Postnatal age is a critical determinant of the neonatal host response to sepsis

Molecular Medicine

Volumn 21, Issue , 2015, Pages 496-504

  Wynn, James L ^a   Guthrie, Scott O ^a,b   Wong, Hector R ^c   Lahni, Patrick ^c   Ungaro, Ricardo ^d   Lopez, M Cecilia ^d   Baker, Henry V ^d   Moldawer, Lyle L ^d  

^a VANDERBILT UNIVERSITY   (United States)

^b Jackson Madison County General Hospital   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GAMMA INTERFERON RECEPTOR 1; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 18 BINDING PROTEIN; INTERLEUKIN 19; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 33; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTROPHIL COLLAGENASE; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; UNINDEXED DRUG;

ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; DISEASE CLASSIFICATION; FEMALE; GENE EXPRESSION PROFILING; GENOME; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; LABORATORY TEST; MALE; MICROARRAY ANALYSIS; NEWBORN; NEWBORN DISEASE; ONSET AGE; PERINATAL PERIOD; POSTNATAL AGE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RNA HYBRIDIZATION; RNA ISOLATION; SEPSIS; BLOOD; GENETICS; GESTATIONAL AGE; INFANT; INFLAMMATION; PATHOLOGY; RISK FACTOR;

FEMALE; GESTATIONAL AGE; HUMANS; INFANT; INFANT, NEWBORN; INFLAMMATION; MALE; MICROARRAY ANALYSIS; RISK FACTORS; SEPSIS; TRANSCRIPTOME;

EID: 84941909775     PISSN: 10761551     EISSN: 15283658     Source Type: Journal    
DOI: 10.2119/molmed.2015.00064     Document Type: Article

References (44)

1. Brocklehurst P, et al. (2011) Treatment of neonatal sepsis with intravenous immune globulin. N. Engl. J. Med. 365:1201-11.
2. Hartman ME, Linde-Zwirble WT, Angus DC, Watson RS. (2013) Trends in the epidemiology of pediatric severe sepsis. Pediatr. Criti. Care Med. 14:686-93.
3. Stoll BJ, et al. (2010) Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 126:443-56.
4. Wynn JL, Neu J, Moldawer LL, Levy O. (2009) Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis. J. Peri-natol. 29:79-88.
5. Stoll BJ, et al. (2004) Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA. 292:2357-65.
6. Stoll BJ, et al. (2002) Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants. N. Engl. J. Med. 347:240-7.
7. Wynn J, Cornell TT, Wong HR, Shanley TP, Wheeler DS. (2010) The host response to sepsis and developmental impact. Pediatrics. 125:1031-41.
8. Stoll BJ, et al. (2002) Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 110:285-91.
9. Wynn JL, et al. (2014) Time for a neonatal-specific consensus definition for sepsis. Pediatr. Criti. Care Med. 15:523-8.
10. Maslove DM, Wong HR. (2014) Gene expression profiling in sepsis: timing, tissue, and transla-tional considerations. Trends Mol. Med. 20:204-13.
11. Wynn JL, et al. (2011) The influence of developmental age on the early transcriptomic response of children with septic shock. Mol. Med. 17:1146-56.
12. Wong HR, et al. (2011) Validation of a gene expression-based subclassification strategy for pe-diatric septic shock. Crit. Care Med. 39:2511-7.
13. Wong HR, Freishtat RJ, Monaco M, Odoms K, Shanley TP. (2010) Leukocyte subset-derived genomewide expression profiles in pediatric septic shock. Pediatr Crit. Care Med. 11:349-55.
14. Wong HR, Odoms K, Sakthivel B. (2008) Divergence of canonical danger signals: the genomelevel expression patterns of human mononuclear cells subjected to heat shock or lipopolysaccha-ride. BMC Immunol. 9:24.
15. Wong HR, et al. (2007) Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol. Genomics. 30:146-55.
16. Carrol ED, et al. (2007) Successful downstream application of the Paxgene Blood RNA system from small blood samples in paediatric patients for quantitative PCR analysis. BMC Immunol. 8:20.
17. Xu W, et al. (2011) Human transcriptome array for high-throughput clinical studies. Proc. Natl. Acad. Sci. U. S. A. 108:3707-12.
18. Seok J, et al. (2013) Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl. Acad. Sci. U. S. A. 110:3507-12.
19. Sunden-Cullberg J, et al. (2007) Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock. Crit. Care Med. 35:1536-42.
20. Aliefendioglu D, Gursoy T, Caglayan O, Aktas A, Ovali F. (2014) Can resistin be a new indicator of neonatal sepsis? Pediatr. Neonatol. 55:53-7.
21. Garlanda C, Dinarello CA, Mantovani A. (2013) The interleukin-1 family: back to the future. Immunity. 39:1003-18.
22. Solan PD, et al. (2012) A novel role for matrix metalloproteinase-8 in sepsis. Crit. Care Med. 40:379-87.
23. Clemmensen SN, et al. (2012) Olfactomedin 4 defines a subset of human neutrophils. J. Leukoc. Biol. 91:495-500.
24. Welin A, et al. (2013) The human neutrophil subsets defined by the presence or absence of OLFM4 both transmigrate into tissue in vivo and give rise to distinct NETs in vitro. PLoS One. 8:e69575.
25. Ancuta P, et al. (2009) Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets. BMC Genomics. 10:403.
26. Kaneko T, et al. (2003) Reduced neutrophil CD10 expression in nonhuman primates and humans after in vivo challenge with E. coli or lipopolysac- charide. Shock. 20:130-7.
27. Paunel-Gorgulu A, Flohe S, Scholz M, Windolf J, Logters T. (2011) Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis. Crit. Care. 15:R20.
28. Clark RH, Bloom BT, Spitzer AR, Gerstmann DR. (2006) Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics. 117:1979-87.
29. Schokker D, et al. (2014) Early-life environmental variation affects intestinal microbiota and immune development in new-born piglets. PLoS One. 9:e100040.
30. Cheng SC, et al. (2014) mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 345:1250684.
31. Saeed S, et al. (2014) Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science. 345:1251086.
32. Wynn JL, et al. (2013) Blood stream infection is associated with altered heptavalent pneumococ-cal conjugate vaccine immune responses in very low birth weight infants. J. Perinatol. 33:613-8.
33. Smith CL, et al. (2014) Identification of a human neonatal immune-metabolic network associated with bacterial infection. Nat. Commun. 5:4649.
34. Horan TC, Andrus M, Dudeck MA. (2008) CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am. J. Infect. Control. 36:309-32.
35. Cernada M, et al. (2014) Genome-wide expression profiles in very low birth weight infants with neonatal sepsis. Pediatrics. 133:e1203-11.
36. Ng PC, et al. (2010) Host-response biomarkers for diagnosis of late-onset septicemia and necrotiz-ing enterocolitis in preterm infants. J. Clin. Invest. 120:2989-3000.
37. Wong HR. (2013) Genome-wide expression profiling in pediatric septic shock. Pediatr. Res. 73:564-9.
38. Cuenca AG, et al. (2013) Development of a ge-nomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit. Care Med. 41:1175-85.
39. Wong HR, et al. (2015) Developing a clinically feasible personalized medicine approach to pedi-atric septic shock. Am. J. Respir. Crit. Care Med. 191:309-15.
40. Hornik CP, et al. (2012) Use of the complete blood cell count in late-onset neonatal sepsis. Pediatr. Infect. Dis. J. 31:803-7.
41. Hornik CP, et al. (2012) Use of the complete blood cell count in early-onset neonatal sepsis. Pediatr Infect. Dis J31:799-802.
42. Shanley TP, et al. (2007) Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol. Med. 13:495-508.
43. Wong HR, et al. (2009) Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum. Crit. Care Med. 37:1558-66.
44. Wong HR, et al. (2009) Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med. 7:34.