Characterization of Contents of Distal Ileum and Cecum to Which Drugs/Drug Products are Exposed during Bioavailability/Bioequivalence Studies in Healthy Adults

Pharmaceutical Research

Volumn 32, Issue 10, 2015, Pages 3338-3349

  Reppas, Christos ^a   Karatza, Eleni ^a   Goumas, Constantinos ^b   Markopoulos, Constantinos ^a   Vertzoni, Maria ^a  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^b RED CROSS HOSPITAL   (Greece)

Author keywords

fasted state; fed state; human cecum; human ileum; luminal composition

Indexed keywords

ACYLGLYCEROL; BISACODYL; CHENODEOXYCHOLIC ACID; CHOLESTEROL; CHOLIC ACID; DEOXYCHOLIC ACID; FATTY ACID; GLYCOCHENODEOXYCHOLIC ACID; GLYCOCHOLIC ACID; GLYCODEOXYCHOLIC ACID; PHOSPHATIDYLCHOLINE; SHORT CHAIN FATTY ACID; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; URSODEOXYCHOLIC ACID; BUFFER; DRUG;

ADULT; ARTICLE; ASCENDING COLON; BIOEQUIVALENCE; CARBOHYDRATE ANALYSIS; CECUM; COLONOSCOPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISTAL ILEUM; DRUG BIOAVAILABILITY; HUMAN; HUMAN EXPERIMENT; ILEUM; MALE; MEAL; NORMAL HUMAN; OSMOLALITY; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN CONTENT; SUPERNATANT; TELEMETRY; ULTRACENTRIFUGATION; BIOAVAILABILITY; DIET RESTRICTION; FOOD; METABOLISM; ORAL DRUG ADMINISTRATION; OSMOLARITY; THERAPEUTIC EQUIVALENCE; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; BUFFERS; CECUM; COLON, ASCENDING; CROSS-OVER STUDIES; FASTING; FOOD; HEALTHY VOLUNTEERS; HUMANS; HYDROGEN-ION CONCENTRATION; ILEUM; MALE; OSMOLAR CONCENTRATION; PHARMACEUTICAL PREPARATIONS; THERAPEUTIC EQUIVALENCY; YOUNG ADULT;

EID: 84942296069     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-015-1710-6     Document Type: Article

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