Use of the complete blood cell count in early-onset neonatal sepsis

Pediatric Infectious Disease Journal

Volumn 31, Issue 8, 2012, Pages 799-802

  Hornik, Christoph P ^a,b   Becker, Kristian C ^b   Benjamin, Daniel K ^a,b,c   Li, Jennifer ^a,b   Clark, Reese H ^d   Cohen Wolkowiez, Michael ^a,b   Brian Smith, P ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^c CLEMSON UNIVERSITY   (United States)

^d Pediatrix Obstetrix Center for Research and Education   (United States)

Author keywords

blood cell count; early onset sepsis; neonatal

Indexed keywords

ANTIBIOTIC AGENT;

ANTIBIOTIC THERAPY; ARTICLE; BIRTH WEIGHT; BLOOD CELL COUNT; BLOOD CULTURE; CEREBROSPINAL FLUID; DIAGNOSTIC ACCURACY; EARLY ONSET SEPSIS; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; INTENSIVE CARE UNIT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; NEUTROPHIL; NEUTROPHIL COUNT; NEWBORN; NEWBORN SEPSIS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; THROMBOCYTE COUNT; URINALYSIS;

AGE OF ONSET; BLOOD CELL COUNT; COHORT STUDIES; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; MALE; NEUTROPHILS; ODDS RATIO; RISK FACTORS; ROC CURVE; SEPSIS;

EID: 84863985737     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e318256905c     Document Type: Article

References (23)

1. Stoll BJ, Gordon T, Korones SB, et al. Early-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 1996;129:72-80.
2. Cohen-Wolkowiez M, Moran C, Benjamin DK, et al. Early and late onset sepsis in late preterm infants. Pediatr Infect Dis J. 2009;28:1052-1056.
3. Brodie SB, Sands KE, Gray JE, et al. Occurrence of nosocomial bloodstream infections in six neonatal intensive care units. Pediatr Infect Dis J. 2000;19:56-65.
4. Jiang JH, Chiu NC, Huang FY, et al. Neonatal sepsis in the neonatal intensive care unit: characteristics of early versus late onset. J Microbiol Immunol Infect. 2004;37:301-306.
5. Ng PC. Diagnostic markers of infection in neonates. Arch Dis Child Fetal Neonatal Ed. 2004;89:F229-F235.
6. Puopolo KM, Madoff LC, Eichenwald EC. Early-onset group B streptococcal disease in the era of maternal screening. Pediatrics. 2005;115:1240-1246.
7. Connell TG, Rele M, Cowley D, et al. How reliable is a negative blood culture result? Volume of blood submitted for culture in routine practice in a children's hospital. Pediatrics. 2007;119:891-896.
8. Hammerschlag MR, Klein JO, Herschel M, et al. Patterns of use of antibiotics in two newborn nurseries. N Engl J Med. 1977;296:1268-1269.
9. Clark R, Powers R, White R, et al. Prevention and treatment of nosocomial sepsis in the NICU. J Perinatol. 2004;24:446-453.
10. Manroe BL, Rosenfeld CR, Weinberg AG, et al. The differential leukocyte count in the assessment and outcome of early-onset neonatal group B streptococcal disease. J Pediatr. 1977;91:632-637.
11. Escobar GJ, Li DK, Armstrong MA, et al. Neonatal sepsis workups in infants ≥2000 grams at birth: a population-based study. Pediatrics. 2000;106(2 pt 1):256-263.
12. Ottolini MC, Lundgren K, Mirkinson LJ, et al. Utility of complete blood count and blood culture screening to diagnose neonatal sepsis in the asymptomatic at risk newborn. Pediatr Infect Dis J. 2003;22:430-434.
13. Philip AG, Hewitt JR. Early diagnosis of neonatal sepsis. Pediatrics. 1980;65:1036-1041.
14. Rodwell RL, Leslie AL, Tudehope DI. Early diagnosis of neonatal sepsis using a hematologic scoring system. J Pediatr. 1988;112:761-767.
15. Newman TB, Puopolo KM, Wi S, et al. Interpreting complete blood counts soon after birth in newborns at risk for sepsis. Pediatrics. 2010;126:903-909.
16. Kite P, Millar M. Diagnosis of neonatal bacteraemia using combinations of tests. Midwifery. 1988;4:123-129.
17. Manucha V, Rusia U, Sikka M, et al. Utility of haematological parameters and C-reactive protein in the detection of neonatal sepsis. J Paediatr Child Health. 2002;38:459-464.
18. Blommendahl J, Janas M, Laine S, et al. Comparison of procalcitonin with CRP and differential white blood cell count for diagnosis of culture-proven neonatal sepsis. Scand J Infect Dis. 2002;34:620-622.
19. Rodwell RL, Taylor KM, Tudehope DI, et al. Hematologic scoring system in early diagnosis of sepsis in neutropenic newborns. Pediatr Infect Dis J. 1993;12:372-376.
20. Spector SA, Ticknor W, Grossman M. Study of the usefulness of clinical and hematologic findings in the diagnosis of neonatal bacterial infections. Clin Pediatr (Phila). 1981;20:385-392.
21. Jackson GL, Engle WD, Sendelbach DM, et al. Are complete blood cell counts useful in the evaluation of asymptomatic neonates exposed to suspected chorioamnionitis? Pediatrics. 2004;113:1173-1180.
22. Manroe BL, Weinberg AG, Rosenfeld CR, et al. The neonatal blood count in health and disease. I. Reference values for neutrophilic cells. J Pediatr. 1979;95:89-98.
23. Mouzinho A, Rosenfeld CR, Sánchez PJ, et al. Revised reference ranges for circulating neutrophils in very-low-birth-weight neonates. Pediatrics. 1994;94:76-82.