SCOPUS 정보 검색 플랫폼

Volumn 20, Issue 10, 2012, Pages 3223-3232

COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates

(6) Fagan, Vincent a Bonham, Sarah a Carty, Michael P a Saenz Méndez, Patricia b Eriksson, Leif A c Aldabbagh, Fawaz a

a NATIONAL UNIVERSITY OF IRELAND (Ireland)

b UNIVERSIDAD DE LA REPÚBLICA (Uruguay)

c UNIVERSITY OF GOTHENBURG (Sweden)

Author keywords

Anti tumor; Bioreductive; DT diaphorase; Heterocyclic compound

Indexed keywords

1,5 DIBUTYLIMIDAZO[5,4 F]BENZIMIDAZOL 4,8 DIONE; 2,3,4,5,10,11,12,13 OCTAHYDRO 1H,9H AZEPINO[1,2 A]AZEPINO[1',2':1,2]IMIDAZO[5,4 F]BENZIMIDAZOL 7,15 DIONE; 2,3,8,9 TETRAHYDRO 1H,7H PYRROLO[1,2 A]PYRROLO[1',2':1,2]IMIDAZO[5,4 F]BENZIMIDAZOL 5,11 DIONE; 3 BUTYL 6,7,8,9 TETRAHYDROIMIDAZO[5,4 F]PYRIDO[1,2 A]BENZIMIDAZOL 4,11 DIONE; IMIDAZO[5,4 F]BENZIMIDAZOLE DERIVATIVE; IMIDAZOLE DERIVATIVE; IMINOQUINONE; MITOMYCIN C; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; BINDING SITES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NAD(P)H DEHYDROGENASE (QUINONE); QUINONES; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84860426005 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.03.063 Document Type: Article

Times cited : (33)

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