An obesity-predisposing variant of the FTO gene regulates D2R-dependent reward learning

Journal of Neuroscience

Volumn 35, Issue 36, 2015, Pages 12584-12592

  Sevgi, Meltem ^a   Rigoux, Lionel ^a   Kühn, Anne B ^a,b   Mauer, Jan ^c   Schilbach, Leonhard ^b,d   Hess, Martin E ^a   Gruendler, Theo O J ^b,e,f   Ullsperger, Markus ^e,f,g   Stephan, Klaas Enno ^a,h,i   Brüning, Jens C ^a,b,j   Tittgemeyer, Marc ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^e OTTO VON GUERICKE UNIVERSITY   (Germany)

^f CENTER FOR BEHAVIORAL BRAIN SCIENCES   (Germany)

^g RADBOUD UNIVERSITY   (Netherlands)

^h UNIVERSITY OF ZURICH   (Switzerland)

ⁱ UNIVERSITY COLLEGE LONDON   (United Kingdom)

^j UNIVERSITY OF COLOGNE   (Germany)

more..

Author keywords

Dopamine; FMRI; Genetics; Modeling; Obesity; Reinforcement learning

Indexed keywords

DOPAMINE 2 RECEPTOR; ANKK1 PROTEIN, HUMAN; FTO PROTEIN, HUMAN; PROTEIN; PROTEIN SERINE THREONINE KINASE;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; DECISION MAKING; DNA ISOLATION; FAT MASS; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC VARIABILITY; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; LEARNING; MALE; MATHEMATICAL MODEL; NORMAL HUMAN; OBESITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REWARD; STIMULUS RESPONSE; TASK PERFORMANCE; WECHSLER ADULT INTELLIGENCE SCALE; CONNECTOME; GENETICS; MESENCEPHALON; METABOLISM; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CONNECTOME; FEMALE; HUMANS; MALE; MESENCEPHALON; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RECEPTORS, DOPAMINE D2; REWARD;

EID: 84941241692     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1589-15.2015     Document Type: Article

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