-
2
-
-
0029764411
-
Leuprolide acetate 22. 5 mg 12-week depot formulation in the treatment of patients with advanced prostate cancer
-
R. Sharifi, R.C. Bruskewitz, M.C. Gittleman, S.D. Graham Jr., P.B. Hudson, and B. Stein Leuprolide acetate 22. 5 mg 12-week depot formulation in the treatment of patients with advanced prostate cancer Clin. Ther. 18 1996 647 657
-
(1996)
Clin. Ther.
, vol.18
, pp. 647-657
-
-
Sharifi, R.1
Bruskewitz, R.C.2
Gittleman, M.C.3
Graham, S.D.4
Hudson, P.B.5
Stein, B.6
-
3
-
-
77952554163
-
Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer
-
K. Knudsen, and T.M. Penning Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer Trends Endocrinol. Metab. 21 2010 315 324
-
(2010)
Trends Endocrinol. Metab.
, vol.21
, pp. 315-324
-
-
Knudsen, K.1
Penning, T.M.2
-
4
-
-
0842311632
-
The androgen axis in recurrent prostate cancer
-
J.L. Mohler, C.W. Gregory, O.H. Ford 3rd, D. Kim, C.M. Weaver, P. Petrusz, E.M. Wilson, and F.S. French The androgen axis in recurrent prostate cancer Clin. Cancer Res. 10 2004 440 448
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 440-448
-
-
Mohler, J.L.1
Gregory, C.W.2
Ford, O.H.3
Kim, D.4
Weaver, C.M.5
Petrusz, P.6
Wilson, E.M.7
French, F.S.8
-
5
-
-
80054021222
-
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
-
C. Cai, S. Chen, P. Ng, G.J. Bubley, P.S. Nelson, E.A. Mostaghel, B. Marck, A.M. Matsumoto, N.I. Simon, H. Wang, S. Chen, and S.P. Balk Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors Cancer Res. 71 2011 6503 6513
-
(2011)
Cancer Res.
, vol.71
, pp. 6503-6513
-
-
Cai, C.1
Chen, S.2
Ng, P.3
Bubley, G.J.4
Nelson, P.S.5
Mostaghel, E.A.6
Marck, B.7
Matsumoto, A.M.8
Simon, N.I.9
Wang, H.10
Chen, S.11
Balk, S.P.12
-
6
-
-
84904663703
-
Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model
-
M. Knuuttila, E. Yatkin, J. Kallio, S. Savolainen, T.D. Laajala, T. Aittokallio, R. Oksala, M. Häkkinen, P. Keski-Rahkonen, S. Auriola, M. Poutanen, and S. Mäkelä Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model Am. J. Pathol. 184 2014 2163 2173
-
(2014)
Am. J. Pathol.
, vol.184
, pp. 2163-2173
-
-
Knuuttila, M.1
Yatkin, E.2
Kallio, J.3
Savolainen, S.4
Laajala, T.D.5
Aittokallio, T.6
Oksala, R.7
Häkkinen, M.8
Keski-Rahkonen, P.9
Auriola, S.10
Poutanen, M.11
Mäkelä, S.12
-
7
-
-
76149137405
-
Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
-
C.G. Leon, J.A. Locke, H.H. Adomat, S.L. Etinger, A.L. Twiddy, R.D. Neumann, C.C. Nelson, E.S. Guns, and K.M. Wasan Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model Prostate 70 2010 390 400
-
(2010)
Prostate
, vol.70
, pp. 390-400
-
-
Leon, C.G.1
Locke, J.A.2
Adomat, H.H.3
Etinger, S.L.4
Twiddy, A.L.5
Neumann, R.D.6
Nelson, C.C.7
Guns, E.S.8
Wasan, K.M.9
-
8
-
-
51049098138
-
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
-
J.A. Locke, E.S. Guns, A.A. Lubik, H.H. Adomat, S.C. Hendy, C.A. Wood, S.L. Ettinger, M.E. Gleave, and C.C. Nelson Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer Cancer Res. 68 2008 6407 6415
-
(2008)
Cancer Res.
, vol.68
, pp. 6407-6415
-
-
Locke, J.A.1
Guns, E.S.2
Lubik, A.A.3
Adomat, H.H.4
Hendy, S.C.5
Wood, C.A.6
Ettinger, S.L.7
Gleave, M.E.8
Nelson, C.C.9
-
9
-
-
49249119358
-
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
-
R.B. Montgomery, E.A. Mostaghel, R. Vessella, D.L. Hess, T.F. Kalhorn, C.S. Higian, L.D. True, and P.S. Nelson Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth Cancer Res. 68 2008 4447 4454
-
(2008)
Cancer Res.
, vol.68
, pp. 4447-4454
-
-
Montgomery, R.B.1
Mostaghel, E.A.2
Vessella, R.3
Hess, D.L.4
Kalhorn, T.F.5
Higian, C.S.6
True, L.D.7
Nelson, P.S.8
-
10
-
-
0030877225
-
Functional characterization of mutant androgen receptors from androgen-independent prostate cancer
-
M.A. Fenton, T.D. Shuster, A.M. Fertig, M.E. Taplin, G. Kolvenbag, G.J. Bubley, and S.P. Balk Functional characterization of mutant androgen receptors from androgen-independent prostate cancer Clin. Cancer Res. 3 1997 1383 1388
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 1383-1388
-
-
Fenton, M.A.1
Shuster, T.D.2
Fertig, A.M.3
Taplin, M.E.4
Kolvenbag, G.5
Bubley, G.J.6
Balk, S.P.7
-
11
-
-
0037226103
-
Novel mutations of the androgen receptor: a possible mechanism of bicalutamide withdrawal
-
T. Hara, J. Miyazaki, H. Araki, M. Yamaoka, N. Kanzaki, M. Kusaka, and M. Miyamoto Novel mutations of the androgen receptor: a possible mechanism of bicalutamide withdrawal Cancer Res. 63 2003 149 153
-
(2003)
Cancer Res.
, vol.63
, pp. 149-153
-
-
Hara, T.1
Miyazaki, J.2
Araki, H.3
Yamaoka, M.4
Kanzaki, N.5
Kusaka, M.6
Miyamoto, M.7
-
12
-
-
77952105685
-
Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study
-
H.I. Scher, T.M. Beer, C.S. Higano, A. Anand, M.E. Taplin, E. Efstathiou, D. Rathkopf, J. Shelkey, E.Y. Yu, J. Alumkal, D. Hung, M. Hirmand, L. Seely, M.J. Morris, D.C. Danila, J. Humm, S. Larson, M. Fleisher, C.L. Sawyers, and Prostate Cancer Foundation/Department of Defense Prostate Cancer Clinical Trials Consortium Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study Lancet 375 2010 1437 1446
-
(2010)
Lancet
, vol.375
, pp. 1437-1446
-
-
Prostate Cancer Foundation1
Department Of Defense Prostate Cancer Clinical Trials Consortium2
Scher, H.I.3
Beer, T.M.4
Higano, C.S.5
Anand, A.6
Taplin, M.E.7
Efstathiou, E.8
Rathkopf, D.9
Shelkey, J.10
Yu, E.Y.11
Alumkal, J.12
Hung, D.13
Hirmand, M.14
Seely, L.15
Morris, M.J.16
Danila, D.C.17
Humm, J.18
Larson, S.19
Fleisher, M.20
Sawyers, C.L.21
more..
-
13
-
-
0036494196
-
Mutational analysis of 44 mutant androgen receptors from human prostate cancer
-
X.-B. Shi, A.-H. Ma, L. Xia, H.-J. Kung, and R.W. de Vere White Mutational analysis of 44 mutant androgen receptors from human prostate cancer Cancer Res. 62 2002 1496 1502
-
(2002)
Cancer Res.
, vol.62
, pp. 1496-1502
-
-
Shi, X.-B.1
Ma, A.-H.2
Xia, L.3
Kung, H.-J.4
De Vere White, R.W.5
-
14
-
-
0029011116
-
Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
-
M.E. Taplin, G.J. Bubley, T.D. Shuster, M.E. Frantz, A.E. Spooner, G.K. Ogata, H.N. Keer, and S.P. Balk Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer N. Engl. J. Med. 332 1995 1393 1398
-
(1995)
N. Engl. J. Med.
, vol.332
, pp. 1393-1398
-
-
Taplin, M.E.1
Bubley, G.J.2
Shuster, T.D.3
Frantz, M.E.4
Spooner, A.E.5
Ogata, G.K.6
Keer, H.N.7
Balk, S.P.8
-
15
-
-
0033152164
-
Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
-
M.E. Taplin, G.J. Bubley, Y.J. Ko, E.J. Small, M. Upton, B. Rajeshkumar, and S.P. Balk Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist Cancer Res. 59 1999 2511 2515
-
(1999)
Cancer Res.
, vol.59
, pp. 2511-2515
-
-
Taplin, M.E.1
Bubley, G.J.2
Ko, Y.J.3
Small, E.J.4
Upton, M.5
Rajeshkumar, B.6
Balk, S.P.7
-
16
-
-
0028944138
-
In vivo amplification of the androgen receptor gene and progression of human prostate cancer
-
T. Visakorpi, E. Hyytinen, P. Koivisto, M. Tanner, R. Keinänen, C. Palmberg, A. Palotie, T. Tammela, J. Isola, and O.P. Kallioniemi In vivo amplification of the androgen receptor gene and progression of human prostate cancer Nat. Genet. 9 1995 401 406
-
(1995)
Nat. Genet.
, vol.9
, pp. 401-406
-
-
Visakorpi, T.1
Hyytinen, E.2
Koivisto, P.3
Tanner, M.4
Keinänen, R.5
Palmberg, C.6
Palotie, A.7
Tammela, T.8
Isola, J.9
Kallioniemi, O.P.10
-
17
-
-
53749090666
-
Phase 1 clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confrims that castration-resistant prostate cancer commonly remains hormone driven
-
G. Attard, A.H.M. Reid, T.A. Yap, F. Raynaud, M. Dowsett, S. Settatree, M. Barrett, C. Parker, V. Martinins, E. Folkerd, J. Clark, C.S. Cooper, S.B. Kaye, D. Dearnaley, G. Lee, and J.S. de Bono Phase 1 clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confrims that castration-resistant prostate cancer commonly remains hormone driven J. Clin. Oncol. 28 2008 4563 4571
-
(2008)
J. Clin. Oncol.
, vol.28
, pp. 4563-4571
-
-
Attard, G.1
Reid, A.H.M.2
Yap, T.A.3
Raynaud, F.4
Dowsett, M.5
Settatree, S.6
Barrett, M.7
Parker, C.8
Martinins, V.9
Folkerd, E.10
Clark, J.11
Cooper, C.S.12
Kaye, S.B.13
Dearnaley, D.14
Lee, G.15
De Bono, J.S.16
-
18
-
-
68949094223
-
Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer
-
G. Attard, A.H. Reid, R. A'Hern, C. Parker, N.B. Oommen, E. Folkerd, C. Messiou, L.R. Molife, G. Maier, E. Thompson, D. Olmos, R. Sinha, G. Lee, M. Dowsett, S.B. Kaye, D. Dearnaley, T. Kheoh, A. Molina, and J.S. de Bono Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer J. Clin. Oncol. 27 2009 3742 37482
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 3742-37482
-
-
Attard, G.1
Reid, A.H.2
A'hern, R.3
Parker, C.4
Oommen, N.B.5
Folkerd, E.6
Messiou, C.7
Molife, L.R.8
Maier, G.9
Thompson, E.10
Olmos, D.11
Sinha, R.12
Lee, G.13
Dowsett, M.14
Kaye, S.B.15
Dearnaley, D.16
Kheoh, T.17
Molina, A.18
De Bono, J.S.19
-
19
-
-
67449119425
-
Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven
-
G. Attard, A.H. Reid, D. Olmos, and J.S. de Bono Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven Cancer Res. 69 2009 4937 4940
-
(2009)
Cancer Res.
, vol.69
, pp. 4937-4940
-
-
Attard, G.1
Reid, A.H.2
Olmos, D.3
De Bono, J.S.4
-
20
-
-
77951591066
-
Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer
-
D.C. Danila, M.J. Morris, J.S. de Bono, C.J. Ryan, S.R. Denmeade, M.R. Smith, M.E. Taplin, G.J. Bubley, T. Kheoh, C. Haqq, A. Molina, A. Anand, M. Koscuiszka, S.M. Larson, L.H. Schwartz, M. Fleisher, and H.I. Scher Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer J. Clin. Oncol. 28 2010 1496 1501
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1496-1501
-
-
Danila, D.C.1
Morris, M.J.2
De Bono, J.S.3
Ryan, C.J.4
Denmeade, S.R.5
Smith, M.R.6
Taplin, M.E.7
Bubley, G.J.8
Kheoh, T.9
Haqq, C.10
Molina, A.11
Anand, A.12
Koscuiszka, M.13
Larson, S.M.14
Schwartz, L.H.15
Fleisher, M.16
Scher, H.I.17
-
21
-
-
65649090203
-
Development of a second-generation antiandrogen for treatment of advanced prostate cancer
-
C. Tran, S. Ouk, N.J. Clegg, Y. Chen, P.A. Watson, V. Arora, J. Wongvipat, P.M. Smith-Jones, D. Yoo, A. Kwon, T. Wasielewska, D. Welsbie, C.D. Chen, C.S. Higano, T.M. Beer, D.T. Hung, H.I. Scher, M.E. Jung, and C.L. Sawyers Development of a second-generation antiandrogen for treatment of advanced prostate cancer Science 324 2009 787 790
-
(2009)
Science
, vol.324
, pp. 787-790
-
-
Tran, C.1
Ouk, S.2
Clegg, N.J.3
Chen, Y.4
Watson, P.A.5
Arora, V.6
Wongvipat, J.7
Smith-Jones, P.M.8
Yoo, D.9
Kwon, A.10
Wasielewska, T.11
Welsbie, D.12
Chen, C.D.13
Higano, C.S.14
Beer, T.M.15
Hung, D.T.16
Scher, H.I.17
Jung, M.E.18
Sawyers, C.L.19
-
22
-
-
84908450155
-
Enzalutamide in metastatic prostate cancer before chemotherapy
-
for the PREVAIL Investigators
-
T.M. Beer, A.J. Armstrong, D.E. Rathkopf, Y. Loroit, C.N. Sternberg, C.S. Higano, P. Iverson, S. Bhattacharya, J. Carles, S. Chowdury, I.D. Davis, J.S. de Bono, C.P. Evans, K. Fizazi, A.M. Joshua, C.-S. Kim, G. Kimura, P. Mainwairng, H. Mansbach, K. Miller, S.B. Nonnberg, F. Perabo, D. Phung, F. Sadd, H.I. Scher, M.-E. Taplin, P.M. Venner, and B. Tombal Enzalutamide in metastatic prostate cancer before chemotherapy for the PREVAIL Investigators N. Engl. J. Med. 371 2014 424 433
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 424-433
-
-
Beer, T.M.1
Armstrong, A.J.2
Rathkopf, D.E.3
Loroit, Y.4
Sternberg, C.N.5
Higano, C.S.6
Iverson, P.7
Bhattacharya, S.8
Carles, J.9
Chowdury, S.10
Davis, I.D.11
De Bono, J.S.12
Evans, C.P.13
Fizazi, K.14
Joshua, A.M.15
Kim, C.-S.16
Kimura, G.17
Mainwairng, P.18
Mansbach, H.19
Miller, K.20
Nonnberg, S.B.21
Perabo, F.22
Phung, D.23
Sadd, F.24
Scher, H.I.25
Taplin, M.-E.26
Venner, P.M.27
Tombal, B.28
more..
-
23
-
-
84866948935
-
Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study
-
for the COU-AA-301 Investigators
-
K. Fizazi, I. Scher, A. Malina, C.J. Logothetis, K.N. Chi, R.J. Jones, J.N. Staffurth, S. North, N.J. Vogelzang, F. Saad, P. Mainwairing, S. Harland, O.B. Goodman Jr., C.N. Sternberg, J.H. Li, T. Kehoh, C.M. Haqq, and J.S. de Bono Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study for the COU-AA-301 Investigators Lancet Oncol. 13 2012 983 992
-
(2012)
Lancet Oncol.
, vol.13
, pp. 983-992
-
-
Fizazi, K.1
Scher, I.2
Malina, A.3
Logothetis, C.J.4
Chi, K.N.5
Jones, R.J.6
Staffurth, J.N.7
North, S.8
Vogelzang, N.J.9
Saad, F.10
Mainwairing, P.11
Harland, S.12
Goodman, O.B.13
Sternberg, C.N.14
Li, J.H.15
Kehoh, T.16
Haqq, C.M.17
De Bono, J.S.18
-
24
-
-
77951523950
-
Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy
-
C.J. Ryan, M.R. Smith, L. Fong, J.E. Rosenberg, P. Kantoff, F. Raynaus, V. Martins, G. Lee, T. Kheoh, J. Kim, A. Molina, and E.J. Small Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy J. Clin. Oncol. 28 2010 1481 1488
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1481-1488
-
-
Ryan, C.J.1
Smith, M.R.2
Fong, L.3
Rosenberg, J.E.4
Kantoff, P.5
Raynaus, F.6
Martins, V.7
Lee, G.8
Kheoh, T.9
Kim, J.10
Molina, A.11
Small, E.J.12
-
25
-
-
84884762609
-
Serum androgens as prognostic biomarkers in castration-resistant prostate cancer: results from an analysis of a randomized phase III trial
-
C.J. Ryan, A. Molina, J. Li, T. Khoh, E.J. Small, C.M. Haqq, R.P. Grant, J.S. de Bono, and H.I. Scher Serum androgens as prognostic biomarkers in castration-resistant prostate cancer: results from an analysis of a randomized phase III trial J. Clin. Oncol. 31 2013 2791 2798
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 2791-2798
-
-
Ryan, C.J.1
Molina, A.2
Li, J.3
Khoh, T.4
Small, E.J.5
Haqq, C.M.6
Grant, R.P.7
De Bono, J.S.8
Scher, H.I.9
-
26
-
-
84905993578
-
Intense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadjuvant study
-
M.E. Taplin, B. Montgomery, C.J. Logothetis, G.J. Bubley, J.P. Richie, B.L. Dalkin, M.G. Sanda, J.W. Davis, M. Loda, L.D. True, P. Troncoso, H. Ye, R.T. Lis, B.T. Marck, A.M. Matsumoto, S.P. Balk, E.A. Mostaghel, T.M. Penning, P.S. Nelson, W. Xie, Z. Jiang, C.M. Haqq, D. Tamae, N. Tran, W. Peng, T. Kheoh, A. Molina, and P.W. Kantoff Intense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadjuvant study J. Clin. Oncol. 32 2014 3705 3715
-
(2014)
J. Clin. Oncol.
, vol.32
, pp. 3705-3715
-
-
Taplin, M.E.1
Montgomery, B.2
Logothetis, C.J.3
Bubley, G.J.4
Richie, J.P.5
Dalkin, B.L.6
Sanda, M.G.7
Davis, J.W.8
Loda, M.9
True, L.D.10
Troncoso, P.11
Ye, H.12
Lis, R.T.13
Marck, B.T.14
Matsumoto, A.M.15
Balk, S.P.16
Mostaghel, E.A.17
Penning, T.M.18
Nelson, P.S.19
Xie, W.20
Jiang, Z.21
Haqq, C.M.22
Tamae, D.23
Tran, N.24
Peng, W.25
Kheoh, T.26
Molina, A.27
Kantoff, P.W.28
more..
-
27
-
-
79951518634
-
Drug safety is a barrier to the discovery and development of new androgen receptor antagonists
-
W.R. Foster, B.D. Car, H. Shi, P.C. Levesque, M.T. Obermeier, J. Gan, J.C. Arezzo, S.S. Powlin, J.E. Dinchuk, A. Balog, M.E. Salvati, R.M. Attar, and M.M. Gottardis Drug safety is a barrier to the discovery and development of new androgen receptor antagonists Prostate 71 2011 480 488
-
(2011)
Prostate
, vol.71
, pp. 480-488
-
-
Foster, W.R.1
Car, B.D.2
Shi, H.3
Levesque, P.C.4
Obermeier, M.T.5
Gan, J.6
Arezzo, J.C.7
Powlin, S.S.8
Dinchuk, J.E.9
Balog, A.10
Salvati, M.E.11
Attar, R.M.12
Gottardis, M.M.13
-
28
-
-
84863230424
-
ARN-509: a novel antiandrogen for prostate cancer treatment
-
N.J. Clegg, J. Wongvipat, J.D. Joseph, C. Tran, S. Ouk, A. Dilhas, Y. Chen, K. Grillot, E.D. Bischoff, L. Cai, A. Aparicio, S. Dorow, V. Arora, G. Shao, J. Qian, H. Zhao, G. Yang, C. Cao, J. Sensintaffar, T. Wasielewska, M.R. Herbert, C. Bonnefous, B. Darimont, H.I. Scher, P. Smith-Jones, M. Klang, N.D. Smith, E. De Stanchina, N. Wu, O. Ouerfelli, P.J. Rix, R.A. Heyman, M.E. Jung, C.L. Sawyers, and J.H. Hager ARN-509: a novel antiandrogen for prostate cancer treatment Cancer Res. 72 2012 1494 1503
-
(2012)
Cancer Res.
, vol.72
, pp. 1494-1503
-
-
Clegg, N.J.1
Wongvipat, J.2
Joseph, J.D.3
Tran, C.4
Ouk, S.5
Dilhas, A.6
Chen, Y.7
Grillot, K.8
Bischoff, E.D.9
Cai, L.10
Aparicio, A.11
Dorow, S.12
Arora, V.13
Shao, G.14
Qian, J.15
Zhao, H.16
Yang, G.17
Cao, C.18
Sensintaffar, J.19
Wasielewska, T.20
Herbert, M.R.21
Bonnefous, C.22
Darimont, B.23
Scher, H.I.24
Smith-Jones, P.25
Klang, M.26
Smith, N.D.27
De Stanchina, E.28
Wu, N.29
Ouerfelli, O.30
Rix, P.J.31
Heyman, R.A.32
Jung, M.E.33
Sawyers, C.L.34
Hager, J.H.35
more..
-
29
-
-
77952105685
-
Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study
-
H.I. Scher, T.M. Beer, C.S. Higano, A. Anand, M.E. Taplin, E. Efstathiou, D. Rathkopf, J. Shelkey, E.Y. Yu, J. Alumkal, D. Hung, M. Hirmand, L. Seely, M.J. Morris, D.C. Danila, J. Humm, S. Larson, M. Fleisher, C.L. Sawyers, and Prostate Cancer Foundation/Department of Defense Prostate Cancer Clinical Trials Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study Lancet 375 2010 1437 1446
-
(2010)
Lancet
, vol.375
, pp. 1437-1446
-
-
Prostate Cancer Foundation1
Department Of Defense Prostate Cancer Clinical Trials2
Scher, H.I.3
Beer, T.M.4
Higano, C.S.5
Anand, A.6
Taplin, M.E.7
Efstathiou, E.8
Rathkopf, D.9
Shelkey, J.10
Yu, E.Y.11
Alumkal, J.12
Hung, D.13
Hirmand, M.14
Seely, L.15
Morris, M.J.16
Danila, D.C.17
Humm, J.18
Larson, S.19
Fleisher, M.20
Sawyers, C.L.21
more..
-
30
-
-
84866770294
-
Increased survival with enzalutamide in prostate cancer after chemotherapy
-
AFFIRM Investigators
-
H.I. Scher, K. Fizazi, F. Saad, M.E. Taplin, C.N. Sternberg, K. Miller, P. Mulders, N.D. Shore, A.J. Armstrong, T.W. Flaig, A. Fléchon, P. Mainwaring, M. Fleming, J.D. Hainsworth, M. Hirmand, B. Selby, L. Seely, and J.S. de Bono Increased survival with enzalutamide in prostate cancer after chemotherapy AFFIRM Investigators N. Engl. J. Med. 367 2012 1187 1197
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1187-1197
-
-
Scher, H.I.1
Fizazi, K.2
Saad, F.3
Taplin, M.E.4
Sternberg, C.N.5
Miller, K.6
Mulders, P.7
Shore, N.D.8
Armstrong, A.J.9
Flaig, T.W.10
Fléchon, A.11
Mainwaring, P.12
Fleming, M.13
Hainsworth, J.D.14
Hirmand, M.15
Selby, B.16
Seely, L.17
De Bono, J.S.18
-
31
-
-
84908032935
-
Minireview: SLCO and ABC transporters: a role for steroid transport in prostate cancer progression
-
E. Cho, R.B. Montgomery, and E.A. Mostaghel Minireview: SLCO and ABC transporters: a role for steroid transport in prostate cancer progression Endocrinology 155 2014 4124 4132
-
(2014)
Endocrinology
, vol.155
, pp. 4124-4132
-
-
Cho, E.1
Montgomery, R.B.2
Mostaghel, E.A.3
-
32
-
-
79959294088
-
SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer
-
M. Yang, W. Xie, E. Mostaghel, M. Nakabayashi, L. Werner, T. Sun, M. Pomerantz, M. Freedman, R. Ross, M. Regan, N. Sharifi, W.D. Figg, S. Balk, M. Brown, M.E. Taplin, W.K. Oh, G.S. Lee, and P.W. Kantoff SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer J. Clin. Oncol. 29 2011 2565 2573
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 2565-2573
-
-
Yang, M.1
Xie, W.2
Mostaghel, E.3
Nakabayashi, M.4
Werner, L.5
Sun, T.6
Pomerantz, M.7
Freedman, M.8
Ross, R.9
Regan, M.10
Sharifi, N.11
Figg, W.D.12
Balk, S.13
Brown, M.14
Taplin, M.E.15
Oh, W.K.16
Lee, G.S.17
Kantoff, P.W.18
-
33
-
-
84883367616
-
A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer
-
K.-H. Chang, R. Li, B. Kuri, Y. Lotan, C.G. Roehrborn, J. Liu, R. Vessella, P.S. Nelson, P. Kapur, X. Guo, H. Mirzaei, R.J. Auchus, and N. Sharifi A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer Cell 154 2013 1074 1084
-
(2013)
Cell
, vol.154
, pp. 1074-1084
-
-
Chang, K.-H.1
Li, R.2
Kuri, B.3
Lotan, Y.4
Roehrborn, C.G.5
Liu, J.6
Vessella, R.7
Nelson, P.S.8
Kapur, P.9
Guo, X.10
Mirzaei, H.11
Auchus, R.J.12
Sharifi, N.13
-
34
-
-
84866125863
-
Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions
-
H. Arakawa, T. Nakanishi, C. Yanagihara, T. Nishimoto, T. Wakayama, A. Mizokami, M. Namiki, K. Kawai, and I. Tamai Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions Biochem. Pharmacol. 84 2012 1070 1077
-
(2012)
Biochem. Pharmacol.
, vol.84
, pp. 1070-1077
-
-
Arakawa, H.1
Nakanishi, T.2
Yanagihara, C.3
Nishimoto, T.4
Wakayama, T.5
Mizokami, A.6
Namiki, M.7
Kawai, K.8
Tamai, I.9
-
35
-
-
33645987281
-
Increased expression of type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with the androgen receptor in prostate carcinoma
-
K.-M. Fung, E.H. Shea-Samara, C. Wong, R. Krin, A.M. Jones, B. Bane, C.Z. Liu, J.T. Yang, J.V. Pitha, D.J. Culkin, B.P. Koop, T.M. Penning, and H.-K. Lin Increased expression of type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with the androgen receptor in prostate carcinoma Endocrinol. Relat. Cancer 13 2006 169 180
-
(2006)
Endocrinol. Relat. Cancer
, vol.13
, pp. 169-180
-
-
Fung, K.-M.1
Shea-Samara, E.H.2
Wong, C.3
Krin, R.4
Jones, A.M.5
Bane, B.6
Liu, C.Z.7
Yang, J.T.8
Pitha, J.V.9
Culkin, D.J.10
Koop, B.P.11
Penning, T.M.12
Lin, H.-K.13
-
36
-
-
0030784509
-
Expression and characterization of recombinant type 2 3α-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3α/17β-HSD activity and cellular distribution
-
H.-K. Lin, J.M. Jez, B.P. Schlegel, D.M. Peehl, J.A. Pachter, and T.M. Penning Expression and characterization of recombinant type 2 3α-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3α/17β-HSD activity and cellular distribution Mol. Endocrinol. 11 1997 1971 1984
-
(1997)
Mol. Endocrinol.
, vol.11
, pp. 1971-1984
-
-
Lin, H.-K.1
Jez, J.M.2
Schlegel, B.P.3
Peehl, D.M.4
Pachter, J.A.5
Penning, T.M.6
-
37
-
-
0034287545
-
Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
-
T.M. Penning, M.E. Burczynski, J.M. Jez, C.-F. Hung, H.-K. Lin, H. Ma, M. Moore, N. Palackal, and K. Ratnam Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones Biochem. J. 351 2000 67 77
-
(2000)
Biochem. J.
, vol.351
, pp. 67-77
-
-
Penning, T.M.1
Burczynski, M.E.2
Jez, J.M.3
Hung, C.-F.4
Lin, H.-K.5
Ma, H.6
Moore, M.7
Palackal, N.8
Ratnam, K.9
-
38
-
-
33644881888
-
Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors
-
T.M. Penning, S. Steckelbroeck, D.R. Bauman, M.W. Miller, D.M. Peehl, K.-M. Fung, and H.K. Lin Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors Mol. Cell. Endocrinol. 248 2006 182 191
-
(2006)
Mol. Cell. Endocrinol.
, vol.248
, pp. 182-191
-
-
Penning, T.M.1
Steckelbroeck, S.2
Bauman, D.R.3
Miller, M.W.4
Peehl, D.M.5
Fung, K.-M.6
Lin, H.K.7
-
39
-
-
84872256884
-
Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer
-
A.R. Hamid, M.J. Pfeiffer, G.W. Verhaegh, E. Schaafsma, A. Brandt, F.C. Sweep, J.P. Sedelaar, and J.A. Schalken Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer Mol. Med. 18 2012 1449 1455
-
(2012)
Mol. Med.
, vol.18
, pp. 1449-1455
-
-
Hamid, A.R.1
Pfeiffer, M.J.2
Verhaegh, G.W.3
Schaafsma, E.4
Brandt, A.5
Sweep, F.C.6
Sedelaar, J.P.7
Schalken, J.A.8
-
40
-
-
76249096762
-
Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer
-
J. Hofland, W.M. van Weerden, N.F.J. Dits, J. Steenbergen, G.J.L.H. van Leenders, G. Jenster, F.H. Schroder, and F.H. de Jomg Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer Cancer Res. 70 2010 1256 1264
-
(2010)
Cancer Res.
, vol.70
, pp. 1256-1264
-
-
Hofland, J.1
Van Weerden, W.M.2
Dits, N.F.J.3
Steenbergen, J.4
Van Leenders, G.J.L.H.5
Jenster, G.6
Schroder, F.H.7
De Jomg, F.H.8
-
41
-
-
84939279104
-
Intracrine androgens and AKR1C3 activation confer resistance to enzalutamide in prostate cancer
-
pii: canres.3080.2014. [Epub ahead of print]
-
C. Liu, W. Lou, Y. Zhu, J.C. Yang, N. Natiminty, N. Gaikwad, C.P. Evans, and A.C. Gao Intracrine androgens and AKR1C3 activation confer resistance to enzalutamide in prostate cancer Cancer Res. February 2015 pii: canres.3080.2014. [Epub ahead of print]
-
(2015)
Cancer Res.
, Issue.February
-
-
Liu, C.1
Lou, W.2
Zhu, Y.3
Yang, J.C.4
Natiminty, N.5
Gaikwad, N.6
Evans, C.P.7
Gao, A.C.8
-
42
-
-
79960738374
-
Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer
-
M.J. Pfeiffer, F.P. Smit, J.P. Sedelaar, and J.A. Schalken Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer Mol. Med. 17 2011 657 664
-
(2011)
Mol. Med.
, vol.17
, pp. 657-664
-
-
Pfeiffer, M.J.1
Smit, F.P.2
Sedelaar, J.P.3
Schalken, J.A.4
-
43
-
-
84895141227
-
AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression
-
Y. Tian, L. Zhao, H. Zhang, X. Liu, L. Zhao, X. Zhao, and J. Li AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression Diagn. Pathol. 9 2014 42 48
-
(2014)
Diagn. Pathol.
, vol.9
, pp. 42-48
-
-
Tian, Y.1
Zhao, L.2
Zhang, H.3
Liu, X.4
Zhao, L.5
Zhao, X.6
Li, J.7
-
44
-
-
84870336847
-
Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors
-
N. Mitsiades, C.C. Sung, N. Schultz, D.C. Danila, B. He, V.K. Eedunuri, M. Fleisher, C. Sander, C.L. Sawyers, and H.I. Scher Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors Cancer Res. 72 2012 6142 6152
-
(2012)
Cancer Res.
, vol.72
, pp. 6142-6152
-
-
Mitsiades, N.1
Sung, C.C.2
Schultz, N.3
Danila, D.C.4
He, B.5
Eedunuri, V.K.6
Fleisher, M.7
Sander, C.8
Sawyers, C.L.9
Scher, H.I.10
-
45
-
-
84941263731
-
ERG/AKR 1C3/AR constitutes a feed-forward loop for AR signaling in prostate cancer cells
-
K. Powell, L. Semann, M.K. Conley-LaComb, I. Asangani, Y.-M. Wu, K.B. Ginsburg, J. Williams, J.A. Squire, K.R. Maddipati, M.L. Cher, and S.R. Chinni ERG/AKR 1C3/AR constitutes a feed-forward loop for AR signaling in prostate cancer cells Clin. Cancer Res. March 2015 10.1158/1078-0432.CCR-14-2352
-
(2015)
Clin. Cancer Res.
, Issue.March
-
-
Powell, K.1
Semann, L.2
Conley-Lacomb, M.K.3
Asangani, I.4
Wu, Y.-M.5
Ginsburg, K.B.6
Williams, J.7
Squire, J.A.8
Maddipati, K.R.9
Cher, M.L.10
Chinni, S.R.11
-
46
-
-
33645056171
-
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
-
M. Stanbrough, G.J. Bubley, K. Ross, T.R. Golub, M.A. Rubin, T.M. Penning, P.G. Febbo, and S.P. Balk Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer Cancer Res. 66 2006 2815 2825
-
(2006)
Cancer Res.
, vol.66
, pp. 2815-2825
-
-
Stanbrough, M.1
Bubley, G.J.2
Ross, K.3
Golub, T.R.4
Rubin, M.A.5
Penning, T.M.6
Febbo, P.G.7
Balk, S.P.8
-
47
-
-
84892421933
-
Characterization of the prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants
-
E. Jernberg, E. Thysell, E.B. Ylitalo, S. Rudolfsson, S. Crnalic, A. Widmark, A. Bergh, and P. Wikstrom Characterization of the prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants PLoS One 8 2013 e77407
-
(2013)
PLoS One
, vol.8
-
-
Jernberg, E.1
Thysell, E.2
Ylitalo, E.B.3
Rudolfsson, S.4
Crnalic, S.5
Widmark, A.6
Bergh, A.7
Wikstrom, P.8
-
48
-
-
31444440675
-
Identification of the major oxidative 3α-hydroxysteroid dehydrogenase in human prostate that converts 5α-androstane-3α,17β-diol to 5α-dihydrotestosterone. A potential therapeutic target for androgen dependent disease
-
D.R. Bauman, S. Steckelbroeck, M.V. Williams, D.M. Peehl, and T.M. Penning Identification of the major oxidative 3α-hydroxysteroid dehydrogenase in human prostate that converts 5α-androstane-3α,17β-diol to 5α-dihydrotestosterone. A potential therapeutic target for androgen dependent disease Mol. Endocrinol. 20 2006 444 458
-
(2006)
Mol. Endocrinol.
, vol.20
, pp. 444-458
-
-
Bauman, D.R.1
Steckelbroeck, S.2
Williams, M.V.3
Peehl, D.M.4
Penning, T.M.5
-
49
-
-
79951838692
-
Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer
-
J.L. Mohler, M.A. Titus, S. Bai, B.J. Kennerley, F.B. Lih, K.B. Tomer, and E.M. Wilson Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer Cancer Res. 71 2011 1486 1496
-
(2011)
Cancer Res.
, vol.71
, pp. 1486-1496
-
-
Mohler, J.L.1
Titus, M.A.2
Bai, S.3
Kennerley, B.J.4
Lih, F.B.5
Tomer, K.B.6
Wilson, E.M.7
-
50
-
-
80052846905
-
Potential prostate cancer drug target: bioactivation of androstanediol by conversion to dihydrotestosterone
-
J.L. Mohler, M.A. Titus, and E.M. Wilson Potential prostate cancer drug target: bioactivation of androstanediol by conversion to dihydrotestosterone Clin. Cancer Res. 17 2011 5844 5849
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5844-5849
-
-
Mohler, J.L.1
Titus, M.A.2
Wilson, E.M.3
-
51
-
-
84875795158
-
Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer
-
F. Ishizaki, T. Nishiyama, T. Kawasaki, Y. Miyashiro, N. Hara, I. Takizawa, M. Naito, and K. Takahashi Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer Sci. Rep. 3 2013 1528 10.1038/srep01528
-
(2013)
Sci. Rep.
, vol.3
, pp. 1528
-
-
Ishizaki, F.1
Nishiyama, T.2
Kawasaki, T.3
Miyashiro, Y.4
Hara, N.5
Takizawa, I.6
Naito, M.7
Takahashi, K.8
-
52
-
-
80052827038
-
Resistance to CYP17A1 inhibition with abiraterone in castrate-resistance prostate cancer: induction of steroidogenesis and androgen receptor splice variants
-
E.A. Mostaghel, B.T. Marck, S.R. Plymate, R.L. Vessella, S.P. Balk, A.M. Matsumoto, P.S. Nelson, and R.B. Montgomery Resistance to CYP17A1 inhibition with abiraterone in castrate-resistance prostate cancer: induction of steroidogenesis and androgen receptor splice variants Clin. Cancer Res. 17 2011 5913 5925
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5913-5925
-
-
Mostaghel, E.A.1
Marck, B.T.2
Plymate, S.R.3
Vessella, R.L.4
Balk, S.P.5
Matsumoto, A.M.6
Nelson, P.S.7
Montgomery, R.B.8
-
53
-
-
84904159704
-
The link between androgen receptor splice variants and castration-resistant prostate cancer
-
C.C.T. Sprenger, and S.R. Plymate The link between androgen receptor splice variants and castration-resistant prostate cancer Horm. Cancer 5 2014 207 2014
-
(2014)
Horm. Cancer
, vol.5
, pp. 207-2014
-
-
Sprenger, C.C.T.1
Plymate, S.R.2
-
54
-
-
78049280194
-
Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
-
P.A. Watson, Y.F. Chen, M.D. Balbas, J. Wongvipat, N.D. Socci, A. Viale, K. Kim, and C.L. Sawyers Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor Proc. Natl. Acad. Sci. U. S. A. 107 2010 16759 16765
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 16759-16765
-
-
Watson, P.A.1
Chen, Y.F.2
Balbas, M.D.3
Wongvipat, J.4
Socci, N.D.5
Viale, A.6
Kim, K.7
Sawyers, C.L.8
-
55
-
-
84904256379
-
Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy
-
B. Cao, Y. Qi, G. Zhang, D. Xu, Y. Zhan, X. Alvarez, Z. Guo, X. Fu, S.R. Plymate, O. Sartor, H. Zhang, and Y. Dong Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy Oncotarget 5 2014 1646 1656
-
(2014)
Oncotarget
, vol.5
, pp. 1646-1656
-
-
Cao, B.1
Qi, Y.2
Zhang, G.3
Xu, D.4
Zhan, Y.5
Alvarez, X.6
Guo, Z.7
Fu, X.8
Plymate, S.R.9
Sartor, O.10
Zhang, H.11
Dong, Y.12
-
56
-
-
84863979005
-
Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer
-
R. Hu, C. Lu, E.A. Mostaghel, S. Yegnasubramanian, M. Gurel, C. Tannahill, J. Edwards, W.B. Isaacs, P.S. Nelson, E. Bluemn, S.R. Plymate, and J. Luo Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer Cancer Res. 72 2012 3457 3462
-
(2012)
Cancer Res.
, vol.72
, pp. 3457-3462
-
-
Hu, R.1
Lu, C.2
Mostaghel, E.A.3
Yegnasubramanian, S.4
Gurel, M.5
Tannahill, C.6
Edwards, J.7
Isaacs, W.B.8
Nelson, P.S.9
Bluemn, E.10
Plymate, S.R.11
Luo, J.12
-
57
-
-
84907057471
-
AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer
-
E.S. Antonarakis, C. Lu, H. Wang, B. Luber, M. Nakazawa, J.C. Roeser, Y. Chen, T.A. Mohammad, Y. Chen, H.L. Fedor, T.L. Lotan, Q. Zheng, A.M. De Marzo, J.T. Isaacs, W.B. Isaacs, R. Nadal, C.J. Paller, S.R. Denmeade, M.A. Carducci, M.A. Eisenberger, and J. Luo AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer N. Engl. J. Med. 371 2014 1028 1038
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 1028-1038
-
-
Antonarakis, E.S.1
Lu, C.2
Wang, H.3
Luber, B.4
Nakazawa, M.5
Roeser, J.C.6
Chen, Y.7
Mohammad, T.A.8
Chen, Y.9
Fedor, H.L.10
Lotan, T.L.11
Zheng, Q.12
De Marzo, A.M.13
Isaacs, J.T.14
Isaacs, W.B.15
Nadal, R.16
Paller, C.J.17
Denmeade, S.R.18
Carducci, M.A.19
Eisenberger, M.A.20
Luo, J.21
more..
-
58
-
-
84896536370
-
Rapid induction of androgen receptor splice variants by androgen deprivation in prostate cancer
-
Z. Yu, S. Chen, A.G. Sowalsky, O.S. Voznesensky, E.A. Mostaghel, P.S. Nelson, C. Cai, and S.P. Balk Rapid induction of androgen receptor splice variants by androgen deprivation in prostate cancer Clin. Cancer Res. 20 2014 1590 1600
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 1590-1600
-
-
Yu, Z.1
Chen, S.2
Sowalsky, A.G.3
Voznesensky, O.S.4
Mostaghel, E.A.5
Nelson, P.S.6
Cai, C.7
Balk, S.P.8
-
59
-
-
84885214146
-
An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide)
-
M. Korpal, J.M. Korn, X. Gao, D.P. Rakiec, D.A. Ruddy, S. Doshi, J. Yuan, S.G. Kovats, S. Kim, V.G. Cooke, J.E. Monahan, F. Stegmeier, T.M. Roberts, W.R. Sellers, W. Zhou, and P. Zhu An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide) Cancer Discov. 3 2013 1030 1043
-
(2013)
Cancer Discov.
, vol.3
, pp. 1030-1043
-
-
Korpal, M.1
Korn, J.M.2
Gao, X.3
Rakiec, D.P.4
Ruddy, D.A.5
Doshi, S.6
Yuan, J.7
Kovats, S.G.8
Kim, S.9
Cooke, V.G.10
Monahan, J.E.11
Stegmeier, F.12
Roberts, T.M.13
Sellers, W.R.14
Zhou, W.15
Zhu, P.16
-
60
-
-
84933510527
-
Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance in castration-resistant prostate cancer
-
pii: clincanres.2666.2014. [Epub ahead of print]
-
A.A. Azad, S.V. Volik, A.W. Wyatt, A. Haegert, S. Le Bihan, R.H. Bell, S. Anderson, B. McConeghy, R. Shukin, J. Bazov, J. Youngren, P.L. Paris, G.V. Thomas, E.J. Small, Y. Wang, M.E. Gleave, C.C. Collins, and K.N. Chi Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance in castration-resistant prostate cancer Clin. Cancer Res. February 2015 pii: clincanres.2666.2014. [Epub ahead of print]
-
(2015)
Clin. Cancer Res.
, Issue.February
-
-
Azad, A.A.1
Volik, S.V.2
Wyatt, A.W.3
Haegert, A.4
Le Bihan, S.5
Bell, R.H.6
Anderson, S.7
Mcconeghy, B.8
Shukin, R.9
Bazov, J.10
Youngren, J.11
Paris, P.L.12
Thomas, G.V.13
Small, E.J.14
Wang, Y.15
Gleave, M.E.16
Collins, C.C.17
Chi, K.N.18
-
61
-
-
84904670472
-
Dihydrotestosterone enhances castration-resistant prostate cancer cell proliferation through STAT5 activation via glucocorticoid receptor pathway
-
C. Song, Y. Kim, G.E. Min, and H. Ahn Dihydrotestosterone enhances castration-resistant prostate cancer cell proliferation through STAT5 activation via glucocorticoid receptor pathway Prostate 74 2014 1240 1248
-
(2014)
Prostate
, vol.74
, pp. 1240-1248
-
-
Song, C.1
Kim, Y.2
Min, G.E.3
Ahn, H.4
-
62
-
-
84890078624
-
Glucocorticoid receptor confers resistance to anti-androgens by by-passing androgen receptor blockade
-
V.K. Aora, E. Schenkein, R. Murali, S.K. Subudhi, J. Wongvipat, M.D. Balbas, N. Sah, L. Cai, E. Efstathiou, C. Logothetis, D. Zhang, and C.L. Sawyers Glucocorticoid receptor confers resistance to anti-androgens by by-passing androgen receptor blockade Cell 155 2013 1309 1322
-
(2013)
Cell
, vol.155
, pp. 1309-1322
-
-
Aora, V.K.1
Schenkein, E.2
Murali, R.3
Subudhi, S.K.4
Wongvipat, J.5
Balbas, M.D.6
Sah, N.7
Cai, L.8
Efstathiou, E.9
Logothetis, C.10
Zhang, D.11
Sawyers, C.L.12
-
63
-
-
84895453094
-
Steroid receptors aplenty in prostate cancer
-
N. Sharifi Steroid receptors aplenty in prostate cancer N. Engl. J. Med. 370 2014 970 971
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 970-971
-
-
Sharifi, N.1
-
64
-
-
84907015314
-
Reappraisal of glucocorticoids in castrate-resistant prostate cancer
-
O. Sartor, C.C. Parker, and J. de Bono Reappraisal of glucocorticoids in castrate-resistant prostate cancer Asian J. Androl. 16 2014
-
(2014)
Asian J. Androl.
, vol.16
-
-
Sartor, O.1
Parker, C.C.2
De Bono, J.3
-
65
-
-
84929277295
-
Activity of enzalutamide in men with metastatic castration-resistant prostate cancer is affected by prior treatment with abiraterone and/or docetaxel
-
Epub ahead of print
-
H.H. Cheng, R. Gulati, A. Azad, R. Nadal, P. Twardowski, U.N. Vaishampayan, N. Agarwal, E.I. Heath, S.K. Pal, H.T. Rehman, A. Leiter, J.A. Batten, R.B. Montgomery, M.D. Galsky, E.S. Antonarakis, K.N. Chi, and E.Y. Yu Activity of enzalutamide in men with metastatic castration-resistant prostate cancer is affected by prior treatment with abiraterone and/or docetaxel Prostate Cancer Prostatic Dis. January 2015 10.1038/pcan.2014.53 [Epub ahead of print]
-
(2015)
Prostate Cancer Prostatic Dis.
, Issue.January
-
-
Cheng, H.H.1
Gulati, R.2
Azad, A.3
Nadal, R.4
Twardowski, P.5
Vaishampayan, U.N.6
Agarwal, N.7
Heath, E.I.8
Pal, S.K.9
Rehman, H.T.10
Leiter, A.11
Batten, J.A.12
Montgomery, R.B.13
Galsky, M.D.14
Antonarakis, E.S.15
Chi, K.N.16
Yu, E.Y.17
-
66
-
-
84856786322
-
Steroid sulfatase inhibitors for estrogen- and androgen-dependent cancers
-
A. Purohit, and P.A. Foster Steroid sulfatase inhibitors for estrogen- and androgen-dependent cancers J. Endocrinol. 212 2012 99 110
-
(2012)
J. Endocrinol.
, vol.212
, pp. 99-110
-
-
Purohit, A.1
Foster, P.A.2
-
67
-
-
84880175396
-
Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase
-
J. Roy, J. Lefebvre, R. Maltais, and D. Poirier Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase Mol. Cell. Endocrinol. 376 2013 148 155
-
(2013)
Mol. Cell. Endocrinol.
, vol.376
, pp. 148-155
-
-
Roy, J.1
Lefebvre, J.2
Maltais, R.3
Poirier, D.4
-
68
-
-
84905436109
-
Galeterone prevents androgen receptor binding to chromatin and enhances degradation of mutant androgen receptor
-
Z. Yu, C. Cai, S. Gao, N.I. Simon, H.C. Shen, and S.P. Balk Galeterone prevents androgen receptor binding to chromatin and enhances degradation of mutant androgen receptor Clin. Cancer Res. 20 2014 4075 4085
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 4075-4085
-
-
Yu, Z.1
Cai, C.2
Gao, S.3
Simon, N.I.4
Shen, H.C.5
Balk, S.P.6
-
69
-
-
79951726954
-
Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)
-
A.O. Adeniji, B.M. Twenter, M.C. Byrns, Y. Jin, J.D. Winkler, and T.M. Penning Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) Bioorg. Med. Chem. Lett. 21 2011 1464 1468
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 1464-1468
-
-
Adeniji, A.O.1
Twenter, B.M.2
Byrns, M.C.3
Jin, Y.4
Winkler, J.D.5
Penning, T.M.6
-
70
-
-
84863230589
-
Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships
-
A.O. Adeniji, B.M. Twenter, M.C. Byrns, Y. Jin, M. Chen, J.D. Winkler, and T.M. Penning Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships J. Med. Chem. 55 2012 2311 2323
-
(2012)
J. Med. Chem.
, vol.55
, pp. 2311-2323
-
-
Adeniji, A.O.1
Twenter, B.M.2
Byrns, M.C.3
Jin, Y.4
Chen, M.5
Winkler, J.D.6
Penning, T.M.7
-
71
-
-
37349047898
-
An indomethacin analogue N-(4-chlorobenzoyl) melatonin is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies
-
M.C. Byrns, S. Steckelbroeck, and T.M. Penning An indomethacin analogue N-(4-chlorobenzoyl) melatonin is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies Biochem. Pharmacol. 75 2008 484 493
-
(2008)
Biochem. Pharmacol.
, vol.75
, pp. 484-493
-
-
Byrns, M.C.1
Steckelbroeck, S.2
Penning, T.M.3
-
72
-
-
84875751054
-
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer
-
A.J. Liedtke, A.O. Adeniji, M. Chen, M.C. Byrns, Y. Jin, D.W. Christianson, L.J. Marnett, and T.M. Penning Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer J. Med. Chem. 56 2013 2429 2446
-
(2013)
J. Med. Chem.
, vol.56
, pp. 2429-2446
-
-
Liedtke, A.J.1
Adeniji, A.O.2
Chen, M.3
Byrns, M.C.4
Jin, Y.5
Christianson, D.W.6
Marnett, L.J.7
Penning, T.M.8
-
73
-
-
84860493930
-
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer
-
M. Chen, A.O. Adeniji, B.M. Twenter, J.D. Winkler, D.W. Christianson, and T.M. Penning Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer Bioorg. Med. Chem. Lett. 22 2012 3492 3497
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 3492-3497
-
-
Chen, M.1
Adeniji, A.O.2
Twenter, B.M.3
Winkler, J.D.4
Christianson, D.W.5
Penning, T.M.6
-
74
-
-
84886413827
-
Steroidogenic enzyme AKR1C3 is a novel androgen receptor-selective coactivator that promotes prostate cancer growth
-
M. Yepuru, Z. Wu, A. Kyulkarni, F. Yin, C.M. Barrett, J. Kim, M.S. Steiner, D.D. Miller, J.T. Dalton, and R. Narayanan Steroidogenic enzyme AKR1C3 is a novel androgen receptor-selective coactivator that promotes prostate cancer growth Clin. Cancer Res. 19 2013 5613 5625
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 5613-5625
-
-
Yepuru, M.1
Wu, Z.2
Kyulkarni, A.3
Yin, F.4
Barrett, C.M.5
Kim, J.6
Steiner, M.S.7
Miller, D.D.8
Dalton, J.T.9
Narayanan, R.10
-
75
-
-
84927596103
-
In vitro and in vivo characterization of ASP9521: a novel selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5; AKR1C3)
-
A. Kikuchi, T. Furutani, H. Azami, K. Watanbe, T. Nimi, Y. Kamiyama, S. Kuromitsu, E. Bakin-Bey, M. Heeringa, T. Uoatas, and K. Enjo In vitro and in vivo characterization of ASP9521: a novel selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5; AKR1C3) Invest. New Drugs 32 2014 860 870
-
(2014)
Invest. New Drugs
, vol.32
, pp. 860-870
-
-
Kikuchi, A.1
Furutani, T.2
Azami, H.3
Watanbe, K.4
Nimi, T.5
Kamiyama, Y.6
Kuromitsu, S.7
Bakin-Bey, E.8
Heeringa, M.9
Uoatas, T.10
Enjo, K.11
-
76
-
-
84927652789
-
Safety, tolerability and anti-tumor activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study
-
Y. Loriot, K. Fizazi, R.J. Jones, Brand, J. Van den, R.L. Molife, A. Omlin, N.D. James, E. Baskin-Bey, M. Heeringa, B. Baron, G.M. Holtkamp, T. Ouatas, and J.S. de Bono Safety, tolerability and anti-tumor activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study Invest. New Drugs 32 2014 995 1004
-
(2014)
Invest. New Drugs
, vol.32
, pp. 995-1004
-
-
Loriot, Y.1
Fizazi, K.2
Jones, R.J.3
Brand4
Van Den, J.5
Molife, R.L.6
Omlin, A.7
James, N.D.8
Baskin-Bey, E.9
Heeringa, M.10
Baron, B.11
Holtkamp, G.M.12
Ouatas, T.13
De Bono, J.S.14
-
77
-
-
84896738421
-
Molecular pathways: targeting resistance in the androgen receptor for therapeutic benefit
-
E.A. Mostaghel, S.R. Plymate, and B. Montgomery Molecular pathways: targeting resistance in the androgen receptor for therapeutic benefit Clin. Cancer Res. 20 2014 791 798
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 791-798
-
-
Mostaghel, E.A.1
Plymate, S.R.2
Montgomery, B.3
-
78
-
-
84873033326
-
Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells
-
M. Nakka, I.U. Agoulnik, and N.L. Weigel Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells Int. J. Biochem. Cell. Biol. 45 2013 763 772
-
(2013)
Int. J. Biochem. Cell. Biol.
, vol.45
, pp. 763-772
-
-
Nakka, M.1
Agoulnik, I.U.2
Weigel, N.L.3
-
79
-
-
84907393368
-
Canoncial androstenedione reduction is the predominat source of signaling androgens in hormone-refractory prostate cancer
-
M. Fankhauser, Y. Tan, G. Macintyre, I. Haviv, M.K.H. Hong, A. Nguyen, J.S. Pederson, A.J. Costello, C.M. Hovens, and N.M. Corcoran Canoncial androstenedione reduction is the predominat source of signaling androgens in hormone-refractory prostate cancer Clin. Cancer Res. 20 2014 5547 5557
-
(2014)
Clin. Cancer Res.
, vol.20
, pp. 5547-5557
-
-
Fankhauser, M.1
Tan, Y.2
Macintyre, G.3
Haviv, I.4
Hong, M.K.H.5
Nguyen, A.6
Pederson, J.S.7
Costello, A.J.8
Hovens, C.M.9
Corcoran, N.M.10
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