Development of a broad toxicological screening technique for urine using ultra-performance liquid chromatography and time-of-flight mass spectrometry

Analytica Chimica Acta

Volumn 649, Issue 1, 2009, Pages 80-90

  Lee, Hon Kit ^a   Ho, Chung Shun ^b   Iu, Yan Ping Heidi ^c   Lai, Po Shan Judy ^c   Shek, Chi Chung ^c   Lo, Yun Chuen ^d   Klinke, Helene Bendstrup ^e   Wood, Michelle ^f  

^a TUEN MUN HOSPITAL   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c QUEEN ELIZABETH HOSPITAL   (Hong Kong)

^d PAMELA YOUDE NETHERSOLE EASTERN HOSPITAL   (Hong Kong)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f WATERS CORPORATION   (United States)

Author keywords

REMEDi HS; Systematic toxicological analysis; Time of flight mass spectrometry; Ultra performance liquid chromatography

Indexed keywords

DRUG PROFILING; EXTRACTION RECOVERY; FRAGMENTATION PATTERNS; HPLC-DAD; MATRIX EFFECTS; NOVEL METHODS; PARALLEL ANALYSIS; REMEDI HS; RETENTION TIME; ROUTINE ANALYSIS; SCREENING TECHNIQUES; SYSTEMATIC TOXICOLOGICAL ANALYSIS; TIME-OF-FLIGHT MASS SPECTROMETRY; ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY; UPLC-MS/MS; URINE SAMPLE; VALIDATION DATA;

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DRUG PRODUCTS; HYDRAULIC STRUCTURES; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; NEGATIVE IONS;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALPRAZOLAM; AMPHETAMINE; BENZOYLECGONINE; CODEINE; COTININE; DEXTROPROPOXYPHENE; DIAZEPAM; DOSULEPIN; ECGONINE METHYL ESTER; EPHEDRINE; FENTANYL; GLAFENINE; HYDROCODONE; IMIPRAMINE; KETAMINE; LEUCINE ENKEPHALIN; LYSERGIDE; MEPHENTERMINE; METHADONE; METHAMPHETAMINE; METHAQUALONE; MIDAZOLAM; MORPHINE; NORDAZEPAM; NORDOXEPIN; NORTRIPTYLINE; PETHIDINE; ZOLPIDEM;

ACCURACY; ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PRODUCT RECOVERY; SENSITIVITY AND SPECIFICITY; TIME OF FLIGHT MASS SPECTROMETRY; URINALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; METABOLOME; PATTERN RECOGNITION, AUTOMATED; PHARMACEUTICAL PREPARATIONS; TANDEM MASS SPECTROMETRY; TOXICITY TESTS;

EID: 68049135677     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2009.06.068     Document Type: Article

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