Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius

Journal of Ethnopharmacology

Volumn 111, Issue 1, 2007, Pages 22-28

  Dufour, Dominic ^a   Pichette, André ^a   Mshvildadze, Vakhtang ^a   Bradette Hébert, Marie Eve ^a   Lavoie, Serge ^a   Longtin, Angélique ^a   Laprise, Catherine ^a   Legault, Jean ^a  

^a UNIVERSITÉ DU QUÉBEC À CHICOUTIMI   (Canada)

Author keywords

Anti inflammatory; Anticancer; Antioxidant; Ledum groenlandicum Retzius; Ursolic acid

Indexed keywords

LEDUM GROENLANDICUM RETZIUS EXTRACT; LIPOPOLYSACCHARIDE; METHANOL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PLANT EXTRACT; TRITERPENE; UNCLASSIFIED DRUG; URSOLIC ACID;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; COLON CARCINOMA; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG ISOLATION; HUMAN; HUMAN CELL; IC 50; LEDUM; LEDUM GRONLANDICUM RETZIUS; LUNG CARCINOMA; MEDICINAL PLANT; MOUSE; NONHUMAN; PLANT LEAF; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; CANADA; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LEDUM; MACROPHAGES; METHANOL; MICE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATION-REDUCTION; PHENOLS; PLANT BARK; PLANT EXTRACTS; PLANT LEAVES; REACTIVE OXYGEN SPECIES; SOLVENTS; TRITERPENES;

ERICACEAE; RHODODENDRON; RHODODENDRON GROENLANDICUM;

EID: 33947693346     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.10.021     Document Type: Article

References (40)

1. Andreadis A.A., Hazen S.L., Comhair S.A., and Erzurum S.C. Oxidative and nitrosative events in asthma. Free Radical Biology & Medicine 35 (2003) 213-225
2. Andersson D., Liu J.J., Nilsson A., and Duan R.D. Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase. Anticancer Research 23 (2003) 3317-3322
3. Basnet P., Kadota S., Terashima S., Shimizu M., and Namba T. Two new 2-arylbenzofuran derivatives from hypoglycemic activity-bearing fractions of Morus insignis. Chemical and Pharmaceutical Bulletin (Tokyo) 41 (1993) 1238-1243
4. Bauerova K., and Bezek A. Role of reactive oxygen and nitrogen species in etiopathogenesis of rheumatoid arthritis. General Physiology and Biophysics 18 (1999) 15-20
5. Burgesse J.A. The woman and the child among the Lac-St.-Jean Montagnais. Primitive Man 17 (1944) 1-18
6. Chandler R.F., Freeman L., and Hooper S.H. Herbal remedies of the maritime Indians. Journal of Ethnopharmacology 1 (1979) 49-68
7. Chandramu C., Manohar R.D., Krupadanam D.G.L., and Dashavantha R.V. Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytotherapy Research 17 (2003) 129-134
8. Collins M.A., and Charles H.P. Antimicrobial activity of carnosol and ursolic acid: two anti-oxidant constituents of Rosmarinus officinalis. Food Microbiology 4 (1987) 311-315
9. Costa V.B., Coube C.S., Marinho B.G., Matheus M.E., Leitao S.G., and Fernandes P.D. Anti-inflammatory and analgesic activity of Bouchea fluminensis. Fitoterapia 74 (2003) 364-371
10. Fan Y.M., Xu L.Z., Gao J., Wang Y., Tang X.H., Zhao X.N., and Zhang Z.X. Phytochemical and antiinflammatory studies on Terminalia catappa. Fitoterapia 75 (2004) 253-260
11. Frère M.-V. Flore Laurentienne. Troisième ed. (1995), Les Presses de l'Université de Montréal, Montréal, Canada
12. Green S.J., Meltzer M.S., Hibbs Jr. J.B., and Nacy C.A. Activated macrophages destroy intracellular Leishmania major amastigotes by an l-arginine-dependent killing mechanism. Journal of Immunology 144 (1990) 278-283
13. Gunther E. Ethnobotany of Western Washington. revised ed. (1973), University of Washington Press, Seattle, USA
14. Gupta M.B., Nath R., Gupta G.P., and Bhargava K.P. Antiulcer activity os some plant triterpenoids. Indian Journal of Medical Research 73 (1981) 649-652
15. Horton J.W. Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy. Toxicology 189 (2003) 75-88
16. Hsu H.-Y., Yang J.J., and Lin C.-C. Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of hematopoeietic system postirradiation in mice. Cancer Letters 111 (1997) 7-13
17. Jiang F., and Dusting G.J. Natural phenolic compounds as cardiovascular therapeutics: potential role of their antiinflammatory effects. Current Vascular Pharmacology 1 (2003) 135-156
18. Jin C., Strembiski W., Kulchytska Y., Micetich R.G., and Daneshtalab M. Flavonoid glycosides from Ledum palustre subsp. decumbens. Daru 7 (1999) 5-8
19. Jobidon, R., 1995. Autoécologie de quelques espèces de compétition d'importance pour la régénération forestière au Québec. Mémoire de recherche forestière 117, Gouvernement du Québec.
20. Kim S.H., Ahn B.-Z., and Ryu S.Y. Antitumor effects of ursolic acid isolated from Oldenlandia diffus. Phytotherapy Research 12 (1998) 553-556
21. Kriwacki R.W., and Pitner T.P. Current aspects of pratical two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy: applications to structure elucidation. Pharmaceutical Research 7 (1989) 531-554
22. Legault J., Dahl W., Debiton E., Pichette A., and Madelmont J.C. Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as possible mechanism of action. Planta Medica 69 (2003) 402-407
23. Leighton A.L. Wild Plant Use by the Woods Cree (Nihithawak) of East-Central Saskatchewan (1985), National Museums of Canada, Mercury Series, Ottawa, Canada
24. Li J., Guo W.J., and Yang Q.Y. Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15. World Journal of Gastroenterology 8 (2002) 493-495
25. Liu J. Pharmacology of oleanolic acid and ursolic acid. Journal of Ethnopharmacology 49 (1995) 57-68
26. Middleton Jr. E. Effect of plant flavonoids on immune and inflammatory cell function. Advances in Experimental Medicine and Biology 439 (1998) 175-182
27. Moerman D.E. Native American Ethnobotany. third ed. (2000), Timber Press Inc., Portland, USA
28. Mshvildadze V., Elias R., Faure R., Rondeau D., Debrauwer L., Dekanosidze G., Kemertelidze E., Balansard G., and Triterpenoid. Saponins from Leaves of Hedera pastuchowii. Chemical & Pharmaceutical Bulletin 52 (2004) 1411-1415
29. Muto Y., Ninomiya M., and Fujiki H. Present status research on cancer chemoprevention in Japan. Japanese Journal of Clinical Oncology 20 (1990) 219-224
30. O'Brien J., Wilson I., Orton T., and Pognan F. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. European Journal of Biochemistry 267 (2000) 5421-5426
31. Ou B., Hampsch-Woodill M., and Prior R.L. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. Journal of Agricultural and Food Chemistry 49 (2001) 4619-4626
32. Owen P.L., and Johns T. Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout. Journal of Ethnopharmacology 64 (1999) 149-160
33. Paul A., Bryant C., Lawson M.F., Chilvers E.R., and Plevin R. Dissociation of lipopolysaccharide-mediated induction of nitric oxide synthase and inhibition of DNA synthesis in RAW 264.7 macrophages and rat aortic smooth muscle cells. British Journal of Pharmacology 120 (1997) 1439-1444
34. Rahman I. Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets. Current Drug Targets Inflammation & Allergy 1 (2002) 291-315
35. Rousseau J. Ethnobotanique Abenakise. Archives de Folklore 11 (1947) 145-182
36. Ryu S.Y., Oak M.H., Yoon S.K., Cho D.I., Yoo G.S., Kim T.S., and Kim K.M. Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris. Planta Medica 66 (2000) 358-360
37. Shukla B., Visen P.K.S., Patnaik G.K., Tripathi S.C., Srimal R.C., Dayal R., and Dobhal D.C. Hepatoprotective activity in the rat of ursolic acid isolated from Eucalyptus hybrid. Phytotherapy Research 6 (1992) 74-79
38. Singleton V.L., and Rossi J.A. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture 16 (1965) 144-158
39. Szabo C. Multiple pathways of peroxynitrite cytotoxicity. Toxicology Letters 140-141 (2003) 105-112
40. Turner N.J., Bouchard R., and Kennedy D.I.D. Ethnobotany of the Okanagan-Colville Indians of British Columbia and Washington (1980), British Columbia Provincial Museum, Victoria, Canada