Orbitrap technology for comprehensive metabolite-based liquid chromatographic-high resolution-tandem mass spectrometric urine drug screening - Exemplified for cardiovascular drugs

Analytica Chimica Acta

Volumn 891, Issue , 2015, Pages 221-233

  Helfer, Andreas G ^a   Michely, Julian A ^a   Weber, Armin A ^a   Meyer, Markus R ^a,b   Maurer, Hans H ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Drug screening; High resolution mass spectrometry; Liquid chromatography mass spectrometry; Orbitrap; Urine

Indexed keywords

BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHY; DIAGNOSIS; DRUG PRODUCTS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; MOLECULAR BIOLOGY; SPECTROMETRY;

DRUG SCREENING; HIGH RESOLUTION MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; ORBITRAP; URINE;

LIQUID CHROMATOGRAPHY;

ALISKIREN; AMIODARONE; AMLODIPINE; BEZAFIBRATE; BISOPROLOL; CARDIOVASCULAR AGENT; DOXAZOSIN; DRUG METABOLITE; HYDROCHLOROTHIAZIDE; IVABRADINE; LOSARTAN; MINOXIDIL; MOLSIDOMINE; MOXONIDINE; PHENPROCOUMON; RAMIPRIL; SPIRONOLACTONE; TORASEMIDE; TRIAMTERENE; VERAPAMIL;

ALGORITHM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG INTOXICATION; DRUG SCREENING; FALSE POSITIVE RESULT; FORENSIC TOXICOLOGY; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETER; MEDICATION COMPLIANCE; NONHUMAN; PRIORITY JOURNAL; RAT; REFERENCE DATABASE; REPRODUCIBILITY; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; URINALYSIS; LIMIT OF DETECTION; METABOLISM; PROCEDURES; SUBSTANCE ABUSE; URINE; VALIDATION STUDY;

CARDIOVASCULAR AGENTS; CHROMATOGRAPHY, LIQUID; FORENSIC TOXICOLOGY; HUMANS; LIMIT OF DETECTION; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY;

EID: 84941875875     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2015.08.018     Document Type: Article

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