Characteristics of suppressor macrophages induced by mycobacterial and protozoal infections in relation to alternatively activated M2 macrophages

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Tomioka, Haruaki ^a   Tatano, Yutaka ^a   Maw, Win Win ^a   Sano, Chiaki ^a   Kanehiro, Yuichi ^a   Shimizu, Toshiaki ^b  

^a SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

^b YASUDA WOMEN'S UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CCL1 CHEMOKINE; CHEMOKINE; CXCL11 CHEMOKINE; CXCL16 CHEMOKINE; CXCL9 CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PRESENTING CELL; B LYMPHOCYTE; BACTERICIDAL ACTIVITY; CYTOKINE PRODUCTION; EXPERIMENTAL INFECTION; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNE SYSTEM; LUNG TUBERCULOSIS; MACROPHAGE; MACROPHAGE ACTIVATION; MYCOBACTERIOSIS; MYCOBACTERIUM INTRACELLULARE AVIUM; MYCOBACTERIUM TUBERCULOSIS; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTOZOAL INFECTION; REVIEW; T LYMPHOCYTE; TUBERCULOSIS; ANIMAL; COMPLEMENT ALTERNATIVE PATHWAY; GRAM POSITIVE INFECTION; HUMAN; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; MICROBIOLOGY;

ANIMALS; COMPLEMENT PATHWAY, ALTERNATIVE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; IMMUNOSUPPRESSION; MACROPHAGES; MYCOBACTERIUM AVIUM COMPLEX; MYCOBACTERIUM TUBERCULOSIS; PROTOZOAN INFECTIONS; TUBERCULOSIS;

EID: 84862297719     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/635451     Document Type: Review

References (115)

1. Tiruviluamala P., Reichman L. B., Tuberculosis Annual Review of Public Health 2002 23 403 426 (Pubitemid 34508081)
2. Frieden T. R., Sterling T. R., Munsiff S. S., Watt C. J., Dye C., Tuberculosis The Lancet 2003 362 9387 887 899 (Pubitemid 37130100)
3. Zahorka M., Merkle R., Bodiang C. K., Current Issues in Tuberculosis Control 2004 Swiss Tropical Institute
4. Aliyu M. H., Salihu H. M., Tuberculosis and HIV disease: two decades of a dual epidemic Wiener Klinische Wochenschrift 2003 115 19-20 685 697 (Pubitemid 37484292)
5. Iseman M. D., Treatment and implications of multidrug-resistant tuberculosis for the 21 st century Chemotherapy 1999 45 Supplement 2 34 40 (Pubitemid 29353994)
6. Goldman R. C., Plumley K. V., Laughon B. E., The evolution of extensively drug resistant tuberculosis (XDR-TB): history, status and issues for global control Infectious Disorders 2007 7 2 73 91 (Pubitemid 47099121)
7. O'Brien R. J., Vernon A. A., New tuberculosis drug development: how can we do better? American Journal of Respiratory and Critical Care Medicine 1998 157 6 I 1705 1707 (Pubitemid 28311249)
8. Blanc D. C., Nunn P., Duncan K., Incentives and disincentives for new anti-tuberculous drug development. Situational analysis World Health Organization 2000 2000 1 59
9. Chan J., Flynn J., The immunological aspects of latency in tuberculosis Clinical Immunology 2004 110 1 2 12 (Pubitemid 38177416)
10. Gomez J. E., McKinney J. D., M. tuberculosis persistence, latency, and drug tolerance Tuberculosis 2004 84 1-2 29 44 (Pubitemid 38082931)
11. Jo E. K., Park J. K., Dockrell H. M., Dynamics of cytokine generation in patients with active pulmonary tuberculosis Current Opinion in Infectious Diseases 2003 16 3 205 210 (Pubitemid 36677313)
12. Tomioka H., Tatano Y., Sano C., Shimizu T., Development of new antituberculous drugs based on bacterial virulence factors interfering with host cytokine networks Journal of Infection and Chemotherapy 2011 17 302 317
13. Dlugovitzky D., Torres-Morales A., Rateni L., Farroni M. A., Largacha C., Molteni O., Bottasso O., Circulating profile of Th1 and Th2 cytokines in tuberculosis patients with different degrees of pulmonary involvement FEMS Immunology and Medical Microbiology 1997 18 3 203 207 (Pubitemid 27323702)
14. Bermudez L. E., Wagner D., Sosnowska D., Mechanisms of Mycobacterium avium pathogenesis ArcHIVum Immunologiae et Therapiae Experimentalis 2000 48 6 521 527 (Pubitemid 33622207)
15. Raju B., Hoshino Y., Belitskaya-Lévy I., Dawson R., Ress S., Gold J. A., Condos R., Pine R., Brown S., Nolan A., Rom W. N., Weiden M. D., Gene expression profiles of bronchoalveolar cells in pulmonary TB Tuberculosis 2008 88 1 39 51 (Pubitemid 350267356)
16. Schreiber T., Ehlers S., Heitmann L., Rausch A., Mages J., Murray P. J., Lang R., Holscher C., Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity Journal of Immunology 2009 183 2 1301 1312
17. Lugo-Villarino G., Verollet C., maridonneau-Parini I., Neyrolles O., Macrophage polirazation: convergence point targeted by Mycobacterium tuberculosis and HIV Frontiers in Immunology 2011 2, article 43 1 7
18. Benoit M., Desnues B., Mege J. L., Macrophage polarization in bacterial infections Journal of Immunology 2008 181 6 3733 3739
19. Murray P. J., Wynn T. A., Protective and pathogenic functions of macrophage subsets Nature Reviews Immunology 2011 11 723 737
20. Gordon S., Alternative activation of macrophages Nature Reviews Immunology 2003 3 1 23 35 (Pubitemid 37328697)
21. Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M., The chemokine system in diverse forms of macrophage activation and polarization Trends in Immunology 2004 25 12 677 686 (Pubitemid 39457982)
22. Katakura T., Miyazaki M., Kobayashi M., Herndon D. N., Suzuki F., CCL17 and IL-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages Journal of Immunology 2004 172 3 1407 1413 (Pubitemid 38116782)
23. Murray P. J., Wynn T. A., Obstacles and opportunities for understanding macrophage polarization Journal of Leukocyte Biology 2011 89 4 557 563
24. Mantovani A., Sozzani S., Locati M., Allavena P., Sica A., Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes Trends in Immunology 2002 23 11 549 555 (Pubitemid 35223554)
25. Mantovani A., Sica A., Macrophages, innate immunity and cancer: balance, tolerance, and diversity Current Opinion in Immunology 2010 22 2 231 237
26. Stein M., Keshav S., Harris N., Gordon S., Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation Journal of Experimental Medicine 1992 176 1 287 292
27. Nair M. G., Cochrane D. W., Allen J. E., Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro Immunology Letters 2003 85 2 173 180 (Pubitemid 36071573)
28. Gerber J. S., Mosser D. M., Reversing lipopolysaccharide toxicity by ligating the macrophage Fc receptors Journal of Immunology 2001 166 11 6861 6868 (Pubitemid 32467232)
29. Edwards J. P., Zhang X., Frauwirth K. A., Mosser D. M., Biochemical and functional characterization of three activated macrophage populations Journal of Leukocyte Biology 2006 80 6 1298 1307 (Pubitemid 44904968)
30. Mosser D. M., Edwards J. P., Exploring the full spectrum of macrophage activation Nature Reviews Immunology 2008 8 12 958 969
31. Fong C. H., Bebien M., Didierlaurent A., Nebauer R., Hussell T., Broide D., Karin M., Lawrence T., An antiinflammatory role for IKK through the inhibition of classical macrophage activation Journal of Experimental Medicine 2008 205 6 1269 1276 (Pubitemid 351831484)
32. Krausgruber T., Blazek K., Smallie T., Alzabin S., Lockstone H., Sahgal N., Hussell T., Feldmann M., Udalova I. A., IRF5 promotes inflammatory macrophage polarization and Th1-Th17 responses Nature Immunology 2011 12 3 231 238
33. Cao S., Liu J., Chesi M., Bergsagel P. L., Ho I. C., Donnelly R. P., Ma X., Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-MAF fibrosarcoma Journal of Immunology 2002 169 10 5715 5725 (Pubitemid 35291673)
34. MacKinnon A. C., Farnworth S. L., Hodkinson P. S., Henderson N. C., Atkinson K. M., Leffler H., Nilsson U. J., Haslett C., Forbes S. J., Sethi T., Regulation of alternative macrophage activation by galectin-3 Journal of Immunology 2008 180 4 2650 2658
35. Verreck F. A., de Boer T., Langenberg D. M., Hoeve M. A., Kramer M., Vaisberg E., Kastelein R., Kolk A., de Waal-Malefyt R., Ottenhoff T. H. M., Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria Proceedings of the National Academy of Sciences of the United States of America 2004 101 13 4560 4565 (Pubitemid 38437450)
36. Martinez F. O., Gordon S., Locati M., Mantovani A., Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression Journal of Immunology 2006 177 10 7303 7311 (Pubitemid 44715100)
37. Martinez F. O., Regulators of macrophage activation European Journal of Immunology 2011 41 6 1531 1534
38. Novak R., Dabelic S., Dumic J., Galectin-1 and galectin-3 expression profiles in classically and alternatively activated human macrophages. Biochimica et Biophysica Acta. In press
39. Raes G., van den Bergh R., de Baetselier P., Ghassabeh G. H., Scotton C., Locati M., Mantovani A., Sozzani S., Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells Journal of Immunology 2005 174 11 6561 6562 (Pubitemid 40705613)
40. Macatonia S. E., Hsieh C. S., Murphy K. M., O'Garra A., Dendritic cells and macrophages are required for Th1 development of CD4 + T cells from TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN- production is IFN- -dependent International Immunology 1993 5 9 1119 1128 (Pubitemid 23291161)
41. Stritesky G. L., Yeh N., Kaplan M. H., IL-23 promotes maintenance but not commitment to the Th17 lineage Journal of Immunology 2008 181 9 5948 5955
42. Roberts A. B., Sporn M. B., Assoian R. K., Transforming growth factor type : rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro Proceedings of the National Academy of Sciences of the United States of America 1986 83 12 4167 4171 (Pubitemid 16057012)
43. Barron L., Wynn T. A., Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages American Journal of Physiology 2011 300 5 G723 G728
44. Boldrick J. C., Alizadeh A. A., Diehn M., Dudoit S., Liu C. L., Belcher C. E., Botstein D., Staudt L. M., Brown P. O., Relman D. A., Stereotyped and specific gene expression programs in human innate immune responses to bacteria Proceedings of the National Academy of Sciences of the United States of America 2002 99 2 972 977 (Pubitemid 34106620)
45. Mge J. L., Mehraj V., Capo C., Macrophage polarization and bacterial infections Current Opinion in Infectious Diseases 2011 24 3 230 234
46. Redente E. F., Higgins D. M., Dwyer-Nield L. D., Orme I. M., Gonzalez-Juarrero M., Malkinson A. M., Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation Journal of Leukocyte Biology 2010 88 1 159 168
47. Ito T., Schaller M., Hogaboam C. M., Standiford T. J., Chensue S. W., Kunkel S. L., TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response European Journal of Immunology 2007 37 10 2847 2855 (Pubitemid 47578304)
48. Charo I. F., Macrophage polarization and insulin resistance: PPAR in control Cell Metabolism 2007 6 2 96 98 (Pubitemid 47163624)
49. Montoya D., Cruz D., Teles R. M. B., Lee D. J., Ochoa M. T., Krutzik S. R., Chun R., Schenk M., Zhang X., Ferguson B. G., Burdick A. E., Sarno E. N., Rea T. H., Hewison M., Adams J. S., Cheng G., Modlin R. L., Divergence of macrophage phagocytic and antimicrobial programs in leprosy Cell Host and Microbe 2009 6 4 343 353
50. Liao X., Sharma N., Kapadia F., Zhou G., Lu Y., Hong H., Paruchuri K., Mahabeleshwar G. H., Dalmas E., Venteclef N., Flask C. A., Kim J., Doreian B. W., Lu K. Q., Kaestner K. H., Hamik A., Clément K., Jain M. K., Krppel-like factor 4 regulates macrophage polarization Journal of Clinical Investigation 2011 121 7 2736 2749
51. Rajaram M. V., Brooks M. N., Morris J. D., Torrelles J. B., Azad A. K., Schlesinger L. S., Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor linking mannose receptor recognition to regulation of immune responses Journal of Immunology 2010 185 2 929 942
52. Franois M., Romieu-Mourez R., Li M., Galipeau J., Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation Molecular Therapy 2012 20 1 187 -195
53. Qualls J. E., Neale G., Smith A. M., Koo M. S., DeFreitas A. A., Zhang H., Kaplan G., Watowich S. S., Murray P. J., Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling Science Signaling 2010 3 135, article ra62
54. Medot-Pirenne M., Heilman M. J., Saxena M., McDermott P. E., Mills C. D., Augmentation of an antitumor CTL response in vivo by inhibition of suppressor macrophage nitric oxide Journal of Immunology 1999 163 11 5877 5882
55. Smith M. R., Standiford T. J., Reddy R. C., PPARs in alveolar macrophage biology PPAR Research 2007 2007
56. Spiteri M. A., Poulter L. W., Characterization of immune inducer and suppressor macrophages from the normal human lung Clinical and Experimental Immunology 1991 83 1 157 162
57. Upham J. W., Strickland D. H., Robinson B. W. S., Holt P. G., Selective inhibition of T cell proliferation but not expression of effector function by human alveolar macrophages Thorax 1997 52 9 786 795 (Pubitemid 27412558)
58. Zhang X., McMurray D. N., Suppression of lymphoproliferation by alveolar macrophages in the guinea pig Tubercle and Lung Disease 1998 79 2 119 126 (Pubitemid 29078281)
59. Rich E. A., Cooper C., Toossi Z., Leonard M. L., Stucky R. M., Wiblin R. T., Ellner J. J., Requirement for cell-to-cell contact for the immunosuppressive activity of human alveolar macrophages American Journal of Respiratory Cell and Molecular Biology 1991 4 3 287 294
60. Kawabe T., Isobe K. I., Hasegawa Y., Nakashima I., Shimokata K., Immunosuppressive activity induced by nitric oxide in culture supernatant of activated rat alveolar macrophages Immunology 1992 76 1 72 78
61. Steele M. G., Herscowitz H. B., Suppression of murine IgM, IgG, IgA and IgE antibody responses by alveolar macrophages Immunology 1993 80 1 62 67 (Pubitemid 23284189)
62. Kobayashi H., Kobayashi M., Heming T. A., Bidani A., Pollard R. B., Suzuki F., Cytokine production by rabbit alveolar macrophages: differences between activated and suppressor cell phenotypes Immunology Letters 1999 69 3 339 346 (Pubitemid 29459138)
63. Arikawa T., Saita N., Oomizu S., Ueno M., Matsukawa A., Katoh S., Kojima K., Nagahara K., Miyake M., Yamauchi A., Kohrogi H., Hirashima M., Galectin-9 expands immunosuppressive macrophages to ameliorate T-cell-mediated lung inflammation European Journal of Immunology 2010 40 2 548 558
64. Flynn J. N., Sileghem M., The role of the macrophage in induction of immunosuppression in Trypanosoma congolense -infected cattle Immunology 1991 74 2 310 316
65. Schleifer K. W., Mansfield J. M., Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins Journal of Immunology 1993 151 10 5492 5503 (Pubitemid 23332359)
66. Sternberg J. M., Mabbott N. A., Nitric oxide-mediated suppression of T cell responses during Trypanosoma brucei infection: soluble trypanosome products and interferon- are synergistic inducers of nitric oxide synthase European Journal of Immunology 1996 26 3 539 543 (Pubitemid 26091380)
67. Khan I. A., Matsuura T., Kasper L. H., IL-10 mediates immunosuppression following primary infection with toxoplasma gondii in mice Parasite Immunology 1995 17 4 185 195
68. Allen J. E., Macdonald A. S., Profound suppression of cellular proliferation mediated by the secretions of nematodes Parasite Immunology 1998 20 5 241 247 (Pubitemid 28255397)
69. Allen J. E., Lawrence R. A., Maizels R. M., APC from mice harbouring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production International Immunology 1996 8 1 143 151 (Pubitemid 26029277)
70. Preston P. M., Darghouth M., Boulter N. R., Hall R. F., Tall R., Kirvar E., Brown D. C., A dual role for immunosuppressor mechanisms in infection with Theileria annulata: well-regulated suppressor macrophages help in recovery from infection; profound immunosuppression promotes non-healing disease Parasitology Research 2002 88 6 522 534 (Pubitemid 34810717)
71. MacDonald A. S., Maizels R. M., Lawrence R. A., Dransfield I., Allen J. E., Requirement for in vivo production of IL-4, but not IL-10, in the induction of proliferative suppression by filarial parasites Journal of Immunology 1998 160 8 4124 4132 (Pubitemid 28176124)
72. Atochina O., Daly-Engel T., Piskorska D., McGuire E., Harn D. A., A schistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1 + macrophages that suppress naive CD4 + T cell proliferation via an IFN- and nitric oxide-dependent mechanism Journal of Immunology 2001 167 8 4293 4302 (Pubitemid 32954304)
73. Girons N., Valero M. A., Garca-Bodeln M. A., Chico-Calero I., Punzn C., Fresno M., Mas-Coma S., Immune suppression in advanced chronic fascioliasis: an experimental study in a rat model Journal of Infectious Diseases 2007 195 10 1504 1512 (Pubitemid 46717469)
74. Potian J. A., Rafi W., Bhatt K., McBride A., Gause W. C., Salgame P., Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway Journal of Experimental Medicine 2011 208 9 1863 1874
75. Hingley-Wilson S. M., Sly L. M., Reiner N. E., The immunobiology of the mycobacterial infected macrophage Modern Aspects of Immunobiology 2000 1 96 101
76. Spellberg B., Edwards J. E., Type 1/type 2 immunity in infectious diseases Clinical Infectious Diseases 2001 32 1 76 102 (Pubitemid 32150953)
77. North R. J., Jung Y. J., Immunity to tuberculosis Annual Review of Immunology 2004 22 599 623 (Pubitemid 38680435)
78. Cooper A. M., Khader S. A., The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis Immunological Reviews 2008 226 1 191 204
79. Cooper A. M., T cells in mycobacterial infection and disease Current Opinion in Immunology 2009 21 4 378 384
80. van Crevel R., Ottenhoff T. H. M., van der Meer J. W. M., Innate immunity to Mycobacterium tuberculosis Clinical Microbiology Reviews 2002 15 2 294 309 (Pubitemid 34303767)
81. Wu B., Huang C., Kato-Maeda M., Hopewell P. C., Daley C. L., Krensky A. M., Clayberger C., IL-9 is associated with an impaired Th1 immune response in patients with tuberculosis Clinical Immunology 2008 126 2 202 210
82. Edwards D., Kirkpatrick C. H., The immunology of mycobacterial diseases American Review of Respiratory Disease 1986 134 5 1062 1071
83. Ellner J. J., Suppressor adherent cells in human tuberculosis Journal of Immunology 1978 121 6 2573 2579 (Pubitemid 9075167)
84. Klimpel G. R., Henney C. S., BCG-induced suppressor cells. I. Demonstration of a macrophage-like suppressor cell that inhibits cytotoxic T cell generation in vitro Journal of Immunology 1978 120 2 563 569 (Pubitemid 8275941)
85. Couper K. N., Blount D. G., Riley E. M., IL-10: the master regulator of immunity to infection Journal of Immunology 2008 180 9 5771 5777
86. Li M. O., Wan Y. Y., Sanjabi S., Robertson A. K. L., Flavell R. A., Transforming growth factor- regulation of immune responses Annual Review of Immunology 2006 24 99 146
87. Tomioka H., Saito H., Yamada Y., Characteristics of immunosuppressive macrophages induced in spleen cells by Mycobacterium avium complex infections in mice Journal of General Microbiology 1990 136 5 965 973 (Pubitemid 20165342)
88. Tomioka H., Saito H., Sato K., Characteristics of immunosuppressive macrophages induced in host spleen cells by Mycobacterium avium complex and Mycobacterium tuberculosis infections in mice Microbiology and Immunology 1990 34 3 283 297 (Pubitemid 20244891)
89. Tomioka H., Saito H., Characterization of immunosuppressive functions of murine peritoneal macrophages induced with various agents Journal of Leukocyte Biology 1992 51 1 24 31
90. Boraschi D., Soldateschi D., Tagliabue A., Macrophage activation by interferon: dissociation between tumoricidal capacity and suppressive activity European Journal of Immunology 1982 12 4 320 326 (Pubitemid 12101009)
91. Tomioka H., Maw W. W., Sato K., Saito H., The role of tumour necrosis factor- in combination with interferon- or interleukin-1 in the induction of immunosuppressive macrophages because of Mycobacterium avium complex infection Immunology 1996 88 1 61 67 (Pubitemid 26166377)
92. Tatano Y., Shimizu T., Tomioka H., Properties of immunosuppressive macrophages generated by Mycobacterium intracellulare infection in M. intracellulare -susceptible and resistant mice New Microbiologica 2010 33 1 87 91
93. Gosselin D., Turcotte R., Lemieux S., Phenotypic characterization of two cell populations involved in the acquisition of suppressor activity by cultured spleen cells from Mycobacterium lepraemurium -infected mice Clinical and Experimental Immunology 1995 102 3 515 522 (Pubitemid 26014834)
94. Gosselin D., Turcotte R., Lemieux S., Cyclophosphamide treatment antagonizes the in vitro development of Mycobacterium lepraemurium -induced suppressor cell precursors Clinical and Experimental Immunology 1992 89 2 185 191
95. Gosselin D., Turcotte R., Lemieux S., Cellular target of in vitro -induced suppressor cells derived from the spleen of Mycobacterium lepraemurium -infected mice and role of IFN- in their development Journal of Leukocyte Biology 1995 57 1 122 128
96. Tomioka H., Sato K., Maw W. W., Saito H., The role of tumor necrosis factor, interferon-, transforming growth factor-, and nitric oxide in the expression of immunosuppressive functions of splenic macrophages induced by Mycobacterium avium complex infection Journal of Leukocyte Biology 1995 58 6 704 712 (Pubitemid 26033859)
97. Tomioka H., Kishimoto T., Maw W. W., Phospholipids and reactive nitrogen intermediates collaborate in expression of the T cell mitogenesis-inhibitory activity of immunosuppressive macrophages induced in mycobacterial infection Clinical and Experimental Immunology 1996 103 2 219 225 (Pubitemid 26045362)
98. Maw W. W., Shimizu T., Sato K., Tomioka H., Further study on the roles of the effector molecules of immunosuppressive macrophages induced by mycobacterial infection in expression of their suppressor function against mitogen-stimulated T cell proliferation Clinical and Experimental Immunology 1997 108 1 26 33 (Pubitemid 27140326)
99. Cai S., Shimizu T., Tomioka H., Comparative studies on the roles of mediator molecules in expression of the suppressor activity of Mycobacterium avium complex-induced immunosuppressive macrophages against T cell and B cell mitogenic responses Clinical and Experimental Immunology 2006 143 3 560 571
100. Ogasawara K., Tomioka H., Shimizu T., Sano C., Kawauchi H., Sato K., Profiles of cell-to-cell interaction of Mycobacterium intracellulare -induced immunosuppressive macrophages with target T cells in terms of suppressor signal transmission Clinical and Experimental Immunology 2002 129 2 272 280
101. Schauble T. L., Boom W. H., Finegan C. K., Rich E. A., Characterization of suppressor function of human alveolar macrophages for T lymphocyte responses to phytohemagglutinin: cellular selectivity, reversibility, and early events in T cell activation American Journal of Respiratory Cell and Molecular Biology 1993 8 1 89 97
102. Martin S. J., Reutelingsperger C. P. M., McGahon A. J., Rader J. A., van Schie R. C. A. A., LaFace D. M., Green D. R., Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl Journal of Experimental Medicine 1995 182 5 1545 1556
103. Shimizu T., Sano C., Tomioka H., The role of B7 molecules in the cell contact-mediated suppression of T cell mitogenesis by immunosuppressive macrophages induced with mycobacterial infection Clinical and Experimental Immunology 2004 135 3 373 379 (Pubitemid 38297137)
104. Smith-Garvin J. E., Koretzky G. A., Jordan M. S., T cell activation Annual Review of Immunology 2009 27 591 619
105. Nakayama T., Yamashita M., The TCR-mediated signaling pathways that control the direction of helper T cell differentiation Seminars in Immunology 2010 22 5 303 309
106. Suzuki Y., Demoliere C., Kitamura D., Takeshita H., Deuschle U., Watanabe T., HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases Journal of Immunology 1997 158 6 2736 2744 (Pubitemid 127470532)
107. Deindl S., Kadlecek T. A., Brdicka T., Cao X., Weiss A., Kuriyan J., Structural basis for the inhibition of tyrosine kinase activity of ZAP-70 Cell 2007 129 4 735 746 (Pubitemid 46802380)
108. Barber E. K., Dasgupta J. D., Schlossman S. F., Trevillyan J. M., Rudd C. E., The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p5 6lck) that phosphorylates the CD3 complex Proceedings of the National Academy of Sciences of the United States of America 1989 86 9 3277 3281 (Pubitemid 19129594)
109. Tamir A., Granot Y., Isakov N., Inhibition of T lymphocyte activation by cAMP is associated with down-regulation of two parallel mitogen-activated protein kinase pathways, the extracellular signal-related kinase and c-Jun N-terminal kinase Journal of Immunology 1996 157 4 1514 1522 (Pubitemid 126449088)
110. Ramstad C., Sundvold V., Johansen H. K., Lea T., cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of raf-1 in the MAPK/ERK pathway Cellular Signalling 2000 12 8 557 563
111. Lammas D. A., Stober C., Harvey C. J., Kendrick N., Panchalingam S., Kumararatne D. S., ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X 7) receptors Immunity 1997 7 3 433 444 (Pubitemid 27446017)
112. Kusner D. J., Adams J., ATP-induced killing of virulent Mycobacterium tuberculosis within human macrophages requires phospholipase D Journal of Immunology 2000 164 1 379 388 (Pubitemid 30013012)
113. Filardy A. A., Pires D. R., Nunes M. P., Takiya C. M., Freire-de-Lima C. G., Ribeiro-Gomes F. L., DosReis G. A., Proinflammatory clearance of apoptotic neutrophils induces an IL-1 2low IL-1 0high regulatory phenotype in macrophages Journal of Immunology 2010 185 4 2044 2050
114. Wang G. W., Huang B. K., Qin L. P., The genus Broussonetia: a review of its phytochemistry and pharmacology Phytotherapy Research 2012 26 1 1 10
115. Amsden G. W., Anti-inflammatory effects of macrolidesan underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions? Journal of Antimicrobial Chemotherapy 2005 55 1 10 21 (Pubitemid 40192609)