Biomonitoring using dried blood spots: Detection of ochratoxin A and its degradation product 2'R-ochratoxin A in blood from coffee drinkers*

Molecular Nutrition and Food Research

Volumn 59, Issue 9, 2015, Pages 1837-1843

  Cramer, Benedikt ^a   Osteresch, Bernd ^a   Muñoz, Katherine A ^b   Hillmann, Hartmut ^c   Sibrowski, Walter ^c   Humpf, Hans Ulrich ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b University of Koblenz Landau   (Germany)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Coffee; Dried blood spot; Exposure; Mycotoxin; Ochratoxin

Indexed keywords

COFFEE; OCHRATOXIN;

ADOLESCENT; ADULT; BLOOD; CALIBRATION; CHEMISTRY; COFFEE; DRIED BLOOD SPOT TESTING; FEMALE; FOOD CONTAMINATION; FOOD CONTROL; FOOD HANDLING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MIDDLE AGED; QUESTIONNAIRE; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

ADOLESCENT; ADULT; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COFFEE; DRIED BLOOD SPOT TESTING; FEMALE; FOOD CONTAMINATION; FOOD HANDLING; FOOD MICROBIOLOGY; HUMANS; MALE; MIDDLE AGED; OCHRATOXINS; SURVEYS AND QUESTIONNAIRES; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84942837449     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201500220     Document Type: Article

References (42)

1. Muñoz, K., Vega, M., Rios, G., Geisen, R., Degen, G. H., Mycotoxin production by different ochratoxigenic Aspergillus and Penicillium species on coffee- and wheat-based media. Mycotox. Res. 2011, 27, 239-247.
2. Vander Merwe, K. J., Steyn, P. S., Fourie, L., Scott, D. B., Theron, J. J., Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature 1965, 205, 1112-1113.
3. Lund, F., Frisvad, J. C., Penicillium verrucosum in wheat and barley indicates presence of ochratoxin A. J. Appl. Microbiol. 2003, 95, 1117-1123.
4. Larsen, T. O., Svendsen, A., Smedsgaard, J., Biochemical characterization of ochratoxin A-producing strains of the genus Penicillium. Appl. Environ. Microb. 2001, 67, 3630-3635.
5. Taniwaki, M. H., Pitt, J. I., Teixeira, A. A., Iamanaka, B. T., The source of ochratoxin A in Brazilian coffee and its formation in relation to processing methods. Int. J. Food Microbiol. 2003, 82, 173-179.
6. Copetti, M. V., Pereira, J. L., Iamanaka, B. T., Pitt, J. I., Taniwaki, M. H., Ochratoxigenic fungi and ochratoxin A in cocoa during farm processing. Int. J. Food Microbiol. 2010, 143, 67-70.
7. Somma, S., Perrone, G., Logrieco, A. F., Diversity of black Aspergilli and mycotoxin risks in grape, wine and dried vine fruits. Phytopathol. Mediterr. 2012, 51, 131-147.
8. Yogendrarajah, P., Deschuyffeleer, N., Jacxsens, L., Sneyers, P. J. et al., Mycological quality and mycotoxin contamination of Sri Lankan peppers (Piper nigrum L.) and subsequent exposure assessment. Food Control 2014, 41, 219-230.
9. Frisvad, J. C., Thrane, U., Samson, R. A., Pitt, J. I., Important mycotoxins and the fungi which produce them. Adv. Food Mycol. 2006, 571, 3-31.
10. EFSA, Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to ochratoxin A in food, adopted on 4 April 2006. EFSA J. 2006, 365, 1-56.
11. IARC, Ochratoxin A (Group 2B). IARC monographs on the evaluation of carcinogenic risks to humans 1993, 56. Available at: http://www.inchem.org/documents/iarc/vol56/13-ochra.html.
12. Mantle, P. G., Faucet-Marquis, V., Manderville, R. A., Squillaci, B., Pfohl-Leszkowicz, A., Structures of covalent adducts between DNA and ochratoxin A: a new factor in debate about genotoxicity and human risk assessment. Chem. Res. Toxicol. 2010, 23, 89-98.
13. Pfohl-Leszkowicz, A., Gabryelski, W., Manderville, R. A., Formation of 2'-deoxyguanosine-carbon 8-bound ochratoxin A adduct in rat kidney DNA. Mol. Nutr. Food Res. 2009, 53, 154-155.
14. Tozlovanu, M., Faucet-Marquis, V., Pfohl-Leszkowicz, A., Manderville, R. A., Genotoxicity of the hydroquinone metabolite of ochratoxin A: structure-activity relationships for covalent DNA adduction. Chem. Res. Toxicol. 2006, 19, 1241-1247.
15. Delatour, T., Mally, A., Richoz, J., Özden, S. et al., Absence of 2'-deoxyguanosine-carbon 8-bound ochratoxin A adduct in rat kidney DNA monitored by isotope dilution LC-MS/MS. Mol. Nutr. Food Res. 2008, 52, 472-482.
16. Mally, A., Dekant, W., Mycotoxins and the kidney: modes of action for renal tumor formation by ochratoxin A in rodents. Mol. Nutr. Food Res. 2009, 53, 467-478.
17. Ringot, D., Chango, A., Schneider, Y. J., Larondelle, Y., Toxicokinetics and toxicodynamics of ochratoxin A, an update. Chem. Biol. Interact. 2006, 159, 18-46.
18. FAO/WHO, WHO Food Additives Series 47, Geneva, Switzerland 2001, pp. 281-387.
19. European Community, Assessment of dietary intake of ochratoxin A by the population of EU Member States. Report of the Scientific Cooperation, Task 3.2.7 Directorate-General Health and Consumer Protection, European Commission. Available at: europa.eu.int/comm/food/fs/scoop/3.2.7._en.pdf 2002.
20. Malir, F., Ostry, V., Dofkova, M., Roubal, T. et al., Ochratoxin A levels in blood serum of Czech women in the first trimester of pregnancy and its correspondence with dietary intake of the mycotoxin contaminant. Biomarkers 2013, 18, 673-678.
21. Bittner, A., Cramer, B., Humpf, H. U., Matrix binding of ochratoxin A during roasting. J. Agric. Food Chem. 2013, 61, 12737-12743.
22. Cramer, B., Königs, M., Humpf, H.-U., Identification and in vitro cytotoxicity of ochratoxin A degradation products formed during coffee roasting. J. Agric. Food Chem. 2008, 56, 5673-5681.
23. Bittner, A., Cramer, B., Harrer, H., Humpf, H. U., Structure elucidation and in vitro cytotoxicity of ochratoxin α amide, a new degradation product of ochratoxin A. Mycotox. Res. 2015, 31, 83-90.
24. Cramer, B., Harrer, H., Nakamura, K., Uemura, D., Humpf, H.-U., Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers. Bioorg. Med. Chem. 2010, 18, 343-347.
25. Munoz, K., Blaszkewicz, M., Degen, G. H., Simultaneous analysis of ochratoxin A and its major metabolite ochratoxin alpha in plasma and urine for an advanced biomonitoring of the mycotoxin. J. Chromatogr. B 2010, 878, 2623-2629.
26. Korn, M., Frank, O., Hofmann, T., Rychlik, M., Development of stable isotope dilution assays for ochratoxin A in blood samples. Anal. Biochem. 2011, 419, 88-94.
27. Ali, N., Blaszkewicz, M., Manirujjaman, M., Perveen, R. et al., Biomonitoring of ochratoxin A in blood plasma and exposure assessment of adult students in Bangladesh. Mol. Nutr. Food Res. 2014, 58, 2219-2225.
28. Schmidt, V., Bang, Ivar, Christian (1869-1918), founder of modern clinical microchemistry. Clin. Chem. 1986, 32, 213-215.
29. Guthrie, R., Susi, A., A Simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants. Pediatrics 1963, 32, 338-343.
30. Blumenfeld, T. A., Hertelendy, W. G., Ford, S. H., Simultaneously obtained skin-puncture serum, skin-puncture plasma, and venous serum compared, and effects of warming skin before puncture. Clin. Chem. 1977, 23, 1705-1710.
31. Kiyoshi, M., Keiko, N., Minoru, K., Toshiaki, O., Tsuneo, T., An improved assay of thyrotropin in dried blood samples on filter paper as a screening test for neonatal hypothyroidism. Clin. Chim. Acta 1976, 73, 241-249.
32. Hoogtanders, K., vander Heijden, J., Christiaans, M., Edelbroek, P. et al., Therapeutic drug monitoring of tacrolimus with the dried blood spot method. J. Pharm. Biomed. Anal. 2007, 44, 658-664.
33. Fingerhut, R., Ensenauer, R., Rochinger, W., Arnecke, R. et al., Stability of acylcarnitines and free carnitine in dried blood samples: implications for retrospective diagnosis of inborn errors of metabolism and neonatal screening for carnitine transporter deficiency. Anal. Chem. 2009, 81, 3571-3575.
34. Török, D., Mühl, A., Votava, F., Heinze, G. et al., Stability of 17 alpha-hydroxyprogesterone in dried blood spots after autoclaving and prolonged storage. Clin. Chem. 2002, 48, 370-372.
35. Patel, P., Tanna, S., Mulla, H., Kairamkonda, V. et al., Dexamethasone quantification in dried blood spot samples using LC-MS: the potential for application to neonatal pharmacokinetic studies. J. Chromatogr. B 2010, 878, 3277-3282.
36. Gerding, J., Cramer, B., Humpf, H. U., Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach. Mol. Nutr. Food Res. 2014, 58, 2358-2368.
37. Becker, M., Degelmann, P., Herderich, M., Schreier, P., Humpf, H.-U., Column liquid chromatography-electrospray ionisation-tandem mass spectrometry for the analysis of ochratoxin. J. Chrom. A 1998, 818, 260-264.
38. Mercolini, L., Mandrioli, R., Sorella, V., Somaini, L. et al., Dried blood spots: liquid chromatography-mass spectrometry analysis of delta(9)-tetrahydrocannabinol and its main metabolites. J. Chrom. A 2013, 1271, 33-40.
39. Degen, G. H., Mayer, S., Blaszkewicz, M., Biomonitoring of ochratoxin A in grain workers. Mycotox. Res. 2007, 23, 88-93.
40. Duarte, S. C., Pena, A., Lino, C. M., Human ochratoxin a biomarkers-from exposure to effect. Crit. Rev. Toxicol. 2011, 41, 187-212.
41. Gilbert, J., Brereton, P., MacDonald, S., Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach and analysis of urine and plasma samples. Food Addit. Contam. 2001, 18, 1088-1093.
42. Märtlbauer, E., Usleber, E., Dietrich, R., Schneider, E., Ochratoxin A in human blood serum-retrospective long-term data. Mycotox. Res. 2009, 25, 175-186.