Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation

Molecular Biology of the Cell

Volumn 22, Issue 8, 2011, Pages 1340-1352

  Shirai, Yasuhito ^a   Morioka, Shoko ^a   Sakuma, Megumi ^a   Yoshino, Ken Ichi ^a   Otsujia, Chihiro ^a   Sakai, Norio ^b   Kashiwagi, Kaori ^a   Chida, Kazuhiro ^c   Shirakawa, Ryutaro ^d   Horiuchi, Hisanori ^d   Nishigori, Chikako ^a   Ueyama, Takehiko ^a   Saito, Naoaki ^a  

^a KOBE UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CALCIUM; CHOLESTEROL SULFATE; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE C ETA; RALA PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; DEPOLYMERIZATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN POLYMERIZATION;

ACTINS; ADENOVIRIDAE; BINDING SITES; CALCIUM; CELL DIFFERENTIATION; CELL SHAPE; CHOLESTEROL ESTERS; ENZYME ACTIVATION; EPIDERMIS; ESCHERICHIA COLI; GENE EXPRESSION; GENE SILENCING; HEK293 CELLS; HUMANS; KERATINOCYTES; MUTATION; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; RAL GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 79954613668     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-09-0754     Document Type: Article

References (45)

1. Arimura N, Kaibuchi K (2008). Key regulators in neuronal polarity. Neuron 48, 881-884. (Pubitemid 41814693)
2. Benitah SA, Frye M, Glogauer M, Watt FM (2005). Stem cell depletion through epidermal deletion of Rac1. Science 309, 933-935. (Pubitemid 41099929)
3. Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dorbransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SSG (2002). β-Arrestins regulate a Ral-GDS-Ral effector pathway that mediates cytoskeletal reorganization. Nat Cell Biol 4, 547-555.
4. Cammonis JH, White MA (2005). Ral GTPases: Corrupting the exocyst in cancer cells. Trends Cell Biol 15, 327-332. (Pubitemid 40805329)
5. Cantor SB, Urano T, Feig L (1995). Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. Mol Cell Biol 15, 4578-4584.
6. Ceriani M, Scandiuzzi C, Amigoni L, Tisi R, Berruti G, Martegani E (2007). Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for Ral A GTPase. Exp Cell Res 313, 2293-2307. (Pubitemid 46891467)
7. Colon-Gonzalez F, Kazanietz MG (2006). C1 domains exposed: From diacylglycerol binding to protein-protein interactions. Biochem Biophys Acta 1761, 827-837. (Pubitemid 44404081)
8. Denning MF (2004). Epidermal keratinocytes: Regulation of multiple cell phenotypes by multiple protein kinase C isoforms. Int J Biochem Cell Biol 36, 1141-1146. (Pubitemid 38515654)
9. Denning MF, Kazanietz M, Blumberg P, Yaspa H (1995). Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes. Cell Growth Differ 6, 1619-1626.
10. Dlugosz AA, Yaspa SH (1994). Protein kinase C regulates keratinocytes transglutaminase (TGk) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by calcium. J Invest Dermatol 102, 409-414. (Pubitemid 24117177)
11. Feig LA (2003). Ral-GTPases: Approaching their 15 minutes of fame. Trends Cell Biol 13, 419-425. (Pubitemid 36897646)
12. Feig LA, Urano T, Cantor S (1996). Evidence for a Ras/Ral signaling cascade. Trends Biochem Sci 21, 438-450.
13. Fuchs E (1990). Epidermal differentiation: The bare essentials. J Cell Biol 111, 2807-2814. (Pubitemid 120034022)
14. Ikuta T, Chida K, Tajima O, Matsuura Y, Iwamori M, Ueda Y, Mizuno K, Ohno S, Kuroki T (1994). Cholesterol sulfate, a novel activator for the η isoform of protein kinase C. Cell Growth Differ 5, 943-947. (Pubitemid 24275108)
15. Jenkins GM, Frohman MA (2005). Phospholipase D: A lipid centric review. Cell Mol Life Sci 62, 2305-2316. (Pubitemid 41500546)
16. Jjung EM, Betancourt-Calle S, Mann-Blakeney R, Griner RD, Bollag WB (1998). A potential role for ceramide in the regulation of mouse epidermal keratinocyte proliferation and differentiation. J Invest Dermatol 110, 318-323. (Pubitemid 28158643)
17. Jjung EM, Betancourt-Calle S, Mann-Blakeney R, Griner RD, Bollag WB (1999). Sustained phospholipase D activation is associated with keratinocyte differentiation. Carcinogenesis 20, 569-576. (Pubitemid 29151291)
18. Kagehara M, Tachi M, Harii K, Iwamori M (1994). Programmed expression of cholesterol sulfotransferase and transglutaminase during epidermal differentiation of murine skin development. Biochem Biophys Acta 1215, 183-189. (Pubitemid 24345073)
19. Kashiwagi M, Ohba M, Chida K, Kuroki T (2002). Protein kinase Cη (PKCη): Its involvement in keratinocyte differentiation. J Biochem 132, 853-857. (Pubitemid 36090650)
20. Kawato M, Shirakawa R, Kondo H, Higashi T, Ikedaq T, Okawa K, Fukai S, Nureki O, Kita T, Horiuchi H (2008). Regulation of platelet dense granule secretion by Ral GTPase-exocyst pathway. J Biol Chem 283, 166-174.
21. Koster MI, Roop DR (2007). Mechanism regulating epithelial stratification. Annu Rev Cell Biol 23, 93-113.
22. Lalli G, Hall A (2005). Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex. J Cell Biol 171, 857-869. (Pubitemid 41746587)
23. Lingm M, Troller U, Zeidman R, Stensman H, Schultz A, Larssonm C (2005). Identification of conserved amino acids N-terminal of the PKCeC1b domain crucial for protein kinase Ce-mediated induction of neurite outgrowth. J Cell Biol 280, 17910-17919. (Pubitemid 41389032)
24. Narumiya S (1996). The small GTPase Rho: Cellular functions and signal transduction. J Biochem 120, 215-228. (Pubitemid 26335910)
25. Newton AC (2006). The ins and outs of protein kinase C. In: Methods in Molecular Biology (vol. 233), ed. AC Newton, Totowa, NJ: Humana Press, 3-7.
26. Nikolove E, Mitev V, Minner F, Deroanne CF, Poumay Y (2008). The inhibition of the expression of the small Rho GTPase Rac 1 induces differentiation with no effect on cell proliferation in growing human adult keratinocytes. J Cell Biochem 103, 857-864. (Pubitemid 351240621)
27. Nishizuka Y (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614.
28. Ohba M, Ishino K, Kashiwagi M, Kawanabe S, Chida K, Hou NH, Kuroki T (1998). Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the η and d isoforms of protein kinase C. Mol Cell Biol 18, 5199-5207. (Pubitemid 28388103)
29. Ohta Y, Suzuki N, Nakamura S, Hartwig JH, Stossel TP (1999). The small GTPase Ral A targets filamin to induce filopodia. Proc Natl Acad Sci USA 96, 2122-2128.
30. Osada S, Mizuno K, Saido TC, Akita Y, Suzuki K, Kuroki T, Ohno S (1990). A phorbol ester receptor/protein kinase, nPKCη, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem 265, 22434-22440. (Pubitemid 120014319)
31. 2+-independent isoform of protein kinase C in epithelial tissues, in association with epithelial differentiation. Cell Growth Differ 4, 167-175.
32. Rebhum JF (2000). Identification and characterization of a new family of guanine nucleotide exchange factors of the Ras-related GTPase Ral. J Biol Chem 275, 13406-13410.
33. Shirai Y, Kashiwagi K, Yagi K, Sakai N, Saito N (1998). Distinct effects of fatty acids on translocation of g- and e-subspecies of protein kinase C. J Cell Biol 143, 511-521. (Pubitemid 28487867)
34. Shirai Y, Murakami T, Kuramasu M, Iijima L, Saito N (2007). A novel PIP2 biding of ePKC and its contribution to the neurite induction ability. J Neurochem 102, 1635-1644. (Pubitemid 47256206)
35. Stephens L, Milne L, Hawkins P (2008). Moving towards a better understanding of chemotaxis. Curr Biol 18, R485-R494. (Pubitemid 351734644)
36. Sugihira K, Asano S, Tanaka K, Iwamatsu A, Okawa K, Ohta Y (2001). The exocyst complex binds the small GTPase Ral A to mediate filopodia formation. Nat Cell Biol 4, 73-78. (Pubitemid 34071983)
37. Takai Y, Sasaki T, Matozaki T (2001). Small GTP-binding proteins. Physiol Rev 81, 153-208. (Pubitemid 32098004)
38. Tojima T, Ito E (2004). Signal transduction cascades underlying de novo protein synthesis required for neural morphogenesis in differentiating neurons. Prog Neurobiol 72, 183-193. (Pubitemid 38591295)
39. Tscharntke M et al. (2007). Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1. J Cell Sci 120, 1480-1490. (Pubitemid 46780040)
40. Ueda E, Ohno S, Kuroki T, Livneh E, Yamada K, Yamanishi K, Yasuno H (1996). The η isoform of protein kinase C mediates transcriptional activation of the human transglutaminase 1 gene. J Biol Chem 271, 9790-9794. (Pubitemid 26137391)
41. van Dam EM, Robinson PJ (2006). Ral: Mediator of membrane trafficking. Int J Biochem Cell Biol 38, 1841-1847. (Pubitemid 44425246)
42. Wiesmann C, de Vos AM (2001). Nerve growth factor: Structure and function. Cell Mol Life Sci 58, 748-759. (Pubitemid 32553032)
43. Yamaguchi Y, Shirai Y, Matsubara T, Sanse K, Kuriyama M, Oshiro N, Yoshino K, Yonezawa K, Ono Y, Saito N (2006). Phosphorylation and up-regulation of diacylglycerol kinaseγ via its interaction with protein kinase Cγ. J Biol Chem 182, 73613-72613.
44. Zeidman R, Lofgren B, Pahlman S, Larsson C (1999). PKCe, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells. J Cell Biol 145, 713-726. (Pubitemid 29240850)
45. Zeidman R, Troller U, Raghunath A, Pahlman S, Larsson C (2002). Protein kinase C ε actin-binding site is important for neurite outgrowth during neuronal differentiation. Mol Biol Cell 13, 12-24. (Pubitemid 34106055)