Periostin facilitates skin sclerosis via PI3K/Akt dependent mechanism in a mouse model of scleroderma

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Yang, Lingli ^a,b   Serada, Satoshi ^b   Fujimoto, Minoru ^b   Terao, Mika ^a   Kotobuki, Yorihisa ^a,b   Kitaba, Shun ^a   Matsui, Saki ^a   Kudo, Akira ^c   Naka, Tetsuji ^b   Murota, Hiroyuki ^a   Katayama, Ichiro ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BLEOMYCIN; NEUTRALIZING ANTIBODY; PHOSPHATE BUFFERED SALINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROCOLLAGEN C PROTEINASE; PROTEIN KINASE B; SCLEROPROTEIN; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCLERODERMA; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; SKIN FIBROSIS;

ADULT; AGED; ANIMALS; BLEOMYCIN; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; FEMALE; FIBROSIS; GENE KNOCKOUT TECHNIQUES; HUMANS; INTEGRIN ALPHAV; MALE; MICE; MIDDLE AGED; MYOFIBROBLASTS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SCLERODERMA, SYSTEMIC; SCLEROSIS; SKIN; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; YOUNG ADULT;

MURINAE; MUS;

EID: 84864186641     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041994     Document Type: Article

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