Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-γ by CD4+ naïve T cells

European Journal of Pharmacology

Volumn 643, Issue 2-3, 2010, Pages 297-303

  Jung, Tae Young ^b   Pham, Thanh Nhan Nguyen ^a   Umeyama, Akemi ^c   Shoji, Noboru ^c   Hashimoto, Toshihiro ^c   Lee, Je Jung ^a,b   Takei, Masao ^a  

^a Chonnam National University Hwasun Hospital and Medical School   (South Korea)

^b Chonnam National University Medical School   (South Korea)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Dendritic cell; IL 12p70; Th1; TLR2 and TLR4; Ursolic acid

Indexed keywords

B7 ANTIGEN; CD83 ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE; T6 ANTIGEN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; URSOLIC ACID;

ARTICLE; CD4+ T LYMPHOCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE REACTION; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; UNCARIA; UNCARIA RHYNCHOPHYLLA;

EID: 77955282458     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.030     Document Type: Article

References (29)

1. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 106:245-252.
2. Banchereau J., Biere F., Caux C. Immunobiology of dendritic cells. Annu. Rev. Immunol. 2000, 18:767-811.
3. Forster R., Schube l.A., Breitfeld D. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organ. Cell 1999, 99:23-33.
4. Gately M.K., Renzetti L.M., Magram J. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 1998, 16:495-521.
5. Grage-Griebenow D., Lorenzen R., Fetting H.D. Phenotypical and functional characterization of FCγ receptor 1 (CD64)-negative Mo, a minor human monocyte subpoplation with high accessory and antiviral activity. Eur. J. Immunol. 1993, 23:3126-3131.
6. Hermann P., Rubio M., Nakajima T., Delespesse G., Sarfati M. IFN-γ priming of human monocytes differentially regulates Gram positive and Gram negative bacteria-induced IL-10 release and selectively enhances IL-12p70, CD80 and MHC class I expression. J. Immunol. 1998, 161:2011-2018.
7. Hsieh C.S., Macatonia S.E., Tripp C.S. Development of Th1 CD4+ T cells through IL-12 produced by Losteria-induced macrophages. Science 1997, 260:547-549.
8. Kanzler H., Barrat F.J., Hessel E.M., Coffman R.L. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat. Med. 2007, 13:552-559.
9. Kawasaki K., Akashi S., Shimazu R., Yoshida T., Miyake K., Nishijima M. Mouse Toll-like receptor 4. MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J. Biol. Chem. 2000, 275:2251-2254.
10. Krieg A.M. Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov. 2006, 5:471-484.
11. Kuchroo V.K., Dasa M.P., Brown A.M. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathways: application to autoimmune disease therapy. Cell 1995, 80:707-713.
12. Lanzavecchia A., Sallustoa A.F. Regulation of T cell immunity by dendritic cells. Cell 2001, 106:263-266.
13. Lederer J.A., Perez V.L., Desroches L., Kim S.M., Abbas A., Lichtman A.H. Cytokine transcriptional events during helper T cell subset differentiation. J. Exp. Med. 1996, 184:397-406.
14. Lee J.S., Kim J., Kim B.Y., Lee H.S., Ahn J.S., Chang Y.S. Inhibition of phospholipase Cγ1 and cancer cell proliferation by triterpene ester from Uncaria rhynchophylla. J. Nat. Prod. 2000, 63:753-756.
15. Lezz G., Scotet E., Scheidegger D., Lanzavecchia A. The interplay between the duration of TCR and cytokine signaling determines T cell polarization. Eur. J. Immunol. 1999, 29:4092-4101.
16. Mellman I., Steinman R.M. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001, 106:2555-2558.
17. O'garra A.C. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 2001, 8:275-278.
18. Okamoto M., Sato M. Toll-like receptor signaling in anti-cancer immunity. J. Med. Invest. 2003, 50:9-24.
19. Romagnani S. Lymphokine production by human T cells in disease state. Annu. Rev. Immunol. 1994, 12:227-257.
20. Seya T., Matsumoto M., Tsuji S., Begum N.A., Nomura M., Azuma I., Hayashi A., Toyoshima K. Two receptor theory in innate immune activation: studies on the receptors for bacillus Calmette-Guerin-cell wall skeleton. Arch. Immunol. Ther. Exp. 2001, 49:S13-S21.
21. Steinman R.M. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat. Med. 2007, 13:139-145.
22. Steinman R.M., Dhodapkar M. Active immunization against cancer with dendritic cells: the near future. Int. J. Cancer 2001, 95:459-473.
23. Takei M., Umeyam A., Hashimoto T. Epicubenol and Ferruginol induce DC from human monocytes and differentiate IL-10-producing regulatory T cells in vitro. Biochem. Biophys. Res. Commun. 2005, 337:730-738.
24. Takei M., Umeyama A., Shoji N., Hashimoto T. Diterpenes inhibit IL-12 production by DC and enhance Th2 cells polarization. Biochem. Biophys. Res. Commun. 2007, 355:603-610.
25. Takei M., Umeyama A., Shoji N., Hashimoto T. Diterpene, 16-phyllocladanol enhances Th1 polarization induced by LPS-primed DC, but not TNF-α-primed DC. Biochem. Biophys. Res. Commun. 2008, 370:6-10.
26. Tanaka H., Demeure C.E., Rubio M., Delespesse G., Sarfati M. Human monocyte-derived dendritic cells induce naïve T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors: role of stimulator/responder ratio. J. Exp. Med. 2000, 192:403-411.
27. Tao X., Grant S., Constant K., Bottomly K. Induction of IL-4 producing CD4+ T cells by antigenic peptides altered for TCR binding. J. Immunol. 1997, 158:4237-4244.
28. Trepiakas R., Pedersen A.E., Met O., Svane I.M. Addition of interferon-alpha to a standard maturation cocktail induces CD38 up-regulation and increases dendritic cell function. Vaccine 2009, 27:2213-2219.
29. Trinchieri G., Scott P. The role of interleukin 12 in the immune response, disease and therapy. Immunol. Today 1994, 15:460-463.