The importance of hypoxia and extra physiologic oxygen shock/stress for collection and processing of stem and progenitor cells to understand true physiology/pathology of these cells ex vivo

Current Opinion in Hematology

Volumn 22, Issue 4, 2015, Pages 273-278

  Broxmeyer, Hal E ^a   O'Leary, Heather A ^a   Huang, Xinxin ^a   Mantel, Charlie ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Extra physiologic oxygen shock stress and its mitigation; Hematopoietic stem and progenitor cells; Microenvironment; Oxygen tension

Indexed keywords

CYCLOPHILIN D; MICRORNA 210; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; CARRIER PROTEIN; CYCLOPHILIN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MICRORNA; MIRN210 MICRORNA, HUMAN; PPID PROTEIN, HUMAN;

ADULT STEM CELL; AMBIENT AIR; BLASTOCYTE; CELL AGING; CELL DIFFERENTIATION; CELL EXTRA PHYSIOLOGIC OXYGEN SHOCK STRESS; CELL FUNCTION; CELL GROWTH; CELL HYPOXIA; CELL METABOLISM; CELL STRESS; CRYOPRESERVATION; EMBRYONIC STEM CELL; EX VIVO STUDY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; MESENCHYMAL STEM CELL; NEURAL STEM CELL; NONHUMAN; OXYGEN TENSION; PHENOTYPE; PRIORITY JOURNAL; PROCEDURES CONCERNING CELLS; REVIEW; BLOOD SAMPLING; BONE MARROW CELL; CYTOLOGY; FETUS BLOOD; GENE EXPRESSION REGULATION; GENETICS; HYPOXIA; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY; PROCEDURES;

BLOOD SPECIMEN COLLECTION; BONE MARROW CELLS; CELL DIFFERENTIATION; CYCLOPHILINS; FETAL BLOOD; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICRORNAS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84942779220     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0000000000000144     Document Type: Review

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