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Volumn 134, Issue 6, 2015, Pages 1104-1115

Quantitative targeted absolute proteomics of rat blood-cerebrospinal fluid barrier transporters: Comparison with a human specimen

Author keywords

blood cerebrospinal fluid barrier; human rat difference; MATE1; oatp1a5; PEPT2; protein expression level

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; GLUCOSE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER F; PEPTIDE TRANSPORTER 2; PROTEIN MDR1A; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A2; UNCLASSIFIED DRUG;

EID: 84941809505     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13147     Document Type: Article
Times cited : (90)

References (51)
  • 1
    • 0141891217 scopus 로고    scopus 로고
    • Functional interaction between the two halves of the photoreceptor-specific ATP binding cassette protein ABCR (ABCA4). Evidence for a non-exchangeable ADP in the first nucleotide binding domain
    • Ahn J., Beharry S., Molday L. L., and, Molday R. S., (2003) Functional interaction between the two halves of the photoreceptor-specific ATP binding cassette protein ABCR (ABCA4). Evidence for a non-exchangeable ADP in the first nucleotide binding domain. J. Biol. Chem. 278, 39600-39608.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39600-39608
    • Ahn, J.1    Beharry, S.2    Molday, L.L.3    Molday, R.S.4
  • 2
    • 0033794507 scopus 로고    scopus 로고
    • Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2
    • Asaba H., Hosoya K., Takanaga H., Ohtsuki S., Tamura E., Takizawa T., and, Terasaki T., (2000) Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2. J. Neurochem. 75, 1907-1916.
    • (2000) J. Neurochem. , vol.75 , pp. 1907-1916
    • Asaba, H.1    Hosoya, K.2    Takanaga, H.3    Ohtsuki, S.4    Tamura, E.5    Takizawa, T.6    Terasaki, T.7
  • 3
    • 14844336904 scopus 로고    scopus 로고
    • Retinal-specific ATP-binding cassette transporter (ABCR/ABCA4) is expressed at the choroid plexus in rat brain
    • Bhongsatiern J., Ohtsuki S., Tachikawa M., Hori S., and, Terasaki T., (2005) Retinal-specific ATP-binding cassette transporter (ABCR/ABCA4) is expressed at the choroid plexus in rat brain. J. Neurochem. 92, 1277-1280.
    • (2005) J. Neurochem. , vol.92 , pp. 1277-1280
    • Bhongsatiern, J.1    Ohtsuki, S.2    Tachikawa, M.3    Hori, S.4    Terasaki, T.5
  • 4
    • 0035188883 scopus 로고    scopus 로고
    • Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3
    • Cattori V., van Montfoort J. E., Stieger B., Landmann L., Meijer D. K., Winterhalter K. H., Meier P. J., and, Hagenbuch B., (2001) Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch. 443, 188-195.
    • (2001) Pflugers Arch. , vol.443 , pp. 188-195
    • Cattori, V.1    Van Montfoort, J.E.2    Stieger, B.3    Landmann, L.4    Meijer, D.K.5    Winterhalter, K.H.6    Meier, P.J.7    Hagenbuch, B.8
  • 5
    • 34347327217 scopus 로고    scopus 로고
    • Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney
    • Ci L., Kusuhara H., Adachi M., Schuetz J. D., Takeuchi K., and, Sugiyama Y., (2007) Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney. Mol. Pharmacol. 71, 1591-1597.
    • (2007) Mol. Pharmacol. , vol.71 , pp. 1591-1597
    • Ci, L.1    Kusuhara, H.2    Adachi, M.3    Schuetz, J.D.4    Takeuchi, K.5    Sugiyama, Y.6
  • 6
    • 84873311854 scopus 로고    scopus 로고
    • Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4) gene
    • Duan H., and, Wang J., (2013) Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4) gene. J. Biol. Chem. 288, 3535-3544.
    • (2013) J. Biol. Chem. , vol.288 , pp. 3535-3544
    • Duan, H.1    Wang, J.2
  • 7
    • 0031584092 scopus 로고    scopus 로고
    • Nutrient regulation of the intestinal Na+/glucose co-transporter (SGLT1) gene expression
    • Dyer J., Barker P. J., and, Shirazi-Beechey S. P., (1997) Nutrient regulation of the intestinal Na+/glucose co-transporter (SGLT1) gene expression. Biochem. Biophys. Res. Commun. 230, 624-629.
    • (1997) Biochem. Biophys. Res. Commun. , vol.230 , pp. 624-629
    • Dyer, J.1    Barker, P.J.2    Shirazi-Beechey, S.P.3
  • 8
    • 70350054854 scopus 로고    scopus 로고
    • Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids
    • Friden M., Winiwarter S., Jerndal G., Bengtsson O., Wan H., Bredberg U., Hammarlund-Udenaes M., and, Antonsson M., (2009) Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. J. Med. Chem. 52, 6233-6243.
    • (2009) J. Med. Chem. , vol.52 , pp. 6233-6243
    • Friden, M.1    Winiwarter, S.2    Jerndal, G.3    Bengtsson, O.4    Wan, H.5    Bredberg, U.6    Hammarlund-Udenaes, M.7    Antonsson, M.8
  • 9
    • 0028318761 scopus 로고
    • Cerebrospinal fluid production and dynamics in normal aging: A MRI phase-mapping study
    • Gideon P., Thomsen C., Stahlberg F., and, Henriksen O., (1994) Cerebrospinal fluid production and dynamics in normal aging: a MRI phase-mapping study. Acta Neurol. Scand. 89, 362-366.
    • (1994) Acta Neurol. Scand. , vol.89 , pp. 362-366
    • Gideon, P.1    Thomsen, C.2    Stahlberg, F.3    Henriksen, O.4
  • 10
    • 84881609722 scopus 로고    scopus 로고
    • Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset
    • Hoshi Y., Uchida Y., Tachikawa M., Inoue T., Ohtsuki S., and, Terasaki T., (2013) Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset. J. Pharm. Sci. 102, 3343-3355.
    • (2013) J. Pharm. Sci. , vol.102 , pp. 3343-3355
    • Hoshi, Y.1    Uchida, Y.2    Tachikawa, M.3    Inoue, T.4    Ohtsuki, S.5    Terasaki, T.6
  • 11
    • 36248954510 scopus 로고    scopus 로고
    • Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity
    • Hu Y., Shen H., Keep R. F., and, Smith D. E., (2007) Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity. J. Neurochem. 103, 2058-2065.
    • (2007) J. Neurochem. , vol.103 , pp. 2058-2065
    • Hu, Y.1    Shen, H.2    Keep, R.F.3    Smith, D.E.4
  • 12
    • 43049114146 scopus 로고    scopus 로고
    • Quantitative atlas of membrane transporter proteins: Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria
    • Kamiie J., Ohtsuki S., Iwase R., et al., (2008) Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm. Res. 25, 1469-1483.
    • (2008) Pharm. Res. , vol.25 , pp. 1469-1483
    • Kamiie, J.1    Ohtsuki, S.2    Iwase, R.3
  • 13
    • 0029078231 scopus 로고
    • Identification and characterization of a prostaglandin transporter
    • Kanai N., Lu R., Satriano J. A., Bao Y., Wolkoff A. W., and, Schuster V. L., (1995) Identification and characterization of a prostaglandin transporter. Science 268, 866-869.
    • (1995) Science , vol.268 , pp. 866-869
    • Kanai, N.1    Lu, R.2    Satriano, J.A.3    Bao, Y.4    Wolkoff, A.W.5    Schuster, V.L.6
  • 14
    • 84862192063 scopus 로고    scopus 로고
    • Choroid plexus transport: Gene deletion studies
    • Keep R. F., and, Smith D. E., (2011) Choroid plexus transport: gene deletion studies. Fluids Barriers CNS 8, 26.
    • (2011) Fluids Barriers CNS , vol.8 , pp. 26
    • Keep, R.F.1    Smith, D.E.2
  • 15
    • 0034108608 scopus 로고    scopus 로고
    • In-vivo and in-vitro evidence of a carrier-mediated efflux transport system for oestrone-3-sulphate across the blood-cerebrospinal fluid barrier
    • Kitazawa T., Hosoya K., Takahashi T., Sugiyama Y., and, Terasaki T., (2000) In-vivo and in-vitro evidence of a carrier-mediated efflux transport system for oestrone-3-sulphate across the blood-cerebrospinal fluid barrier. J. Pharm. Pharmacol. 52, 281-288.
    • (2000) J. Pharm. Pharmacol. , vol.52 , pp. 281-288
    • Kitazawa, T.1    Hosoya, K.2    Takahashi, T.3    Sugiyama, Y.4    Terasaki, T.5
  • 16
    • 81555210969 scopus 로고    scopus 로고
    • Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate
    • Kodaira H., Kusuhara H., Fujita T., Ushiki J., Fuse E., and, Sugiyama Y., (2011) Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate. J. Pharmacol. Exp. Ther. 339, 935-944.
    • (2011) J. Pharmacol. Exp. Ther. , vol.339 , pp. 935-944
    • Kodaira, H.1    Kusuhara, H.2    Fujita, T.3    Ushiki, J.4    Fuse, E.5    Sugiyama, Y.6
  • 17
    • 22944459556 scopus 로고    scopus 로고
    • Rapid elimination of cefaclor from the cerebrospinal fluid is mediated by a benzylpenicillin-sensitive mechanism distinct from organic anion transporter 3
    • Kuroda M., Kusuhara H., Endou H., and, Sugiyama Y., (2005) Rapid elimination of cefaclor from the cerebrospinal fluid is mediated by a benzylpenicillin-sensitive mechanism distinct from organic anion transporter 3. J. Pharmacol. Exp. Ther. 314, 855-861.
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 855-861
    • Kuroda, M.1    Kusuhara, H.2    Endou, H.3    Sugiyama, Y.4
  • 18
    • 4644371364 scopus 로고    scopus 로고
    • Efflux transport systems for organic anions and cations at the blood-CSF barrier
    • Kusuhara H., and, Sugiyama Y., (2004) Efflux transport systems for organic anions and cations at the blood-CSF barrier. Adv. Drug Deliv. Rev. 56, 1741-1763.
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 1741-1763
    • Kusuhara, H.1    Sugiyama, Y.2
  • 19
    • 0033560646 scopus 로고    scopus 로고
    • Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria
    • Lindberg R. L., Martini R., Baumgartner M., et al., (1999) Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria. J. Clin. Invest. 103, 1127-1134.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1127-1134
    • Lindberg, R.L.1    Martini, R.2    Baumgartner, M.3
  • 20
    • 84929940631 scopus 로고    scopus 로고
    • Amyloid-beta transporter expression at the choroid plexus in normal aging: The possibility of reduced resistance to oxidative stress insults
    • Liu C. B., Wang R., Dong M. W., Gao X. R., and, Yu F., (2014) Amyloid-beta transporter expression at the choroid plexus in normal aging: the possibility of reduced resistance to oxidative stress insults. Sheng Li Xue Bao 66, 158-168.
    • (2014) Sheng Li Xue Bao , vol.66 , pp. 158-168
    • Liu, C.B.1    Wang, R.2    Dong, M.W.3    Gao, X.R.4    Yu, F.5
  • 21
    • 9644252691 scopus 로고    scopus 로고
    • Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: Analysis of affinity constants and comparison with PEPT1
    • Luckner P., and, Brandsch M., (2005) Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur. J. Pharm. Biopharm. 59, 17-24.
    • (2005) Eur. J. Pharm. Biopharm. , vol.59 , pp. 17-24
    • Luckner, P.1    Brandsch, M.2
  • 22
    • 0017613802 scopus 로고
    • Delta-Aminolevulinic acid: Influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria
    • Muller W. E., and, Snyder S. H., (1977) delta-Aminolevulinic acid: influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria. Ann. Neurol. 2, 340-342.
    • (1977) Ann. Neurol. , vol.2 , pp. 340-342
    • Muller, W.E.1    Snyder, S.H.2
  • 23
    • 84915803712 scopus 로고    scopus 로고
    • Putative roles of organic anion transporting polypeptides (OATPs) in cell survival and progression of human cancers
    • Nakanishi T., and, Tamai I., (2014) Putative roles of organic anion transporting polypeptides (OATPs) in cell survival and progression of human cancers. Biopharm. Drug Dispos. 35, 463-484.
    • (2014) Biopharm. Drug Dispos. , vol.35 , pp. 463-484
    • Nakanishi, T.1    Tamai, I.2
  • 24
    • 0036788234 scopus 로고    scopus 로고
    • Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: Its involvement in neurotransmitter metabolite clearance from the brain
    • Ohtsuki S., Asaba H., Takanaga H., Deguchi T., Hosoya K., Otagiri M., and, Terasaki T., (2002) Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J. Neurochem. 83, 57-66.
    • (2002) J. Neurochem. , vol.83 , pp. 57-66
    • Ohtsuki, S.1    Asaba, H.2    Takanaga, H.3    Deguchi, T.4    Hosoya, K.5    Otagiri, M.6    Terasaki, T.7
  • 25
    • 79960116572 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: Methodology, advantages, strategy, and prospects
    • Ohtsuki S., Uchida Y., Kubo Y., and, Terasaki T., (2011) Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects. J. Pharm. Sci. 100, 3547-3559.
    • (2011) J. Pharm. Sci. , vol.100 , pp. 3547-3559
    • Ohtsuki, S.1    Uchida, Y.2    Kubo, Y.3    Terasaki, T.4
  • 26
    • 84455194082 scopus 로고    scopus 로고
    • Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: Comparison with mRNA levels and activities
    • Ohtsuki S., Schaefer O., Kawakami H., et al., (2012) Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities. Drug Metab. Dispos. 40, 83-92.
    • (2012) Drug Metab. Dispos. , vol.40 , pp. 83-92
    • Ohtsuki, S.1    Schaefer, O.2    Kawakami, H.3
  • 27
    • 84872159164 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model
    • Ohtsuki S., Ikeda C., Uchida Y., et al., (2013) Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model. Mol. Pharm. 10, 289-296.
    • (2013) Mol. Pharm. , vol.10 , pp. 289-296
    • Ohtsuki, S.1    Ikeda, C.2    Uchida, Y.3
  • 28
    • 29144523534 scopus 로고    scopus 로고
    • A human transporter protein that mediates the final excretion step for toxic organic cations
    • Otsuka M., Matsumoto T., Morimoto R., Arioka S., Omote H., and, Moriyama Y., (2005) A human transporter protein that mediates the final excretion step for toxic organic cations. Proc. Natl Acad. Sci. USA 102, 17923-17928.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 17923-17928
    • Otsuka, M.1    Matsumoto, T.2    Morimoto, R.3    Arioka, S.4    Omote, H.5    Moriyama, Y.6
  • 31
    • 0035984819 scopus 로고    scopus 로고
    • Improved brain delivery of benzylpenicillin with a peptide-vector-mediated strategy
    • Rousselle C., Clair P., Temsamani J., and, Scherrmann J. M., (2002) Improved brain delivery of benzylpenicillin with a peptide-vector-mediated strategy. J. Drug Target. 10, 309-315.
    • (2002) J. Drug Target. , vol.10 , pp. 309-315
    • Rousselle, C.1    Clair, P.2    Temsamani, J.3    Scherrmann, J.M.4
  • 32
    • 79961096875 scopus 로고    scopus 로고
    • Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels
    • Shawahna R., Uchida Y., Decleves X., et al., (2011) Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol. Pharm. 8, 1332-1341.
    • (2011) Mol. Pharm. , vol.8 , pp. 1332-1341
    • Shawahna, R.1    Uchida, Y.2    Decleves, X.3
  • 33
    • 4644239463 scopus 로고    scopus 로고
    • Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain
    • Shen H., Smith D. E., Keep R. F., and, Brosius F. C., 3rd, (2004) Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain. Mol. Pharm. 1, 248-256.
    • (2004) Mol. Pharm. , vol.1 , pp. 248-256
    • Shen, H.1    Smith, D.E.2    Keep, R.F.3    Brosius, F.C.4
  • 34
    • 78650871022 scopus 로고    scopus 로고
    • Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice
    • Smith D. E., Hu Y., Shen H., Nagaraja T. N., Fenstermacher J. D., and, Keep R. F., (2011) Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice. J. Cereb. Blood Flow Metab. 31, 250-261.
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 250-261
    • Smith, D.E.1    Hu, Y.2    Shen, H.3    Nagaraja, T.N.4    Fenstermacher, J.D.5    Keep, R.F.6
  • 35
    • 77957328846 scopus 로고    scopus 로고
    • Vectorial ligand transport through mammalian choroid plexus
    • Spector R., and, Johanson C. E., (2010) Vectorial ligand transport through mammalian choroid plexus. Pharm. Res. 27, 2054-2062.
    • (2010) Pharm. Res. , vol.27 , pp. 2054-2062
    • Spector, R.1    Johanson, C.E.2
  • 36
    • 0033948974 scopus 로고    scopus 로고
    • Choroid plexus in the central nervous system: Biology and physiopathology
    • Strazielle N., and, Ghersi-Egea J. F., (2000) Choroid plexus in the central nervous system: biology and physiopathology. J. Neuropathol. Exp. Neurol. 59, 561-574.
    • (2000) J. Neuropathol. Exp. Neurol. , vol.59 , pp. 561-574
    • Strazielle, N.1    Ghersi-Egea, J.F.2
  • 37
    • 0032895108 scopus 로고    scopus 로고
    • Low levels of transthyretin in the CSF of depressed patients
    • Sullivan G. M., Hatterer J. A., Herbert J., et al., (1999) Low levels of transthyretin in the CSF of depressed patients. Am. J. Psychiatry 156, 710-715.
    • (1999) Am. J. Psychiatry , vol.156 , pp. 710-715
    • Sullivan, G.M.1    Hatterer, J.A.2    Herbert, J.3
  • 39
    • 53149142766 scopus 로고    scopus 로고
    • The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: Involvement of transporter-mediated process
    • Tachikawa M., Kasai Y., Takahashi M., Fujinawa J., Kitaichi K., Terasaki T., and, Hosoya K., (2008) The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: involvement of transporter-mediated process. J. Neurochem. 107, 432-442.
    • (2008) J. Neurochem. , vol.107 , pp. 432-442
    • Tachikawa, M.1    Kasai, Y.2    Takahashi, M.3    Fujinawa, J.4    Kitaichi, K.5    Terasaki, T.6    Hosoya, K.7
  • 40
    • 84868661468 scopus 로고    scopus 로고
    • Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E(2) produced in the brain
    • Tachikawa M., Ozeki G., Higuchi T., Akanuma S., Tsuji K., and, Hosoya K., (2012) Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E(2) produced in the brain. J. Neurochem. 123, 750-760.
    • (2012) J. Neurochem. , vol.123 , pp. 750-760
    • Tachikawa, M.1    Ozeki, G.2    Higuchi, T.3    Akanuma, S.4    Tsuji, K.5    Hosoya, K.6
  • 41
    • 34250005960 scopus 로고    scopus 로고
    • Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters
    • Tanihara Y., Masuda S., Sato T., Katsura T., Ogawa O., and, Inui K., (2007) Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem. Pharmacol. 74, 359-371.
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 359-371
    • Tanihara, Y.1    Masuda, S.2    Sato, T.3    Katsura, T.4    Ogawa, O.5    Inui, K.6
  • 42
    • 33746508758 scopus 로고    scopus 로고
    • Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1
    • Terada T., Masuda S., Asaka J., Tsuda M., Katsura T., and, Inui K., (2006) Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1. Pharm. Res. 23, 1696-1701.
    • (2006) Pharm. Res. , vol.23 , pp. 1696-1701
    • Terada, T.1    Masuda, S.2    Asaka, J.3    Tsuda, M.4    Katsura, T.5    Inui, K.6
  • 44
    • 35948934719 scopus 로고    scopus 로고
    • Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter
    • Uchida Y., Kamiie J., Ohtsuki S., and, Terasaki T., (2007) Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter. Pharm. Res. 24, 2281-2296.
    • (2007) Pharm. Res. , vol.24 , pp. 2281-2296
    • Uchida, Y.1    Kamiie, J.2    Ohtsuki, S.3    Terasaki, T.4
  • 45
    • 79953686193 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
    • Uchida Y., Ohtsuki S., Katsukura Y., Ikeda C., Suzuki T., Kamiie J., and, Terasaki T., (2011) Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J. Neurochem. 117, 333-345.
    • (2011) J. Neurochem. , vol.117 , pp. 333-345
    • Uchida, Y.1    Ohtsuki, S.2    Katsukura, Y.3    Ikeda, C.4    Suzuki, T.5    Kamiie, J.6    Terasaki, T.7
  • 46
    • 84878654332 scopus 로고    scopus 로고
    • A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: Application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice
    • Uchida Y., Tachikawa M., Obuchi W., Hoshi Y., Tomioka Y., Ohtsuki S., and, Terasaki T., (2013) A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice. Fluids Barriers CNS 10, 21.
    • (2013) Fluids Barriers CNS , vol.10 , pp. 21
    • Uchida, Y.1    Tachikawa, M.2    Obuchi, W.3    Hoshi, Y.4    Tomioka, Y.5    Ohtsuki, S.6    Terasaki, T.7
  • 47
    • 84904979602 scopus 로고    scopus 로고
    • Blood-brain barrier pharmacoproteomics-based reconstruction of the in vivo brain distribution of P-glycoprotein substrates in cynomolgus monkeys
    • Uchida Y., Wakayama K., Ohtsuki S., Chiba M., Ohe T., Ishii Y., and, Terasaki T., (2014) Blood-brain barrier pharmacoproteomics-based reconstruction of the in vivo brain distribution of P-glycoprotein substrates in cynomolgus monkeys. J. Pharmacol. Exp. Ther. 350, 578-588.
    • (2014) J. Pharmacol. Exp. Ther. , vol.350 , pp. 578-588
    • Uchida, Y.1    Wakayama, K.2    Ohtsuki, S.3    Chiba, M.4    Ohe, T.5    Ishii, Y.6    Terasaki, T.7
  • 48
    • 11444250619 scopus 로고    scopus 로고
    • Autotoxicity, methylation and a road to the prevention of Parkinson's disease
    • Williams A. C., and, Ramsden D. B., (2005) Autotoxicity, methylation and a road to the prevention of Parkinson's disease. J. Clin. Neurosci. 12, 6-11.
    • (2005) J. Clin. Neurosci. , vol.12 , pp. 6-11
    • Williams, A.C.1    Ramsden, D.B.2
  • 49
    • 26244447845 scopus 로고    scopus 로고
    • Cadherin-10 is a novel blood-brain barrier adhesion molecule in human and mouse
    • Williams M. J., Lowrie M. B., Bennett J. P., Firth J. A., and, Clark P., (2005) Cadherin-10 is a novel blood-brain barrier adhesion molecule in human and mouse. Brain Res. 1058, 62-72.
    • (2005) Brain Res. , vol.1058 , pp. 62-72
    • Williams, M.J.1    Lowrie, M.B.2    Bennett, J.P.3    Firth, J.A.4    Clark, P.5
  • 50
    • 84881614134 scopus 로고    scopus 로고
    • Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8)
    • Yee S. W., Nguyen A. N., Brown C., et al., (2013) Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J. Pharm. Sci. 102, 3451-3457.
    • (2013) J. Pharm. Sci. , vol.102 , pp. 3451-3457
    • Yee, S.W.1    Nguyen, A.N.2    Brown, C.3
  • 51
    • 63649120784 scopus 로고    scopus 로고
    • Role of the C terminus of the photoreceptor ABCA4 transporter in protein folding, function, and retinal degenerative diseases
    • Zhong M., Molday L. L., and, Molday R. S., (2009) Role of the C terminus of the photoreceptor ABCA4 transporter in protein folding, function, and retinal degenerative diseases. J. Biol. Chem. 284, 3640-3649.
    • (2009) J. Biol. Chem. , vol.284 , pp. 3640-3649
    • Zhong, M.1    Molday, L.L.2    Molday, R.S.3


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