Nrl is required for rod photoreceptor development

Nature Genetics

Volumn 29, Issue 4, 2001, Pages 447-452

  Mears, Alan J ^a   Kondo, Mineo ^a,c   Swain, Prabodha K ^a   Takada, Yuichiro ^a   Bush, Ronald A ^a   Saunders, Thomas L ^a   Sieving, Paul A ^a,b   Swaroop, Anand ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; LEUCINE ZIPPER PROTEIN; NEURAL RETINA LEUCINE ZIPPER PROTEIN; PROTEIN NR2E3; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; GENE DELETION; GENE EXPRESSION; GENE SWITCHING; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA CONE; RETINA NEUROEPITHELIAL LAYER; RETINA ROD; RETINA ROD OUTER SEGMENT; RETINITIS PIGMENTOSA;

ANIMALS; BASE SEQUENCE; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; DNA PRIMERS; DNA-BINDING PROTEINS; EYE PROTEINS; IMMUNOHISTOCHEMISTRY; LEUCINE ZIPPERS; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RODS (RETINA); TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0035734382     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng774     Document Type: Article

References (31)

1. A conserved retina-specific gene encodes a basic motif/leucine zipper domain
2. Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors
3. The basic motif-leucine zipper transcription factor Nrl can positively regulate rhodopsin gene expression
4. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
5. The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation
6. A mutation in NRL is associated with autosomal dominant retinitis pigmentosa
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