-
1
-
-
0022779153
-
The ral gene: A new ras related gene isolated by the use of a synthetic probe
-
Chardin, P. and Tavitian, A. (1986) The ral gene: A new ras related gene isolated by the use of a synthetic probe. EMBO J. 5, 2203-2208
-
(1986)
EMBO J.
, vol.5
, pp. 2203-2208
-
-
Chardin, P.1
Tavitian, A.2
-
2
-
-
0024412469
-
Coding sequences of human ralA and ralB cDNAs
-
Chardin, P. and Tavitian, A. (1989) Coding sequences of human ralA and ralB cDNAs. Nucleic Acids Res. 17, 4380
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 4380
-
-
Chardin, P.1
Tavitian, A.2
-
3
-
-
16844387479
-
The Ras superfamily at a glance
-
Wennerberg, K., Rossman, K.L., and Der, C.J. (2005) The Ras superfamily at a glance. J. Cell Sci. 118, 843-846
-
(2005)
J. Cell Sci.
, vol.118
, pp. 843-846
-
-
Wennerberg, K.1
Rossman, K.L.2
Der, C.J.3
-
4
-
-
36048968159
-
Geranylgeranyltransferase i inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth
-
Falsetti, S.C., Wang, D.A., Peng, H., Carrico, D., Cox, A.D., Der, C.J., Hamilton, A.D., and Sebti, S.M. (2007) Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol. Cell. Biol. 27, 8003-8014
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 8003-8014
-
-
Falsetti, S.C.1
Wang, D.A.2
Peng, H.3
Carrico, D.4
Cox, A.D.5
Der, C.J.6
Hamilton, A.D.7
Sebti, S.M.8
-
5
-
-
84875246715
-
Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding
-
Nishimura, A. and Linder, M.E. (2013) Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding. Mol. Cell. Biol. 33, 1417-1429
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 1417-1429
-
-
Nishimura, A.1
Linder, M.E.2
-
6
-
-
0025861485
-
A family of ras-like GTP-binding proteins expressed in electromotor neurons
-
Ngsee, J.K., Elferink, L.A., and Scheller, R.H. (1991) A family of ras-like GTP-binding proteins expressed in electromotor neurons. J. Biol. Chem. 266, 2675-2680
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 2675-2680
-
-
Ngsee, J.K.1
Elferink, L.A.2
Scheller, R.H.3
-
7
-
-
0030570831
-
Association of Ral GTP-binding protein with human platelet dense granules
-
Mark, B.L., Jilkina, O., and Bhullar, R.P. (1996) Association of Ral GTP-binding protein with human platelet dense granules. Biochem. Biophy. Res. Commun. 225, 40-46
-
(1996)
Biochem. Biophy. Res. Commun.
, vol.225
, pp. 40-46
-
-
Mark, B.L.1
Jilkina, O.2
Bhullar, R.P.3
-
8
-
-
33846011880
-
RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis
-
Chen, X.W., Inoue, M., Hsu, S.C., and Saltiel, A.R. (2006) RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis. J. Biol. Chem. 281, 38609-38616
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 38609-38616
-
-
Chen, X.W.1
Inoue, M.2
Hsu, S.C.3
Saltiel, A.R.4
-
9
-
-
0027518574
-
Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase
-
Albright, C.F., Giddings, B.W., Liu, J., Vito, M., and Weinberg, R.A. (1993) Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. EMBO J. 12, 339-347
-
(1993)
EMBO J.
, vol.12
, pp. 339-347
-
-
Albright, C.F.1
Giddings, B.W.2
Liu, J.3
Vito, M.4
Weinberg, R.A.5
-
10
-
-
0033545328
-
Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation
-
Matsubara, K., Kishida, S., Matsuura, Y., Kitayama, H., Noda, M., and Kikuchi, A. (1999) Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation. Oncogene 18, 1303-1312
-
(1999)
Oncogene
, vol.18
, pp. 1303-1312
-
-
Matsubara, K.1
Kishida, S.2
Matsuura, Y.3
Kitayama, H.4
Noda, M.5
Kikuchi, A.6
-
11
-
-
0027986765
-
RalGDS family members interact with the effector loop of ras p21
-
Kikuchi, A., Demo, S.D., Ye, Z.H., Chen, Y.W., and Williams, L.T. (1994) ralGDS family members interact with the effector loop of ras p21. Mol. Cell. Biol. 14, 7483-7491
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 7483-7491
-
-
Kikuchi, A.1
Demo, S.D.2
Ye, Z.H.3
Chen, Y.W.4
Williams, L.T.5
-
12
-
-
0029965544
-
Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1
-
Peterson, S.N., Trabalzini, L., Brtva, T.R., Fischer, T., Altschuler, D.L., Martelli, P., Lapetina, E.G., Der, C.J., and White, G.C. II (1996) Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1. J. Biol. Chem. 271, 29903-29908
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 29903-29908
-
-
Peterson, S.N.1
Trabalzini, L.2
Brtva, T.R.3
Fischer, T.4
Altschuler, D.L.5
Martelli, P.6
Lapetina, E.G.7
Der, C.J.8
White, G.C.I.I.9
-
13
-
-
0029831581
-
RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein
-
Wolthuis, R.M., Bauer, B., van 't Veer, L.J., de Vries-Smits, A.M., Cool, R.H., Spaargaren, M., Wittinghofer, A., Burgering, B.M., and Bos, J.L. (1996) RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein. Oncogene 13, 353-362
-
(1996)
Oncogene
, vol.13
, pp. 353-362
-
-
Wolthuis, R.M.1
Bauer, B.2
Van 't Veer, L.J.3
De Vries-Smits, A.M.4
Cool, R.H.5
Spaargaren, M.6
Wittinghofer, A.7
Burgering, B.M.8
Bos, J.L.9
-
14
-
-
0034282408
-
A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras
-
Shao, H. and Andres, D.A. (2000) A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras. J. Biol. Chem. 275, 26914-26924
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26914-26924
-
-
Shao, H.1
Andres, D.A.2
-
15
-
-
0032499175
-
Ras-dependent activation of the small GTPase Ral
-
Wolthuis, R.M., Zwartkruis, F., Moen, T.C., and Bos, J.L. (1998) Ras-dependent activation of the small GTPase Ral. Curr. Biol. 8, 471-474
-
(1998)
Curr. Biol.
, vol.8
, pp. 471-474
-
-
Wolthuis, R.M.1
Zwartkruis, F.2
Moen, T.C.3
Bos, J.L.4
-
16
-
-
0031944085
-
Activation of the small GTPase Ral in platelets
-
Wolthuis, R.M., Franke, B., van Triest, M., Bauer, B., Cool, R.H., Camonis, J.H., Akkerman, J.W., and Bos, J.L. (1998) Activation of the small GTPase Ral in platelets. Mol. Cell. Biol. 18, 2486-2491
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 2486-2491
-
-
Wolthuis, R.M.1
Franke, B.2
Van Triest, M.3
Bauer, B.4
Cool, R.H.5
Camonis, J.H.6
Akkerman, J.W.7
Bos, J.L.8
-
17
-
-
34248222607
-
R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes
-
Takaya, A., Kamio, T., Masuda, M., Mochizuki, N., Sawa, H., Sato, M., Nagashima, K., Mizutani, A., Matsuno, A., Kiyokawa, E., and Matsuda, M. (2007) R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes. Mol. Biol. Cell 18, 1850-1860
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 1850-1860
-
-
Takaya, A.1
Kamio, T.2
Masuda, M.3
Mochizuki, N.4
Sawa, H.5
Sato, M.6
Nagashima, K.7
Mizutani, A.8
Matsuno, A.9
Kiyokawa, E.10
Matsuda, M.11
-
18
-
-
84862827148
-
The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras
-
Gus-Brautbar, Y., Johnson, D., Zhang, L., Sun, H., Wang, P., Zhang, S., Zhang, L., and Chen, Y.H. (2012) The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras. Mol. Cell 45, 610-618
-
(2012)
Mol. Cell
, vol.45
, pp. 610-618
-
-
Gus-Brautbar, Y.1
Johnson, D.2
Zhang, L.3
Sun, H.4
Wang, P.5
Zhang, S.6
Zhang, L.7
Chen, Y.H.8
-
19
-
-
42349101312
-
RalGDS couples growth factor signaling to Akt activation
-
Hao, Y., Wong, R., and Feig, L.A. (2008) RalGDS couples growth factor signaling to Akt activation. Mol. Cell. Biol. 28, 2851-2859
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 2851-2859
-
-
Hao, Y.1
Wong, R.2
Feig, L.A.3
-
20
-
-
47249113075
-
Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells
-
Rondaij, M.G., Bierings, R., van Agtmaal, E.L., Gijzen, K.A., Sellink, E., Kragt, A., Ferguson, S.S., Mertens, K., Hannah, M.J., van Mourik, J.A., Fernandez-Borja, M., and Voorberg, J. (2008) Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. Blood 112, 56-63
-
(2008)
Blood
, vol.112
, pp. 56-63
-
-
Rondaij, M.G.1
Bierings, R.2
Van Agtmaal, E.L.3
Gijzen, K.A.4
Sellink, E.5
Kragt, A.6
Ferguson, S.S.7
Mertens, K.8
Hannah, M.J.9
Van Mourik, J.A.10
Fernandez-Borja, M.11
Voorberg, J.12
-
21
-
-
0035081259
-
Regulation of Ras signaling specificity by protein kinase C
-
Rusanescu, G., Gotoh, T., Tian, X., and Feig, L.A. (2001) Regulation of Ras signaling specificity by protein kinase C. Mol. Cell. Biol. 21, 2650-2658
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2650-2658
-
-
Rusanescu, G.1
Gotoh, T.2
Tian, X.3
Feig, L.A.4
-
22
-
-
0034713356
-
The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways
-
Hernandez-Munoz, I., Malumbres, M., Leonardi, P., and Pellicer, A. (2000) The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways. Oncogene 19, 2745-2757
-
(2000)
Oncogene
, vol.19
, pp. 2745-2757
-
-
Hernandez-Munoz, I.1
Malumbres, M.2
Leonardi, P.3
Pellicer, A.4
-
23
-
-
4344642864
-
The Rgr oncogene induces tumorigenesis in transgenic mice
-
Jimenez, M., Perez de Castro, I., Benet, M., Garcia, J.F., Inghirami, G., and Pellicer, A. (2004) The Rgr oncogene induces tumorigenesis in transgenic mice. Cancer Res. 64, 6041-6049
-
(2004)
Cancer Res.
, vol.64
, pp. 6041-6049
-
-
Jimenez, M.1
Perez De Castro, I.2
Benet, M.3
Garcia, J.F.4
Inghirami, G.5
Pellicer, A.6
-
24
-
-
80052055746
-
The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral
-
Osei-Sarfo, K., Martello, L., Ibrahim, S., and Pellicer, A. (2011) The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral. Oncogene 30, 3661-3671
-
(2011)
Oncogene
, vol.30
, pp. 3661-3671
-
-
Osei-Sarfo, K.1
Martello, L.2
Ibrahim, S.3
Pellicer, A.4
-
25
-
-
0034607989
-
Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral
-
Rebhun, J.F., Chen, H., and Quilliam, L.A. (2000) Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. J. Biol. Chem. 275, 13406-13410
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 13406-13410
-
-
Rebhun, J.F.1
Chen, H.2
Quilliam, L.A.3
-
26
-
-
0034702970
-
RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral
-
de Bruyn, K.M., de Rooij, J., Wolthuis, R.M., Rehmann, H., Wesenbeek, J., Cool, R.H., Wittinghofer, A.H., and Bos, J.L. (2000) RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral. J. Biol. Chem. 275, 29761-29766
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29761-29766
-
-
De Bruyn, K.M.1
De Rooij, J.2
Wolthuis, R.M.3
Rehmann, H.4
Wesenbeek, J.5
Cool, R.H.6
Wittinghofer, A.H.7
Bos, J.L.8
-
27
-
-
34249985839
-
Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase
-
Ceriani, M., Scandiuzzi, C., Amigoni, L., Tisi, R., Berruti, G., and Martegani, E. (2007) Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase. Exp. Cell Res. 313, 2293-2307
-
(2007)
Exp. Cell Res.
, vol.313
, pp. 2293-2307
-
-
Ceriani, M.1
Scandiuzzi, C.2
Amigoni, L.3
Tisi, R.4
Berruti, G.5
Martegani, E.6
-
28
-
-
0025912628
-
Characterization of a GTPase-activating protein for the Ras-related Ral protein
-
Emkey, R., Freedman, S., and Feig, L.A. (1991) Characterization of a GTPase-activating protein for the Ras-related Ral protein. J. Biol. Chem. 266, 9703-9706
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 9703-9706
-
-
Emkey, R.1
Freedman, S.2
Feig, L.A.3
-
29
-
-
69249109593
-
Tuberous sclerosis tumor suppressor complexlike complexes act as GTPase-activating proteins for Ral GTPases
-
Shirakawa, R., Fukai, S., Kawato, M., Higashi, T., Kondo, H., Ikeda, T., Nakayama, E., Okawa, K., Nureki, O., Kimura, T., Kita, T., and Horiuchi, H. (2009) Tuberous sclerosis tumor suppressor complexlike complexes act as GTPase-activating proteins for Ral GTPases. J. Biol. Chem. 284, 21580-21588
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 21580-21588
-
-
Shirakawa, R.1
Fukai, S.2
Kawato, M.3
Higashi, T.4
Kondo, H.5
Ikeda, T.6
Nakayama, E.7
Okawa, K.8
Nureki, O.9
Kimura, T.10
Kita, T.11
Horiuchi, H.12
-
30
-
-
33747078270
-
Adipocytes contain a novel complex similar to the tuberous sclerosis complex
-
Gridley, S., Chavez, J.A., Lane, W.S., and Lienhard, G.E. (2006) Adipocytes contain a novel complex similar to the tuberous sclerosis complex. Cell. Signal. 18, 1626-1632
-
(2006)
Cell. Signal.
, vol.18
, pp. 1626-1632
-
-
Gridley, S.1
Chavez, J.A.2
Lane, W.S.3
Lienhard, G.E.4
-
31
-
-
78651085682
-
A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
-
Chen, X.W., Leto, D., Xiong, T., Yu, G., Cheng, A., Decker, S., and Saltiel, A.R. (2011) A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol. Biol. Cell 22, 141-152
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 141-152
-
-
Chen, X.W.1
Leto, D.2
Xiong, T.3
Yu, G.4
Cheng, A.5
Decker, S.6
Saltiel, A.R.7
-
32
-
-
81455151255
-
The tuberous sclerosis complex
-
Crino, P.B., Nathanson, K.L., and Henske, E.P. (2006) The tuberous sclerosis complex. N. Engl. J. Med 355, 1345-1356
-
(2006)
N. Engl. J. Med
, vol.355
, pp. 1345-1356
-
-
Crino, P.B.1
Nathanson, K.L.2
Henske, E.P.3
-
33
-
-
34249018367
-
GEFs and GAPs: Critical elements in the control of small G proteins
-
Bos, J.L., Rehmann, H., and Wittinghofer, A. (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129, 865-877
-
(2007)
Cell
, vol.129
, pp. 865-877
-
-
Bos, J.L.1
Rehmann, H.2
Wittinghofer, A.3
-
34
-
-
2442669194
-
The GTPase-activating protein Rap1GAP uses a catalytic asparagine
-
Daumke, O., Weyand, M., Chakrabarti, P.P., Vetter, I.R., and Wittinghofer, A. (2004) The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature 429, 197-201
-
(2004)
Nature
, vol.429
, pp. 197-201
-
-
Daumke, O.1
Weyand, M.2
Chakrabarti, P.P.3
Vetter, I.R.4
Wittinghofer, A.5
-
35
-
-
41949114173
-
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues
-
Scrima, A., Thomas, C., Deaconescu, D., and Wittinghofer, A. (2008) The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO J. 27, 1145-1153
-
(2008)
EMBO J.
, vol.27
, pp. 1145-1153
-
-
Scrima, A.1
Thomas, C.2
Deaconescu, D.3
Wittinghofer, A.4
-
36
-
-
84899992427
-
GARNL1, a major RalGAP alpha subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins
-
Chen, Q., Quan, C., Xie, B., Chen, L., Zhou, S., Toth, R., Campbell, D.G., Lu, S., Shirakawa, R., Horiuchi, H., Li, C., Yang, Z., MacKintosh, C., Wang, H.Y., and Chen, S. (2014) GARNL1, a major RalGAP alpha subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins. Cell. Signal. 26, 1636-1648
-
(2014)
Cell. Signal.
, vol.26
, pp. 1636-1648
-
-
Chen, Q.1
Quan, C.2
Xie, B.3
Chen, L.4
Zhou, S.5
Toth, R.6
Campbell, D.G.7
Lu, S.8
Shirakawa, R.9
Horiuchi, H.10
Li, C.11
Yang, Z.12
MacKintosh, C.13
Wang, H.Y.14
Chen, S.15
-
37
-
-
84875987609
-
Negative regulation of the RalGAP complex by 14-3-3
-
Leto, D., Uhm, M., Williams, A., Chen, X.W., and Saltiel, A.R. (2013) Negative regulation of the RalGAP complex by 14-3-3. J. Biol. Chem. 288, 9272-9283
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 9272-9283
-
-
Leto, D.1
Uhm, M.2
Williams, A.3
Chen, X.W.4
Saltiel, A.R.5
-
38
-
-
84907389633
-
KappaBRas proteins regulate both NF-kappaB-dependent inflammation and Ral-dependent proliferation
-
Oeckinghaus, A., Postler, T.S., Rao, P., Schmitt, H., Schmitt, V., Grinberg-Bleyer, Y., Kuhn, L.I., Gruber, C.W., Lienhard, G.E., and Ghosh, S. (2014) kappaBRas proteins regulate both NF-kappaB-dependent inflammation and Ral-dependent proliferation. Cell Rep. 8, 1793-1807
-
(2014)
Cell Rep.
, vol.8
, pp. 1793-1807
-
-
Oeckinghaus, A.1
Postler, T.S.2
Rao, P.3
Schmitt, H.4
Schmitt, V.5
Grinberg-Bleyer, Y.6
Kuhn, L.I.7
Gruber, C.W.8
Lienhard, G.E.9
Ghosh, S.10
-
39
-
-
3042796979
-
GAP control: Regulating the regulators of small GTPases
-
Bernards, A. and Settleman, J. (2004) GAP control: regulating the regulators of small GTPases. Trends Cell Biol. 14, 377-385
-
(2004)
Trends Cell Biol.
, vol.14
, pp. 377-385
-
-
Bernards, A.1
Settleman, J.2
-
40
-
-
0035839569
-
The brain exocyst complex interacts with RalA in a GTP-dependent manner: Identification of a novel mammalian Sec3 gene and a second Sec15 gene
-
Brymora, A., Valova, V.A., Larsen, M.R., Roufogalis, B.D., and Robinson, P.J. (2001) The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. J. Biol. Chem. 276, 29792-29797
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29792-29797
-
-
Brymora, A.1
Valova, V.A.2
Larsen, M.R.3
Roufogalis, B.D.4
Robinson, P.J.5
-
41
-
-
0036141393
-
The exocyst is a Ral effector complex
-
Moskalenko, S., Henry, D.O., Rosse, C., Mirey, G., Camonis, J.H., and White, M.A. (2002) The exocyst is a Ral effector complex. Nat. Cell Biol. 4, 66-72
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 66-72
-
-
Moskalenko, S.1
Henry, D.O.2
Rosse, C.3
Mirey, G.4
Camonis, J.H.5
White, M.A.6
-
42
-
-
0036141434
-
The exocyst complex binds the small GTPase RalA to mediate filopodia formation
-
Sugihara, K., Asano, S., Tanaka, K., Iwamatsu, A., Okawa, K., and Ohta, Y. (2002) The exocyst complex binds the small GTPase RalA to mediate filopodia formation. Nat. Cell Biol. 4, 73-78
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 73-78
-
-
Sugihara, K.1
Asano, S.2
Tanaka, K.3
Iwamatsu, A.4
Okawa, K.5
Ohta, Y.6
-
43
-
-
0038602702
-
Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex
-
Fukai, S., Matern, H.T., Jagath, J.R., Scheller, R.H., and Brunger, A.T. (2003) Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex. EMBO J. 22, 3267-3278
-
(2003)
EMBO J.
, vol.22
, pp. 3267-3278
-
-
Fukai, S.1
Matern, H.T.2
Jagath, J.R.3
Scheller, R.H.4
Brunger, A.T.5
-
44
-
-
21844443829
-
Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase
-
Jin, R., Junutula, J.R., Matern, H.T., Ervin, K.E., Scheller, R.H., and Brunger, A.T. (2005) Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. EMBO J. 24, 2064-2074
-
(2005)
EMBO J.
, vol.24
, pp. 2064-2074
-
-
Jin, R.1
Junutula, J.R.2
Matern, H.T.3
Ervin, K.E.4
Scheller, R.H.5
Brunger, A.T.6
-
45
-
-
38049129400
-
Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway
-
Kawato, M., Shirakawa, R., Kondo, H., Higashi, T., Ikeda, T., Okawa, K., Fukai, S., Nureki, O., Kita, T., and Horiuchi, H. (2008) Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway. J. Biol. Chem. 283, 166-174
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 166-174
-
-
Kawato, M.1
Shirakawa, R.2
Kondo, H.3
Higashi, T.4
Ikeda, T.5
Okawa, K.6
Fukai, S.7
Nureki, O.8
Kita, T.9
Horiuchi, H.10
-
46
-
-
2442586577
-
RalA-exocyst interaction mediates GTP-dependent exocytosis
-
Wang, L., Li, G., and Sugita, S. (2004) RalA-exocyst interaction mediates GTP-dependent exocytosis. J. Biol. Chem. 279, 19875-19881
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 19875-19881
-
-
Wang, L.1
Li, G.2
Sugita, S.3
-
47
-
-
33846176049
-
RalA and RalB function as the critical GTP sensors for GTP-dependent exocytosis
-
Li, G., Han, L., Chou, T.C., Fujita, Y., Arunachalam, L., Xu, A., Wong, A., Chiew, S.K., Wan, Q., Wang, L., and Sugita, S. (2007) RalA and RalB function as the critical GTP sensors for GTP-dependent exocytosis. J. Neurosci. 27, 190-202
-
(2007)
J. Neurosci.
, vol.27
, pp. 190-202
-
-
Li, G.1
Han, L.2
Chou, T.C.3
Fujita, Y.4
Arunachalam, L.5
Xu, A.6
Wong, A.7
Chiew, S.K.8
Wan, Q.9
Wang, L.10
Sugita, S.11
-
48
-
-
1642275392
-
Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets
-
Shirakawa, R., Higashi, T., Tabuchi, A., Yoshioka, A., Nishioka, H., Fukuda, M., Kita, T., and Horiuchi, H. (2004) Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. J. Biol. Chem. 279, 10730-10737
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 10730-10737
-
-
Shirakawa, R.1
Higashi, T.2
Tabuchi, A.3
Yoshioka, A.4
Nishioka, H.5
Fukuda, M.6
Kita, T.7
Horiuchi, H.8
-
49
-
-
0032872821
-
Small GTP-binding protein RalA associates with Weibel-Palade bodies in endothelial cells
-
de Leeuw, H.P., Wijers-Koster, P.M., van Mourik, J.A., and Voorberg, J. (1999) Small GTP-binding protein RalA associates with Weibel-Palade bodies in endothelial cells. Thromb Haemost. 82, 1177-1181
-
(1999)
Thromb Haemost.
, vol.82
, pp. 1177-1181
-
-
De Leeuw, H.P.1
Wijers-Koster, P.M.2
Van Mourik, J.A.3
Voorberg, J.4
-
50
-
-
0035718501
-
Small GTP-binding protein Ral modulates regulated exocytosis of von Willebrand factor by endothelial cells
-
de Leeuw, H.P., Fernandez-Borja, M., Reits, E.A., Romani de Wit, T., Wijers-Koster, P.M., Hordijk, P.L., Neefjes, J., van Mourik, J.A., and Voorberg, J. (2001) Small GTP-binding protein Ral modulates regulated exocytosis of von Willebrand factor by endothelial cells. Arterioscler. Thromb. Vasc. Biol. 21, 899-904
-
(2001)
Arterioscler. Thromb. Vasc. Biol.
, vol.21
, pp. 899-904
-
-
De Leeuw, H.P.1
Fernandez-Borja, M.2
Reits, E.A.3
Romani De Wit, T.4
Wijers-Koster, P.M.5
Hordijk, P.L.6
Neefjes, J.7
Van Mourik, J.A.8
Voorberg, J.9
-
51
-
-
3042777661
-
Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells
-
Rondaij, M.G., Sellink, E., Gijzen, K.A., ten Klooster, J.P., Hordijk, P.L., van Mourik, J.A., and Voorberg, J. (2004) Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells. Arterioscler. Thromb. Vasc. Biol. 24, 1315-1320
-
(2004)
Arterioscler. Thromb. Vasc. Biol.
, vol.24
, pp. 1315-1320
-
-
Rondaij, M.G.1
Sellink, E.2
Gijzen, K.A.3
Ten Klooster, J.P.4
Hordijk, P.L.5
Van Mourik, J.A.6
Voorberg, J.7
-
52
-
-
21844459500
-
Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis
-
Tsuboi, T., Ravier, M.A., Xie, H., Ewart, M.A., Gould, G.W., Baldwin, S.A., and Rutter, G.A. (2005) Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. J. Biol. Chem. 280, 25565-25570
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 25565-25570
-
-
Tsuboi, T.1
Ravier, M.A.2
Xie, H.3
Ewart, M.A.4
Gould, G.W.5
Baldwin, S.A.6
Rutter, G.A.7
-
53
-
-
44449125651
-
Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion
-
Saito, T., Shibasaki, T., and Seino, S. (2008) Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Biomed. Res 29, 85-91
-
(2008)
Biomed. Res
, vol.29
, pp. 85-91
-
-
Saito, T.1
Shibasaki, T.2
Seino, S.3
-
54
-
-
49649090688
-
The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells
-
Lopez, J.A., Kwan, E.P., Xie, L., He, Y., James, D.E., and Gaisano, H.Y. (2008) The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells. J. Biol. Chem. 283, 17939-17945
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 17939-17945
-
-
Lopez, J.A.1
Kwan, E.P.2
Xie, L.3
He, Y.4
James, D.E.5
Gaisano, H.Y.6
-
55
-
-
34548188298
-
Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c
-
Chen, X.W., Leto, D., Chiang, S.H., Wang, Q., and Saltiel, A.R. (2007) Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev. Cell 13, 391-404
-
(2007)
Dev. Cell
, vol.13
, pp. 391-404
-
-
Chen, X.W.1
Leto, D.2
Chiang, S.H.3
Wang, Q.4
Saltiel, A.R.5
-
56
-
-
80052681341
-
Ral GTPases regulate cell-mediated cytotoxicity in NK cells
-
Sanchez-Ruiz, J., Mejias, R., Garcia-Belando, M., Barber, D.F., and Gonzalez-Garcia, A. (2011) Ral GTPases regulate cell-mediated cytotoxicity in NK cells. J. Immunol. 187, 2433-2441
-
(2011)
J. Immunol.
, vol.187
, pp. 2433-2441
-
-
Sanchez-Ruiz, J.1
Mejias, R.2
Garcia-Belando, M.3
Barber, D.F.4
Gonzalez-Garcia, A.5
-
57
-
-
79953189734
-
Control of secondary granule release in neutrophils by Ral GTPase
-
Chen, C.X., Soto, I., Guo, Y.L., and Liu, Y. (2011) Control of secondary granule release in neutrophils by Ral GTPase. J. Biol. Chem. 286, 11724-11733
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 11724-11733
-
-
Chen, C.X.1
Soto, I.2
Guo, Y.L.3
Liu, Y.4
-
58
-
-
0038713372
-
NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
-
Sans, N., Prybylowski, K., Petralia, R.S., Chang, K., Wang, Y.X., Racca, C., Vicini, S., and Wenthold, R.J. (2003) NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat. Cell Biol. 5, 520-530
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 520-530
-
-
Sans, N.1
Prybylowski, K.2
Petralia, R.S.3
Chang, K.4
Wang, Y.X.5
Racca, C.6
Vicini, S.7
Wenthold, R.J.8
-
59
-
-
33646123087
-
Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane
-
Gerges, N.Z., Backos, D.S., Rupasinghe, C.N., Spaller, M.R., and Esteban, J.A. (2006) Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. EMBO J. 25, 1623-1634
-
(2006)
EMBO J.
, vol.25
, pp. 1623-1634
-
-
Gerges, N.Z.1
Backos, D.S.2
Rupasinghe, C.N.3
Spaller, M.R.4
Esteban, J.A.5
-
60
-
-
84880324624
-
Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst
-
Teodoro, R.O., Pekkurnaz, G., Nasser, A., Higashi-Kovtun, M.E., Balakireva, M., McLachlan, I.G., Camonis, J., and Schwarz, T.L. (2013) Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst. EMBO J. 32, 2039-2055
-
(2013)
EMBO J.
, vol.32
, pp. 2039-2055
-
-
Teodoro, R.O.1
Pekkurnaz, G.2
Nasser, A.3
Higashi-Kovtun, M.E.4
Balakireva, M.5
McLachlan, I.G.6
Camonis, J.7
Schwarz, T.L.8
-
61
-
-
0036178046
-
Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles
-
Polzin, A., Shipitsin, M., Goi, T., Feig, L.A., and Turner, T.J. (2002) Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. Mol. Cell. Biol. 22, 1714-1722
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1714-1722
-
-
Polzin, A.1
Shipitsin, M.2
Goi, T.3
Feig, L.A.4
Turner, T.J.5
-
62
-
-
0032577562
-
Sec6/8 complex is recruited to cellcell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells
-
Grindstaff, K.K., Yeaman, C., Anandasabapathy, N., Hsu, S.C., Rodriguez-Boulan, E., Scheller, R.H., and Nelson, W.J. (1998) Sec6/8 complex is recruited to cellcell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Cell 93, 731-740
-
(1998)
Cell
, vol.93
, pp. 731-740
-
-
Grindstaff, K.K.1
Yeaman, C.2
Anandasabapathy, N.3
Hsu, S.C.4
Rodriguez-Boulan, E.5
Scheller, R.H.6
Nelson, W.J.7
-
63
-
-
2942711520
-
RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells
-
Shipitsin, M. and Feig, L.A. (2004) RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells. Mol. Cell. Biol. 24, 5746-5756
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5746-5756
-
-
Shipitsin, M.1
Feig, L.A.2
-
64
-
-
84894095098
-
RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development
-
Das, A., Gajendra, S., Falenta, K., Oudin, M.J., Peschard, P., Feng, S., Wu, B., Marshall, C.J., Doherty, P., Guo, W., and Lalli, G. (2014) RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development. J. Cell Sci. 127, 686-699
-
(2014)
J. Cell Sci.
, vol.127
, pp. 686-699
-
-
Das, A.1
Gajendra, S.2
Falenta, K.3
Oudin, M.J.4
Peschard, P.5
Feng, S.6
Wu, B.7
Marshall, C.J.8
Doherty, P.9
Guo, W.10
Lalli, G.11
-
65
-
-
30644463689
-
RalB mobilizes the exocyst to drive cell migration
-
Rosse, C., Hatzoglou, A., Parrini, M.C., White, M.A., Chavrier, P., and Camonis, J. (2006) RalB mobilizes the exocyst to drive cell migration. Mol. Cell. Biol. 26, 727-734
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 727-734
-
-
Rosse, C.1
Hatzoglou, A.2
Parrini, M.C.3
White, M.A.4
Chavrier, P.5
Camonis, J.6
-
66
-
-
23844472876
-
RalA and RalB: Antagonistic relatives in cancer cell migration
-
Oxford, G., Owens, C.R., Titus, B.J., Foreman, T.L., Herlevsen, M.C., Smith, S.C., and Theodorescu, D. (2005) RalA and RalB: antagonistic relatives in cancer cell migration. Cancer Res. 65, 7111-7120
-
(2005)
Cancer Res.
, vol.65
, pp. 7111-7120
-
-
Oxford, G.1
Owens, C.R.2
Titus, B.J.3
Foreman, T.L.4
Herlevsen, M.C.5
Smith, S.C.6
Theodorescu, D.7
-
67
-
-
43549085341
-
The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells
-
de Gorter, D.J., Reijmers, R.M., Beuling, E.A., Naber, H.P., Kuil, A., Kersten, M.J., Pals, S.T., and Spaargaren, M. (2008) The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells. Blood 111, 3364-3372
-
(2008)
Blood
, vol.111
, pp. 3364-3372
-
-
De Gorter, D.J.1
Reijmers, R.M.2
Beuling, E.A.3
Naber, H.P.4
Kuil, A.5
Kersten, M.J.6
Pals, S.T.7
Spaargaren, M.8
-
68
-
-
2542476025
-
RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells
-
Takaya, A., Ohba, Y., Kurokawa, K., and Matsuda, M. (2004) RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells. Mol. Biol. Cell 15, 2549-2557
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 2549-2557
-
-
Takaya, A.1
Ohba, Y.2
Kurokawa, K.3
Matsuda, M.4
-
69
-
-
53349175462
-
Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration
-
Spiczka, K.S. and Yeaman, C. (2008) Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration. J. Cell Sci. 121, 2880-2891
-
(2008)
J. Cell Sci.
, vol.121
, pp. 2880-2891
-
-
Spiczka, K.S.1
Yeaman, C.2
-
70
-
-
26244439675
-
Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission
-
Gromley, A., Yeaman, C., Rosa, J., Redick, S., Chen, C.T., Mirabelle, S., Guha, M., Sillibourne, J., and Doxsey, S.J. (2005) Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. Cell 123, 75-87
-
(2005)
Cell
, vol.123
, pp. 75-87
-
-
Gromley, A.1
Yeaman, C.2
Rosa, J.3
Redick, S.4
Chen, C.T.5
Mirabelle, S.6
Guha, M.7
Sillibourne, J.8
Doxsey, S.J.9
-
71
-
-
51949085937
-
Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs
-
Cascone, I., Selimoglu, R., Ozdemir, C., Del Nery, E., Yeaman, C., White, M., and Camonis, J. (2008) Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. EMBO J. 27, 2375-2387
-
(2008)
EMBO J.
, vol.27
, pp. 2375-2387
-
-
Cascone, I.1
Selimoglu, R.2
Ozdemir, C.3
Del Nery, E.4
Yeaman, C.5
White, M.6
Camonis, J.7
-
72
-
-
33751538120
-
Exo70 interacts with the Arp2/3 complex and regulates cell migration
-
Zuo, X., Zhang, J., Zhang, Y., Hsu, S.C., Zhou, D., and Guo, W. (2006) Exo70 interacts with the Arp2/3 complex and regulates cell migration. Nat. Cell Biol. 8, 1383-1388
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 1383-1388
-
-
Zuo, X.1
Zhang, J.2
Zhang, Y.3
Hsu, S.C.4
Zhou, D.5
Guo, W.6
-
73
-
-
28544437382
-
Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex
-
Lalli, G. and Hall, A. (2005) Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex. J. Cell Biol. 171, 857-869
-
(2005)
J. Cell Biol.
, vol.171
, pp. 857-869
-
-
Lalli, G.1
Hall, A.2
-
74
-
-
0029001797
-
Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases
-
Cantor, S.B., Urano, T., and Feig, L.A. (1995) Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. Mol. Cell. Biol. 15, 4578-4584
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 4578-4584
-
-
Cantor, S.B.1
Urano, T.2
Feig, L.A.3
-
75
-
-
0029089074
-
Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity
-
Jullien-Flores, V., Dorseuil, O., Romero, F., Letourneur, F., Saragosti, S., Berger, R., Tavitian, A., Gacon, G., and Camonis, J.H. (1995) Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J. Biol. Chem 270, 22473-22477
-
(1995)
J. Biol. Chem
, vol.270
, pp. 22473-22477
-
-
Jullien-Flores, V.1
Dorseuil, O.2
Romero, F.3
Letourneur, F.4
Saragosti, S.5
Berger, R.6
Tavitian, A.7
Gacon, G.8
Camonis, J.H.9
-
76
-
-
0031465736
-
An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1
-
Yamaguchi, A., Urano, T., Goi, T., and Feig, L.A. (1997) An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1. J. Biol. Chem. 272, 31230-31234
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 31230-31234
-
-
Yamaguchi, A.1
Urano, T.2
Goi, T.3
Feig, L.A.4
-
77
-
-
0031974491
-
Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral
-
Ikeda, M., Ishida, O., Hinoi, T., Kishida, S., and Kikuchi, A. (1998) Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. J. Biol. Chem. 273, 814-821
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 814-821
-
-
Ikeda, M.1
Ishida, O.2
Hinoi, T.3
Kishida, S.4
Kikuchi, A.5
-
78
-
-
0033592669
-
Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis
-
Morinaka, K., Koyama, S., Nakashima, S., Hinoi, T., Okawa, K., Iwamatsu, A., and Kikuchi, A. (1999) Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis. Oncogene 18, 5915-5922
-
(1999)
Oncogene
, vol.18
, pp. 5915-5922
-
-
Morinaka, K.1
Koyama, S.2
Nakashima, S.3
Hinoi, T.4
Okawa, K.5
Iwamatsu, A.6
Kikuchi, A.7
-
79
-
-
0033832942
-
RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: Involvement of the Ral pathway in receptor endocytosis
-
Jullien-Flores, V., Mahe, Y., Mirey, G., Leprince, C., Meunier-Bisceuil, B., Sorkin, A., and Camonis, J.H. (2000) RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. J. Cell Sci. 113 (Pt 16), 2837-2844
-
(2000)
J. Cell Sci.
, vol.113
, pp. 2837-2844
-
-
Jullien-Flores, V.1
Mahe, Y.2
Mirey, G.3
Leprince, C.4
Meunier-Bisceuil, B.5
Sorkin, A.6
Camonis, J.H.7
-
80
-
-
0033168176
-
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors
-
Nakashima, S., Morinaka, K., Koyama, S., Ikeda, M., Kishida, M., Okawa, K., Iwamatsu, A., Kishida, S., and Kikuchi, A. (1999) Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. EMBO J. 18, 3629-3642
-
(1999)
EMBO J.
, vol.18
, pp. 3629-3642
-
-
Nakashima, S.1
Morinaka, K.2
Koyama, S.3
Ikeda, M.4
Kishida, M.5
Okawa, K.6
Iwamatsu, A.7
Kishida, S.8
Kikuchi, A.9
-
81
-
-
84867496141
-
RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization
-
Lee, S., Wurtzel, J.G., Singhal, S.S., Awasthi, S., and Goldfinger, L.E. (2012) RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization. Cancer Res. 72, 5165-5173
-
(2012)
Cancer Res.
, vol.72
, pp. 5165-5173
-
-
Lee, S.1
Wurtzel, J.G.2
Singhal, S.S.3
Awasthi, S.4
Goldfinger, L.E.5
-
82
-
-
84874622432
-
Spatial regulation of VEGF receptor endocytosis in angiogenesis
-
Nakayama, M., Nakayama, A., van Lessen, M., Yamamoto, H., Hoffmann, S., Drexler, H.C., Itoh, N., Hirose, T., Breier, G., Vestweber, D., Cooper, J.A., Ohno, S., Kaibuchi, K., and Adams, R.H. (2013) Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat. Cell Biol. 15, 249-260
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 249-260
-
-
Nakayama, M.1
Nakayama, A.2
Van Lessen, M.3
Yamamoto, H.4
Hoffmann, S.5
Drexler, H.C.6
Itoh, N.7
Hirose, T.8
Breier, G.9
Vestweber, D.10
Cooper, J.A.11
Ohno, S.12
Kaibuchi, K.13
Adams, R.H.14
-
83
-
-
80052514798
-
RALA and RALBP1 regulate mitochondrial fission at mitosis
-
Kashatus, D.F., Lim, K.H., Brady, D.C., Pershing, N.L., Cox, A.D., and Counter, C.M. (2011) RALA and RALBP1 regulate mitochondrial fission at mitosis. Nat. Cell Biol. 13, 1108-1115
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1108-1115
-
-
Kashatus, D.F.1
Lim, K.H.2
Brady, D.C.3
Pershing, N.L.4
Cox, A.D.5
Counter, C.M.6
-
84
-
-
0042023468
-
Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): A novel link between G-protein and tyrosine kinase signaling and drug resistance
-
Awasthi, S., Singhal, S.S., Sharma, R., Zimniak, P., and Awasthi, Y.C. (2003) Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): A novel link between G-protein and tyrosine kinase signaling and drug resistance. Int. J. Cancer 106, 635-646
-
(2003)
Int. J. Cancer
, vol.106
, pp. 635-646
-
-
Awasthi, S.1
Singhal, S.S.2
Sharma, R.3
Zimniak, P.4
Awasthi, Y.C.5
-
85
-
-
21344454610
-
RLIP76 is a major determinant of radiation sensitivity
-
Awasthi, S., Singhal, S.S., Yadav, S., Singhal, J., Drake, K., Nadkar, A., Zajac, E., Wickramarachchi, D., Rowe, N., Yacoub, A., Boor, P., Dwivedi, S., Dent, P., Jarman, W.E., John, B., and Awasthi, Y.C. (2005) RLIP76 is a major determinant of radiation sensitivity. Cancer Res. 65, 6022-6028
-
(2005)
Cancer Res.
, vol.65
, pp. 6022-6028
-
-
Awasthi, S.1
Singhal, S.S.2
Yadav, S.3
Singhal, J.4
Drake, K.5
Nadkar, A.6
Zajac, E.7
Wickramarachchi, D.8
Rowe, N.9
Yacoub, A.10
Boor, P.11
Dwivedi, S.12
Dent, P.13
Jarman, W.E.14
John, B.15
Awasthi, Y.C.16
-
86
-
-
0028818914
-
Involvement of Ral GTPase in v-Src-induced phospholipase D activation
-
Jiang, H., Luo, J.Q., Urano, T., Frankel, P., Lu, Z., Foster, D.A., and Feig, L.A. (1995) Involvement of Ral GTPase in v-Src-induced phospholipase D activation. Nature 378, 409-412
-
(1995)
Nature
, vol.378
, pp. 409-412
-
-
Jiang, H.1
Luo, J.Q.2
Urano, T.3
Frankel, P.4
Lu, Z.5
Foster, D.A.6
Feig, L.A.7
-
87
-
-
13144305034
-
Functional association between Arf and RalA in active phospholipase D complex
-
Luo, J.Q., Liu, X., Frankel, P., Rotunda, T., Ramos, M., Flom, J., Jiang, H., Feig, L.A., Morris, A.J., Kahn, R.A., and Foster, D.A. (1998) Functional association between Arf and RalA in active phospholipase D complex. Proc. Natl Acad. Sci. USA. 95, 3632-3637
-
(1998)
Proc. Natl Acad. Sci. USA.
, vol.95
, pp. 3632-3637
-
-
Luo, J.Q.1
Liu, X.2
Frankel, P.3
Rotunda, T.4
Ramos, M.5
Flom, J.6
Jiang, H.7
Feig, L.A.8
Morris, A.J.9
Kahn, R.A.10
Foster, D.A.11
-
88
-
-
73349111312
-
M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex
-
Hase, K., Kimura, S., Takatsu, H., Ohmae, M., Kawano, S., Kitamura, H., Ito, M., Watarai, H., Hazelett, C.C., Yeaman, C., and Ohno, H. (2009) M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex. Nat. Cell Biol. 11, 1427-1432
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1427-1432
-
-
Hase, K.1
Kimura, S.2
Takatsu, H.3
Ohmae, M.4
Kawano, S.5
Kitamura, H.6
Ito, M.7
Watarai, H.8
Hazelett, C.C.9
Yeaman, C.10
Ohno, H.11
-
89
-
-
13244260780
-
RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity
-
Frankel, P., Aronheim, A., Kavanagh, E., Balda, M.S., Matter, K., Bunney, T.D., and Marshall, C.J. (2005) RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity. EMBO J. 24, 54-62
-
(2005)
EMBO J.
, vol.24
, pp. 54-62
-
-
Frankel, P.1
Aronheim, A.2
Kavanagh, E.3
Balda, M.S.4
Matter, K.5
Bunney, T.D.6
Marshall, C.J.7
-
90
-
-
0033514510
-
The small GTPase RalA targets filamin to induce filopodia
-
Ohta, Y., Suzuki, N., Nakamura, S., Hartwig, J.H., and Stossel, T.P. (1999) The small GTPase RalA targets filamin to induce filopodia. Proc. Natl Acad. Sci. USA. 96, 2122-2128
-
(1999)
Proc. Natl Acad. Sci. USA.
, vol.96
, pp. 2122-2128
-
-
Ohta, Y.1
Suzuki, N.2
Nakamura, S.3
Hartwig, J.H.4
Stossel, T.P.5
-
91
-
-
79954613668
-
Direct binding of RalA to PKCeta and its crucial role in morphological change during keratinocyte differentiation
-
Shirai, Y., Morioka, S., Sakuma, M., Yoshino, K., Otsuji, C., Sakai, N., Kashiwagi, K., Chida, K., Shirakawa, R., Horiuchi, H., Nishigori, C., Ueyama, T., and Saito, N. (2011) Direct binding of RalA to PKCeta and its crucial role in morphological change during keratinocyte differentiation. Mol. Biol. Cell 22, 1340-1352
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 1340-1352
-
-
Shirai, Y.1
Morioka, S.2
Sakuma, M.3
Yoshino, K.4
Otsuji, C.5
Sakai, N.6
Kashiwagi, K.7
Chida, K.8
Shirakawa, R.9
Horiuchi, H.10
Nishigori, C.11
Ueyama, T.12
Saito, N.13
-
92
-
-
11244320393
-
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
-
Essers, M.A., Weijzen, S., de Vries-Smits, A.M., Saarloos, I., de Ruiter, N.D., Bos, J.L., and Burgering, B.M. (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23, 4802-4812
-
(2004)
EMBO J.
, vol.23
, pp. 4802-4812
-
-
Essers, M.A.1
Weijzen, S.2
De Vries-Smits, A.M.3
Saarloos, I.4
De Ruiter, N.D.5
Bos, J.L.6
Burgering, B.M.7
-
93
-
-
84881228219
-
The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex
-
van den Berg, M.C., van Gogh, I.J., Smits, A.M., van Triest, M., Dansen, T.B., Visscher, M., Polderman, P.E., Vliem, M.J., Rehmann, H., and Burgering, B.M. (2013) The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex. J. Biol. Chem. 288, 21729-21741
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 21729-21741
-
-
Van Den Berg, M.C.1
Van Gogh, I.J.2
Smits, A.M.3
Van Triest, M.4
Dansen, T.B.5
Visscher, M.6
Polderman, P.E.7
Vliem, M.J.8
Rehmann, H.9
Burgering, B.M.10
-
94
-
-
0033606814
-
The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway
-
Sawamoto, K., Winge, P., Koyama, S., Hirota, Y., Yamada, C., Miyao, S., Yoshikawa, S., Jin, M.H., Kikuchi, A., and Okano, H. (1999) The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway. J. Cell Biol. 146, 361-372
-
(1999)
J. Cell Biol.
, vol.146
, pp. 361-372
-
-
Sawamoto, K.1
Winge, P.2
Koyama, S.3
Hirota, Y.4
Yamada, C.5
Miyao, S.6
Yoshikawa, S.7
Jin, M.H.8
Kikuchi, A.9
Okano, H.10
-
95
-
-
33845202483
-
The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster
-
Balakireva, M., Rosse, C., Langevin, J., Chien, Y.C., Gho, M., Gonzy-Treboul, G., Voegeling-Lemaire, S., Aresta, S., Lepesant, J.A., Bellaiche, Y., White, M., and Camonis, J. (2006) The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster. Mol. Cell. Biol. 26, 8953-8963
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 8953-8963
-
-
Balakireva, M.1
Rosse, C.2
Langevin, J.3
Chien, Y.C.4
Gho, M.5
Gonzy-Treboul, G.6
Voegeling-Lemaire, S.7
Aresta, S.8
Lepesant, J.A.9
Bellaiche, Y.10
White, M.11
Camonis, J.12
-
96
-
-
0033781565
-
Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB
-
Henry, D.O., Moskalenko, S.A., Kaur, K.J., Fu, M., Pestell, R.G., Camonis, J.H., and White, M.A. (2000) Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB. Mol. Cell. Biol. 20, 8084-8092
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 8084-8092
-
-
Henry, D.O.1
Moskalenko, S.A.2
Kaur, K.J.3
Fu, M.4
Pestell, R.G.5
Camonis, J.H.6
White, M.A.7
-
97
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante, M. and Sabatini, D.M. (2012) mTOR signaling in growth control and disease. Cell 149, 274-293
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
98
-
-
58049216316
-
RalA functions as an indispensable signal mediator for the nutrient-sensing system
-
Maehama, T., Tanaka, M., Nishina, H., Murakami, M., Kanaho, Y., and Hanada, K. (2008) RalA functions as an indispensable signal mediator for the nutrient-sensing system. J. Biol. Chem. 283, 35053-35059
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 35053-35059
-
-
Maehama, T.1
Tanaka, M.2
Nishina, H.3
Murakami, M.4
Kanaho, Y.5
Hanada, K.6
-
99
-
-
84892853050
-
Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion
-
Martin, T.D., Chen, X.W., Kaplan, R.E., Saltiel, A.R., Walker, C.L., Reiner, D.J., and Der, C.J. (2014) Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol. Cell 53, 209-220
-
(2014)
Mol. Cell
, vol.53
, pp. 209-220
-
-
Martin, T.D.1
Chen, X.W.2
Kaplan, R.E.3
Saltiel, A.R.4
Walker, C.L.5
Reiner, D.J.6
Der, C.J.7
-
100
-
-
79960387847
-
Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1)
-
Xu, L., Salloum, D., Medlin, P.S., Saqcena, M., Yellen, P., Perrella, B., and Foster, D.A. (2011) Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J. Biol. Chem. 286, 25477-25486
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 25477-25486
-
-
Xu, L.1
Salloum, D.2
Medlin, P.S.3
Saqcena, M.4
Yellen, P.5
Perrella, B.6
Foster, D.A.7
-
101
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn, W.C., Counter, C.M., Lundberg, A.S., Beijersbergen, R.L., Brooks, M.W., and Weinberg, R.A. (1999) Creation of human tumour cells with defined genetic elements. Nature 400, 464-468
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
102
-
-
0037102561
-
Distinct requirements for Ras oncogenesis in human versus mouse cells
-
Hamad, N.M., Elconin, J.H., Karnoub, A.E., Bai, W., Rich, J.N., Abraham, R.T., Der, C.J., and Counter, C.M. (2002) Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev. 16, 2045-2057
-
(2002)
Genes Dev.
, vol.16
, pp. 2045-2057
-
-
Hamad, N.M.1
Elconin, J.H.2
Karnoub, A.E.3
Bai, W.4
Rich, J.N.5
Abraham, R.T.6
Der, C.J.7
Counter, C.M.8
-
103
-
-
4344646902
-
Species-and cell type-specific requirements for cellular transformation
-
Rangarajan, A., Hong, S.J., Gifford, A., and Weinberg, R.A. (2004) Species-and cell type-specific requirements for cellular transformation. Cancer Cell 6, 171-183
-
(2004)
Cancer Cell
, vol.6
, pp. 171-183
-
-
Rangarajan, A.1
Hong, S.J.2
Gifford, A.3
Weinberg, R.A.4
-
104
-
-
20444410041
-
Activation of RalA is critical for Ras-induced tumorigenesis of human cells
-
Lim, K.H., Baines, A.T., Fiordalisi, J.J., Shipitsin, M., Feig, L.A., Cox, A.D., Der, C.J., and Counter, C.M. (2005) Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell 7, 533-545
-
(2005)
Cancer Cell
, vol.7
, pp. 533-545
-
-
Lim, K.H.1
Baines, A.T.2
Fiordalisi, J.J.3
Shipitsin, M.4
Feig, L.A.5
Cox, A.D.6
Der, C.J.7
Counter, C.M.8
-
105
-
-
78651380816
-
Activation and involvement of Ral GTPases in colorectal cancer
-
Martin, T.D., Samuel, J.C., Routh, E.D., Der, C.J., and Yeh, J.J. (2011) Activation and involvement of Ral GTPases in colorectal cancer. Cancer Res. 71, 206-215
-
(2011)
Cancer Res.
, vol.71
, pp. 206-215
-
-
Martin, T.D.1
Samuel, J.C.2
Routh, E.D.3
Der, C.J.4
Yeh, J.J.5
-
106
-
-
77951620399
-
Dissection of RAS downstream pathways in melanomagenesis: A role for Ral in transformation
-
Mishra, P.J., Ha, L., Rieker, J., Sviderskaya, E.V., Bennett, D.C., Oberst, M.D., Kelly, K., and Merlino, G. (2010) Dissection of RAS downstream pathways in melanomagenesis: A role for Ral in transformation. Oncogene 29, 2449-2456
-
(2010)
Oncogene
, vol.29
, pp. 2449-2456
-
-
Mishra, P.J.1
Ha, L.2
Rieker, J.3
Sviderskaya, E.V.4
Bennett, D.C.5
Oberst, M.D.6
Kelly, K.7
Merlino, G.8
-
107
-
-
77956171799
-
Ral activation promotes melanomagenesis
-
Zipfel, P.A., Brady, D.C., Kashatus, D.F., Ancrile, B.D., Tyler, D.S., and Counter, C.M. (2010) Ral activation promotes melanomagenesis. Oncogene 29, 4859-4864
-
(2010)
Oncogene
, vol.29
, pp. 4859-4864
-
-
Zipfel, P.A.1
Brady, D.C.2
Kashatus, D.F.3
Ancrile, B.D.4
Tyler, D.S.5
Counter, C.M.6
-
108
-
-
67650095150
-
Ral overactivation in malignant peripheral nerve sheath tumors
-
Bodempudi, V., Yamoutpoor, F., Pan, W., Dudek, A.Z., Esfandyari, T., Piedra, M., Babovick-Vuksanovic, D., Woo, R.A., Mautner, V.F., Kluwe, L., Clapp, D.W., De Vries, G.H., Thomas, S.L., Kurtz, A., Parada, L.F., and Farassati, F. (2009) Ral overactivation in malignant peripheral nerve sheath tumors. Mol. Cell. Biol. 29, 3964-3974
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 3964-3974
-
-
Bodempudi, V.1
Yamoutpoor, F.2
Pan, W.3
Dudek, A.Z.4
Esfandyari, T.5
Piedra, M.6
Babovick-Vuksanovic, D.7
Woo, R.A.8
Mautner, V.F.9
Kluwe, L.10
Clapp, D.W.11
De Vries, G.H.12
Thomas, S.L.13
Kurtz, A.14
Parada, L.F.15
Farassati, F.16
-
109
-
-
84903534965
-
RalA signaling pathway as a therapeutic target in hepatocellular carcinoma (HCC)
-
Ezzeldin, M., Borrego-Diaz, E., Taha, M., Esfandyari, T., Wise, A.L., Peng, W., Rouyanian, A., Asvadi Kermani, A., Soleimani, M., Patrad, E., Lialyte, K., Wang, K., Williamson, S., Abdulkarim, B., Olyaee, M., and Farassati, F. (2014) RalA signaling pathway as a therapeutic target in hepatocellular carcinoma (HCC). Mol. Oncol. 8, 1043-1053
-
(2014)
Mol. Oncol.
, vol.8
, pp. 1043-1053
-
-
Ezzeldin, M.1
Borrego-Diaz, E.2
Taha, M.3
Esfandyari, T.4
Wise, A.L.5
Peng, W.6
Rouyanian, A.7
Asvadi Kermani, A.8
Soleimani, M.9
Patrad, E.10
Lialyte, K.11
Wang, K.12
Williamson, S.13
Abdulkarim, B.14
Olyaee, M.15
Farassati, F.16
-
110
-
-
84907517208
-
The role of RalA in biology and therapy of ovarian cancer
-
Wang, K., Terai, K., Peng, W., Rouyanian, A., Liu, J., Roby, K.F., Wise, A.L., Ezzeldin, M., Larson, J., Woo, R.A., Lialyte, K., and Farassati, F. (2013) The role of RalA in biology and therapy of ovarian cancer. Oncotarget
-
(2013)
Oncotarget
-
-
Wang, K.1
Terai, K.2
Peng, W.3
Rouyanian, A.4
Liu, J.5
Roby, K.F.6
Wise, A.L.7
Ezzeldin, M.8
Larson, J.9
Woo, R.A.10
Lialyte, K.11
Farassati, F.12
-
111
-
-
0034899045
-
Signal pathways which promote invasion and metastasis: Critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways
-
Ward, Y., Wang, W., Woodhouse, E., Linnoila, I., Liotta, L., and Kelly, K. (2001) Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways. Mol. Cell. Biol. 21, 5958-5969
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5958-5969
-
-
Ward, Y.1
Wang, W.2
Woodhouse, E.3
Linnoila, I.4
Liotta, L.5
Kelly, K.6
-
112
-
-
35648970538
-
Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone
-
Yin, J., Pollock, C., Tracy, K., Chock, M., Martin, P., Oberst, M., and Kelly, K. (2007) Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone. Mol. Cell. Biol. 27, 7538-7550
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 7538-7550
-
-
Yin, J.1
Pollock, C.2
Tracy, K.3
Chock, M.4
Martin, P.5
Oberst, M.6
Kelly, K.7
-
113
-
-
33845448647
-
Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells
-
Lim, K.H., O'Hayer, K., Adam, S.J., Kendall, S.D., Campbell, P.M., Der, C.J., and Counter, C.M. (2006) Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr. Biol. 16, 2385-2394
-
(2006)
Curr. Biol.
, vol.16
, pp. 2385-2394
-
-
Lim, K.H.1
O'Hayer, K.2
Adam, S.J.3
Kendall, S.D.4
Campbell, P.M.5
Der, C.J.6
Counter, C.M.7
-
114
-
-
84874112967
-
Downregulation of Ral GTPaseactivating protein promotes tumor invasion and metastasis of bladder cancer
-
Saito, R., Shirakawa, R., Nishiyama, H., Kobayashi, T., Kawato, M., Kanno, T., Nishizawa, K., Matsui, Y., Ohbayashi, T., Horiguchi, M., Nakamura, T., Ikeda, T., Yamane, K., Nakayama, E., Nakamura, E., Toda, Y., Kimura, T., Kita, T., Ogawa, O., and Horiuchi, H. (2013) Downregulation of Ral GTPaseactivating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene 32, 894-902
-
(2013)
Oncogene
, vol.32
, pp. 894-902
-
-
Saito, R.1
Shirakawa, R.2
Nishiyama, H.3
Kobayashi, T.4
Kawato, M.5
Kanno, T.6
Nishizawa, K.7
Matsui, Y.8
Ohbayashi, T.9
Horiguchi, M.10
Nakamura, T.11
Ikeda, T.12
Yamane, K.13
Nakayama, E.14
Nakamura, E.15
Toda, Y.16
Kimura, T.17
Kita, T.18
Ogawa, O.19
Horiuchi, H.20
more..
-
115
-
-
77249083257
-
Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis
-
Issaq, S.H., Lim, K.H., and Counter, C.M. (2010) Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. Mol. Cancer Res. 8, 223-231
-
(2010)
Mol. Cancer Res.
, vol.8
, pp. 223-231
-
-
Issaq, S.H.1
Lim, K.H.2
Counter, C.M.3
-
116
-
-
73449083717
-
RalA-exocyst complex regulates integrindependent membrane raft exocytosis and growth signaling
-
Balasubramanian, N., Meier, J.A., Scott, D.W., Norambuena, A., White, M.A., and Schwartz, M.A. (2010) RalA-exocyst complex regulates integrindependent membrane raft exocytosis and growth signaling. Curr. Biol. 20, 75-79
-
(2010)
Curr. Biol.
, vol.20
, pp. 75-79
-
-
Balasubramanian, N.1
Meier, J.A.2
Scott, D.W.3
Norambuena, A.4
White, M.A.5
Schwartz, M.A.6
-
117
-
-
69949103110
-
The role of the exocyst in matrix metalloproteinase secretion and actin dynamics during tumor cell invadopodia formation
-
Liu, J., Yue, P., Artym, V.V., Mueller, S.C., and Guo, W. (2009) The role of the exocyst in matrix metalloproteinase secretion and actin dynamics during tumor cell invadopodia formation. Mol. Biol. Cell 20, 3763-3771
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 3763-3771
-
-
Liu, J.1
Yue, P.2
Artym, V.V.3
Mueller, S.C.4
Guo, W.5
-
118
-
-
84897950507
-
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia
-
Monteiro, P., Rosse, C., Castro-Castro, A., Irondelle, M., Lagoutte, E., Paul-Gilloteaux, P., Desnos, C., Formstecher, E., Darchen, F., Perrais, D., Gautreau, A., Hertzog, M., and Chavrier, P. (2013) Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia. J Cell Biol. 203, 1063-1079
-
(2013)
J Cell Biol.
, vol.203
, pp. 1063-1079
-
-
Monteiro, P.1
Rosse, C.2
Castro-Castro, A.3
Irondelle, M.4
Lagoutte, E.5
Paul-Gilloteaux, P.6
Desnos, C.7
Formstecher, E.8
Darchen, F.9
Perrais, D.10
Gautreau, A.11
Hertzog, M.12
Chavrier, P.13
-
119
-
-
33749165933
-
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival
-
Chien, Y., Kim, S., Bumeister, R., Loo, Y.M., Kwon, S.W., Johnson, C.L., Balakireva, M.G., Romeo, Y., Kopelovich, L., Gale, M. Jr, Yeaman, C., Camonis, J.H., Zhao, Y., and White, M.A. (2006) RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell 127, 157-170
-
(2006)
Cell
, vol.127
, pp. 157-170
-
-
Chien, Y.1
Kim, S.2
Bumeister, R.3
Loo, Y.M.4
Kwon, S.W.5
Johnson, C.L.6
Balakireva, M.G.7
Romeo, Y.8
Kopelovich, L.9
Gale, M.10
Yeaman, C.11
Camonis, J.H.12
Zhao, Y.13
White, M.A.14
-
120
-
-
78651488777
-
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly
-
Bodemann, B.O., Orvedahl, A., Cheng, T., Ram, R.R., Ou, Y.H., Formstecher, E., Maiti, M., Hazelett, C.C., Wauson, E.M., Balakireva, M., Camonis, J.H., Yeaman, C., Levine, B., and White, M.A. (2011) RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell 144, 253-267
-
(2011)
Cell
, vol.144
, pp. 253-267
-
-
Bodemann, B.O.1
Orvedahl, A.2
Cheng, T.3
Ram, R.R.4
Ou, Y.H.5
Formstecher, E.6
Maiti, M.7
Hazelett, C.C.8
Wauson, E.M.9
Balakireva, M.10
Camonis, J.H.11
Yeaman, C.12
Levine, B.13
White, M.A.14
-
121
-
-
84885183894
-
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response
-
Simicek, M., Lievens, S., Laga, M., Guzenko, D., Aushev, V.N., Kalev, P., Baietti, M.F., Strelkov, S.V., Gevaert, K., Tavernier, J., and Sablina, A.A. (2013) The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response. Nat. Cell Biol. 15, 1220-1230
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 1220-1230
-
-
Simicek, M.1
Lievens, S.2
Laga, M.3
Guzenko, D.4
Aushev, V.N.5
Kalev, P.6
Baietti, M.F.7
Strelkov, S.V.8
Gevaert, K.9
Tavernier, J.10
Sablina, A.A.11
-
122
-
-
84909952634
-
Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation
-
Tecleab, A., Zhang, X., and Sebti, S.M. (2014) Ral GTPase Down-regulation Stabilizes and Reactivates p53 to Inhibit Malignant Transformation. J. Biol. Chem. 289, 31296-31309
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 31296-31309
-
-
Tecleab, A.1
Zhang, X.2
Sebti, S.M.3
-
123
-
-
78951475020
-
P53 and its mutants in tumor cell migration and invasion
-
Muller, P.A., Vousden, K.H., and Norman, J.C. (2011) p53 and its mutants in tumor cell migration and invasion. J. Cell Biol. 192, 209-218
-
(2011)
J. Cell Biol.
, vol.192
, pp. 209-218
-
-
Muller, P.A.1
Vousden, K.H.2
Norman, J.C.3
-
124
-
-
78049370949
-
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms
-
Vigil, D., Martin, T.D., Williams, F., Yeh, J.J., Campbell, S.L., and Der, C.J. (2010) Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms. J. Biol. Chem. 285, 34729-34740
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 34729-34740
-
-
Vigil, D.1
Martin, T.D.2
Williams, F.3
Yeh, J.J.4
Campbell, S.L.5
Der, C.J.6
-
125
-
-
20444475352
-
Downregulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer
-
Chen, H., Tu, S.W., and Hsieh, J.T. (2005) Downregulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. J. Biol. Chem. 280, 22437-22444
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22437-22444
-
-
Chen, H.1
Tu, S.W.2
Hsieh, J.T.3
-
126
-
-
77749297990
-
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB
-
Min, J., Zaslavsky, A., Fedele, G., McLaughlin, S.K., Reczek, E.E., De Raedt, T., Guney, I., Strochlic, D.E., Macconaill, L.E., Beroukhim, R., Bronson, R.T., Ryeom, S., Hahn, W.C., Loda, M., and Cichowski, K. (2010) An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat. Med 16, 286-294
-
(2010)
Nat. Med
, vol.16
, pp. 286-294
-
-
Min, J.1
Zaslavsky, A.2
Fedele, G.3
McLaughlin, S.K.4
Reczek, E.E.5
De Raedt, T.6
Guney, I.7
Strochlic, D.E.8
Macconaill, L.E.9
Beroukhim, R.10
Bronson, R.T.11
Ryeom, S.12
Hahn, W.C.13
Loda, M.14
Cichowski, K.15
-
127
-
-
20144373746
-
Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening
-
Wu, J.C., Chen, T.Y., Yu, C.T., Tsai, S.J., Hsu, J.M., Tang, M.J., Chou, C.K., Lin, W.J., Yuan, C.J., and Huang, C.Y. (2005) Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J. Biol. Chem. 280, 9013-9022
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 9013-9022
-
-
Wu, J.C.1
Chen, T.Y.2
Yu, C.T.3
Tsai, S.J.4
Hsu, J.M.5
Tang, M.J.6
Chou, C.K.7
Lin, W.J.8
Yuan, C.J.9
Huang, C.Y.10
-
128
-
-
73549119929
-
Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA
-
Lim, K.H., Brady, D.C., Kashatus, D.F., Ancrile, B.B., Der, C.J., Cox, A.D., and Counter, C.M. (2010) Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol. Cell. Biol. 30, 508-523
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 508-523
-
-
Lim, K.H.1
Brady, D.C.2
Kashatus, D.F.3
Ancrile, B.B.4
Der, C.J.5
Cox, A.D.6
Counter, C.M.7
-
129
-
-
34249291096
-
The tumor suppressor PP2A Abeta regulates the RalA GTPase
-
Sablina, A.A., Chen, W., Arroyo, J.D., Corral, L., Hector, M., Bulmer, S.E., DeCaprio, J.A., and Hahn, W.C. (2007) The tumor suppressor PP2A Abeta regulates the RalA GTPase. Cell 129, 969-982
-
(2007)
Cell
, vol.129
, pp. 969-982
-
-
Sablina, A.A.1
Chen, W.2
Arroyo, J.D.3
Corral, L.4
Hector, M.5
Bulmer, S.E.6
DeCaprio, J.A.7
Hahn, W.C.8
-
130
-
-
84862084695
-
Phosphorylation by protein kinase Calpha regulates RalB small GTPase protein activation, subcellular localization, and effector utilization
-
Martin, T.D., Mitin, N., Cox, A.D., Yeh, J.J., and Der, C.J. (2012) Phosphorylation by protein kinase Calpha regulates RalB small GTPase protein activation, subcellular localization, and effector utilization. J. Biol. Chem. 287, 14827-14836
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 14827-14836
-
-
Martin, T.D.1
Mitin, N.2
Cox, A.D.3
Yeh, J.J.4
Der, C.J.5
-
131
-
-
78449292864
-
Phosphorylation of RalB is important for bladder cancer cell growth and metastasis
-
Wang, H., Owens, C., Chandra, N., Conaway, M.R., Brautigan, D.L., and Theodorescu, D. (2010) Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer Res. 70, 8760-8769
-
(2010)
Cancer Res.
, vol.70
, pp. 8760-8769
-
-
Wang, H.1
Owens, C.2
Chandra, N.3
Conaway, M.R.4
Brautigan, D.L.5
Theodorescu, D.6
-
132
-
-
84868593574
-
Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis
-
Peschard, P., McCarthy, A., Leblanc-Dominguez, V., Yeo, M., Guichard, S., Stamp, G., and Marshall, C.J. (2012) Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis. Curr. Biol. 22, 2063-2068
-
(2012)
Curr. Biol.
, vol.22
, pp. 2063-2068
-
-
Peschard, P.1
McCarthy, A.2
Leblanc-Dominguez, V.3
Yeo, M.4
Guichard, S.5
Stamp, G.6
Marshall, C.J.7
-
133
-
-
17644408725
-
RalGDS is required for tumor formation in a model of skin carcinogenesis
-
Gonzalez-Garcia, A., Pritchard, C.A., Paterson, H.F., Mavria, G., Stamp, G., and Marshall, C.J. (2005) RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell 7, 219-226
-
(2005)
Cancer Cell
, vol.7
, pp. 219-226
-
-
Gonzalez-Garcia, A.1
Pritchard, C.A.2
Paterson, H.F.3
Mavria, G.4
Stamp, G.5
Marshall, C.J.6
-
134
-
-
0030774573
-
The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner
-
Vogt, A., Sun, J., Qian, Y., Hamilton, A.D., and Sebti, S.M. (1997) The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner. J. Biol. Chem. 272, 27224-27229
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 27224-27229
-
-
Vogt, A.1
Sun, J.2
Qian, Y.3
Hamilton, A.D.4
Sebti, S.M.5
-
135
-
-
84859463451
-
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
-
Maurer, T., Garrenton, L.S., Oh, A., Pitts, K., Anderson, D.J., Skelton, N.J., Fauber, B.P., Pan, B., Malek, S., Stokoe, D., Ludlam, M.J., Bowman, K.K., Wu, J., Giannetti, A.M., Starovasnik, M.A., Mellman, I., Jackson, P.K., Rudolph, J., Wang, W., and Fang, G. (2012) Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc. Natl Acad. Sci. USA. 109, 5299-5304
-
(2012)
Proc. Natl Acad. Sci. USA.
, vol.109
, pp. 5299-5304
-
-
Maurer, T.1
Garrenton, L.S.2
Oh, A.3
Pitts, K.4
Anderson, D.J.5
Skelton, N.J.6
Fauber, B.P.7
Pan, B.8
Malek, S.9
Stokoe, D.10
Ludlam, M.J.11
Bowman, K.K.12
Wu, J.13
Giannetti, A.M.14
Starovasnik, M.A.15
Mellman, I.16
Jackson, P.K.17
Rudolph, J.18
Wang, W.19
Fang, G.20
more..
-
136
-
-
84862649997
-
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation
-
Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., and Fesik, S.W. (2012) Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew. Chem. 51, 6140-6143
-
(2012)
Angew. Chem.
, vol.51
, pp. 6140-6143
-
-
Sun, Q.1
Burke, J.P.2
Phan, J.3
Burns, M.C.4
Olejniczak, E.T.5
Waterson, A.G.6
Lee, T.7
Rossanese, O.W.8
Fesik, S.W.9
-
137
-
-
84877863454
-
In silico discovery of smallmolecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction
-
Shima, F., Yoshikawa, Y., Ye, M., Araki, M., Matsumoto, S., Liao, J., Hu, L., Sugimoto, T., Ijiri, Y., Takeda, A., Nishiyama, Y., Sato, C., Muraoka, S., Tamura, A., Osoda, T., Tsuda, K., Miyakawa, T., Fukunishi, H., Shimada, J., Kumasaka, T., Yamamoto, M., and Kataoka, T. (2013) In silico discovery of smallmolecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc. Natl Acad. Sci. USA. 110, 8182-8187
-
(2013)
Proc. Natl Acad. Sci. USA.
, vol.110
, pp. 8182-8187
-
-
Shima, F.1
Yoshikawa, Y.2
Ye, M.3
Araki, M.4
Matsumoto, S.5
Liao, J.6
Hu, L.7
Sugimoto, T.8
Ijiri, Y.9
Takeda, A.10
Nishiyama, Y.11
Sato, C.12
Muraoka, S.13
Tamura, A.14
Osoda, T.15
Tsuda, K.16
Miyakawa, T.17
Fukunishi, H.18
Shimada, J.19
Kumasaka, T.20
Yamamoto, M.21
Kataoka, T.22
more..
-
138
-
-
84888639050
-
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
-
Ostrem, J.M., Peters, U., Sos, M.L., Wells, J.A., and Shokat, K.M. (2013) K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503, 548-551
-
(2013)
Nature
, vol.503
, pp. 548-551
-
-
Ostrem, J.M.1
Peters, U.2
Sos, M.L.3
Wells, J.A.4
Shokat, K.M.5
-
139
-
-
84911479371
-
Discovery and characterization of small molecules that target the GTPase Ral
-
Yan, C., Liu, D., Li, L., Wempe, M.F., Guin, S., Khanna, M., Meier, J., Hoffman, B., Owens, C., Wysoczynski, C.L., Nitz, M.D., Knabe, W.E., Ahmed, M., Brautigan, D.L., Paschal, B.M., Schwartz, M.A., Jones, D.N., Ross, D., Meroueh, S.O., and Theodorescu, D. (2014) Discovery and characterization of small molecules that target the GTPase Ral. Nature 515, 443-447
-
(2014)
Nature
, vol.515
, pp. 443-447
-
-
Yan, C.1
Liu, D.2
Li, L.3
Wempe, M.F.4
Guin, S.5
Khanna, M.6
Meier, J.7
Hoffman, B.8
Owens, C.9
Wysoczynski, C.L.10
Nitz, M.D.11
Knabe, W.E.12
Ahmed, M.13
Brautigan, D.L.14
Paschal, B.M.15
Schwartz, M.A.16
Jones, D.N.17
Ross, D.18
Meroueh, S.O.19
Theodorescu, D.20
more..
-
140
-
-
84911918024
-
Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension
-
Yaoita, N., Shirakawa, R., Fukumoto, Y., Sugimura, K., Miyata, S., Miura, Y., Nochioka, K., Miura, M., Tatebe, S., Aoki, T., Yamamoto, S., Satoh, K., Kimura, T., Shimokawa, H., and Horiuchi, H. (2014) Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension. Arterioscler. Thromb. Vasc. Biol. 34, 2486-2494
-
(2014)
Arterioscler. Thromb. Vasc. Biol.
, vol.34
, pp. 2486-2494
-
-
Yaoita, N.1
Shirakawa, R.2
Fukumoto, Y.3
Sugimura, K.4
Miyata, S.5
Miura, Y.6
Nochioka, K.7
Miura, M.8
Tatebe, S.9
Aoki, T.10
Yamamoto, S.11
Satoh, K.12
Kimura, T.13
Shimokawa, H.14
Horiuchi, H.15
|