Doxorubicin-loaded, charge reversible, folate modified HPMA copolymer conjugates for active cancer cell targeting

Biomaterials

Volumn 35, Issue 19, 2014, Pages 5171-5187

  Li, Lian ^a   Yang, Qingqing ^a   Zhou, Zhou ^a   Zhong, Jiaju ^a   Huang, Yuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Charge reverse; Folate dilemma; HPMA copolymer; Tumor extracellular acidity

Indexed keywords

ANTIBODIES; BINDING ENERGY; CELL DEATH; CELL MEMBRANES; CONJUGATED POLYMERS; DERIVATIVES; DRUG DELIVERY; DRUG PRODUCTS; LIGANDS; MOLECULAR BIOLOGY; PH; TUMORS;

CHARGE REVERSE; EXTRACELLULAR; FOLATE DILEMMA; FOLATE-FUNCTIONALIZED; HPMA COPOLYMER CONJUGATES; HPMA COPOLYMERS; RECEPTOR-MEDIATED ENDOCYTOSIS; TUMOR EXTRACELLULAR PH;

COPOLYMERS;

ACID ANHYDRIDE; CLATHRIN; COPOLYMER; DOXORUBICIN; DRUG CARRIER; FOLATE RECEPTOR; FOLIC ACID; HYDRAZONE DERIVATIVE; N (2 HYDROXYPROPYL)METHACRYLAMIDE; 2,3-DIMETHYLMALEIC ANHYDRIDE; HYDROXYPROPYL METHACRYLATE; MALEIC ANHYDRIDE; METHACRYLIC ACID DERIVATIVE; POLYMER;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CAVEOLA; CELL ADHESION; CELL PH; CELL SURFACE; CIRCULATION; CONJUGATE; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; EMBRYO; ENDOCYTOSIS; HELA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHOBICITY; INTERNALIZATION; LYSOSOME; PH; PINOCYTOSIS; PRIORITY JOURNAL; STATIC ELECTRICITY; SYSTEMATIC REVIEW; TARGET CELL; ANIMAL; APOPTOSIS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HELA CELL LINE; PROCEDURES; RAT; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HELA CELLS; HUMANS; MALEIC ANHYDRIDES; METHACRYLATES; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84898440945     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.03.027     Document Type: Article

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