Targeted disruption of MCPIP1/Zc3h12a results in fatal inflammatory disease

Immunology and Cell Biology

Volumn 91, Issue 5, 2013, Pages 368-376

  Miao, Ruidong ^a,b   Huang, Shengping ^a   Zhou, Zhou ^c   Quinn, Tim ^a   Van Treeck, Benjamin ^a   Nayyar, Tehreem ^a   Dim, Daniel ^d   Jiang, Zhisheng ^e   Papasian, Christopher J ^a   Eugene Chen, Y ^c   Liu, Gang ^f   Fu, Mingui ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^b LANZHOU UNIVERSITY   (China)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^e UNIVERSITY OF SOUTH CHINA   (China)

^f University of Alabama at Birmingham   (United States)

Author keywords

autoimmune disease; cytokine; inflammation; lymphocyte; MCPIP1

Indexed keywords

AMPICILLIN; GAMMA INTERFERON; IMMUNOGLOBULIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MESSENGER RNA; METRONIDAZOLE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN INDUCED PROTEIN 1; NEOMYCIN; PROTEIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ADAPTIVE IMMUNITY; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONTROLLED STUDY; DEATH; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HISTOLOGY; HYPERIMMUNOGLOBULINEMIA; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATORY DISEASE; INTESTINE FLORA; LIFESPAN; LUNG INFILTRATE; LYMPHOCYTIC INFILTRATION; LYMPHOID TISSUE; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN DEFICIENCY; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN; SURVIVAL RATE; T LYMPHOCYTE ACTIVATION; THYMUS;

3' UNTRANSLATED REGIONS; ANIMALS; ANTI-BACTERIAL AGENTS; CELL MOVEMENT; DYSBIOSIS; GENE EXPRESSION REGULATION; HUMANS; IMMUNE TOLERANCE; INFLAMMATION; LIVER; LUNG; MICE; MICE, KNOCKOUT; MICROBIOTA; MUCOUS MEMBRANE; MYELOID DIFFERENTIATION FACTOR 88; RNA STABILITY; TRANSCRIPTION FACTORS;

MUS;

EID: 84878557056     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2013.11     Document Type: Article

References (24)

1. Van Parijs L, Abbas AK. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 1998; 280: 243-248.
2. Stockinger B, Kassiotis G, Bourgeois C. Homeostasis and T cell regulation. Curr Opin Immunol 2004; 16: 775-779.
3. Zhou L, Azfer A, Niu J, Graham S, Choudhury M, Adamski FM et al. Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. Circ Res 2006; 98: 1177-1185
4. Liang J, Wang J, Azfer A, Song W, Tromp G, Kolattukudy PE et al. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. J Biol Chem 2008; 283: 6337-6346.
5. Liang J, Song W, Tromp G, Kolattukudy PE, Fu M. Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. PLoS One 2008; 3: e2880
6. Skalniak L, Mizgalska D, Zarebski A, Wyrzykowska P, Koj A, Jura J. Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase. FEBS J 2009; 276: 5892-5905
7. Kasza A, Wyrzykowska P, Horwacik I, Tymoszuk P, Mizgalska D, Palmer K et al. Transcription factors Elk-1 and SRF are engaged in IL1-dependent regulation of ZC3H12A expression. BMC Mol Biol 2010; 11: 14
8. Liang J, Saad Y, Lei T, Wang J, Qi D, Yang Q et al. MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling. J Exp Med 2010; 207: 2959-2973
9. Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T et al. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 2009; 458: 1185-1190
10. Huang S, Miao R, Zhou Z, Wang T, Liu J, Liu G et al. MCPIP1 negatively regulates Tolllike receptor 4 signaling and protects mice from LPS-induced septic shock. Cell Signal 2013; 25: 1228-1234
11. Lin RJ, Chien HL, Lin SY, Chang BL, Yu HP, Tang WC et al. MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation. Nucleic Acids Res 2013; 41: 3314-3326
12. Saleh M, Elson CO. Experimental inflammatory bowel disease: insights into the hostmicrobiota dialog. Immunity 2011; 34: 293-302
13. Feng T, Elson CO. Adaptive immunity in the host-microbiota dialog. Mucosal Immunol 2011; 4: 15-21
14. Taylor GA, Carballo E, Lee DM, Lai WS, Thompson MJ, Patel DD et al. A pathogenetic role for TNFalpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 1996; 4: 445-454.
15. Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM et al. A RINGtype ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 2005; 435: 452-458.
16. Kawagoe T, Takeuchi O, Takabatake Y, Kato H, Isaka Y, Tsujimura T et al. TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat Immunol 2009; 10: 965-972
17. Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J et al. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell 2008; 133: 415-426
18. Qiu LQ, Stumpo DJ, Blackshear PJ. Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype. J Immunol 2012; 188: 5150-5159
19. Mizgalska D, Wegrzyn P, Murzyn K, Kasza A, Koj A, Jura J et al. Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA. FEBS J 2009; 276: 7386-7399
20. Xu J, Peng W, Sun Y, Wang X, Xu Y, Li X et al. Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase. Nucleic Acids Res 2012; 40: 6957-6965
21. Li M, Cao W, Liu H, Zhang W, Liu X, Cai Z et al. MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway. PLoS One 2012; 7: e49841
22. Qi D, Huang S, Miao R, She ZG, Quinn T, Chang Y et al. Monocyte chemotactic proteininduced protein 1 (MCPIP1) suppresses stress granule formation and determines apoptosis under stress. J Biol Chem 2011; 286: 41692-41700
23. Liang J, Wang J, Saad Y, Warble L, Becerra E, Kolattukudy PE. Participation of MCP-induced protein 1 in lipopolysaccharide preconditioning-induced ischemic stroke tolerance by regulating the expression of proinflammatory cytokines. J Neuroinflammation 2011; 8: 182
24. Niu J, Wang K, Graham S, Azfer A, Kolattukudy PE. MCP-1-induced protein attenuates endotoxin-induced myocardial dysfunction by suppressing cardiac NF-kB activation via inhibition of IkB kinase activation. J Mol Cell Cardiol 2011; 51: 177-186