Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: A potential target for new drugs for leprosy treatment

Cellular Microbiology

Volumn 16, Issue 6, 2014, Pages 797-815

  Mattos, Katherine A ^a,g   Oliveira, Viviane C G ^a   Berrêdo Pinho, Marcia ^a   Amaral, Julio J ^a,h   Antunes, Luis Caetano M ^a,b   Melo, Rossana C N ^c   Acosta, Chyntia C D ^a   Moura, Danielle F ^a   Olmo, Roberta ^a   Han, Jun ^d   Rosa, Patricia S ^e   Almeida, Patrícia E ^a,c   Finlay, B Brett ^b   Borchers, Christoph H ^d   Sarno, Euzenir N ^a   Bozza, Patricia T ^a   Atella, Georgia C ^f   Pessolani, Maria Cristina V ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

^d UNIVERSITY OF VICTORIA   (Canada)

^e INSTITUTO LAURO DE SOUZA LIMA   (Brazil)

^f FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^g Instituto de Technologia em Imunobiologicos   (Brazil)

^h INSTITUTO NACIONAL DE METROLOGIA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; CHOLESTEROL; FAT DROPLET; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; SCAVENGER RECEPTOR BI; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; BACTERIAL SURVIVAL; BIOACCUMULATION; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LEPROMATOUS LEPROSY; LEPROSY; MACROPHAGE; MOUSE; MYCOBACTERIUM LEPRAE; NONHUMAN; PATHOPHYSIOLOGY; PHAGOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BIOPSY; TUBERCULOID LEPROSY; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; GENE EXPRESSION PROFILING; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; MICROBIAL VIABILITY; MICROBIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM LEPRAE;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CHOLESTEROL; GENE EXPRESSION PROFILING; HOST-PATHOGEN INTERACTIONS; HUMANS; LEPROSY; MACROPHAGES; MICE, INBRED C57BL; MICROBIAL VIABILITY; MYCOBACTERIUM LEPRAE; PHAGOSOMES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, LDL; STEROL REGULATORY ELEMENT BINDING PROTEINS;

EID: 84900549160     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/cmi.12279     Document Type: Article

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