Biodegradation and Toxicity of Protease/Redox/pH Stimuli-Responsive PEGlated PMAA Nanohydrogels for Targeting Drug delivery

ACS Applied Materials and Interfaces

Volumn 7, Issue 35, 2015, Pages 19843-19852

  Jin, Sha ^a   Wan, Jiaxun ^a   Meng, Lizheng ^b   Huang, Xiaoxing ^b   Guo, Jia ^a   Liu, Li ^b   Wang, Changchun ^a  

^a FUDAN UNIVERSITY   (China)

^b Shanghai Institute of Phamaceutical Industry ^*  (China)

Author keywords

acute toxicity; biodegradable; dual drug loading; intravital fluorescence imaging; multi stimuli responsive; nanohydrogels; surface modification

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADABLE POLYMERS; BIODEGRADATION; COVALENT BONDS; CROSSLINKING; DISEASES; DRUG PRODUCTS; FLUORESCENCE; FUNCTIONAL POLYMERS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SURFACE TREATMENT; TOXICITY; TUMORS;

ACUTE TOXICITY; BIODEGRADABLE; DRUG LOADING; FLUORESCENCE IMAGING; NANOHYDROGELS; STIMULI-RESPONSIVE;

BIOMATERIALS;

ANTINEOPLASTIC AGENT; DOXORUBICIN; DRUG CARRIER; FOLIC ACID; GLUTATHIONE; HYDROGEL; MACROGOL DERIVATIVE; NANOMATERIAL; PACLITAXEL; PEPTIDE HYDROLASE; POLYMETHACRYLIC ACID; POLYMETHACRYLIC ACID DERIVATIVE;

ANIMAL; BIOREMEDIATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG RELEASE; HELA CELL LINE; HUMAN; HYDROGEL; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; PH;

ANIMALS; ANTINEOPLASTIC AGENTS; BIODEGRADATION, ENVIRONMENTAL; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; DRUG LIBERATION; FOLIC ACID; GLUTATHIONE; HELA CELLS; HUMANS; HYDROGELS; HYDROGEN-ION CONCENTRATION; MICE; MICE, INBRED ICR; NANOSTRUCTURES; OXIDATION-REDUCTION; PACLITAXEL; PEPTIDE HYDROLASES; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS;

EID: 84941123039     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b05984     Document Type: Article

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