Elucidation of the metabolites of the novel psychoactive substance 4-methyl-N-ethyl-cathinone (4-MEC) in human urine and pooled liver microsomes by GC-MS and LC-HR-MS/MS techniques and of its detectability by GC-MS or LC-MSn standard screening approaches

Drug Testing and Analysis

Volumn 7, Issue 5, 2015, Pages 368-375

  Helfer, Andreas G ^a   Turcant, Alain ^b   Boels, David ^b   Ferec, Séverine ^b   Lelièvre, Bénédicte ^b   Welter, Jessica ^a   Meyer, Markus R ^a   Maurer, Hans H ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b ANGERS UNIVERSITY HOSPITAL   (France)

Author keywords

4 MEC; Designer drugs; GC MS; Human liver microsomes; LC HR MS MS; Urine

Indexed keywords

BIOMOLECULES; BODY FLUIDS; GAS CHROMATOGRAPHY; ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM;

4-METHYL-N-ETHYL-CATHINONE; CATHINONE; DESIGNER DRUGS; GASCHROMATOGRAPHY-MASS SPECTROMETRY; HUMAN LIVER MICROSOMES; HUMAN URINE; LC-HR-MS/MS; LC-MS N; SCREENING APPROACHES; URINE;

METABOLITES;

4 METHYL N ETHYL CATHINONE; 4' METHYLMETHCATHINONE; GLUCURONIDE; PSYCHOTROPIC AGENT; UNCLASSIFIED DRUG; 4-METHYLETHCATHINONE; AMPHETAMINE DERIVATIVE; DESIGNER DRUG; PROPIOPHENONE DERIVATIVE;

ARTICLE; DRUG METABOLISM; DRUG SCREENING; GLUCURONIDATION; HUMAN; HYDROXYLATION; INCUBATION TIME; ISOMER; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY HIGH RESOLUTION TANDEM MASS SPECTROMETRY; LIVER MICROSOME; MASS FRAGMENTOGRAPHY; OXIDATION; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; URINALYSIS; ANIMAL; CHEMISTRY; RAT; URINE;

AMPHETAMINES; ANIMALS; CHROMATOGRAPHY, LIQUID; DESIGNER DRUGS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MICROSOMES, LIVER; PROPIOPHENONES; RATS; TANDEM MASS SPECTROMETRY;

EID: 84929130413     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1682     Document Type: Article

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