Bupivacaine-the deadly friend of intervertebral disc cells?

Spine Journal

Volumn 11, Issue 1, 2011, Pages 46-53

  Quero, Lilian ^a   Klawitter, Marina ^a   Nerlich, Andreas G ^b   Leonardi, Massimo ^c   Boos, Norbert ^a,c,d   Wuertz, Karin ^a,d  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b KLINIKUM BOGENHAUSEN   (Germany)

^c BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^d AOSpine Research Network   (Switzerland)

Author keywords

bupivacaine; cytotoxicity; gene expression; Human intervertebral disc cells; provocative discography

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AGGRECANASE 1; BUPIVACAINE; COLLAGENASE 3; CYCLOOXYGENASE 2; CYTOKINE; GELATINASE B; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; METALLOPROTEINASE; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EXPOSURE; EXPLANT; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BUPIVACAINE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; INTERVERTEBRAL DISK; MATRIX METALLOPROTEINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC;

EID: 78650260629     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2010.11.001     Document Type: Article

References (29)

1. M. Leonardi, C.W. Pfirrmann, and N. Boos Injection studies in spinal disorders Clin Orthop Relat Res 443 2006 168 182 (Pubitemid 44324947)
2. J.W. Simmons, J.N. McMillin, S.F. Emery, and S.J. Kimmich Intradiscal steroids. A prospective double-blind clinical trial Spine 17 6 Suppl 1992 S172 S175
3. E. Kotilainen, P. Muittari, and O. Kirvela Intradiscal glycerol or bupivacaine in the treatment of low back pain Acta Neurochir (Wien) 139 1997 541 545 (Pubitemid 27267675)
4. M.R. Miller, R.S. Mathews, and K.D. Reeves Treatment of painful advanced internal lumbar disc derangement with intradiscal injection of hypertonic dextrose Pain Physician 9 2006 115 121
5. F. Yanagidate, and G.R. Strichartz Bupivacaine inhibits activation of neuronal spinal extracellular receptor-activated kinase through selective effects on ionotropic receptors Anesthesiology 104 2006 805 814
6. J. Nilsson, M. Madeja, F. Elinder, and P. Arhem Bupivacaine blocks N-type inactivating Kv channels in the open state: no allosteric effect on inactivation kinetics Biophys J 95 2008 5138 5152
7. Y.H. Huang, P.S. Tsai, and C.J. Huang Bupivacaine inhibits COX-2 expression, PGE2, and cytokine production in endotoxin-activated macrophages Acta Anaesthesiol Scand 52 2008 530 535
8. M. Lahav, M. Levite, and L. Bassani Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells Clin Exp Immunol 127 2002 226 233 (Pubitemid 34233927)
9. H. Beloeil, Z. Ababneh, and R. Chung Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 1): hyperalgesia, edema, and systemic cytokines Anesthesiology 105 2006 128 138 (Pubitemid 44305201)
10. A. De Iuliis, L. Zanatta, E. Vincenti, and L. Galzigna Differences of ropivacaine and bupivacaine relevant to antiinflammatory activity, platelet aggregation and antioxidant activity in vitro Farmaco 56 2001 153 157 (Pubitemid 32455325)
11. J. Weinstein, W. Claverie, and S. Gibson The pain of discography Spine 13 1988 1344 1348 (Pubitemid 19019768)
12. B.A. Johnson Epidural steroid injections and selective nerve blocks 2003 Springer Berlin, Germany
13. P.J. Maddison, D.A. Isenberg, P. Woo, and D.N. Glass Oxford textbook of rheumatology 2004 Oxford University Press Oxford, UK 1300 pp
14. E.J. Carragee, A.S. Don, and E.L. Hurwitz 2009 ISSLS Prize Winner: does discography cause accelerated progression of degeneration changes in the lumbar disc: a ten-year matched cohort study Spine 34 2009 2338 2345
15. C.R. Chu, N.J. Izzo, and C.H. Coyle The in vitro effects of bupivacaine on articular chondrocytes J Bone Joint Surg Br 90 2008 814 820 (Pubitemid 351859815)
16. C.R. Chu, N.J. Izzo, N.E. Papas, and F.H. Fu In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes Arthroscopy 22 2006 693 699
17. S.L. Piper, and H.T. Kim Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes J Bone Joint Surg Am 90 2008 986 991
18. A.H. Gomoll, R.W. Kang, and J.M. Williams Chondrolysis after continuous intra-articular bupivacaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder Arthroscopy 22 2006 813 819
19. H. Lee, G. Sowa, and N. Vo Effect of bupivacaine on intervertebral disc cell viability Spine J 10 2010 159 166
20. M.T. Bogatch, D.G. Ferachi, and B. Kyle Is chemical incompatibility responsible for chondrocyte death induced by local anesthetics? Am J Sports Med 38 2010 520 526
21. K.L. Harris, N.J. Bainbridge, N.R. Jordan, and J.R. Sharpe The effect of topical analgesics on ex vivo skin growth and human keratinocyte and fibroblast behavior Wound Repair Regen 17 2009 340 346
22. A. Maroudas, R.A. Stockwell, A. Nachemson, and J. Urban Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro J Anat 120 pt 1 1975 113 130
23. Vo N, Sowa G, Ngo K, et al. Bupivacaine toxicity in intervertebral disc tissue. Presented in ISSLS, 2010 (Proceedings). Auckland, New Zealand.
24. A.R. Aitkenhead, G. Smith, and D.J. Rowbotham The textbook of anaesthesia 2006 Oxford: Churchill Livingstone 868 pp
25. N. Dogan, A.F. Erdem, Z. Erman, and M. Kizilkaya The effects of bupivacaine and neostigmine on articular cartilage and synovium in the rabbit knee joint J Int Med Res 32 2004 513 519 (Pubitemid 39255596)
26. S.M. Gordon, B.P. Chuang, and X.M. Wang The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model Anesth Analg 106 2008 321 327 table of contents
27. P.D. Ribeiro Jr., M.G. Sanches, and T. Okamoto Comparative analysis of tissue reactions to anesthetic solutions: histological analysis in subcutaneous tissue of rats Anesth Prog 50 2003 169 180
28. R. Morris, W. McKay, and P. Mushlin Comparison of pain associated with intradermal and subcutaneous infiltration with various local anesthetic solutions Anesth Analg 66 1987 1180 1182 (Pubitemid 18028677)
29. J. Cassuto, R. Sinclair, and M. Bonderovic Anti-inflammatory properties of local anesthetics and their present and potential clinical implications Acta Anaesthesiol Scand 50 2006 265 282