MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation

Immunity

Volumn 43, Issue 3, 2015, Pages 475-487

  Garg, Abhishek V ^a   Amatya, Nilesh ^a   Chen, Kong ^a   Cruz, J Agustin ^a   Grover, Prerna ^a   Whibley, Natasha ^a   Conti, Heather R ^a   Hernandez Mir, Gerard ^a   Sirakova, Tatiana ^b   Childs, Erin C ^a   Smithgall, Thomas E ^a   Biswas, Partha S ^a   Kolls, Jay K ^a   McGeachy, Mandy J ^a   Kolattukudy, Pappachan E ^a   Gaffen, Sarah L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Autoimmunity; Fungal immunity; IL 17; Negative regulation; Regnase 1; Signal transduction

Indexed keywords

DEUBIQUITINASE; I KAPPA B KINASE EPSILON; I KAPPA B ZETA; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 6; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; REGNASE 1; RIBONUCLEASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFKBIZ; UNCLASSIFIED DRUG; ACUTE PHASE PROTEIN; LCN2 PROTEIN, MOUSE; LIPOCALIN; NFKBIZ PROTEIN, MOUSE; NUCLEAR PROTEIN; ONCOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; ZC3H12A PROTEIN, MOUSE;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDIASIS; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; DISEASE EXACERBATION; DOWN REGULATION; ENZYME ACTIVITY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENE EXPRESSION; HAPLOINSUFFICIENCY; HUMAN; HUMAN CELL; IMMUNOREGULATION; INFLAMMATION; KERATINOCYTE; MALE; MOUSE; MYCOSIS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RNA DEGRADATION; RNA STABILITY; SIGNAL TRANSDUCTION; THRUSH; ANIMAL; C57BL MOUSE; CANDIDA ALBICANS; CELL CULTURE; CELL LINE; GENETICS; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; IMMUNOBLOTTING; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACUTE-PHASE PROTEINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; CELL LINE; CELLS, CULTURED; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOBLOTTING; INFLAMMATION; INTERLEUKIN-17; INTERLEUKIN-6; LIPOCALIN-2; LIPOCALINS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PNEUMONIA; RECEPTORS, INTERLEUKIN-17; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEASES; SIGNAL TRANSDUCTION;

EID: 84941732348     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.07.021     Document Type: Article

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