Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity

Biochemical and Biophysical Research Communications

Volumn 466, Issue 1, 2015, Pages 131-137

  Park, Jeong Su ^a   Kang, Dong Hoon ^b   Lee, Da Hyun ^a   Bae, Soo Han ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

Autophagy; FFA; Keap1; Nrf2; p62; PA; ROS

Indexed keywords

PROTEIN P62; TRANSCRIPTION FACTOR NRF2; CYTOSKELETON PROTEIN; HEAT SHOCK PROTEIN; KEAP1 PROTEIN, MOUSE; NFE2L2 PROTEIN, MOUSE; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CELL PROTECTION; CONTROLLED STUDY; DEGRADATION; EMBRYO; GENE; LIPOTOXICITY; LIVER CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PALMITIC ACID INDUCED LIPOTOXICITY; PRIORITY JOURNAL; ANIMAL; APOPTOSIS; CELL LINE; METABOLISM; PROTEIN DEGRADATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; AUTOPHAGY; CELL LINE; CYTOSKELETAL PROTEINS; HEAT-SHOCK PROTEINS; MICE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PALMITIC ACID; PROTEOLYSIS; REACTIVE OXYGEN SPECIES;

EID: 84941938731     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.08.120     Document Type: Article

References (25)

1. C.P. Day, and O.F. James Steatohepatitis: a tale of two "hits"? Gastroenterology 114 1998 842 845
2. J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J. Clin. Invest 114 2004 147 152
3. G. Marchesini, M. Brizi, G. Bianchi, S. Tomassetti, E. Bugianesi, M. Lenzi, A.J. McCullough, S. Natale, G. Forlani, and N. Melchionda Nonalcoholic fatty liver disease: a feature of the metabolic syndrome Diabetes 50 2001 1844 1850
4. G.V. Richieri, and A.M. Kleinfeld Unbound free fatty acid levels in human serum J. Lipid Res. 36 1995 229 240
5. H. Malhi, S.F. Bronk, N.W. Werneburg, and G.J. Gores Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis J. Biol. Chem. 281 2006 12093 12101
6. R.H. Lambertucci, S.M. Hirabara, R. Silveira Ldos, A.C. Levada-Pires, R. Curi, and T.C. Pithon-Curi Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells J. Cell Physiol. 216 2008 796 804
7. T.W. Kensler, N. Wakabayashi, and S. Biswal Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway Annu. Rev. Pharmacol. Toxicol. 47 2007 89 116
8. K. Itoh, J. Mimura, and M. Yamamoto Discovery of the negative regulator of Nrf2, Keap1: a historical overview Antioxid. Redox Signal 13 2010 1665 1678
9. K. Taguchi, H. Motohashi, and M. Yamamoto Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution Genes Cells 16 2011 123 140
10. K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J.D. Engel, and M. Yamamoto Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes Dev. 13 1999 76 86
11. S.H. Bae, S.H. Sung, S.Y. Oh, J.M. Lim, S.K. Lee, Y.N. Park, H.E. Lee, D. Kang, and S.G. Rhee Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage Cell Metab. 17 2013 73 84
12. Y. Tanaka, L.M. Aleksunes, R.L. Yeager, M.A. Gyamfi, N. Esterly, G.L. Guo, and C.D. Klaassen NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet J. Pharmacol. Exp. Ther. 325 2008 655 664
13. S. Chowdhry, M.H. Nazmy, P.J. Meakin, A.T. Dinkova-Kostova, S.V. Walsh, T. Tsujita, J.F. Dillon, M.L. Ashford, and J.D. Hayes Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis Free Radic. Biol. Med. 48 2010 357 371
14. M. Komatsu, H. Kurokawa, S. Waguri, K. Taguchi, A. Kobayashi, Y. Ichimura, Y.S. Sou, I. Ueno, A. Sakamoto, K.I. Tong, M. Kim, Y. Nishito, S. Iemura, T. Natsume, T. Ueno, E. Kominami, H. Motohashi, K. Tanaka, and M. Yamamoto The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Nat. Cell Biol. 12 2010 213 223
15. Y. Ichimura, S. Waguri, Y.S. Sou, S. Kageyama, J. Hasegawa, R. Ishimura, T. Saito, Y. Yang, T. Kouno, T. Fukutomi, T. Hoshii, A. Hirao, K. Takagi, T. Mizushima, H. Motohashi, M.S. Lee, T. Yoshimori, K. Tanaka, M. Yamamoto, and M. Komatsu Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy Mol. Cell 51 2013 618 631
16. D.H. Kang, D.J. Lee, K.W. Lee, Y.S. Park, J.Y. Lee, S.H. Lee, Y.J. Koh, G.Y. Koh, C. Choi, D.Y. Yu, J. Kim, and S.W. Kang Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells Mol. Cell 44 2011 545 558
17. D. Chen, X. Chen, M. Li, H. Zhang, W.X. Ding, and X.M. Yin CCCP-Induced LC3 lipidation depends on Atg9 whereas FIP200/Atg13 and Beclin 1/Atg14 are dispensable Biochem. Biophys. Res. Commun. 432 2013 226 230
18. A.M. Gusdon, K.X. Song, and S. Qu Nonalcoholic fatty liver disease: pathogenesis and therapeutics from a mitochondria-centric perspective Oxid. Med. Cell Longev. 2014 2014 637027
19. T. Inoguchi, P. Li, F. Umeda, H.Y. Yu, M. Kakimoto, M. Imamura, T. Aoki, T. Etoh, T. Hashimoto, M. Naruse, H. Sano, H. Utsumi, and H. Nawata High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells Diabetes 49 2000 1939 1945
20. S. Mei, H.M. Ni, S. Manley, A. Bockus, K.M. Kassel, J.P. Luyendyk, B.L. Copple, and W.X. Ding Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes J. Pharmacol. Exp. Ther. 339 2011 487 498
21. H. Okawa, H. Motohashi, A. Kobayashi, H. Aburatani, T.W. Kensler, and M. Yamamoto Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity Biochem. Biophys. Res. Commun. 339 2006 79 88
22. H. Sugimoto, K. Okada, J. Shoda, E. Warabi, K. Ishige, T. Ueda, K. Taguchi, T. Yanagawa, A. Nakahara, I. Hyodo, T. Ishii, and M. Yamamoto Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice Am. J. Physiol. Gastrointest. Liver Physiol. 298 2010 G283 G294
23. D.D. Zhang, S.C. Lo, Z. Sun, G.M. Habib, M.W. Lieberman, and M. Hannink Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway J. Biol. Chem. 280 2005 30091 30099
24. K. Taguchi, N. Fujikawa, M. Komatsu, T. Ishii, M. Unno, T. Akaike, H. Motohashi, and M. Yamamoto Keap1 degradation by autophagy for the maintenance of redox homeostasis Proc. Natl. Acad. Sci. U. S. A. 109 2012 13561 13566
25. J. Liu, F. Chang, F. Li, H. Fu, J. Wang, S. Zhang, J. Zhao, and D. Yin Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK Biochem. Biophys. Res. Commun. 463 2015 262 267