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Volumn 3, Issue 4, 2009, Pages 263-268

The role of cytokines in cancer cachexia

Author keywords

IL 1; IL 6; Myostatin; PIF; TNF ; Transcriptional factors; TWEAK

Indexed keywords

CYTOKINE; TRANSCRIPTION FACTOR;

EID: 74549129085     PISSN: 17514258     EISSN: 17514266     Source Type: Journal    
DOI: 10.1097/SPC.0b013e3283311d09     Document Type: Article
Times cited : (162)

References (66)
  • 1
    • 0000654568 scopus 로고
    • The immediate cause of death in cancer
    • Warren S. The immediate cause of death in cancer. Am J Med Sci 1932; 184:610-615.
    • (1932) Am J Med Sci , vol.184 , pp. 610-615
    • Warren, S.1
  • 2
    • 0033913119 scopus 로고    scopus 로고
    • Cancer cachexia: From experimental models to patient management
    • Costelli P, Baccino FM. Cancer cachexia: from experimental models to patient management. Curr Opin Clin Nutr Metab Care 2000; 3:177-181.
    • (2000) Curr Opin Clin Nutr Metab Care , vol.3 , pp. 177-181
    • Costelli, P.1    Baccino, F.M.2
  • 3
    • 55749085001 scopus 로고    scopus 로고
    • Cachexia: A new definition
    • The definition of cachexia has been defined: 'cachexia is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass'. The prominent clinical feature of cachexia is weight loss in adults (corrected for fluid retention) or growth failure in children (excluding endocrine disorders). Anorexia, inflammation, insulin resistance and increased muscle protein breakdown are frequently associated with cachexia. Cachexia is distinct from starvation, age-related loss of muscle mass, primary depression, malabsorption and hyperthyroidism and is associated with increased morbidity
    • Evans WJ, Morley JE, Argiles J, et al. Cachexia: a new definition. Clin Nutr 2008; 27:793-799. The definition of cachexia has been defined: 'cachexia is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass'. The prominent clinical feature of cachexia is weight loss in adults (corrected for fluid retention) or growth failure in children (excluding endocrine disorders). Anorexia, inflammation, insulin resistance and increased muscle protein breakdown are frequently associated with cachexia. Cachexia is distinct from starvation, age-related loss of muscle mass, primary depression, malabsorption and hyperthyroidism and is associated with increased morbidity.
    • (2008) Clin Nutr , vol.27 , pp. 793-799
    • Evans, W.J.1    Morley, J.E.2    Argiles, J.3
  • 5
    • 33847676338 scopus 로고    scopus 로고
    • Mantovani G, Anker S, Inui A, et al. editors. Berlin: Springer
    • Mantovani G, Anker S, Inui A, et al., editors. Cachexia and wasting: a modern approach. Berlin: Springer; 2006.
    • (2006) Cachexia and Wasting: A Modern Approach
  • 7
    • 0036146460 scopus 로고    scopus 로고
    • Does leptin really influence cancer anorexia?
    • Sato T, Meguid MM, Miyata G, et al. Does leptin really influence cancer anorexia? Nutrition 2002; 18:82-83.
    • (2002) Nutrition , vol.18 , pp. 82-83
    • Sato, T.1    Meguid, M.M.2    Miyata, G.3
  • 8
    • 0035437008 scopus 로고    scopus 로고
    • Plasma concentration of leptin, neuropeptide Y and tumor necrosis factor alpha in patients with cancers, before and after radio- and chemotherapy
    • Kowalczuk A, Wiecek A, Franek E, Kokot F. Plasma concentration of leptin, neuropeptide Y and tumor necrosis factor alpha in patients with cancers, before and after radio- and chemotherapy. Pol Arch Med Wewn 2001; 106:657-668.
    • (2001) Pol Arch Med Wewn , vol.106 , pp. 657-668
    • Kowalczuk, A.1    Wiecek, A.2    Franek, E.3    Kokot, F.4
  • 9
    • 0034164533 scopus 로고    scopus 로고
    • Leptin expression in colorectal and breast cancer patients
    • Tessitore L, Vizio B, Jenkins O, et al. Leptin expression in colorectal and breast cancer patients. Int J Mol Med 2000; 5:421-426.
    • (2000) Int J Mol Med , vol.5 , pp. 421-426
    • Tessitore, L.1    Vizio, B.2    Jenkins, O.3
  • 10
    • 0035143778 scopus 로고    scopus 로고
    • Weight loss is not associated with hyperleptinemia in humans with pancreatic cancer
    • Brown DR, Berkowitz DE, Breslow MJ. Weight loss is not associated with hyperleptinemia in humans with pancreatic cancer. J Clin Endocrinol Metab 2001; 86:162-166.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 162-166
    • Brown, D.R.1    Berkowitz, D.E.2    Breslow, M.J.3
  • 11
    • 0036384280 scopus 로고    scopus 로고
    • Leptin role in advanced lung cancer. A mediator of the acute phase response or a marker of the status of nutrition?
    • Aleman MR, Santolaria F, Batista N, et al. Leptin role in advanced lung cancer. A mediator of the acute phase response or a marker of the status of nutrition? Cytokine 2002; 19:21-26.
    • (2002) Cytokine , vol.19 , pp. 21-26
    • Aleman, M.R.1    Santolaria, F.2    Batista, N.3
  • 12
    • 0034921436 scopus 로고    scopus 로고
    • Serum values of proinflammatory cytokines are inversely correlated with serum leptin levels in patients with advanced stage cancer at different sites
    • Mantovani G, Maccio A, Madeddu C, et al. Serum values of proinflammatory cytokines are inversely correlated with serum leptin levels in patients with advanced stage cancer at different sites. J Mol Med 2001; 79:406- 414.
    • (2001) J Mol Med , vol.79 , pp. 406-414
    • Mantovani, G.1    Maccio, A.2    Madeddu, C.3
  • 13
    • 0034501356 scopus 로고    scopus 로고
    • Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites
    • Mantovani G, Maccio A, Mura L, et al. Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites. J Mol Med 2000; 78:554-561.
    • (2000) J Mol Med , vol.78 , pp. 554-561
    • Mantovani, G.1    Maccio, A.2    Mura, L.3
  • 14
    • 0033771667 scopus 로고    scopus 로고
    • Central nervous system mechanisms contributing to the cachexia-anorexia syndrome
    • Plata-Salaman CR. Central nervous system mechanisms contributing to the cachexia-anorexia syndrome. Nutrition 2000; 16:1009-1012.
    • (2000) Nutrition , vol.16 , pp. 1009-1012
    • Plata-Salaman, C.R.1
  • 15
    • 0028243943 scopus 로고
    • Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorectic tumor-bearing rats
    • Chance WT, Balasubramaniam A, Dayal R, et al. Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorectic tumor-bearing rats. Life Sci 1994; 54:1869-1874.
    • (1994) Life Sci , vol.54 , pp. 1869-1874
    • Chance, W.T.1    Balasubramaniam, A.2    Dayal, R.3
  • 16
    • 0034003336 scopus 로고    scopus 로고
    • Effect of cytokines on hypothalamic neuropeptide Y release in vitro
    • King PJ, Widdowson PS, Doods H, Williams G. Effect of cytokines on hypothalamic neuropeptide Y release in vitro. Peptides 2000; 21:143-146.
    • (2000) Peptides , vol.21 , pp. 143-146
    • King, P.J.1    Widdowson, P.S.2    Doods, H.3    Williams, G.4
  • 18
    • 0035212781 scopus 로고    scopus 로고
    • Cachexia in MAC16 adenocarcinoma: Suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y
    • Bing C, Taylor S, Tisdale MJ, Williams G. Cachexia in MAC16 adenocarcinoma: suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y. J Neurochem 2001; 79:1004-1012.
    • (2001) J Neurochem , vol.79 , pp. 1004-1012
    • Bing, C.1    Taylor, S.2    Tisdale, M.J.3    Williams, G.4
  • 19
    • 66549109127 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and interferon gamma genes polymorphisms and serum levels in pancreatic adenocarcinoma
    • The authors suggested that elevated TNF-a serum level may have clinical significance in the development of cachexia in pancreatic adenocarcinoma patients
    • Talar-Wojnarowska R, Gasiorowska A, Smolarz B, et al. Tumor necrosis factor alpha and interferon gamma genes polymorphisms and serum levels in pancreatic adenocarcinoma. Neoplasma 2009; 56:56-62. The authors suggested that elevated TNF-a serum level may have clinical significance in the development of cachexia in pancreatic adenocarcinoma patients.
    • (2009) Neoplasma , vol.56 , pp. 56-62
    • Talar-Wojnarowska, R.1    Gasiorowska, A.2    Smolarz, B.3
  • 20
    • 0027488473 scopus 로고
    • Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo
    • Strassmann G, Fong M, Freter CE, et al. Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo. J Clin Invest 1993; 92:2152-2159.
    • (1993) J Clin Invest , vol.92 , pp. 2152-2159
    • Strassmann, G.1    Fong, M.2    Freter, C.E.3
  • 21
    • 0034129420 scopus 로고    scopus 로고
    • A model that reproduces syndromes associated with human multiple myeloma in nonirradiated SCID mice
    • Barton BE, Cullison J, Jackson J, Murphy T. A model that reproduces syndromes associated with human multiple myeloma in nonirradiated SCID mice. Proc Soc Exp Biol Med 2000; 223:190-197.
    • (2000) Proc Soc Exp Biol Med , vol.223 , pp. 190-197
    • Barton, B.E.1    Cullison, J.2    Jackson, J.3    Murphy, T.4
  • 22
    • 0035931041 scopus 로고    scopus 로고
    • Cancer cachexia is mediated in part by the induction of IL-6-like cytokines from the spleen
    • Barton BE, Murphy TF. Cancer cachexia is mediated in part by the induction of IL-6-like cytokines from the spleen. Cytokine 2001; 16:251-257.
    • (2001) Cytokine , vol.16 , pp. 251-257
    • Barton, B.E.1    Murphy, T.F.2
  • 23
    • 0035822275 scopus 로고    scopus 로고
    • Role of cytokines in cancer cachexia in a murine model of intracerebral injection of human tumours
    • Negri DR, Mezzanzanica D, Sacco S, et al. Role of cytokines in cancer cachexia in a murine model of intracerebral injection of human tumours. Cytokine 2001; 15:27-38.
    • (2001) Cytokine , vol.15 , pp. 27-38
    • Negri, D.R.1    Mezzanzanica, D.2    Sacco, S.3
  • 24
    • 36549044953 scopus 로고    scopus 로고
    • Decreased IL-10 mRNA expression in patients with advanced renal failure undergoing conservative treatment
    • Bosutti A, Grassi G, Fiotti N, et al. Decreased IL-10 mRNA expression in patients with advanced renal failure undergoing conservative treatment. Cytokine 2007; 40:71-74.
    • (2007) Cytokine , vol.40 , pp. 71-74
    • Bosutti, A.1    Grassi, G.2    Fiotti, N.3
  • 25
    • 39849101635 scopus 로고    scopus 로고
    • Acute-phase response proteins are related to cachexia and accelerated angiogenesis in gastroesophageal cancers
    • Cachexia in gastroesophageal cancers is associated with changes in acute-phase response proteins (APRP) concentrations. This, together with a direct relationship of APRPs with accelerated angiogenesis, may constitute a foundation for the association of APRPs and Glasgow Prognostic Score (GPS) with outcome in these malignancies
    • Krzystek-Korpacka M, Matusiewicz M, Diakowska D, et al. Acute-phase response proteins are related to cachexia and accelerated angiogenesis in gastroesophageal cancers. Clin Chem Lab Med 2008; 46:359-364. Cachexia in gastroesophageal cancers is associated with changes in acute-phase response proteins (APRP) concentrations. This, together with a direct relationship of APRPs with accelerated angiogenesis, may constitute a foundation for the association of APRPs and Glasgow Prognostic Score (GPS) with outcome in these malignancies.
    • (2008) Clin Chem Lab Med , vol.46 , pp. 359-364
    • Krzystek-Korpacka, M.1    Matusiewicz, M.2    Diakowska, D.3
  • 26
    • 60549115947 scopus 로고    scopus 로고
    • Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction
    • The authors indicated that aging is associated with decreased IL-15 signaling in rat gastrocnemius muscle, which may contribute to sarcopenia partly through enhanced TNF-α-mediated apoptosis. Preservation of IL-15 signaling by calorie restriction (CR, 40% calorie intake reduction) may therefore represent a further mechanism contributing to the antiaging effect of this dietary intervention in skeletal muscle
    • Marzetti E, Carter CS, Wohlgemuth SE, et al. Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction. Mech Ageing Dev 2009; 130:272-280. The authors indicated that aging is associated with decreased IL-15 signaling in rat gastrocnemius muscle, which may contribute to sarcopenia partly through enhanced TNF-α-mediated apoptosis. Preservation of IL-15 signaling by calorie restriction (CR, 40% calorie intake reduction) may therefore represent a further mechanism contributing to the antiaging effect of this dietary intervention in skeletal muscle.
    • (2009) Mech Ageing Dev , vol.130 , pp. 272-280
    • Marzetti, E.1    Carter, C.S.2    Wohlgemuth, S.E.3
  • 27
    • 43449137883 scopus 로고    scopus 로고
    • Association of IL-6 gene polymorphisms with cachexia susceptibility and survival time of patients with pancreatic cancer
    • The results of this study indicated that the IL-6-634G allele is associated with increased susceptibility to cachexia and decreased survival time of Chinese patients suffering from pancreatic cancer
    • Zhang D, Zhou Y, Wu L, et al. Association of IL-6 gene polymorphisms with cachexia susceptibility and survival time of patients with pancreatic cancer. Ann Clin Lab Sci 2008; 38:113-119. The results of this study indicated that the IL-6-634G allele is associated with increased susceptibility to cachexia and decreased survival time of Chinese patients suffering from pancreatic cancer.
    • (2008) Ann Clin Lab Sci , vol.38 , pp. 113-119
    • Zhang, D.1    Zhou, Y.2    Wu, L.3
  • 28
    • 62149083382 scopus 로고    scopus 로고
    • IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting
    • The results of this study suggested an interorgan response to high levels of AngII: hepatic production of IL-6 and SAA increases, and these mediators act synergistically to impair insulin/IGF-1 signaling, which promotes muscle proteolysis. Targeting the high levels of IL-6 and SAA in catabolic disorders might be a therapeutic approach to prevent muscle wasting
    • Zhang L, Du J, Hu Z, et al. IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting. J Am Soc Nephrol 2009; 20:604- 612. The results of this study suggested an interorgan response to high levels of AngII: hepatic production of IL-6 and SAA increases, and these mediators act synergistically to impair insulin/IGF-1 signaling, which promotes muscle proteolysis. Targeting the high levels of IL-6 and SAA in catabolic disorders might be a therapeutic approach to prevent muscle wasting.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 604-612
    • Zhang, L.1    Du, J.2    Hu, Z.3
  • 29
    • 0026032432 scopus 로고
    • Antiinterferon-gamma antibody treatment, growth of Lewis lung tumours in mice and tumourassociated cachexia
    • Matthys P, Heremans H, Opdenakker G, Billiau A. Antiinterferon-gamma antibody treatment, growth of Lewis lung tumours in mice and tumourassociated cachexia. Eur J Cancer 1991; 27:182-187.
    • (1991) Eur J Cancer , vol.27 , pp. 182-187
    • Matthys, P.1    Heremans, H.2    Opdenakker, G.3    Billiau, A.4
  • 30
    • 0030267123 scopus 로고    scopus 로고
    • Physiological effects of CNTF-induced wasting
    • Henderson JT, Mullen BJ, Roder JC. Physiological effects of CNTF-induced wasting. Cytokine 1996; 8:784-793.
    • (1996) Cytokine , vol.8 , pp. 784-793
    • Henderson, J.T.1    Mullen, B.J.2    Roder, J.C.3
  • 31
    • 0033987607 scopus 로고    scopus 로고
    • Effects of ciliary neurotrophic factor (CNTF) on protein turnover in cultured muscle cells
    • Wang MC, Forsberg NE. Effects of ciliary neurotrophic factor (CNTF) on protein turnover in cultured muscle cells. Cytokine 2000; 12:41-48.
    • (2000) Cytokine , vol.12 , pp. 41-48
    • Wang, M.C.1    Forsberg, N.E.2
  • 33
    • 0032407443 scopus 로고    scopus 로고
    • In the rat, tumor necrosis factor alpha administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: A possible mechanism for cytokine-induced thermogenesis?
    • Busquets S, Sanchis D, Alvarez B, et al. In the rat, tumor necrosis factor alpha administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine-induced thermogenesis? FEBS Lett 1998; 440:348-350.
    • (1998) FEBS Lett , vol.440 , pp. 348-350
    • Busquets, S.1    Sanchis, D.2    Alvarez, B.3
  • 34
    • 0042389610 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha uncouples respiration in isolated rat mitochondria
    • Busquets S, Aranda X, Ribas-Carbo M, et al. Tumour necrosis factor-alpha uncouples respiration in isolated rat mitochondria. Cytokine 2003; 22:1-4.
    • (2003) Cytokine , vol.22 , pp. 1-4
    • Busquets, S.1    Aranda, X.2    Ribas-Carbo, M.3
  • 35
    • 39749091840 scopus 로고    scopus 로고
    • How relevant are cytokines in colorectal cancer wasting?
    • Ravasco P, Monteiro-Grillo I, Camilo M. How relevant are cytokines in colorectal cancer wasting? Cancer J 2007; 13:392-398.
    • (2007) Cancer J , vol.13 , pp. 392-398
    • Ravasco, P.1    Monteiro-Grillo, I.2    Camilo, M.3
  • 38
    • 0033772110 scopus 로고    scopus 로고
    • Regulation of skeletal-muscle-protein turnover in cancer-associated cachexia
    • Baracos VE. Regulation of skeletal-muscle-protein turnover in cancer-associated cachexia. Nutrition 2000; 16:1015-1018.
    • (2000) Nutrition , vol.16 , pp. 1015-1018
    • Baracos, V.E.1
  • 39
    • 0037196562 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha exerts interleukin-6-dependent and -independent effects on cultured skeletal muscle cells
    • Alvarez B, Quinn LS, Busquets S, et al. Tumor necrosis factor-alpha exerts interleukin-6-dependent and -independent effects on cultured skeletal muscle cells. Biochim Biophys Acta 2002; 1542:66-72.
    • (2002) Biochim Biophys Acta , vol.1542 , pp. 66-72
    • Alvarez, B.1    Quinn, L.S.2    Busquets, S.3
  • 40
    • 0036348143 scopus 로고    scopus 로고
    • Cytokines, apoptosis and cachexia: The potential for TNF antagonism
    • Sharma R, Anker SD. Cytokines, apoptosis and cachexia: the potential for TNF antagonism. Int J Cardiol 2002; 85:161-171.
    • (2002) Int J Cardiol , vol.85 , pp. 161-171
    • Sharma, R.1    Anker, S.D.2
  • 41
    • 0034643248 scopus 로고    scopus 로고
    • DNA fragmentation occurs in skeletal muscle during tumor growth: A link with cancer cachexia?
    • van Royen M, Carbo N, Busquets S, et al. DNA fragmentation occurs in skeletal muscle during tumor growth: a link with cancer cachexia? Biochem Biophys Res Commun 2000; 270:533-537.
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 533-537
    • Van Royen, M.1    Carbo, N.2    Busquets, S.3
  • 42
    • 0035917619 scopus 로고    scopus 로고
    • Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia
    • Belizario JE, Lorite MJ, Tisdale MJ. Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia. Br J Cancer 2001; 84:1135-1140.
    • (2001) Br J Cancer , vol.84 , pp. 1135-1140
    • Belizario, J.E.1    Lorite, M.J.2    Tisdale, M.J.3
  • 43
    • 35448955683 scopus 로고    scopus 로고
    • Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients
    • Busquets S, Deans C, Figueras M, et al. Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients. Clin Nutr 2007; 26: 614-618.
    • (2007) Clin Nutr , vol.26 , pp. 614-618
    • Busquets, S.1    Deans, C.2    Figueras, M.3
  • 44
    • 0037128669 scopus 로고    scopus 로고
    • TNF-alpha is involved in activating DNA fragmentation in skeletal muscle
    • Carbo N, Busquets S, van Royen M, et al. TNF-alpha is involved in activating DNA fragmentation in skeletal muscle. Br J Cancer 2002; 86:1012-1016.
    • (2002) Br J Cancer , vol.86 , pp. 1012-1016
    • Carbo, N.1    Busquets, S.2    Van, R.M.3
  • 45
    • 65949115922 scopus 로고    scopus 로고
    • Modulation of caspase activity regulates skeletal muscle regeneration and function in response to vasopressin and tumor necrosis factor
    • The results showed that AVP counteracts the effects of TNF through cross-talk at the Hsp70 level. Therefore, muscle regeneration, both in the absence and in the presence of cytokines, may be enhanced by increasing Hsp70 expression
    • Moresi V, Garcia-Alvarez G, Pristera A, et al. Modulation of caspase activity regulates skeletal muscle regeneration and function in response to vasopressin and tumor necrosis factor. PLoS One 2009; 4:e5570. The results showed that AVP counteracts the effects of TNF through cross-talk at the Hsp70 level. Therefore, muscle regeneration, both in the absence and in the presence of cytokines, may be enhanced by increasing Hsp70 expression.
    • (2009) PLoS One , vol.4
    • Moresi, V.1    Garcia-Alvarez, G.2    Pristera, A.3
  • 46
    • 53149116307 scopus 로고    scopus 로고
    • Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor
    • The authors described that TNF-α promotes myoblast proliferation through JNK1 and prevents myoblast differentiation through JNK1-mediated secretion of LIF
    • Alter J, Rozentzweig D, Bengal E. Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor. J Biol Chem 2008; 283:23224-23234. The authors described that TNF-α promotes myoblast proliferation through JNK1 and prevents myoblast differentiation through JNK1-mediated secretion of LIF.
    • (2008) J Biol Chem , vol.283 , pp. 23224-23234
    • Alter, J.1    Rozentzweig, D.2    Bengal, E.3
  • 47
    • 63249086636 scopus 로고    scopus 로고
    • Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: A potential role of MMP-9 in myopathy
    • The study unveils a novel mechanism of skeletal muscle tissue destruction in pathological conditions
    • Li H, Mittal A, Paul PK, et al. Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential role of MMP-9 in myopathy. J Biol Chem 2009; 284:4439-4450. The study unveils a novel mechanism of skeletal muscle tissue destruction in pathological conditions.
    • (2009) J Biol Chem , vol.284 , pp. 4439-4450
    • Li, H.1    Mittal, A.2    Paul, P.K.3
  • 48
    • 34249775509 scopus 로고    scopus 로고
    • TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine
    • Dogra C, Changotra H, Wedhas N, et al. TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine. FASEB J 2007; 21:1857-1869.
    • (2007) FASEB J , vol.21 , pp. 1857-1869
    • Dogra, C.1    Changotra, H.2    Wedhas, N.3
  • 49
    • 0034810476 scopus 로고    scopus 로고
    • The transcription factors NF-kappab and AP-1 are differentially regulated in skeletal muscle during sepsis
    • Penner CG, Gang G, Wray C, et al. The transcription factors NF-kappab and AP-1 are differentially regulated in skeletal muscle during sepsis. Biochem Biophys Res Commun 2001; 281:1331-1336.
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 1331-1336
    • Penner, C.G.1    Gang, G.2    Wray, C.3
  • 50
    • 19344368263 scopus 로고    scopus 로고
    • Skeletal muscle wasting in tumorbearing rats is associated with MyoD down-regulation
    • Costelli P, Muscaritoli M, Bossola M, et al. Skeletal muscle wasting in tumorbearing rats is associated with MyoD down-regulation. Int J Oncol 2005; 26:1663-1668.
    • (2005) Int J Oncol , vol.26 , pp. 1663-1668
    • Costelli, P.1    Muscaritoli, M.2    Bossola, M.3
  • 51
    • 0035838123 scopus 로고    scopus 로고
    • Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model
    • Busquets S, Carbo N, Almendro V, et al. Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model. Cancer Lett 2001; 167:33-38.
    • (2001) Cancer Lett , vol.167 , pp. 33-38
    • Busquets, S.1    Carbo, N.2    Almendro, V.3
  • 52
    • 34447306361 scopus 로고    scopus 로고
    • The AP-1/NF-kappaB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexia
    • Moore-Carrasco R, Busquets S, Almendro V, et al. The AP-1/NF-kappaB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexia. Int J Oncol 2007; 30:1239-1245.
    • (2007) Int J Oncol , vol.30 , pp. 1239-1245
    • Moore-Carrasco, R.1    Busquets, S.2    Almendro, V.3
  • 54
    • 0031802331 scopus 로고    scopus 로고
    • Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha
    • Li YP, Schwartz RJ, Waddell ID, et al. Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha. FASEB J 1998; 12:871-880.
    • (1998) FASEB J , vol.12 , pp. 871-880
    • Li, Y.P.1    Schwartz, R.J.2    Waddell, I.D.3
  • 55
    • 0024503589 scopus 로고
    • Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha
    • Brenner DA, O'Hara M, Angel P, et al. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature 1989; 337: 661-663.
    • (1989) Nature , vol.337 , pp. 661-663
    • Brenner, D.A.1    O'hara, M.2    Angel, P.3
  • 56
    • 0027477423 scopus 로고
    • Expression of c-jun/AP-1 during myogenic differentiation in mouse C2C12 myoblasts
    • Thinakaran G, Ojala J, Bag J. Expression of c-jun/AP-1 during myogenic differentiation in mouse C2C12 myoblasts. FEBS Lett 1993; 319:271-276.
    • (1993) FEBS Lett , vol.319 , pp. 271-276
    • Thinakaran, G.1    Ojala, J.2    Bag, J.3
  • 57
    • 67649982995 scopus 로고    scopus 로고
    • Mechanisms of cancer cachexia
    • Very interesting review about the molecular mechanisms of cancer cachexia
    • Tisdale MJ. Mechanisms of cancer cachexia. Physiol Rev 2009; 89:381-410. Very interesting review about the molecular mechanisms of cancer cachexia.
    • (2009) Physiol Rev , vol.89 , pp. 381-410
    • Tisdale, M.J.1
  • 59
    • 0034730251 scopus 로고    scopus 로고
    • NF-kappaB-induced loss of MyoD messenger RNA: Possible role in muscle decay and cachexia
    • Guttridge DC, Mayo MW, Madrid LV, et al. NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science 2000; 289:2363-2366.
    • (2000) Science , vol.289 , pp. 2363-2366
    • Guttridge, D.C.1    Mayo, M.W.2    Madrid, L.V.3
  • 60
    • 0037083867 scopus 로고    scopus 로고
    • TNFalpha inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways
    • Coletti D, Yang E, Marazzi G, Sassoon D. TNFalpha inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways. EMBO J 2002; 21:631-642.
    • (2002) EMBO J , vol.21 , pp. 631-642
    • Coletti, D.1    Yang, E.2    Marazzi, G.3    Sassoon, D.4
  • 61
    • 18244399631 scopus 로고    scopus 로고
    • Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    • Puigserver P, Rhee J, Lin J, et al. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell 2001; 8:971-982.
    • (2001) Mol Cell , vol.8 , pp. 971-982
    • Puigserver, P.1    Rhee, J.2    Lin, J.3
  • 62
    • 45149105837 scopus 로고    scopus 로고
    • Muscle myostatin signalling is enhanced in experimental cancer cachexia
    • The authors suggested that myostatin pathway should be regarded as a potential therapeutic target in cancer cachexia
    • Costelli P, Muscaritoli M, Bonetto A, et al. Muscle myostatin signalling is enhanced in experimental cancer cachexia. Eur J Clin Invest 2008; 38:531- 538. The authors suggested that myostatin pathway should be regarded as a potential therapeutic target in cancer cachexia.
    • (2008) Eur J Clin Invest , vol.38 , pp. 531-538
    • Costelli, P.1    Muscaritoli, M.2    Bonetto, A.3
  • 63
    • 38549170471 scopus 로고    scopus 로고
    • Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice
    • The study demonstrated the feasibility using antisense strategy with myostatin antisense RNA for the treatment of muscle-wasting conditions
    • Liu CM, Yang Z, Liu CW, et al. Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice. Gene Ther 2008; 15:155-160. The study demonstrated the feasibility using antisense strategy with myostatin antisense RNA for the treatment of muscle-wasting conditions.
    • (2008) Gene Ther , vol.15 , pp. 155-160
    • Liu, C.M.1    Yang, Z.2    Liu, C.W.3
  • 64
    • 0034307162 scopus 로고    scopus 로고
    • Experimental cancer cachexia: The role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia
    • Cahlin C, Korner A, Axelsson H, et al. Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia. Cancer Res 2000; 60:5488-5493.
    • (2000) Cancer Res , vol.60 , pp. 5488-5493
    • Cahlin, C.1    Korner, A.2    Axelsson, H.3
  • 65
    • 38949086148 scopus 로고    scopus 로고
    • A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia
    • The authors concluded that adding infliximab to gemcitabine to treat cachexia in advanced pancreatic cancer patients was not associated with statistically significant differences in safety or efficacy when compared with placebo
    • Wiedenmann B, Malfertheiner P, Friess H, et al. A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia. J Support Oncol 2008; 6:18-25. The authors concluded that adding infliximab to gemcitabine to treat cachexia in advanced pancreatic cancer patients was not associated with statistically significant differences in safety or efficacy when compared with placebo.
    • (2008) J Support Oncol , vol.6 , pp. 18-25
    • Wiedenmann, B.1    Malfertheiner, P.2    Friess, H.3
  • 66
    • 15444379633 scopus 로고    scopus 로고
    • Thalidomide in the treatment of cancer cachexia: A randomised placebo controlled trial
    • Gordon JN, Trebble TM, Ellis RD, et al. Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial.Gut 2005; 54:540-545.
    • (2005) Gut , vol.54 , pp. 540-545
    • Gordon, J.N.1    Trebble, T.M.2    Ellis, R.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.