Discovery and characterization of small molecules that target the GTPase Ral

Nature

Volumn 515, Issue 7527, 2014, Pages 443-447

  Yan, Chao ^a   Liu, Degang ^b   Li, Liwei ^b   Wempe, Michael F ^a   Guin, Sunny ^a   Khanna, May ^b   Meier, Jeremy ^a   Hoffman, Brenton ^a   Owens, Charles ^a   Wysoczynski, Christina L ^c   Nitz, Matthew D ^d   Knabe, William E ^b   Ahmed, Mansoor ^e,f   Brautigan, David L ^d   Paschal, Bryce M ^e   Schwartz, Martin A ^e,f   Jones, David N M ^c   Ross, David ^a   Meroueh, Samy O ^b,g   Theodorescu, Dan ^a,c,h  

^a UNIVERSITY OF COLORADO   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF VIRGINIA   (United States)

^f YALE UNIVERSITY   (United States)

^g INDIANA UNIVERSITY   (United States)

^h UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; HYDROGEN; NITROGEN 15; RAS PROTEIN; ABC TRANSPORTER; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MOLECULAR LIBRARY; PROTEIN BINDING; RAL PROTEIN; RALBP1 PROTEIN, HUMAN;

CANCER; CYTOGENETICS; DRUG; GENETIC ANALYSIS; GROWTH; PROTEIN; RESEARCH WORK; TUMOR;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CANCER CELL CULTURE; CELL SPREADING; COMPUTER MODEL; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; MOUSE; NEOPLASM; NONHUMAN; PROTEIN BINDING; PROTEIN STRUCTURE; RNA INTERFERENCE; SCREENING; SURFACE PLASMON RESONANCE; TUMOR GROWTH; XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECTS; DRUG SCREENING; ENZYME SPECIFICITY; ENZYMOLOGY; FEMALE; METABOLISM; MOLECULAR LIBRARY; MOLECULARLY TARGETED THERAPY; NEOPLASMS; PATHOLOGY; PHARMACOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GTPASE-ACTIVATING PROTEINS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; NEOPLASMS; PROTEIN BINDING; RAL GTP-BINDING PROTEINS; RAS PROTEINS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84911479371     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13713     Document Type: Article

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