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Volumn 20, Issue 8, 2015, Pages 14348-14364

Macrophage activation by ursolic and oleanolic acids during mycobacterial infection

Author keywords

CD36; Macrophages; Nitric oxide (NO); Oleanolic acid; Reactive oxygen species (ROS); TGR5; Transforming growth factor (TGF ); Triterpenes; Tuberculosis; Tumor necrosis factor (TNF ); Ursolic acid

Indexed keywords

NITRIC OXIDE; OLEANOLIC ACID; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA1; TRITERPENE; TUMOR NECROSIS FACTOR ALPHA; URSOLIC ACID;

EID: 84941254050     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules200814348     Document Type: Article
Times cited : (41)

References (54)
  • 1
    • 84884625066 scopus 로고    scopus 로고
    • Polyphenols and triterpenes from Chaenomeles fruits: Chemical analysis and antioxidant activities assessment
    • Du, H.; Wu, J.; Li, H.; Zhong, P.X.; Xu, Y.J.; Li, C.H.; Ji, K.X.; Wang, L.S. Polyphenols and triterpenes from Chaenomeles fruits: Chemical analysis and antioxidant activities assessment. Food Chem. 2013, 15, 4260-4268.
    • (2013) Food Chem , vol.15 , pp. 4260-4268
    • Du, H.1    Wu, J.2    Li, H.3    Zhong, P.X.4    Xu, Y.J.5    Li, C.H.6    Ji, K.X.7    Wang, L.S.8
  • 2
    • 84875945544 scopus 로고    scopus 로고
    • Influence of triterpenoids present in apple peel on inflammatory gene expression associated with inflammatory bowel disease (IBD)
    • Muller, D.; Triebel, S.; Rudakovski, O.; Richling, E. Influence of triterpenoids present in apple peel on inflammatory gene expression associated with inflammatory bowel disease (IBD). Food Chem. 2013, 15, 339-346.
    • (2013) Food Chem , vol.15 , pp. 339-346
    • Muller, D.1    Triebel, S.2    Rudakovski, O.3    Richling, E.4
  • 3
    • 67649836518 scopus 로고    scopus 로고
    • Pentacyclic triterpene distribution in various plants-Rich sources for a new group of multi-potent plant extracts
    • Jäger, S.; Trojan, H.; Kopp, T.; Laszczyk, M.N.; Scheffler, A. Pentacyclic triterpene distribution in various plants-Rich sources for a new group of multi-potent plant extracts. Molecules 2009, 14, 2016-2031.
    • (2009) Molecules , vol.14 , pp. 2016-2031
    • Jäger, S.1    Trojan, H.2    Kopp, T.3    Laszczyk, M.N.4    Scheffler, A.5
  • 4
    • 23044440041 scopus 로고    scopus 로고
    • Oleanolic acid and ursolic acid: Research perspectives
    • Liu, J. Oleanolic acid and ursolic acid: Research perspectives. J. Ethnopharmacol. 2005, 22, 92-94.
    • (2005) J. Ethnopharmacol , vol.22 , pp. 92-94
    • Liu, J.1
  • 6
    • 38849130803 scopus 로고    scopus 로고
    • Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids
    • Tanachatchairatana, T.; Bremner, J.B.; Chokchaisiri, R.; Suksamrarn, A. Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids. Chem. Pharm. Bull. 2008, 56, 194-198.
    • (2008) Chem. Pharm. Bull , vol.56 , pp. 194-198
    • Tanachatchairatana, T.1    Bremner, J.B.2    Chokchaisiri, R.3    Suksamrarn, A.4
  • 8
    • 55149083474 scopus 로고    scopus 로고
    • Ursolic, oleanolic and betulinic acids: Antibacterial spectra and selectivity indexes
    • Fontanay, S.; Grare, M.; Mayer, J.; Finance, C.; Duval, R.E. Ursolic, oleanolic and betulinic acids: Antibacterial spectra and selectivity indexes. J. Ethnopharmacol. 2008, 120, 272-276.
    • (2008) J. Ethnopharmacol , vol.120 , pp. 272-276
    • Fontanay, S.1    Grare, M.2    Mayer, J.3    Finance, C.4    Duval, R.E.5
  • 9
    • 57149083088 scopus 로고    scopus 로고
    • Antibacterial and antiparasitic activity of oleanolic acid and its glycosides isolated from marigold (Calendula officinalis)
    • Szakiel, A.; Ruszkowski, D.; Grudniak, A.; Kurek, A.; Wolska, K.; Doligalska, M.; Janiszowska, W. Antibacterial and antiparasitic activity of oleanolic acid and its glycosides isolated from marigold (Calendula officinalis). Planta Medica 2008, 74, 1709-1715.
    • (2008) Planta Medica , vol.74 , pp. 1709-1715
    • Szakiel, A.1    Ruszkowski, D.2    Grudniak, A.3    Kurek, A.4    Wolska, K.5    Doligalska, M.6    Janiszowska, W.7
  • 10
    • 84874626512 scopus 로고    scopus 로고
    • Oleanolic acid and ursolic acid: Novel hepatitis C virus antivirals that inhibit NS5B activity
    • Kong, L.; Li, S.; Liao, Q.; Zhang, Y.; Sun, R.; Zhu, X.; Zhang, Q.; Wang, J.; Wu, X.; Fang, X.; et al. Oleanolic acid and ursolic acid: Novel hepatitis C virus antivirals that inhibit NS5B activity. Antiviral Res. 2013, 98, 44-53.
    • (2013) Antiviral Res , vol.98 , pp. 44-53
    • Kong, L.1    Li, S.2    Liao, Q.3    Zhang, Y.4    Sun, R.5    Zhu, X.6    Zhang, Q.7    Wang, J.8    Wu, X.9    Fang, X.10
  • 13
    • 23344446183 scopus 로고    scopus 로고
    • Secondary metabolites from chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis
    • Jimenez-Arellanes, A.; Meckes, M.; Alvarez, V.; Torres, J.; Parra, R. Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis. Phytother. Res. 2005, 19, 320-322.
    • (2005) Phytother. Res , vol.19 , pp. 320-322
    • Jimenez-Arellanes, A.1    Meckes, M.2    Alvarez, V.3    Torres, J.4    Parra, R.5
  • 14
    • 77955282458 scopus 로고    scopus 로고
    • Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFNγ by CD4+ naive T cells
    • Jung, T.Y.; Pham, T.N.; Umeyama, A.; Shoji, N.; Hashimoto, T.; Lee, J.J.; Takei, M. Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFNγ by CD4+ naive T cells. Eur. J. Pharmacol. 2010, 643, 297-303.
    • (2010) Eur. J. Pharmacol , vol.643 , pp. 297-303
    • Jung, T.Y.1    Pham, T.N.2    Umeyama, A.3    Shoji, N.4    Hashimoto, T.5    Lee, J.J.6    Takei, M.7
  • 15
    • 84914701171 scopus 로고    scopus 로고
    • World Health Organization., Available online:accessed on 6 April 2015
    • World Health Organization. Global Tuberculosis Report 2014. Available online: http://www.apps.who.int/iris/bitstream/10665/137094/1/9789241564809-eng.pdf (accessed on 6 April 2015).
    • (2014) Global Tuberculosis Report
  • 18
    • 84864286029 scopus 로고    scopus 로고
    • Triterpene acids from rose hip powder inhibit self-antigen- And LPS-induced cytokine production and CD4+ T-cell proliferation in human mononuclear cell cultures
    • Saaby, L.M.; Nielsen, C.H. Triterpene acids from rose hip powder inhibit self-antigen- And LPS-induced cytokine production and CD4+ T-cell proliferation in human mononuclear cell cultures. Phytother. Res. 2012, 26, 1142-1147.
    • (2012) Phytother. Res , vol.26 , pp. 1142-1147
    • Saaby, L.M.1    Nielsen, C.H.2
  • 19
    • 84929999130 scopus 로고    scopus 로고
    • Ursolic acid activates intracellular killing effect of macrophages during Mycobacterium tuberculosis infection
    • Podder, B.; Jang, W.S.; Nam, K.W.; Lee, B.E.; Song, H.Y. Ursolic acid activates intracellular killing effect of macrophages during Mycobacterium tuberculosis infection. J. Microbiol. Biotechnol. 2015, 25, 738-744.
    • (2015) J. Microbiol. Biotechnol , vol.25 , pp. 738-744
    • Podder, B.1    Jang, W.S.2    Nam, K.W.3    Lee, B.E.4    Song, H.Y.5
  • 20
    • 78649269241 scopus 로고    scopus 로고
    • CCL20 is overexpressed in Mycobacterium tuberculosis-infected monocytes and inhibits the production of reactive oxygen species (ROS)
    • Rivero-Lezcano, O.M.; González-Cortés, C.; Reyes-Ruvalcaba, D.; Diez-Tascón, C. CCL20 is overexpressed in Mycobacterium tuberculosis-infected monocytes and inhibits the production of reactive oxygen species (ROS). Clin. Exp. Immunol 2010, 162, 289-297.
    • (2010) Clin. Exp. Immunol , vol.162 , pp. 289-297
    • Rivero-Lezcano, O.M.1    González-Cortés, C.2    Reyes-Ruvalcaba, D.3    Diez-Tascón, C.4
  • 22
    • 84861986754 scopus 로고    scopus 로고
    • In vitro anti-breast cancer activity of ethanolic extract of Wrightiatomentosa: Role of pro-apoptotic effects of oleanolic acid and ursolic acid
    • Chakravarti, B.; Maurya, R.; Siddiqui, J.A.; Bid, H.K.; Rajendran, S.M.; Yadav, P.P.; Konwar, R. In vitro anti-breast cancer activity of ethanolic extract of Wrightiatomentosa: Role of pro-apoptotic effects of oleanolic acid and ursolic acid. J. Ethnopharmacol. 2012, 142, 72-79.
    • (2012) J. Ethnopharmacol , vol.142 , pp. 72-79
    • Chakravarti, B.1    Maurya, R.2    Siddiqui, J.A.3    Bid, H.K.4    Rajendran, S.M.5    Yadav, P.P.6    Konwar, R.7
  • 23
    • 84941193648 scopus 로고    scopus 로고
    • A novel PABA/NO-based oleanolic acid derivative induces human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway
    • Liu, L.; Fu, J.; Li, T.; Cui, R.; Ling, J.; Yu, X.; Ji, H.; Zhang, Y. A novel PABA/NO-based oleanolic acid derivative induces human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway. Eur. J. Pharmacol. 2012, 15, 1-3.
    • (2012) Eur. J. Pharmacol , vol.15 , pp. 1-3
    • Liu, L.1    Fu, J.2    Li, T.3    Cui, R.4    Ling, J.5    Yu, X.6    Ji, H.7    Zhang, Y.8
  • 24
    • 84871299970 scopus 로고    scopus 로고
    • The Mycobacterium tuberculosis PE proteins Rv0285 and Rv1386 modulate innate immunity and mediate bacillary survival in macrophages
    • Tiwari, B.M.; Kannan, N.; Vemu, L.; Raghunand, T.R. The Mycobacterium tuberculosis PE proteins Rv0285 and Rv1386 modulate innate immunity and mediate bacillary survival in macrophages. PLoS ONE 2012, 7, e51686.
    • (2012) PLoS ONE , vol.7 , pp. e51686
    • Tiwari, B.M.1    Kannan, N.2    Vemu, L.3    Raghunand, T.R.4
  • 26
    • 75149136962 scopus 로고    scopus 로고
    • Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid
    • Huang, Z.; Zhang, Y.; Zhao, L.; Jing, Y.; Lai, Y.; Zhang, L.; Guo, Q.; Yuan, S.; Zhang, J.; Chen, L.; et al. Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid. Org. Biomol. Chem. 2010, 8, 632-639.
    • (2010) Org. Biomol. Chem , vol.8 , pp. 632-639
    • Huang, Z.1    Zhang, Y.2    Zhao, L.3    Jing, Y.4    Lai, Y.5    Zhang, L.6    Guo, Q.7    Yuan, S.8    Zhang, J.9    Chen, L.10
  • 27
    • 84864075069 scopus 로고    scopus 로고
    • Manipulation of coestimulatory U molecules by intracellular pathogens: Veni, vidi, vici!!
    • Khan, N.; Gowthaman, U.; Pahari, S.; Agrewala, J.N. Manipulation of coestimulatory U molecules by intracellular pathogens: Veni, vidi, vici!! PLoS Pathogen. 2012, 8, e1002676.
    • (2012) PLoS Pathogen , vol.8 , pp. e1002676
    • Khan, N.1    Gowthaman, U.2    Pahari, S.3    Agrewala, J.N.4
  • 28
    • 84862297719 scopus 로고    scopus 로고
    • Characteristics of suppressor macrophages induced by mycobacterial and protozoa infections in relation to alternatively activated M2 macrophages
    • Tomioka, H.; Tatano, Y.; Maw, W.W.; Sano, C.; Kanehiro, Y.; Shimizu, T. Characteristics of suppressor macrophages induced by mycobacterial and protozoa infections in relation to alternatively activated M2 macrophages. Clin. Dev. Immunol. 2012, 2012, doi:10.1155/2012/635451.
    • (2012) Clin. Dev. Immunol , pp. 2012
    • Tomioka, H.1    Tatano, Y.2    Maw, W.W.3    Sano, C.4    Kanehiro, Y.5    Shimizu, T.6
  • 29
    • 38949149637 scopus 로고    scopus 로고
    • Ursolic acid: An anti- And pro-inflammatory triterpenoid
    • Ikeda, Y.; Murakami, A.; Ohigashi, H. Ursolic acid: An anti- And pro-inflammatory triterpenoid. Mol. Nutr. Food Res. 2008, 52, 26-42.
    • (2008) Mol. Nutr. Food Res , vol.52 , pp. 26-42
    • Ikeda, Y.1    Murakami, A.2    Ohigashi, H.3
  • 30
    • 0035914061 scopus 로고    scopus 로고
    • Nitric oxide and tumor necrosis factor-alfa production by oleanolic acid via nuclear factor kappa b activation in macrophages
    • Choi, C.Y.; You, H.J.; Jeong, H.G. Nitric oxide and tumor necrosis factor-alfa production by oleanolic acid via nuclear factor kappa b activation in macrophages. Biochem. Biophys. Res. Commun. 2001, 288, 49-55.
    • (2001) Biochem. Biophys. Res. Commun , vol.288 , pp. 49-55
    • Choi, C.Y.1    You, H.J.2    Jeong, H.G.3
  • 31
    • 76749137504 scopus 로고    scopus 로고
    • Effects of triterpenes on the immune system
    • Ríos, J.L. Effects of triterpenes on the immune system. J. Ethnopharmacol. 2010, 128, 1-14.
    • (2010) J. Ethnopharmacol , vol.128 , pp. 1-14
    • Ríos, J.L.1
  • 32
    • 79151477517 scopus 로고    scopus 로고
    • Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling
    • Szuster-Ciesielska, A.; Plewka, K.; Daniluk, J.; Kandefer-Szerszen, M. Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling. Toxicology 2011, 27, 152-163.
    • (2011) Toxicology , vol.27 , pp. 152-163
    • Szuster-Ciesielska, A.1    Plewka, K.2    Daniluk, J.3    Kandefer-Szerszen, M.4
  • 33
    • 84862275434 scopus 로고    scopus 로고
    • Macrophage polarization: Convergence point targeted by Mycobacterium tuberculosis and HIV
    • Lugo-Villarino, G.; Vérollet, C.; Maridonneau-Parini, I.; Neyrolles, O. Macrophage polarization: Convergence point targeted by Mycobacterium tuberculosis and HIV. Front. Immunol. 2011, 2, 43, doi:10.3389/fimmu.2011.00043.
    • (2011) Front. Immunol , vol.2 , pp. 43
    • Lugo-Villarino, G.1    Vérollet, C.2    Maridonneau-Parini, I.3    Neyrolles, O.4
  • 34
    • 34247172208 scopus 로고    scopus 로고
    • Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: Role of CD36
    • Ikeda, Y.; Murakami, A.; Fujimura, Y.; Tachibana, H.; Yamada, K.; Masuda, D.; Hirano, H.; Yamashita, S.; Ohigashi, H. Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36. J. Immunol. 2007, 178, 4854-4864.
    • (2007) J. Immunol , vol.178 , pp. 4854-4864
    • Ikeda, Y.1    Murakami, A.2    Fujimura, Y.3    Tachibana, H.4    Yamada, K.5    Masuda, D.6    Hirano, H.7    Yamashita, S.8    Ohigashi, H.9
  • 35
    • 74849119709 scopus 로고    scopus 로고
    • Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: Potential impact in diabetes
    • Genet, C.; Strehle, A.; Schmidt, C.; Boudjelal, G.; Lobstein, A.; Schoonjans, K.; Souchet, M.; Auwerx, J.; Saladin, R.; Wagner, A. Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: Potential impact in diabetes. J. Med. Chem. 2010, 53, 178-190.
    • (2010) J. Med. Chem , vol.53 , pp. 178-190
    • Genet, C.1    Strehle, A.2    Schmidt, C.3    Boudjelal, G.4    Lobstein, A.5    Schoonjans, K.6    Souchet, M.7    Auwerx, J.8    Saladin, R.9    Wagner, A.10
  • 36
    • 80053415839 scopus 로고    scopus 로고
    • A high content drug screen identifies ursolic acid as an inhibitor of amyloid β protein interactions with its receptor CD36
    • Wilkinson, K.; Boyd, J.D.; Glicksman, M.; Moore, K.J.; El-Khoury, J. A high content drug screen identifies ursolic acid as an inhibitor of amyloid β protein interactions with its receptor CD36. J. Biol. Chem. 2011, 286, 34914-34922.
    • (2011) J. Biol. Chem , vol.286 , pp. 34914-34922
    • Wilkinson, K.1    Boyd, J.D.2    Glicksman, M.3    Moore, K.J.4    El-Khoury, J.5
  • 37
    • 84903727479 scopus 로고    scopus 로고
    • CD36, a scavenger receptor implicated in atherosclerosis
    • Park, Y.M. CD36, a scavenger receptor implicated in atherosclerosis. Exp. Mol. Med. 2014, 46, e99, doi:10.1038/emm.2014.38.
    • (2014) Exp. Mol. Med , vol.46 , pp. e99
    • Park, Y.M.1
  • 38
    • 84900549160 scopus 로고    scopus 로고
    • Mycobacterium leprae intracelular survival relies on colesterol accumulation in infected macrophages: A potential target for new drugs for leprosy treatment
    • Mattos, K.A.; Oliveira, V.C.; Berrêdo-Pinho, M.; Amaral, J.J.; Antunes, L.C.; Melo, R.C.; Acosta, C.C.; Moura, D.F.; Olmo, R.; Han, J.; et al. Mycobacterium leprae intracelular survival relies on colesterol accumulation in infected macrophages: A potential target for new drugs for leprosy treatment. Cell Microbiol. 2014, 16, 797-815.
    • (2014) Cell Microbiol , vol.16 , pp. 797-815
    • Mattos, K.A.1    Oliveira, V.C.2    Berrêdo-Pinho, M.3    Amaral, J.J.4    Antunes, L.C.5    Melo, R.C.6    Acosta, C.C.7    Moura, D.F.8    Olmo, R.9    Han, J.10
  • 40
    • 33750070631 scopus 로고    scopus 로고
    • Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting
    • Triantafilou, M.; Gamper, F.G.; Haston, R.M.; Mouratis, M.A.; Morath, S.; Hartung, T.; Triantafilou, K. Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J. Biol. Chem. 2006, 281, 31002-3111.
    • (2006) J. Biol. Chem , vol.281 , pp. 31002-33111
    • Triantafilou, M.1    Gamper, F.G.2    Haston, R.M.3    Mouratis, M.A.4    Morath, S.5    Hartung, T.6    Triantafilou, K.7
  • 41
    • 67349217383 scopus 로고    scopus 로고
    • TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis
    • Drage, M.G.; Pecora, N.D.; Hise, A.G.; Febbraio, M.; Silverstein, R.L.; Golenbock, D.T.; Boom, W.H.; Harding, C.V. TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. Cell Immunol. 2009, 258, 29-37.
    • (2009) Cell Immunol , vol.258 , pp. 29-37
    • Drage, M.G.1    Pecora, N.D.2    Hise, A.G.3    Febbraio, M.4    Silverstein, R.L.5    Golenbock, D.T.6    Boom, W.H.7    Harding, C.V.8
  • 43
    • 84895520482 scopus 로고    scopus 로고
    • The bile acid TGR5 membrane receptor: From basic research to clinical application
    • Duboc, H.; Taché, Y.; Hofmann, A.F. The bile acid TGR5 membrane receptor: From basic research to clinical application. Dig. Liver Dis. 2014, 46, 302-312.
    • (2014) Dig. Liver Dis , vol.46 , pp. 302-312
    • Duboc, H.1    Taché, Y.2    Hofmann, A.F.3
  • 46
    • 80053308007 scopus 로고    scopus 로고
    • The G-protein coupled bile acid receptor Gpbar1 (TGR5) negatively regulates hepatic inflammatory response through antagonizing Nuclear Factor κB
    • Wang, Y.D.; Chen, W.D.; Yu, D.; Forman, B.M.; Huang, W. The G-protein coupled bile acid receptor Gpbar1 (TGR5) negatively regulates hepatic inflammatory response through antagonizing Nuclear Factor κB. Hepatology 2011, 54, 1421-1432.
    • (2011) Hepatology , vol.54 , pp. 1421-1432
    • Wang, Y.D.1    Chen, W.D.2    Yu, D.3    Forman, B.M.4    Huang, W.5
  • 48
    • 84912132591 scopus 로고    scopus 로고
    • Shaping macrophages function and innate immunity by bile acids: Mechanisms and implication in cholestatic liver diseases
    • Calmus, Y.; Poupon, R. Shaping macrophages function and innate immunity by bile acids: Mechanisms and implication in cholestatic liver diseases. Clin. Res. Hepatol. Gastroenterol. 2014, 38, 550-556.
    • (2014) Clin. Res. Hepatol. Gastroenterol , vol.38 , pp. 550-556
    • Calmus, Y.1    Poupon, R.2
  • 49
    • 84879103477 scopus 로고    scopus 로고
    • Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells
    • Kida, T.; Tsubosaka, Y.; Hori, M.; Ozaki, H.; Murata, T. Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2013, 33, 1663-1669.
    • (2013) Arterioscler. Thromb. Vasc. Biol , vol.33 , pp. 1663-1669
    • Kida, T.1    Tsubosaka, Y.2    Hori, M.3    Ozaki, H.4    Murata, T.5
  • 50
    • 84941193888 scopus 로고    scopus 로고
    • Activation of the bile acid receptor TGR5 enhances LPS-induced inflammatory responses in a human monocytic cell line
    • Mobraten, K.; Haugbro, T.; Karlstrom, E.; Kleiveland, C.R.; Lea, T. Activation of the bile acid receptor TGR5 enhances LPS-induced inflammatory responses in a human monocytic cell line. J. Recept. Signal Transduct. Res. 2014, 24, 1-8.
    • (2014) J. Recept. Signal Transduct. Res , vol.24 , pp. 1-8
    • Mobraten, K.1    Haugbro, T.2    Karlstrom, E.3    Kleiveland, C.R.4    Lea, T.5
  • 53
    • 0029066248 scopus 로고
    • In-vitro and intracellular activity of rifabutin on drug-susceptible and multiple drug-resistant (MDR) tubercle bacilli
    • Luna-Herrera, J.; Reddy, M.V.; Gangadharam, P.R. In-vitro and intracellular activity of rifabutin on drug-susceptible and multiple drug-resistant (MDR) tubercle bacilli. J. Antimicrob. Chemother. 1995, 36, 355-363.
    • (1995) J. Antimicrob. Chemother , vol.36 , pp. 355-363
    • Luna-Herrera, J.1    Reddy, M.V.2    Gangadharam, P.R.3


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