-
2
-
-
0032493489
-
Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells
-
Knudsen KE, Arden KC, Cavenee WK. Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells. J Biol Chem 1998;273:20213-22.
-
(1998)
J Biol Chem
, vol.273
, pp. 20213-20222
-
-
Knudsen, K.E.1
Arden, K.C.2
Cavenee, W.K.3
-
3
-
-
67650758019
-
Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
-
Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, et al. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 2009;138:245-56.
-
(2009)
Cell
, vol.138
, pp. 245-256
-
-
Wang, Q.1
Li, W.2
Zhang, Y.3
Yuan, X.4
Xu, K.5
Yu, J.6
-
4
-
-
33747880070
-
Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins
-
Xu Y, Chen SY, Ross KN, Balk SP. Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins. Cancer Res 2006;66:7783-92.
-
(2006)
Cancer Res
, vol.66
, pp. 7783-7792
-
-
Xu, Y.1
Chen, S.Y.2
Ross, K.N.3
Balk, S.P.4
-
5
-
-
80054761058
-
Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase
-
Cai C, He HH, Chen S, Coleman I, Wang H, Fang Z, et al. Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase. Cancer Cell 2011;20:457-71
-
(2011)
Cancer Cell
, vol.20
, pp. 457-471
-
-
Cai, C.1
He, H.H.2
Chen, S.3
Coleman, I.4
Wang, H.5
Fang, Z.6
-
6
-
-
84901841652
-
Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis
-
Jun [Epub ahead of print]
-
Yuan X, Cai C, Chen S, Chen S, Yu Z, Balk SP. Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis. Oncogene 2013 Jun [Epub ahead of print]
-
(2013)
Oncogene
-
-
Yuan, X.1
Cai, C.2
Chen, S.3
Chen, S.4
Yu, Z.5
Balk, S.P.6
-
7
-
-
49249119358
-
Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
-
Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 2008;68:4447-54.
-
(2008)
Cancer Res
, vol.68
, pp. 4447-4454
-
-
Montgomery, R.B.1
Mostaghel, E.A.2
Vessella, R.3
Hess, D.L.4
Kalhorn, T.F.5
Higano, C.S.6
-
8
-
-
51049098138
-
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
-
Locke JA, Guns ES, Lubik AA, Adomat HH, Hendy SC, Wood CA, et al. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res 2008;68:6407-15.
-
(2008)
Cancer Res
, vol.68
, pp. 6407-6415
-
-
Locke, J.A.1
Guns, E.S.2
Lubik, A.A.3
Adomat, H.H.4
Hendy, S.C.5
Wood, C.A.6
-
9
-
-
80051963331
-
Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
-
Chang KH, Li R, Papari-Zareei M, Watumull L, Zhao YD, Auchus RJ, et al. Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer. Proc Natl Acad Sci U S A 2011;108:13728-33.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 13728-13733
-
-
Chang, K.H.1
Li, R.2
Papari-Zareei, M.3
Watumull, L.4
Zhao, Y.D.5
Auchus, R.J.6
-
10
-
-
53749090666
-
Phase i clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
-
Attard G, Reid AH, Yap TA, Raynaud F, Dowsett M, Settatree S, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol 2008;26:4563-71.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4563-4571
-
-
Attard, G.1
Reid, A.H.2
Yap, T.A.3
Raynaud, F.4
Dowsett, M.5
Settatree, S.6
-
11
-
-
77951523950
-
Phase i clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy
-
Ryan CJ, Smith MR, Fong L, Rosenberg JE, Kantoff P, Raynaud F, et al. Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy. J Clin Oncol 2010;28:1481-8.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1481-1488
-
-
Ryan, C.J.1
Smith, M.R.2
Fong, L.3
Rosenberg, J.E.4
Kantoff, P.5
Raynaud, F.6
-
12
-
-
80052827038
-
Resistance to CYP17A1 inhibition with abiraterone in castration resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
-
Mostaghel EA, Marck B, Plymate S, Vessella RL, Balk SP, Matsumoto AM, et al. Resistance to CYP17A1 inhibition with abiraterone in castration resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 2011;17:5913-25.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5913-5925
-
-
Mostaghel, E.A.1
Marck, B.2
Plymate, S.3
Vessella, R.L.4
Balk, S.P.5
Matsumoto, A.M.6
-
13
-
-
79957443342
-
Abiraterone and increased survival in metastatic prostate cancer
-
de Bono JS, Logothetis CJ, Molina A, Fizazi K, North S, Chu L, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med 2011;364:1995-2005.
-
(2011)
N Engl J Med
, vol.364
, pp. 1995-2005
-
-
De Bono, J.S.1
Logothetis, C.J.2
Molina, A.3
Fizazi, K.4
North, S.5
Chu, L.6
-
14
-
-
84870243969
-
Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: Exploratory analysis of data from the COU-AA-301 randomised trial
-
Logothetis CJ, Basch E, Molina A, Fizazi K, North SA, Chi KN, et al. Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: exploratory analysis of data from the COU-AA-301 randomised trial. Lancet Oncol 2012;13:1210-7.
-
(2012)
Lancet Oncol
, vol.13
, pp. 1210-1217
-
-
Logothetis, C.J.1
Basch, E.2
Molina, A.3
Fizazi, K.4
North, S.A.5
Chi, K.N.6
-
15
-
-
79960979238
-
Increased androgen receptor transcription: A cause of castration-resistant prostate cancer and a possible therapeutic target
-
Shiota M, Yokomizo A, Naito S. Increased androgen receptor transcription: a cause of castration-resistant prostate cancer and a possible therapeutic target. J Mol Endocrinol 2011;47: R25-41.
-
(2011)
J Mol Endocrinol
, vol.47
-
-
Shiota, M.1
Yokomizo, A.2
Naito, S.3
-
16
-
-
1842612441
-
Molecular determinants of resistance to antiandrogen therapy
-
Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, Vessella R, et al. Molecular determinants of resistance to antiandrogen therapy. Nat Med 2004;10:33-9.
-
(2004)
Nat Med
, vol.10
, pp. 33-39
-
-
Chen, C.D.1
Welsbie, D.S.2
Tran, C.3
Baek, S.H.4
Chen, R.5
Vessella, R.6
-
17
-
-
65649090203
-
Development of a second-generation antiandrogen for treatment of advanced prostate cancer
-
Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009;324:787-90.
-
(2009)
Science
, vol.324
, pp. 787-790
-
-
Tran, C.1
Ouk, S.2
Clegg, N.J.3
Chen, Y.4
Watson, P.A.5
Arora, V.6
-
18
-
-
84866770294
-
Increased survival with enzalutamide in prostate cancer after chemotherapy
-
Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med 2012;367:1187-97.
-
(2012)
N Engl J Med
, vol.367
, pp. 1187-1197
-
-
Scher, H.I.1
Fizazi, K.2
Saad, F.3
Taplin, M.E.4
Sternberg, C.N.5
Miller, K.6
-
19
-
-
84875150133
-
Enzalutamide: A novel antiandrogen for patients with castrate-resistant prostate cancer
-
Hoffman-Censits J, Kelly WK. Enzalutamide: a novel antiandrogen for patients with castrate-resistant prostate cancer. Clin Cancer Res 2013;19:1335-9.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1335-1339
-
-
Hoffman-Censits, J.1
Kelly, W.K.2
-
20
-
-
34047181147
-
Drug insight: Role of the androgen receptor in the development and progression of prostate cancer
-
Taplin ME. Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol 2007;4:236-44.
-
(2007)
Nat Clin Pract Oncol
, vol.4
, pp. 236-244
-
-
Taplin, M.E.1
-
21
-
-
65949113815
-
The role of androgen receptor mutations in prostate cancer progression
-
Brooke GN, Bevan CL. The role of androgen receptor mutations in prostate cancer progression. Curr Genomics 2009;10:18-25.
-
(2009)
Curr Genomics
, vol.10
, pp. 18-25
-
-
Brooke, G.N.1
Bevan, C.L.2
-
22
-
-
84885214146
-
An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (Enzalutamide)
-
Korpal M, Korn JM, Gao X, Rakiec DP, Ruddy DA, Doshi S, et al. An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (Enzalutamide). Cancer Discov 2013.
-
(2013)
Cancer Discov
-
-
Korpal, M.1
Korn, J.M.2
Gao, X.3
Rakiec, D.P.4
Ruddy, D.A.5
Doshi, S.6
-
23
-
-
84885210324
-
A clinically relevant androgen receptor mutation confers resistance to 2nd generation anti-androgens enzalutamide and ARN-509
-
Joseph JD, Lu N, Qian J, Sensintaffar J, Shao G, Brigham D, et al. A clinically relevant androgen receptor mutation confers resistance to 2nd generation anti-androgens enzalutamide and ARN-509. Cancer Discov 2013;3:1020-9.
-
(2013)
Cancer Discov
, vol.3
, pp. 1020-1029
-
-
Joseph, J.D.1
Lu, N.2
Qian, J.3
Sensintaffar, J.4
Shao, G.5
Brigham, D.6
-
24
-
-
84879067087
-
Overcoming mutation-based resistance to antiandrogens with rational drug design
-
Balbas MD, Evans MJ, Hosfield DJ, Wongvipat J, Arora VK, Watson PA, et al. Overcoming mutation-based resistance to antiandrogens with rational drug design. eLife 2013;2:e00499.
-
(2013)
ELife
, vol.2
-
-
Balbas, M.D.1
Evans, M.J.2
Hosfield, D.J.3
Wongvipat, J.4
Arora, V.K.5
Watson, P.A.6
-
25
-
-
34047181147
-
Drug insight: Role of the androgen receptor in the development and progression of prostate cancer
-
Taplin ME. Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol 2007;4:236-44.
-
(2007)
Nat Clin Pract Oncol
, vol.4
, pp. 236-244
-
-
Taplin, M.E.1
-
26
-
-
79955719838
-
Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
-
Hornberg E, Ylitalo EB, Crnalic S, Antti H, Stattin P, Widmark A, et al. Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PLoS One 2011;6:e19059.
-
(2011)
PLoS One
, vol.6
-
-
Hornberg, E.1
Ylitalo, E.B.2
Crnalic, S.3
Antti, H.4
Stattin, P.5
Widmark, A.6
-
27
-
-
48549089747
-
Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
-
Dehm SM, Schmidt LJ, Heemers HV, Vessella RL, Tindall DJ. Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res 2008;68:5469-77.
-
(2008)
Cancer Res
, vol.68
, pp. 5469-5477
-
-
Dehm, S.M.1
Schmidt, L.J.2
Heemers, H.V.3
Vessella, R.L.4
Tindall, D.J.5
-
28
-
-
58249110391
-
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
-
Hu R, Dunn TA, Wei S, Isharwal S, Veltri RW, Humphreys E, et al. Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 2009;69:16-22.
-
(2009)
Cancer Res
, vol.69
, pp. 16-22
-
-
Hu, R.1
Dunn, T.A.2
Wei, S.3
Isharwal, S.4
Veltri, R.W.5
Humphreys, E.6
-
29
-
-
65549168746
-
Anovel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
-
Guo Z, Yang X, Sun F, Jiang R, Linn DE, Chen H, et al. Anovel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res 2009;69:2305-13.
-
(2009)
Cancer Res
, vol.69
, pp. 2305-2313
-
-
Guo, Z.1
Yang, X.2
Sun, F.3
Jiang, R.4
Linn, D.E.5
Chen, H.6
-
30
-
-
77955296562
-
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
-
Sun S, Sprenger CC, Vessella RL, Haugk K, Soriano K, Mostaghel EA, et al. Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J Clin Invest 2010;120:2715-30.
-
(2010)
J Clin Invest
, vol.120
, pp. 2715-2730
-
-
Sun, S.1
Sprenger, C.C.2
Vessella, R.L.3
Haugk, K.4
Soriano, K.5
Mostaghel, E.A.6
-
31
-
-
79959312739
-
A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities
-
Hu R, Isaacs WB, Luo J. A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities. Prostate 2011;71:1656-67.
-
(2011)
Prostate
, vol.71
, pp. 1656-1667
-
-
Hu, R.1
Isaacs, W.B.2
Luo, J.3
-
32
-
-
84863979005
-
Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castrationresistant prostate cancer
-
Hu R, Lu C, Mostaghel EA, Yegnasubramanian S, Gurel M, Tannahill C, et al. Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castrationresistant prostate cancer. Cancer Res 2012;72:3457-62.
-
(2012)
Cancer Res
, vol.72
, pp. 3457-3462
-
-
Hu, R.1
Lu, C.2
Mostaghel, E.A.3
Yegnasubramanian, S.4
Gurel, M.5
Tannahill, C.6
-
33
-
-
84902524198
-
Mechanisms of the androgen receptor splicing in prostate cancer cells
-
Jul [Epub ahead of print]
-
Liu LL, Xie N, Sun S, Plymate S, Mostaghel E, Dong X. Mechanisms of the androgen receptor splicing in prostate cancer cells. Oncogene 2013 Jul [Epub ahead of print]
-
(2013)
Oncogene
-
-
Liu, L.L.1
Xie, N.2
Sun, S.3
Plymate, S.4
Mostaghel, E.5
Dong, X.6
-
34
-
-
84869094406
-
AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression
-
Li Y, Hwang TH, Oseth LA, Hauge A, Vessella RL, Schmechel SC, et al. AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression. Oncogene 2012;31:4759-67.
-
(2012)
Oncogene
, vol.31
, pp. 4759-4767
-
-
Li, Y.1
Hwang, T.H.2
Oseth, L.A.3
Hauge, A.4
Vessella, R.L.5
Schmechel, S.C.6
-
35
-
-
80052808323
-
Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer
-
Darshan MS, Loftus MS, Thadani-Mulero M, Levy BP, Escuin D, Zhou XK, et al. Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer. Cancer Res 2011;71:6019-29.
-
(2011)
Cancer Res
, vol.71
, pp. 6019-6029
-
-
Darshan, M.S.1
Loftus, M.S.2
Thadani-Mulero, M.3
Levy, B.P.4
Escuin, D.5
Zhou, X.K.6
-
36
-
-
84866415731
-
Androgen receptor on the move: Boarding the microtubule expressway to the nucleus
-
Thadani-Mulero M, Nanus DM, Giannakakou P. Androgen receptor on the move: boarding the microtubule expressway to the nucleus. Cancer Res 2012;72:4611-5.
-
(2012)
Cancer Res
, vol.72
, pp. 4611-4615
-
-
Thadani-Mulero, M.1
Nanus, D.M.2
Giannakakou, P.3
-
37
-
-
84861728843
-
Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal
-
Chan SC, Li Y, Dehm SM. Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal. J Biol Chem 2012;287:19736-49.
-
(2012)
J Biol Chem
, vol.287
, pp. 19736-19749
-
-
Chan, S.C.1
Li, Y.2
Dehm, S.M.3
-
38
-
-
84896702716
-
Taxane sensitivity in prostate cancer is determined by androgen receptor splice variants
-
Apr 6-10; Washington, DC. Philadelphia (PA): AACR;2013; Abstract nr 4081
-
Portella L, Thadani-Mulero M, Matov M, Nanus DM, Plymate SR, Giannakakou P. Taxane sensitivity in prostate cancer is determined by androgen receptor splice variants. In: Proceedings of the Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR;2013; Abstract nr 4081.
-
(2013)
Proceedings of the Annual Meeting of the American Association for Cancer Research;
-
-
Portella, L.1
Thadani-Mulero, M.2
Matov, M.3
Nanus, D.M.4
Plymate, S.R.5
Giannakakou, P.6
-
39
-
-
84899496338
-
Taxane mechanisms of action: Potential implications for treatment sequencing in metastatic castration-resistant prostate cancer
-
Jul [Epub ahead of print]
-
Fitzpatrick JM, de Wit R. Taxane mechanisms of action: Potential implications for treatment sequencing in metastatic castration-resistant prostate cancer. Eur Urol 2013 Jul [Epub ahead of print]
-
(2013)
Eur Urol
-
-
Fitzpatrick, J.M.1
De Wit, R.2
-
40
-
-
80053610846
-
Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer
-
Sahu B, Laakso M, Ovaska K, Mirtti T, Lundin J, Rannikko A, et al. Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer. EMBO J 2011;30:3962-76.
-
(2011)
EMBO J
, vol.30
, pp. 3962-3976
-
-
Sahu, B.1
Laakso, M.2
Ovaska, K.3
Mirtti, T.4
Lundin, J.5
Rannikko, A.6
-
41
-
-
84890078624
-
Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade
-
Arora VK, Schenkein E, Murali R, Subudhi SK, Wongvipat J, Balbas MD, et al. Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade. Cell 2013;155: 1309-22.
-
(2013)
Cell
, vol.155
, pp. 1309-1322
-
-
Arora, V.K.1
Schenkein, E.2
Murali, R.3
Subudhi, S.K.4
Wongvipat, J.5
Balbas, M.D.6
-
42
-
-
84904256730
-
Association of baseline corticosteroid with outcomes in a multivariate analysis of the phase 3 affirm study of enzalutamide (ENZA), an androgen receptor signaling inhibitor (ARSI)
-
abstr 899
-
Scher HI, Fizazi K, Saad F, Chi K, Taplin ME, Sternberg CN, et al. Association of baseline corticosteroid with outcomes in a multivariate analysis of the phase 3 affirm study of enzalutamide (ENZA), an androgen receptor signaling inhibitor (ARSI). ESMO 2012 (abstr 899).
-
(2012)
ESMO
-
-
Scher, H.I.1
Fizazi, K.2
Saad, F.3
Chi, K.4
Taplin, M.E.5
Sternberg, C.N.6
-
43
-
-
84882772681
-
Effect of corticosteroid (CS) use at baseline (CUB) on overall survival (OS) in patients (pts) receiving abiraterone acetate (AA): Results from a randomized study (COU-AA-301) in metastatic castration-resistant prostate cancer (mCRPC) post-docetaxel (D)
-
abstr 5014
-
Montgomery B, Kheoh S, Molina A, Li J, Bellmunt J, Ryan CJ, et al. Effect of corticosteroid (CS) use at baseline (CUB) on overall survival (OS) in patients (pts) receiving abiraterone acetate (AA): results from a randomized study (COU-AA-301) in metastatic castration-resistant prostate cancer (mCRPC) post-docetaxel (D). J Clin Oncol 31, 2013 (suppl; abstr 5014).
-
(2013)
J Clin Oncol
, vol.31
, Issue.SUPPL.
-
-
Montgomery, B.1
Kheoh, S.2
Molina, A.3
Li, J.4
Bellmunt, J.5
Ryan, C.J.6
-
44
-
-
27344451557
-
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
-
Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005;310:644-8.
-
(2005)
Science
, vol.310
, pp. 644-648
-
-
Tomlins, S.A.1
Rhodes, D.R.2
Perner, S.3
Dhanasekaran, S.M.4
Mehra, R.5
Sun, X.W.6
-
45
-
-
84871516837
-
Dual roles of PARP-1 promote cancer growth and progression
-
Schiewer MJ, Goodwin JF, Han S, Brenner JC, Augello MA, Dean JL, et al. Dual roles of PARP-1 promote cancer growth and progression. Cancer Discov 2012;2:1134-49.
-
(2012)
Cancer Discov
, vol.2
, pp. 1134-1149
-
-
Schiewer, M.J.1
Goodwin, J.F.2
Han, S.3
Brenner, J.C.4
Augello, M.A.5
Dean, J.L.6
-
46
-
-
79955968629
-
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer
-
Brenner JC, Ateeq B, Li Y, Yocum AK, Cao Q, Asangani IA, et al. Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer cell 2011;19: 664-78.
-
(2011)
Cancer Cell
, vol.19
, pp. 664-678
-
-
Brenner, J.C.1
Ateeq, B.2
Li, Y.3
Yocum, A.K.4
Cao, Q.5
Asangani, I.A.6
-
47
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009;361:123-34.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
Mergui-Roelvink, M.6
-
48
-
-
80052827038
-
Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
-
Mostaghel EA, Marck BT, Plymate SR, Vessella RL, Balk S, Matsumoto AM, et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 2011;17: 5913-25.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5913-5925
-
-
Mostaghel, E.A.1
Marck, B.T.2
Plymate, S.R.3
Vessella, R.L.4
Balk, S.5
Matsumoto, A.M.6
-
49
-
-
80054021222
-
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
-
Cai C, Chen S, Ng P, Bubley GJ, Nelson PS, Mostaghel EA, et al. Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Res 2011;71:6503-13.
-
(2011)
Cancer Res
, vol.71
, pp. 6503-6513
-
-
Cai, C.1
Chen, S.2
Ng, P.3
Bubley, G.J.4
Nelson, P.S.5
Mostaghel, E.A.6
-
50
-
-
84872534568
-
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines
-
Li Y, Chan SC, Brand LJ, Hwang TH, Silverstein KA, Dehm SM. Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res 2013;73: 483-9.
-
(2013)
Cancer Res
, vol.73
, pp. 483-489
-
-
Li, Y.1
Chan, S.C.2
Brand, L.J.3
Hwang, T.H.4
Silverstein, K.A.5
Dehm, S.M.6
-
51
-
-
84872044846
-
Novel strategies to test biological hypotheses in early drug development for advanced prostate cancer
-
Ferraldeschi R, Attard G, deBono JS. Novel strategies to test biological hypotheses in early drug development for advanced prostate cancer. Clin Chem 2013;59:75-84.
-
(2013)
Clin Chem
, vol.59
, pp. 75-84
-
-
Ferraldeschi, R.1
Attard, G.2
Debono, J.S.3
-
52
-
-
84879628727
-
An androgen receptor N-terminal domain antagonist for treating prostate cancer
-
Myung JK, Banuelos CA, Fernandez JG, Mawji NR, Wang J, Tien AH, et al. An androgen receptor N-terminal domain antagonist for treating prostate cancer. J Clin Invest 2013;123:2948-60.
-
(2013)
J Clin Invest
, vol.123
, pp. 2948-2960
-
-
Myung, J.K.1
Banuelos, C.A.2
Fernandez, J.G.3
Mawji, N.R.4
Wang, J.5
Tien, A.H.6
-
53
-
-
77953280591
-
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor
-
Andersen RJ, Mawji NR, Wang J, Wang G, Haile S, Myung JK, et al. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer cell 2010;17:535-46.
-
(2010)
Cancer Cell
, vol.17
, pp. 535-546
-
-
Andersen, R.J.1
Mawji, N.R.2
Wang, J.3
Wang, G.4
Haile, S.5
Myung, J.K.6
-
54
-
-
84858424089
-
Converting cancer therapies into cures: Lessons from infectious diseases
-
Glickman MS, Sawyers CL. Converting cancer therapies into cures: lessons from infectious diseases. Cell 2012;148:1089-98.
-
(2012)
Cell
, vol.148
, pp. 1089-1098
-
-
Glickman, M.S.1
Sawyers, C.L.2
-
55
-
-
84863230424
-
ARN-509: A novel antiandrogen for prostate cancer treatment
-
Clegg NJ, Wongvipat J, Joseph JD, Tran C, Ouk S, Dilhas A, et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res 2012;72:1494-503.
-
(2012)
Cancer Res
, vol.72
, pp. 1494-1503
-
-
Clegg, N.J.1
Wongvipat, J.2
Joseph, J.D.3
Tran, C.4
Ouk, S.5
Dilhas, A.6
-
56
-
-
20944449560
-
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: Synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model
-
Handratta VD, Vasaitis TS, Njar VC, Gediya LK, Kataria R, Chopra P, et al. Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. J Med Chem 2005;48:2972-84.
-
(2005)
J Med Chem
, vol.48
, pp. 2972-2984
-
-
Handratta, V.D.1
Vasaitis, T.S.2
Njar, V.C.3
Gediya, L.K.4
Kataria, R.5
Chopra, P.6
-
57
-
-
84863011652
-
Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells
-
Soifer HS, Souleimanian N, Wu S, Voskresenskiy AM, Collak FK, Cinar B, et al. Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells. J Biol Chem 2012;287: 3777-87.
-
(2012)
J Biol Chem
, vol.287
, pp. 3777-3787
-
-
Soifer, H.S.1
Souleimanian, N.2
Wu, S.3
Voskresenskiy, A.M.4
Collak, F.K.5
Cinar, B.6
-
58
-
-
53349101498
-
Androgen receptor inactivation contributes to antitumor efficacy of 17{a}-hydroxylase/17,20-lyase inhibitor 3b-hydroxy-17-(1H-benzimidazole-1-yl) androsta-5,16-diene in prostate cancer
-
Vasaitis T, Belosay A, Schayowitz A, Khandelwal A, Chopra P, Gediya LK, et al. Androgen receptor inactivation contributes to antitumor efficacy of 17{a}-hydroxylase/17,20-lyase inhibitor 3b-hydroxy-17-(1H-benzimidazole-1-yl) androsta-5,16-diene in prostate cancer. Mol Cancer Ther 2008;7:2348-57.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2348-2357
-
-
Vasaitis, T.1
Belosay, A.2
Schayowitz, A.3
Khandelwal, A.4
Chopra, P.5
Gediya, L.K.6
-
59
-
-
84860523917
-
Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: A rationale for increasing abiraterone exposure or combining with MDV3100
-
Richards J, Lim AC, Hay CW, Taylor AE, Wingate A, Nowakowska K, et al. Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res 2012;72:2176-82.
-
(2012)
Cancer Res
, vol.72
, pp. 2176-2182
-
-
Richards, J.1
Lim, A.C.2
Hay, C.W.3
Taylor, A.E.4
Wingate, A.5
Nowakowska, K.6
-
60
-
-
84878645503
-
Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer
-
Ravindranathan P, Lee TK, Yang L, Centenera MM, Butler L, Tilley WD, et al. Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer. Nat Commun 2013;4:1923.
-
(2013)
Nat Commun
, vol.4
, pp. 1923
-
-
Ravindranathan, P.1
Lee, T.K.2
Yang, L.3
Centenera, M.M.4
Butler, L.5
Tilley, W.D.6
-
62
-
-
84880310089
-
Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors
-
Gillis JL, Selth LA, Centenera MM, Townley SL, Sun S, Plymate SR, et al. Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors. Oncotarget 2013;4:691-704.
-
(2013)
Oncotarget
, vol.4
, pp. 691-704
-
-
Gillis, J.L.1
Selth, L.A.2
Centenera, M.M.3
Townley, S.L.4
Sun, S.5
Plymate, S.R.6
-
63
-
-
84863335299
-
Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors
-
Centenera MM, Gillis JL, Hanson AR, Jindal S, Taylor RA, Risbridger GP, et al. Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors. Clin Cancer Res 2012;18: 3562-70.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 3562-3570
-
-
Centenera, M.M.1
Gillis, J.L.2
Hanson, A.R.3
Jindal, S.4
Taylor, R.A.5
Risbridger, G.P.6
-
64
-
-
84870336847
-
Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors
-
Mitsiades N, Sung CC, Schultz N, Danila DC, He B, Eedunuri VK, et al. Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors. Cancer Res 2012;72:6142-52.
-
(2012)
Cancer Res
, vol.72
, pp. 6142-6152
-
-
Mitsiades, N.1
Sung, C.C.2
Schultz, N.3
Danila, D.C.4
He, B.5
Eedunuri, V.K.6
-
65
-
-
84865242183
-
Evidence for steroidogenic potential in human prostate cell lines and tissues
-
Bennett NC, Hooper JD, Lambie D, Lee CS, Yang T, Vesey DA, et al. Evidence for steroidogenic potential in human prostate cell lines and tissues. Am J Pathol 2012;181:1078-87.
-
(2012)
Am J Pathol
, vol.181
, pp. 1078-1087
-
-
Bennett, N.C.1
Hooper, J.D.2
Lambie, D.3
Lee, C.S.4
Yang, T.5
Vesey, D.A.6
-
66
-
-
84896698113
-
-
cited 2013 September 17
-
Stand Up To Cancer Dream Team. 2013 [cited 2013 September 17]. Available from: http://www.standup2cancer.org/dream-teams/view/ precision-therapy-for- advanced-prostate-cancer)
-
(2013)
-
-
-
67
-
-
83755196341
-
Circulating tumors cells as biomarkers: Progress toward biomarker qualification
-
Danila DC, Pantel K, Fleisher M, Scher HI. Circulating tumors cells as biomarkers: progress toward biomarker qualification. Cancer J 2011;17:438-50.
-
(2011)
Cancer J
, vol.17
, pp. 438-450
-
-
Danila, D.C.1
Pantel, K.2
Fleisher, M.3
Scher, H.I.4
-
69
-
-
68049140791
-
Starving the addiction: New opportunities for durable suppression of AR signaling in prostate cancer
-
Knudsen KE, Scher HI. Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer. Clin Cancer Res 2009;15:4792-8.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4792-4798
-
-
Knudsen, K.E.1
Scher, H.I.2
|