Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset

Journal of Pharmaceutical Sciences

Volumn 102, Issue 9, 2013, Pages 3343-3355

  Hoshi, Yutaro ^a   Uchida, Yasuo ^a   Tachikawa, Masanori ^a   Inoue, Takashi ^b   Ohtsuki, Sumio ^c   Terasaki, Tetsuya ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

ADME; Blood brain barrier; Membrane transporter; Multidrug resistance transporters; P glycoprotein; Permeability; Preclinical pharmacokinetics; Proteomics; Receptors; Tight junction

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMINO ACID TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; CD71 ANTIGEN; CLAUDIN 5; EXCITATORY AMINO ACID TRANSPORTER 1; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; INSULIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MONOCARBOXYLATE TRANSPORTER 1; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; ORGANIC ANION TRANSPORTER 3; RECEPTOR PROTEIN; TIGHT JUNCTION PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CALLITHRIX; COMPARATIVE STUDY; ENCEPHALE ISOLE; FEMALE; HUMAN; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MEMBRANE TRANSPORT; NONHUMAN; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; RAT; SPECIES DIFFERENCE; STRAIN DIFFERENCE; TANDEM MASS SPECTROMETRY;

ADME; BLOOD-BRAIN BARRIER; MEMBRANE TRANSPORTER; MULTIDRUG RESISTANCE TRANSPORTERS; P-GLYCOPROTEIN; PERMEABILITY; PRECLINICAL PHARMACOKINETICS; PROTEOMICS; RECEPTORS; TIGHT JUNCTION;

ANIMALS; BLOOD-BRAIN BARRIER; CALLITHRIX; FEMALE; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, CELL SURFACE; SPECIES SPECIFICITY; TANDEM MASS SPECTROMETRY; TIGHT JUNCTION PROTEINS;

EID: 84881609722     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23575     Document Type: Article

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