Differential anticancer drug delivery with a nanogel sensitive to bacteria-accumulated tumor artificial environment

ACS Nano

Volumn 7, Issue 12, 2013, Pages 10636-10645

  Xiong, Meng Hua ^a   Bao, Yan ^a   Du, Xiao Jiao ^a   Tan, Zi Bin ^a   Jiang, Qiu ^a   Wang, Hong Xia ^a   Zhu, Yan Hua ^a   Wang, Jun ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

bacteria; cancer therapy; differential drug delivery; doxorubicin; nanogel

Indexed keywords

ANTI-CANCER DRUG DELIVERY; ARTIFICIAL ENVIRONMENTS; CANCER THERAPY; DOXORUBICIN; INTRAVENOUS ADMINISTRATION; NANOGELS; NORMAL TISSUE; TUMOR CELLS;

BACTERIA; DRUG DELIVERY; NANOSTRUCTURED MATERIALS; ONCOLOGY;

TUMORS;

ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; DOXORUBICIN; DRUG CARRIER; GREEN FLUORESCENT PROTEIN; TRIACYLGLYCEROL LIPASE;

ANIMAL; ARTICLE; BACTERIUM; BAGG ALBINO MOUSE; BURKHOLDERIA CEPACIA; CANCER TRANSPLANTATION; CELL LINE; CHEMISTRY; DRUG DELIVERY SYSTEM; EXPERIMENTAL NEOPLASM; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER; MALE; METABOLISM; MOUSE; NANOMEDICINE; NEOPLASM; NUDE MOUSE; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ALKALINE PHOSPHATASE; ANIMALS; ANTINEOPLASTIC AGENTS; BACTERIA; BURKHOLDERIA CEPACIA; CELL LINE; CELL LINE, TUMOR; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; GREEN FLUORESCENT PROTEINS; HUMANS; INFUSIONS, INTRAVENOUS; LIPASE; LIVER; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOMEDICINE; NEOPLASM TRANSPLANTATION; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; TISSUE DISTRIBUTION;

EID: 84891362214     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn403146t     Document Type: Article

References (39)

1. LaVan, D. A.; McGuire, T.; Langer, R. Small-Scale Systems for In Vivo Drug Delivery Nat. Biotechnol. 2003, 21, 1184-1191
2. Springer, C. J.; Niculescu Duvaz, I. Antibody-Directed Enzyme Prodrug Therapy (ADEPT): A Review Adv. Drug Delivery Rev. 1997, 26, 151-172
3. Yeo, Y.; Gullotti, E. Extracellularly Activated Nanocarriers: A New Paradigm of Tumor Targeted Drug Delivery Mol. Pharmaceutics 2009, 6, 1041-1051
4. Slowing, I. I.; Vivero-Escoto, J. L.; Wu, C. W.; Lin, V. S. Y. Mesoporous Silica Nanoparticles as Controlled Release Drug Delivery and Gene Transfection Carriers Adv. Drug Delivery Rev. 2008, 60, 1278-1288
5. Du, J. Z.; Du, X. J.; Mao, C. Q.; Wang, J. Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery J. Am. Chem. Soc. 2011, 133, 17560-17563
6. Fleige, E.; Quadir, M. A.; Haag, R. Stimuli-Responsive Polymeric Nanocarriers for the Controlled Transport of Active Compounds: Concepts and Applications Adv. Drug Delivery Rev. 2012, 64, 866-884
7. Zhu, L.; Kate, P.; Torchilin, V. P. Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting ACS Nano 2012, 6, 3491-3498
8. Timko, B. P.; Dvir, T.; Kohane, D. S. Remotely Triggerable Drug Delivery Systems Adv. Mater. 2010, 22, 4925-4943
9. Ferris, D. P.; Zhao, Y. L.; Khashab, N. M.; Khatib, H. A.; Stoddart, J. F.; Zink, J. I. Light-Operated Mechanized Nanoparticles J. Am. Chem. Soc. 2009, 131, 1686-1687
10. Vivero-Escoto, J. L.; Slowing, I. I.; Wu, C. W.; Lin, V. S. Y. Photoinduced Intracellular Controlled Release Drug Delivery in Human Cells by Gold-Capped Mesoporous Silica Nanosphere J. Am. Chem. Soc. 2009, 131, 3462-3463
11. Kong, S. D.; Zhang, W. Z.; Lee, J. H.; Brammer, K.; Lal, R.; Karin, M.; Jin, S. H. Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release Nano Lett. 2010, 10, 5088-5092
12. Mal, N. K.; Fujiwara, M.; Tanaka, Y. Photocontrolled Reversible Release of Guest Molecules from Coumarin-Modified Mesoporous Silica Nature 2003, 421, 350-353
13. Forbes, N. S. Engineering the Perfect (Bacterial) Cancer Therapy Nat. Rev. Cancer 2010, 10, 784-793
14. Arrach, N.; Cheng, P.; Zhao, M.; Santiviago, C. A.; Hoffman, R. M.; McClelland, M. High-Throughput Screening for Salmonella Avirulent Mutants That Retain Targeting of Solid Tumors Cancer Res. 2010, 70, 2165-2170
15. Pawelek, J. M.; Low, K. B.; Bermudes, D. Tumor-Targeted Salmonella as a Novel Anticancer Vector Cancer Res. 1997, 57, 4537-4544
16. Kawai, K.; Miyazaki, J.; Joraku, A.; Nishiyama, H.; Akaza, H. Bacillus Calmette-Guerin (BCG) Immunotherapy for Bladder Cancer: Current Understanding and Perspectives on Engineered BCG Vaccine Cancer Sci. 2013, 104, 22-27
17. Lamm, D. L. Bacillus Calmette-Guerin Immunotherapy for Bladder-Cancer J. Urol. 1985, 134, 40-47
18. Low, K. B.; Ittensohn, M.; Le, T.; Platt, J.; Sodi, S.; Amoss, M.; Ash, O.; Carmichael, E.; Chakraborty, A.; Fischer, J. et al. Lipid A Mutant Salmonella with Suppressed Virulence and TNF Alpha Induction Retain Tumor-Targeting in Vivo Nat. Biotechnol. 1999, 17, 37-41
19. Saccheri, F.; Pozzi, C.; Avogadri, F.; Barozzi, S.; Faretta, M.; Fusi, P.; Rescigno, M. Bacteria-Induced Gap Junctions in Tumors Favor Antigen Cross-Presentation and Antitumor Immunity Sci. Transl. Med. 2010, 2, 44ra57
20. Cheong, I.; Huang, X.; Bettegowda, C.; Diaz, L. A.; Kinzler, K. W.; Zhou, S. B.; Vogelstein, B. A Bacterial Protein Enhances the Release and Efficacy of Liposomal Cancer Drugs Science 2006, 314, 1308-1311
21. Dang, L. H.; Bettegowda, C.; Huso, D. L.; Kinzler, K. W.; Vogelstein, B. Combination Bacteriolytic Therapy for the Treatment of Experimental Tumors Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 15155-15160
22. Zhao, M.; Yang, M.; Ma, H. Y.; Li, X. M.; Tan, X. Y.; Li, S. K.; Yang, Z. J.; Hoffman, R. M. Targeted Therapy with a Salmonella Typhimurium Leucine-Arginine Auxotroph Cures Orthotopic Human Breast Tumors in Nude Mice Cancer Res. 2006, 66, 7647-7652
23. Sznol, M.; Lin, S. L.; Bermudes, D.; Zheng, L. M.; King, I. Use of Preferentially Replicating Bacteria for the Treatment of Cancer J. Clin. Invest. 2000, 105, 1027-1030
24. Yu, Y. A.; Shabahang, S.; Timiryasova, T. M.; Zhang, Q.; Beltz, R.; Gentschev, I.; Goebel, W.; Szalay, A. A. Visualization of Tumors and Metastases in Live Animals with Bacteria and Vaccinia Virus Encoding Light-Emitting Proteins Nat. Biotechnol. 2004, 22, 313-320
25. Diep, D. B.; Skaugen, M.; Salehian, Z.; Holo, H.; Nes, I. F. Common Mechanisms of Target Cell Recognition and Immunity for Class II Bacteriocins Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 2384-2389
26. Yu, B.; Yang, M.; Shi, L.; Yao, Y. D.; Jiang, Q. Q.; Li, X. F.; Tang, L. H.; Zheng, B. J.; Yuen, K. Y.; Smith, D. K. et al. Explicit Hypoxia Targeting with Tumor Suppression by Creating an "Obligate" Anaerobic Salmonella Typhimurium Strain Sci. Rep. 2012, 2, 436
27. Xiong, M. H.; Bao, Y.; Yang, X. Z.; Wang, Y. C.; Sun, B. L.; Wang, J. Lipase-Sensitive Polymeric Triple-Layered Nanogel for "On-Demand" Drug Delivery J. Am. Chem. Soc. 2012, 134, 4355-4362
28. Fang, J.; Nakamura, H.; Maeda, H. The EPR Effect: Unique Features of Tumor Blood Vessels for Drug Delivery, Factors Involved, and Limitations and Augmentation of the Effect Adv. Drug Delivery Rev. 2011, 63, 136-151
29. Bao, Y.; Li, Y.; Jiang, Q.; Zhao, L.; Xue, T.; Hu, B.; Sun, B. Methylthioadenosine/ S -adenosylhomocysteine Nucleosidase (Pfs) of Staphylococcus aureus Is Essential for the Virulence Independent of LuxS/AI-2 System Int. J. Med. Microbiol. 2013, 303, 190-200
30. Chawla, J. S.; Amiji, M. M. Biodegradable Poly(ε-caprolactone) Nanoparticles for Tumor-Targeted Delivery of Tamoxifen Int. J. Pharm. 2002, 249, 127-138
31. Huang, C. F.; Cabot, M. C. Phorbol Diesters Stimulate the Accumulation of Phosphatidate, Phosphatidylethanol, and Diacylglycerol in 3 Cell-Types: Evidence for the Indirect Formation of Phosphatidylcholine-Derived Diacylglycerol by a Phospholipase-D Pathway and Direct Formation of Diacylglycerol by a Phospholipase-C Pathway J. Biol. Chem. 1990, 265, 14858-14863
32. Xiong, M. H.; Li, Y. J.; Bao, Y.; Yang, X. Z.; Hu, B.; Wang, J. Bacteria-Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery Adv. Mater. 2012, 24, 6175-6180
33. Pandey, A.; Benjamin, S.; Soccol, C. R.; Nigam, P.; Krieger, N.; Soccol, V. T. The Realm of Microbial Lipases in Biotechnology Biotechnol. Appl. Biochem. 1999, 29, 119-131
34. Jaeger, K. E.; Ransac, S.; Dijkstra, B. W.; Colson, C.; Vanheuvel, M.; Misset, O. Bacterial Lipases FEMS Microbiol. Rev. 1994, 15, 29-63
35. Leschner, S.; Westphal, K.; Dietrich, N.; Viegas, N.; Jablonska, J.; Lyszkiewicz, M.; Lienenklaus, S.; Falk, W.; Gekara, N.; Loessner, H. et al. Tumor Invasion of Salmonella enterica Serovar Typhimurium Is Accompanied by Strong Hemorrhage Promoted by TNF-alpha PLoS One 2009, 4, e6692
36. Weibel, S.; Stritzker, J.; Eck, M.; Goebel, W.; Szalay, A. A. Colonization of Experimental Murine Breast Tumours by Escherichia coli K-12 Significantly Alters the Tumour Microenvironment Cell. Microbiol. 2008, 10, 1235-1248
37. Westphal, K.; Leschner, S.; Jablonska, J.; Loessner, H.; Weiss, S. Containment of Tumor-Colonizing Bacteria by Host Neutrophils Cancer Res. 2008, 68, 2952-2960
38. Xiong, M. H.; Wu, J.; Wang, Y. C.; Li, L. S.; Liu, X. B.; Zhang, G. Z.; Yan, L. F.; Wang, J. Synthesis of PEG-Armed and Polyphosphoester Core-Cross-Linked Nanogel by One-Step Ring-Opening Polymerization Macromolecules 2009, 42, 893-896
39. Yuan, Y. Y.; Mao, C. Q.; Du, X. J.; Du, J. Z.; Wang, F.; Wang, J. Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor Adv. Mater. 2012, 24, 5476-5480