Gene Therapy Fully Restores Vision to the All-Cone Nrl-/-Gucy2e-/- Mouse Model of Leber Congenital Amaurosis-1

Human Gene Therapy

Volumn 26, Issue 9, 2015, Pages 575-592

  Boye, Sanford L ^a   Peterson, James J ^a   Choudhury, Shreyasi ^a   Min, Seok Hong ^a   Ruan, Qing ^a   McCullough, K Tyler ^a   Zhang, Zhonghong ^a   Olshevskaya, Elena V ^b   Peshenko, Igor V ^b   Hauswirth, William W ^a   Ding, Xi Qin ^c   Dizhoor, Alexander M ^b   Boye, Shannon E ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b SALUS UNIVERSITY   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; GUANYLATE CYCLASE; GUANYLATE CYCLASE 1; OPSIN; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CELL SURFACE RECEPTOR; EYE PROTEIN; GUCY2D PROTEIN, MOUSE; GUCY2E PROTEIN, MOUSE; NRL PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; LEBER CONGENITAL AMAUROSIS; MOUSE; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PHOTORECEPTOR OUTER SEGMENT; RETINA; RETINA DETACHMENT; VIRAL GENE THERAPY; VISION; ANIMAL; C57BL MOUSE; DEPENDOPARVOVIRUS; DISEASE MODEL; GENE THERAPY; GENE VECTOR; GENETICS; INTRAOCULAR DRUG ADMINISTRATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; RETINA CONE; TREATMENT OUTCOME;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; EYE PROTEINS; GENETIC THERAPY; GENETIC VECTORS; GUANYLATE CYCLASE; INJECTIONS, INTRAOCULAR; LEBER CONGENITAL AMAUROSIS; MICE, INBRED C57BL; MICE, KNOCKOUT; OPSINS; RECEPTORS, CELL SURFACE; RETINAL CONE PHOTORECEPTOR CELLS; TREATMENT OUTCOME; VISION, OCULAR;

EID: 84941275655     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2015.053     Document Type: Article

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