endocrinol. Metab. 16(Suppl. 3):587-605.
38. Vesselinovitch, S. D. 1987. Certain aspects of hepatocarcinogenesis in the infant mouse model. Toxicol. Pathol. 15:221-228.
39. Vesselinovitch, S. D. 1990. Perinatal mouse liver carcinogenesis as a sensitive carcinogenesis model and the role of the sex hormonal environment in tumor development. Prog. Clin. Biol. Res. 331:53-68.
40. Wang, A. G., H. B. Moon, S. Y. Chun, T. H. Lee, D. Y. Yu, and D. S. Lee. 2006. Orchiectomy reduces hepatotumorigenesis of H-rasl2V transgenic mice via the MAPK pathway. Life Sri. 79:1974-1980.
41. Wang, J. D., T. K. Chang, H. C. Chen, S. L. Jan, F. L. Huang, C. S. Chi, and C. C. Lin. 2007. Pediatric liver tumors: initial presentation, image finding and outcome. Pediatr. Int. 49:491-496.
42. Waxman, D. J., and C. O'Connor. 2006. Growth hormone regulation of sex-dependent liver gene expression. Mol. Endocrinol 20:2613-2629.
43. Wen, W. H., M. H. Chang, H. Y. Hsu, Y. H. Ni, and H. L. Chen. 2004. The development of hepatocellular carcinoma among prospectively followed children with chronic hepatitis B virus infection. J. Pediatr. 144:397-399.
44. Weng, Y., C. C. DiRusso, A. A. Reilly, P. N. Black, and X. Ding. 2005. Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. J. Biol. Chem. 280:31686-31698.