Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

Nature Medicine

Volumn 13, Issue 2, 2007, Pages 211-217

  O'Connor, Kevin C ^a,b,c   McLaughlin, Katherine A ^c,d   De Jager, Philip L ^a,b,c,e   Chitnis, Tanuja ^a,b,c   Bettelli, Estelle ^a,b,c   Xu, Chenqi ^c,d   Robinson, William H ^f   Cherry, Sunil V ^a,b,c   Bar Or, Amit ^g   Banwell, Brenda ^h   Fukaura, Hikoaki ⁱ   Fukazawa, Toshiyuki ^j   Tenembaum, Silvia ^k   Wong, Susan J ^l   Tavakoli, Norma P ^l   Idrissova, Zhannat ^m   Viglietta, Vissia ^a,b,c   Rostasy, Kevin ⁿ   Pohl, Daniela ⁿ   Dale, Russell C ^o   Freedman, Mark ^p   Steinman, Lawrence ^f   Buckle, Guy J ^a,b,c   Kuchroo, Vijay K ^a,b,c   Hafler, David A ^a,b,c,d   Wucherpfennig, Kai W ^c,d   more..

^a Center for Neurologic Diseases   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e HARVARD UNIVERSITY   (United States)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g MCGILL UNIVERSITY   (Canada)

^h HOSPITAL FOR SICK CHILDREN   (Canada)

ⁱ IWATE MEDICAL UNIVERSITY   (Japan)

^j HOKKAIDO UNIVERSITY   (Japan)

^k JP Garrahan Univ Pediat Hospital   (Argentina)

^l WADSWORTH CENTER   (United States)

^m ASFENDIYAROV KAZAKH NATIONAL MEDICAL UNIVERSITY   (Kazakhstan)

ⁿ UNIVERSITY OF GÖTTINGEN   (Germany)

^o GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^p UNIVERSITY OF OTTAWA   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; TETRAMER;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOPRECIPITATION; ISOTOPE LABELING; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DENATURATION; RADIOIMMUNOASSAY; SENSITIVITY ANALYSIS; SERUM;

ANIMALS; AUTOANTIBODIES; ENCEPHALOMYELITIS, ACUTE DISSEMINATED; HUMANS; IMMUNOASSAY; MICE; MULTIPLE SCLEROSIS; MYELIN-ASSOCIATED GLYCOPROTEIN; PROTEIN FOLDING; SENSITIVITY AND SPECIFICITY;

MUS;

EID: 33846997877     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1488     Document Type: Article

References (30)

1. Linington, C., Bradl, M., Lassmann, H., Brunner, C. & Vass, K. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/ oligodendrocyte glycoprotein. Am. J. Pathol. 130, 443-454 (1988).
2. Schluesener, H.J., Sobel, R.A., Linington, C. & Weiner, H.L. A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J. Immunol. 139, 4016-4021 (1987).
3. Genain, C.P. et al. Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate. J. Clin. Invest. 96, 2966-2974 (1995).
4. Hjelmstrom, P., Juedes, A.E., Fjell, J. & Ruddle, N.H. B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J. Immunol. 161, 4480-4483 (1998).
5. Berger, T. et al. Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N. Engl. J. Med. 349, 139-145 (2003).
6. Lampasona, V. et al. Similar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjects. Neurology 62, 2092-2094 (2004).
7. Lim, E.T. et al. Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosis. Mult. Scler. 11, 492-494 (2005).
8. Reindl, M. et al. Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study. Brain 122, 2047-2056 (1999).
9. Thompson, E.J., Kaufmann, P., Shortman, R.C., Rudge, P. & McDonald, W.I. Oligoclonal immunoglobulins and plasma cells in spinal fluid of patients with multiple sclerosis. Br. Med. J. 1, 16-17 (1979).
10. Lennon, V.A., Kryzer, T.J., Pittock, S.J., Verkman, A.S. & Hinson, S.R. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J. Exp. Med. 202, 473-477 (2005).
11. Wingerchuk, D.M. Postinfectious encephalomyelitis. Curr. Neurol. Neurosci. Rep. 3, 256-264 (2003).
12. Javier, R.S., Kunishita, T., Koike, F. & Tabira, T. Semple rabies vaccine: presence of myelin basic protein and proteolipid protein and its activity in experimental allergic encephalomyelitis. J. Neurol. Sci. 93, 221-230 (1989).
13. Hemachudha, T. et al. Myelin basic protein as an encephalitogen in encephalomyelitis and polyneuritis following rabies vaccination. N. Engl. J. Med. 316, 369-374 (1987).
14. Idrissova, Zh.R. et al. Acute disseminated encephalomyelitis in children: clinical features and HLA-DR linkage. Eur. J. Neurol. 10, 537-546 (2003).
15. Menge, T. et al. Acute disseminated encephalomyelitis: an update. Arch. Neurol. 62, 1673-1680 (2005).
16. Johnson, R.T. et al. Measles encephalomyelitis-clinical and immunologic studies. N. Engl. J. Med. 310, 137-141 (1984).
17. Lisak, R.P., Behan, P.O., Zweiman, B. & Shetty, T. Cell-mediated immunity to myelin basic protein in acute disseminated encephalomyelitis. Neurology 24, 560-564 (1974).
18. Pohl-Koppe, A., Burchett, S.K., Thiele, E.A. & Hafler, D.A. Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis. J. Neuroimmunol. 91, 19-27 (1998).
19. von Budingen, H.C. et al. Epitope recognition on the myelin/oligodendrocyte glycoprotein differentially influences disease phenotype and antibody effector functions in autoimmune demyelination. Eur. J. Immunol. 34, 2072-2083 (2004).
20. Brehm, U., Piddlesden, S.J., Gardinier, M.V. & Linington, C. Epitope specificity of demyelinating monoclonal autoantibodies directed against the human myelin oligodendrocyte glycoprotein (MOG). J. Neuroimmunol. 97, 9-15 (1999).
21. Mathey, E., Breithaupt, C., Schubart, A.S. & Linington, C. Commentary: sorting the wheat from the chaff: identifying demyelinating components of the myelin oligodendrocyte glycoprotein (MOG)-specific autoantibody repertoire. Eur. J. Immunol. 34, 2065-2071 (2004).
22. LaGasse, J.M. et al. Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction Study. Diabetes Care 25, 505-511 (2002).
23. Barker, J.M. et al. Prediction of autoantibody positivity and progression to type 1 diabetes: diabetes autoimmunity study in the young (DAISY). J. Clin. Endocrinol. Metab. 89, 3896-3902 (2004).
24. Fossati-Jimack, L. et al. High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia. J. Exp. Med. 190, 1689-1696 (1999).
25. Call, M.E., Pyrdol, J., Wiedmann, M. & Wucherpfennig, K.W. The organizing principle in the formation of the T cell receptor-CD3 complex. Cell 111, 967-979 (2002).
26. O'Connor, K.C. et al. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J. Immunol. 175, 1974-1982 (2005).
27. Lalive, P.H. et al. Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis. Proc. Natl. Acad. Sci. USA 103, 2280-2285 (2006).
28. Marchioni, E. et al. Postinfectious inflammatory disorders: subgroups based on prospective follow-up. Neurology 65, 1057-1065 (2005).
29. Kanter, D.S. et al. Plasmapheresis in fulminant acute disseminated encephalomyelitis. Neurology 45, 824-827 (1995).
30. Khurana, D.S. et al. Acute disseminated encephalomyelitis in children: discordant neurologic and neuroimaging abnormalities and response to plasmapheresis. Pediatrics 116, 431-436 (2005).