Genome-wide expression profiles in very low birth weight infants with neonatal sepsis

Pediatrics

Volumn 133, Issue 5, 2014, Pages

  Cernada, María ^a,b   Serna, Eva ^c   Bauerl, Christine ^d   Collado, María Carmen ^d   Pérez Martínez, Gaspar ^d   Vento, Máximo ^a,b  

^a Instituto de Investigacion Sanitaria INCLIVA   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

^d INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

Author keywords

Biomarkers; Genome wide expression profile; Premature infant; Sepsis

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CD40 LIGAND; NEUTROPHIL COLLAGENASE; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; TRANSCRIPTOME;

AREA UNDER THE CURVE; ARTICLE; BACTEREMIA; BLOOD SAMPLING; CD177 GENE; CD40 LIGAND GENE; CEBPB GENE; CLINICAL ARTICLE; COAGULASE NEGATIVE STAPHYLOCOCCUS; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; FEMALE; GENE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GRAM NEGATIVE SEPSIS; GRAM POSITIVE SEPSIS; HUMAN; HUMAN GENOME; INFLAMMATION; INNATE IMMUNITY; MALE; MORGANELLA MORGANII; NEWBORN; NEWBORN SEPSIS; NONHUMAN; OBSERVATIONAL STUDY; PATIENT IDENTIFICATION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; TNF ALPHA GENE; TNFB GENE; TRANSLATIONAL RESEARCH; VALIDATION PROCESS; VERY LOW BIRTH WEIGHT; BACTERIAL INFECTIONS; EARLY DIAGNOSIS; GENETIC ASSOCIATION; GENETICS; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIAL INFECTIONS; INFANT, PREMATURE, DISEASES; PRINCIPAL COMPONENT ANALYSIS; SEPSIS;

BACTERIAL INFECTIONS; COHORT STUDIES; CYTOKINES; EARLY DIAGNOSIS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; IMMUNITY, INNATE; INFANT, NEWBORN; INFANT, PREMATURE, DISEASES; INFANT, VERY LOW BIRTH WEIGHT; MALE; PRINCIPAL COMPONENT ANALYSIS; PROSPECTIVE STUDIES; SEPSIS; SIGNAL TRANSDUCTION; TRANSCRIPTOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84899868177     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2013-2552     Document Type: Article

References (44)

1. Polin RA; Committee on Fetus and Newborn. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012;129(5):1006-1015
2. Stoll BJ, Hansen N, Fanaroff AA, et al. Lateonset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110(2 pt 1):285-291
3. López Sastre JB, Coto Cotallo D, Fernández Colomer B; Grupo de Hospitales Castrillo. Neonatal sepsis of nosocomial origin: an epidemiological study from the "Grupo de Hospitales Castrillo." J Perinat Med. 2002; 30(2):149-157
4. Mitha A, Foix-L'Hélias L, Arnaud C, et al; EPIPAGE Study Group. Neonatal infection and 5-year neurodevelopmental outcome of very preterm infants. Pediatrics. 2013;132 (2). Available at: www.pediatrics.org/cgi/ content/full/132/2/e372
5. Kumar Y, Qunibi M, Neal TJ, Yoxall CW. Time to positivity of neonatal blood cultures. Arch Dis Child Fetal Neonatal Ed. 2001;85 (3):F182-F186
6. Towers CV, Carr MH, Padilla G, Asrat T. Potential consequences of widespread antepartal use of ampicillin. Am J Obstet Gynecol. 1998;179(4):879-883
7. Chiesa C, Panero A, Osborn JF, Simonetti AF, Pacifico L. Diagnosis of neonatal sepsis: a clinical and laboratory challenge. Clin Chem. 2004;50(2):279-287
8. Cernada M, Badía N, Modesto V, et al. Cord blood interleukin-6 as a predictor of earlyonset neonatal sepsis. Acta Paediatr. 2012; 101(5):e203-e207
9. Chiesa C, Pellegrini G, Panero A, et al. Creactive protein, interleukin-6, and procalcitonin in the immediate postnatal period: influence of illness severity, risk status, antenatal and perinatal complications, and infection. Clin Chem. 2003; 49(1):60-68
10. Auriti C, Fiscarelli E, Ronchetti MP, et al. Procalcitonin in detecting neonatal nosocomial sepsis. Arch Dis Child Fetal Neonatal Ed. 2012;97(5):F368-F370
11. Stocker M, Fontana M, El Helou S, Wegscheider K, Berger TM. Use of procalcitonin-guided decision-making to shorten antibiotic therapy in suspected neonatal early-onset sepsis: prospective randomized intervention trial. Neonatology. 2010;97(2):165-174
12. Ng PC. Diagnostic markers of infection in neonates. Arch Dis Child Fetal Neonatal Ed. 2004;89(3):F229-F235
13. Pammi M, Flores A, Leeflang M, Versalovic J. Molecular assays in the diagnosis of neonatal sepsis: a systematic review and meta-analysis. Pediatrics. 2011;128(4). Available at: www.pediatrics.org/cgi/content/ full/128/4/e973
14. Wong HR, Shanley TP, Sakthivel B, et al; Genomics of Pediatric SIRS/Septic Shock Investigators. Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics. 2007;30(2): 146-155
15. Prucha M, Ruryk A, Boriss H, et al. Expression profiling: toward an application in sepsis diagnostics. Shock. 2004;22(1):29-33
16. Wong HR, Cvijanovich N, Lin R, et al. Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med. 2009;7:34
17. Tang BM, Huang SJ, McLean AS. Genomewide transcription profiling of human sepsis: a systematic review. Crit Care. 2010; 14(6):R237
18. Ramilo O, Allman W, Chung W, et al. Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood. 2007;109(5):2066-2077
19. López Sastre JB, Coto Cotallo GD, Fernández Colomer B; Grupo de Hospitales Castrillo. Neonatal sepsis of vertical transmission: an epidemiological study from the "Grupo de Hospitales Castrillo." J Perinat Med. 2000;28(4):309-315
20. Töllner U. Early diagnosis of septicemia in the newborn. Clinical studies and sepsis score. Eur J Pediatr. 1982;138(4):331-337
21. Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2-8
22. Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 2003;19(2):185-193
23. Jolliffe I. Principal component analysis. In: Braitman LE, Rosenbaum PR, eds. Encyclopedia of Statistics in Behavioral Science. 2nd ed. New York: Springer-Verlag; 2002:44-47
24. Markel TA, Crisostomo PR, Wang M, Herring CM, Meldrum DR. Activation of individual tumor necrosis factor receptors differentially affects stem cell growth factor and cytokine production. Am J Physiol Gastrointest Liver Physiol. 2007;293(4): G657-G662
25. Edmond K, Zaidi A. New approaches to preventing, diagnosing, and treating neonatal sepsis. PLoS Med. 2010;7(3): e1000213
26. Arnon S, Litmanovitz I. Diagnostic tests in neonatal sepsis. Curr Opin Infect Dis. 2008; 21(3):223-227
27. Vouloumanou EK, Plessa E, Karageorgopoulos DE, Mantadakis E, Falagas ME. Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis. Intensive Care Med. 2011; 37(5):747-762
28. Hofer N, Zacharias E, Müller W, Resch B. An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology. 2012; 102(1):25-36
29. Ng PC, Lam HS. Biomarkers in neonatology: the next generation of tests. Neonatology. 2012;102(2):145-151
30. Kollmann TR, Levy O, Montgomery RR, Goriely S. Innate immune function by Tolllike receptors: distinct responses in newborns and the elderly. Immunity. 2012;37 (5):771-783
31. Wynn JL, Cvijanovich NZ, Allen GL, et al. The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med. 2011;17(11-12): 1146-1156
32. Kissel K, Santoso S, Hofmann C, Stroncek D, Bux J. Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions. Eur J Immunol. 2001; 31(5):1301-1309
33. Bux J. Molecular nature of antigens implicated in immune neutropenias. Int J Hematol. 2002;76(suppl 1):399-403
34. Stroncek DF. Neutrophil-specific antigen HNA-2a, NB1 glycoprotein, and CD177. Curr Opin Hematol. 2007;14(6):688-693
35. Lalezari P, Murphy GB, Allen FH Jr. NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia. J Clin Invest. 1971;50(5):1108-1115
36. Wong HR, Cvijanovich N, Allen GL, et al; Genomics of Pediatric SIRS/Septic Shock Investigators. Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum. Crit Care Med. 2009;37(5): 1558-1566
37. Solan PD, Dunsmore KE, Denenberg AG, Odoms K, Zingarelli B, Wong HR. A novel role for matrix metalloproteinase-8 in sepsis. Crit Care Med. 2012;40(2):379-387
38. Vanlaere I, Libert C. Matrix metalloproteinases as drug targets in infections caused by grame1210 negative bacteria and in septic shock. Clin Microbiol Rev. 2009;22(2):224-239
39. Feezor RJ, Oberholzer C, Baker HV, et al. Molecular characterization of the acute inflammatory response to infections with Gram-negative versus Gram-positive bacteria. Infect Immun. 2003;71(10):5803-5813
40. Yu SL, Chen HW, Yang PC, et al. Differential gene expression in gram-negative and gram-positive sepsis. Am J Respir Crit Care Med. 2004;169(10):1135-1143
41. Tang BM, McLean AS, Dawes IW, Huang SJ, Cowley MJ, Lin RC. Gene-expression profiling of Gram-positive and Gram-negative sepsis in critically ill patients. Crit Care Med. 2008;36(4):1125-1128
42. Tang BM, McLean AS, Dawes IW, Huang SJ, Lin RC. Gene-expression profiling of peripheral blood mononuclear cells in sepsis. Crit Care Med. 2009;37(3):882-888
43. Russell JA. Gene expression in human sepsis: what have we learned? Crit Care. 2011; 15(1):121
44. Johnson SB, Lissauer M, Bochicchio GV, Moore R, Cross AS, Scalea TM. Gene expression profiles differentiate between sterile SIRS and early sepsis. Ann Surg. 2007;245(4):611-621