Alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A

Journal of Biological Chemistry

Volumn 285, Issue 42, 2010, Pages 31974-31984

  Lee, Andrea W ^a,c   Champagne, Nathalie ^a   Wang, Xiaojun ^b   Su, Xiao Dong ^b   Goodyer, Cynthia ^c   LeBlanc, Andrea C ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b PEKING UNIVERSITY   (China)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CASPASE ACTIVATION; CASPASES; CATALYTIC SITES; CELL LINES; HUMAN BRAIN; HUMAN NEURONS; IN-CELL; IN-VITRO; ISOFORMS; PROTEOLYTIC ACTIVATION;

CELL CULTURE;

CASPASE 6; CASPASE 6A; CASPASE 6B; ISOENZYME; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; CATALYSIS; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; NERVE CELL; NERVE FIBER DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ALTERNATIVE SPLICING; BRAIN; CASPASE 6; CELL LINE; ENZYME ACTIVATION; GENE SILENCING; HUMANS; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN ISOFORMS; PROTEIN PRECURSORS; PROTEIN STABILITY; RNA, SMALL INTERFERING;

EID: 77957802330     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.152744     Document Type: Article

References (34)

1. Kumar, S. (2007) Cell Death Differ. 14, 32-43
2. Alnemri, E. S., Fernandes-Alnemri, T., and Litwack, G. (1995) J. Biol. Chem. 270, 4312-4317
3. Huang, Y., Shin, N. H., Sun, Y., and Wang, K. K. (2001) Biochem. Biophys. Res. Commun. 283, 762-769
4. Mohr, A., Zwacka, R. M., Jarmy, G., Büneker, C., Schrezenmeier, H., Döhner, K., Beltinger, C., Wiesneth, M., Debatin, K. M., and Stahnke, K. (2005) Oncogene 24, 2421-2429
5. Himeji, D., Horiuchi, T., Tsukamoto, H., Hayashi, K., Watanabe, T., and Harada, M. (2002) Blood 99, 4070-4078
6. Seol, D. W., and Billiar, T. R. (1999) J. Biol. Chem. 274, 2072-2076
7. Wang, L., Miura, M., Bergeron, L., Zhu, H., and Yuan, J. (1994) Cell 78, 739-750
8. Ito, A., Uehara, T., and Nomura, Y. (2000) FEBS Lett. 470, 360-364
9. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. (1995) Cancer Res. 55, 2737-2742
10. Grossmann, J., Mohr, S., Lapentina, E. G., Fiocchi, C., and Levine, A. D. (1998) Am. J. Physiol. 274, G1117-G1124
11. Olson, N. E., Graves, J. D., Shu, G. L., Ryan, E. J., and Clark, E. A. (2003) J. Immunol. 170, 6065-6072
12. Watanabe, C., Shu, G. L., Zheng, T. S., Flavell, R. A., and Clark, E. A. (2008) J. Immunol. 181, 6810-6819
13. Morozov, V., and Wawrousek, E. F. (2006) Development 133, 813-821
14. Zandy, A. J., Lakhani, S., Zheng, T., Flavell, R. A., and Bassnett, S. (2005) J. Biol. Chem. 280, 30263-30272
15. Zandy, A. J., and Bassnett, S. (2007) Invest. Ophthalmol. Vis. Sci. 48, 293-302
16. Foley, J. D., Rosenbaum, H., and Griep, A. E. (2004) J. Biol. Chem. 279, 32142-32150
17. LeBlanc, A., Liu, H., Goodyer, C., Bergeron, C., and Hammond, J. (1999) J. Biol. Chem. 274, 23426-23436
18. Zhang, Y., Goodyer, C., and LeBlanc, A. (2000) J. Neurosci. 20, 8384-8389
19. Guo, H., Pétrin, D., Zhang, Y., Bergeron, C., Goodyer, C. G., and LeBlanc, A. C. (2006) Cell Death Differ. 13, 285-292
20. Guo, H., Albrecht, S., Bourdeau, M., Petzke, T., Bergeron, C., and LeBlanc, A. C. (2004) Am. J. Pathol. 165, 523-531
21. Albrecht, S., Bogdanovic, N., Ghetti, B., Winblad, B., and LeBlanc, A. C. (2009) J. Neuropathol. Exp. Neurol. 68, 1282-1293
22. Albrecht, S., Bourdeau, M., Bennett, D., Mufson, E. J., Bhattacharjee, M., and LeBlanc, A. C. (2007) Am. J. Pathol. 170, 1200-1209
23. Klaiman, G., Petzke, T. L., Hammond, J., and LeBlanc, A. C. (2008) Mol. Cell Proteomics 7, 1541-1555
24. Klaiman, G., Champagne, N., and LeBlanc, A. C. (2009) Biochim. Biophys. Acta 1793, 592-601
25. Nikolaev, A., McLaughlin, T., O'Leary, D. D., and Tessier-Lavigne, M. (2009) Nature 457, 981-989
26. Giaime, E., Sunyach, C., Druon, C., Scarzello, S., Robert, G., Grosso, S., Auberger, P., Goldberg, M. S., Shen, J., Heutink, P., Pouysségur, J., Pagès, G., Checler, F., and Alves da Costa, C. (2010) Cell Death Differ. 17, 158-169
27. Graham, R. K., Deng, Y., Slow, E. J., Haigh, B., Bissada, N., Lu, G., Pearson, J., Shehadeh, J., Bertram, L., Murphy, Z., Warby, S. C., Doty, C. N., Roy, S., Wellington, C. L., Leavitt, B. R., Raymond, L. A., Nicholson, D. W., and Hayden, M. R. (2006) Cell 125, 1179-1191
28. Vaux, D. L., and Silke, J. (2005) Nat. Rev. Mol. Cell Biol. 6, 287-297
29. Zhang, Y., Tounekti, O., Akerman, B., Goodyer, C. G., and LeBlanc, A. (2001) J. Neurosci. 21, RC176
30. LeBlanc, A. (1995) J. Neurosci. 15, 7837-7846
31. Denault, J., and Salvesen, G. (2002) in Current Protocols in Protein Science, Unit 21.13.21-21.13.15, John Wiley & Sons, Inc., New York
32. Roucou, X., Giannopoulos, P. N., Zhang, Y., Jodoin, J., Goodyer, C. G., and LeBlanc, A. (2005) Cell Death Differ. 12, 783-795
33. Dorsett, Y., and Tuschl, T. (2004) Nat. Rev. Drug Discov. 3, 318-329
34. Tounekti, O., Zhang, Y., Klaiman, G., Goodyer, C. G., and LeBlanc, A. (2004) J. Neurochem. 89, 561-568