Rapid screening for 67 drugs and metabolites in serum or plasma by accurate-mass lc-tof-mS

Journal of Analytical Toxicology

Volumn 36, Issue 7, 2012, Pages 477-486

  Marin, Stephanie J ^a   Hughes, John M ^b   Lawlor, Bryan G ^c   Clark, Chantry J ^c   McMillin, Gwendolyn A ^c,d  

^a ARUP INSTITUTE FOR CLINICAL AND EXPERIMENTAL PATHOLOGY   (United States)

^b AGILENT TECHNOLOGIES   (United States)

^c ARUP LABORATORIES   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 AMINOFLUNITRAZEPAM; ALPHA HYDROXYMIDAZOLAM; ALPRAZOLAM; AMOBARBITAL; BENZODIAZEPINE; BUTALBITAL; CENTRAL STIMULANT AGENT; CHLORDIAZEPOXIDE; CLONAZEPAM; DEALKYLFLURAZEPAM; DIAZEPAM; DRUG METABOLITE; FLUNITRAZEPAM; FLURAZEPAM; HYPNOTIC SEDATIVE AGENT; LORAZEPAM; MIDAZOLAM; MORPHINE 6 ACETATE; NITRAZEPAM; NORDAZEPAM; OPIATE DERIVATIVE; OXAZEPAM; PENTOBARBITAL; PHENOBARBITAL; SECOBARBITAL; TEMAZEPAM; TRIAZOLAM; UNINDEXED DRUG; ZOLPIDEM; ZOPICLONE;

ARTICLE; CHRONIC PAIN; DATA ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EXPOSURE; DRUG SCREENING; DRUG STRUCTURE; GAS CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY TIME OF FLIGHT MASS SPECTROMETRY; PATIENT COMPLIANCE; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 84871103490     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/jat/bks061     Document Type: Article

References (12)

1. Substance Abuse and Mental Health Services Administration, Department of Workplace Programs. Drug Testing, current contents. http://workplace.samhas.gov/Dtesting.html (accessed August 2011).
2. Kraemer, T., Paul, L.D. (2007) Bioanalytical procedures for determination of drugs of abuse in blood. Analytical and Bioanalytical Chemistry, 388, 1415-1435.
3. Braithwaite, R.A., Jarvie, D.R., Minty, P.S., Simpson, D., Widdop, B. (1995) Screening for drugs of abuse. I: Opiates, amphetamines and cocaine. Annals of Clinical Biochemistry, 32, 123-153.
4. Hernández, F., Bijlsma, L., Sancho, J.V., Díaz, R., Ibáñez, M. (2011) Rapid wide-scope screening of drugs of abuse, prescription drugs with potential for abuse and their metabolites in influent and effluent urban wastewater by ultrahigh pressure liquid chromatography-quadrupole-time-of-flight-mass spectrometry. Analytica Chimica Acta, 684, 96-106.
5. Kaufmann, A., Butcher, P., Maden, K., Walker, S., Widmer, M. (2011) Development of an improved high resolution mass spectrometry based multi-residue method for veterinary drugs in various food matrices. Analytica Chimica Acta, 700, 86-94.
6. Nielsen, M.K., Johansen, S.S., Dalsgaard, P.W., Linnet, K. (2010) Simultaneous screening and quantification of 52 common pharmaceuticals and drugs of abuse in hair using UPLC-TOF-MS. Forensic Science International, 20, 85-92.
7. Ristimaa, J., Gergov, M., Pelander, A., Halmesmäki, E., Ojanperä, I. (2010) Broad-spectrum drug screening of meconium by liquid chromatography with tandem mass spectrometry and time-of-flight mass spectrometry. Analytical and Bioanalytical Chemistry, 398, 925-935.
8. Badoud, F., Grata, E., Perrenoud, L., Saugy, M., Rudaz, S., Veuthey, J.L. (2010) Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry. II: Confirmatory analysis. Journal of Chromatography A, 18, 4109-4119.
9. Kolmonen, M., Leinonen, A., Kuuranne, T., Pelander, A., Ojanperä, I. (2009) Generic sample preparation and dual polarity liquid chromatography-time-of-flight mass spectrometry for high-throughput screening in doping analysis. Drug Testing and Analysis, 1, 250-266.
10. Peters, R.J., Oosterink, J.E., Stolker, A.A., Georgakopoulos, C., Nielen, M.W. (2010) Generic sample preparation combined with highresolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and Bioanalytical Chemistry, 396, 2583-2598.
11. Vonaparti, A., Lyris, E., Angelis, Y.S., Panderi, I., Koupparis, M., Tsantili-Kakoulidou, A. et al. (2010) Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry, 15, 1595-609.
12. Matuszewski, B.K., Constanzer, M.L., Chavez-Eng, C.M. (1998) Matrix effect in quantitative LC/MS/MS analyses of biological fluids: A method for determination of finasteride in human plasma at picogram per milliliter concentrations. Analytical Chemistry, 70, 882-889.