Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency

Human Gene Therapy

Volumn 22, Issue 10, 2011, Pages 1179-1190

  Mihelec, Marija ^a   Pearson, Rachael A ^a   Robbie, Scott J ^a   Buch, Prateek K ^a   Azam, Selina A ^a   Bainbridge, James W B ^a   Smith, Alexander J ^a   Ali, Robin R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GUANYLATE CYCLASE; GUANYLATE CYCLASE 1; GUANYLATE CYCLASE 2D; GUANYLATE CYCLASE 2E; RHODOPSIN KINASE; TRANSDUCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ELECTRORETINOGRAPHY; ENZYME DEFICIENCY; GENETIC TRANSDUCTION; GUANYLATE CYCLASE 1 DEFICIENCY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LEBER CONGENITAL AMAUROSIS; MOUSE; NONHUMAN; PHOTORECEPTOR; PROMOTER REGION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; RETINA CONE; RETINA ROD; RETINA ROD OUTER SEGMENT; VIRAL GENE DELIVERY SYSTEM; VISION; VISUAL ACUITY; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; DEPENDOVIRUS; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRORETINOGRAPHY; GENE THERAPY; GENETIC VECTORS; GUANYLATE CYCLASE; IMMUNOHISTOCHEMISTRY; LEBER CONGENITAL AMAUROSIS; MICE; MICE, KNOCKOUT; PHOTORECEPTOR CELLS, VERTEBRATE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VISION, OCULAR;

MUS;

EID: 80155145239     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2011.069     Document Type: Article

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